{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:33:40Z","timestamp":1781562820468,"version":"3.54.5"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Cell"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1007\/s13238-013-2115-0","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T18:20:37Z","timestamp":1363112437000},"page":"186-196","source":"Crossref","is-referenced-by-count":26,"title":["Molecular mechanisms for survival regulation of chronic myeloid leukemia stem cells"],"prefix":"10.1093","volume":"4","author":[{"given":"Haojian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,13]]},"reference":[{"key":"2115_CR1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nchembio760","volume":"2","author":"FJ Adrian","year":"2006","unstructured":"Adrian, F.J., Ding, Q., Sim, T., Velentza, A., Sloan, C., Liu, Y., Zhang, G., Hur, W., Ding, S., Manley, P., et al. (2006). Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat Chem Biol 2, 95\u2013102.","journal-title":"Nat Chem Biol"},{"key":"2115_CR2","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","volume":"100","author":"M Al-Hajj","year":"2003","unstructured":"Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J., and Clarke, M.F. (2003). Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100, 3983\u20133988.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2115_CR3","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1182\/blood-2002-09-2780","volume":"101","author":"R Bhatia","year":"2003","unstructured":"Bhatia, R., Holtz, M., Niu, N., Gray, R., Snyder, D.S., Sawyers, C.L., Arber, D.A., Slovak, M.L., and Forman, S.J. (2003). Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 101, 4701\u20134707.","journal-title":"Blood"},{"key":"2115_CR4","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","volume":"3","author":"D Bonnet","year":"1997","unstructured":"Bonnet, D., and Dick, J.E. (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3, 730\u2013737.","journal-title":"Nat Med"},{"key":"2115_CR5","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ccr.2011.03.003","volume":"19","author":"WW Chan","year":"2011","unstructured":"Chan, W.W., Wise, S.C., Kaufman, M.D., Ahn, Y.M., Ensinger, C.L., Haack, T., Hood, M.M., Jones, J., Lord, J.W., Lu, W.P., et al. (2011). Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell 19, 556\u2013568.","journal-title":"Cancer Cell"},{"key":"2115_CR6","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/ng.389","volume":"41","author":"Y Chen","year":"2009","unstructured":"Chen, Y., Hu, Y., Zhang, H., Peng, C., and Li, S. (2009). Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet 41, 783\u2013792.","journal-title":"Nat Genet"},{"key":"2115_CR7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s13238-010-0016-z","volume":"1","author":"Y Chen","year":"2010","unstructured":"Chen, Y., Peng, C., Li, D., and Li, S. (2010a). Molecular and cellular bases of chronic myeloid leukemia. Protein Cell 1, 124\u2013132.","journal-title":"Protein Cell"},{"key":"2115_CR8","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/leu.2010.143","volume":"24","author":"Y Chen","year":"2010","unstructured":"Chen, Y., Peng, C., Sullivan, C., Li, D., and Li, S. (2010b). Critical molecular pathways in cancer stem cells of chronic myeloid leukemia. Leukemia 24, 1545\u20131554.","journal-title":"Leukemia"},{"key":"2115_CR9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1172\/JCI35721","volume":"121","author":"AS Corbin","year":"2011","unstructured":"Corbin, A.S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M.W., and Druker, B.J. (2011). Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J Clin Invest 121, 396\u2013409.","journal-title":"J Clin Invest"},{"key":"2115_CR10","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1182\/blood-2004-04-1335","volume":"104","author":"J Cortes","year":"2004","unstructured":"Cortes, J., O\u2019Brien, S., and Kantarjian, H. (2004). Discontinuation of imatinib therapy after achieving a molecular response. Blood 104, 2204\u20132205.","journal-title":"Blood"},{"key":"2115_CR11","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1182\/blood-2006-09-046888","volume":"109","author":"J Cortes","year":"2007","unstructured":"Cortes, J., Rousselot, P., Kim, D.W., Ritchie, E., Hamerschlak, N., Coutre, S., Hochhaus, A., Guilhot, F., Saglio, G., Apperley, J., et al. (2007). Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood 109, 3207\u20133213.","journal-title":"Blood"},{"key":"2115_CR12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nature08617","volume":"462","author":"L Dang","year":"2009","unstructured":"Dang, L., White, D.W., Gross, S., Bennett, B.D., Bittinger, M.A., Driggers, E.M., Fantin, V.R., Jang, H.G., Jin, S., Keenan, M.C., et al. (2009). Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739\u2013744.","journal-title":"Nature"},{"key":"2115_CR13","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ccr.2008.08.003","volume":"14","author":"C Dierks","year":"2008","unstructured":"Dierks, C., Beigi, R., Guo, G.R., Zirlik, K., Stegert, M.R., Manley, P., Trussell, C., Schmitt-Graeff, A., Landwerlin, K., Veelken, H., et al. (2008). Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 14, 238\u2013249.","journal-title":"Cancer Cell"},{"key":"2115_CR14","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1182\/blood.V101.2.690","volume":"101","author":"NJ Donato","year":"2003","unstructured":"Donato, N.J., Wu, J.Y., Stapley, J., Gallick, G., Lin, H., Arlinghaus, R., and Talpaz, M. (2003). BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 101, 690\u2013698.","journal-title":"Blood"},{"key":"2115_CR15","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa062867","volume":"355","author":"BJ Druker","year":"2006","unstructured":"Druker, B.J., Guilhot, F., O\u2019Brien, S.G., Gathmann, I., Kantarjian, H., Gattermann, N., Deininger, M.W., Silver, R.T., Goldman, J.M., Stone, R.M., et al. (2006). Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 355, 2408\u20132417.","journal-title":"N Engl J Med"},{"key":"2115_CR16","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJM200104053441402","volume":"344","author":"BJ Druker","year":"2001","unstructured":"Druker, B.J., Sawyers, C.L., Kantarjian, H., Resta, D.J., Reese, S.F., Ford, J.M., Capdeville, R., and Talpaz, M. (2001a). Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 344, 1038\u20131042.","journal-title":"N Engl J Med"},{"key":"2115_CR17","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","volume":"344","author":"BJ Druker","year":"2001","unstructured":"Druker, B.J., Talpaz, M., Resta, D.J., Peng, B., Buchdunger, E., Ford, J.M., Lydon, N.B., Kantarjian, H., Capdeville, R., Ohno-Jones, S., et al. (2001b). Efficacy and safety of a specific inhibitor of the BCRABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344, 1031\u20131037.","journal-title":"N Engl J Med"},{"key":"2115_CR18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm0596-561","volume":"2","author":"BJ Druker","year":"1996","unstructured":"Druker, B.J., Tamura, S., Buchdunger, E., Ohno, S., Segal, G.M., Fanning, S., Zimmermann, J., and Lydon, N.B. (1996). Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 2, 561\u2013566.","journal-title":"Nat Med"},{"key":"2115_CR19","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature09883","volume":"473","author":"C Duy","year":"2011","unstructured":"Duy, C., Hurtz, C., Shojaee, S., Cerchietti, L., Geng, H., Swaminathan, S., Klemm, L., Kweon, S.M., Nahar, R., Braig, M., et al. (2011). BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature 473, 384\u2013388.","journal-title":"Nature"},{"key":"2115_CR20","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1084\/jem.20091299","volume":"207","author":"C Duy","year":"2010","unstructured":"Duy, C., Yu, J.J., Nahar, R., Swaminathan, S., Kweon, S.M., Polo, J.M., Valls, E., Klemm, L., Shojaee, S., Cerchietti, L., et al. (2010). BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med 207, 1209\u20131221.","journal-title":"J Exp Med"},{"key":"2115_CR21","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1093\/carcin\/23.11.1933","volume":"23","author":"FS Falvella","year":"2002","unstructured":"Falvella, F.S., Pascale, R.M., Gariboldi, M., Manenti, G., De Miglio, M.R., Simile, M.M., Dragani, T.A., and Feo, F. (2002). Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Carcinogenesis 23, 1933\u20131936.","journal-title":"Carcinogenesis"},{"key":"2115_CR22","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.2337\/db06-1142","volume":"56","author":"JB Flowers","year":"2007","unstructured":"Flowers, J.B., Rabaglia, M.E., Schueler, K.L., Flowers, M.T., Lan, H., Keller, M.P., Ntambi, J.M., and Attie, A.D. (2007). Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56, 1228\u20131239.","journal-title":"Diabetes"},{"key":"2115_CR23","first-page":"1724","volume":"10","author":"DA Frank","year":"1996","unstructured":"Frank, D.A., and Varticovski, L. (1996). BCR\/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia 10, 1724\u20131730.","journal-title":"Leukemia"},{"key":"2115_CR24","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.1189992","volume":"329","author":"AS Goldstein","year":"2010","unstructured":"Goldstein, A.S., Huang, J., Guo, C., Garraway, I.P., and Witte, O.N. (2010). Identification of a cell of origin for human prostate cancer. Science 329, 568\u2013571.","journal-title":"Science"},{"key":"2115_CR25","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1182\/blood-2002-05-1361","volume":"100","author":"ME Gorre","year":"2002","unstructured":"Gorre, M.E., Ellwood-Yen, K., Chiosis, G., Rosen, N., and Sawyers, C.L. (2002). BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood 100, 3041\u20133044.","journal-title":"Blood"},{"key":"2115_CR26","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.1062538","volume":"293","author":"ME Gorre","year":"2001","unstructured":"Gorre, M.E., Mohammed, M., Ellwood, K., Hsu, N., Paquette, R., Rao, P.N., and Sawyers, C.L. (2001). Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293, 876\u2013880.","journal-title":"Science"},{"key":"2115_CR27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood.V99.1.319","volume":"99","author":"SM Graham","year":"2002","unstructured":"Graham, S.M., Jorgensen, H.G., Allan, E., Pearson, C., Alcorn, M.J., Richmond, L., and Holyoake, T.L. (2002). Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 99, 319\u2013325.","journal-title":"Blood"},{"key":"2115_CR28","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1182\/blood-2006-09-046839","volume":"109","author":"F Guilhot","year":"2007","unstructured":"Guilhot, F., Apperley, J., Kim, D.W., Bullorsky, E.O., Baccarani, M., Roboz, G.J., Amadori, S., de Souza, C.A., Lipton, J.H., Hochhaus, A., et al. (2007). Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase. Blood 109, 4143\u20134150.","journal-title":"Blood"},{"key":"2115_CR29","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1182\/blood-2010-12-326843","volume":"119","author":"A Hamilton","year":"2012","unstructured":"Hamilton, A., Helgason, G., Schemionek, M., Zhang, B., Myssina, S., Allan, E.K., Nicolini, F.E., M\u00fcller-Tidow, C., Bhatia, R., Brunton, V.G., et al. (2012). Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood 119, 1501\u20131510.","journal-title":"Blood"},{"key":"2115_CR30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1074-7613(01)00208-4","volume":"15","author":"KW Harder","year":"2001","unstructured":"Harder, K.W., Parsons, L.M., Armes, J., Evans, N., Kountouri, N., Clark, R., Quilici, C., Grail, D., Hodgson, G.S., Dunn, A.R., et al. (2001). Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity 15, 603\u2013615.","journal-title":"Immunity"},{"key":"2115_CR31","doi-asserted-by":"crossref","first-page":"e11394","DOI":"10.1371\/journal.pone.0011394","volume":"5","author":"D Hess","year":"2010","unstructured":"Hess, D., Chisholm, J.W., and Igal, R.A. (2010). Inhibition of stearoyl-CoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One 5, e11394.","journal-title":"PLoS One"},{"key":"2115_CR32","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1182\/blood-2006-09-047266","volume":"109","author":"A Hochhaus","year":"2007","unstructured":"Hochhaus, A., Kantarjian, H.M., Baccarani, M., Lipton, J.H., Apperley, J.F., Druker, B.J., Facon, T., Goldberg, S.L., Cervantes, F., Niederwieser, D., et al. (2007). Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 109, 2303\u20132309.","journal-title":"Blood"},{"key":"2115_CR33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ng1343","volume":"36","author":"Y Hu","year":"2004","unstructured":"Hu, Y., Liu, Y., Pelletier, S., Buchdunger, E., Warmuth, M., Fabbro, D., Hallek, M., Van Etten, R.A., and Li, S. (2004). Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet 36, 453\u2013461.","journal-title":"Nat Genet"},{"key":"2115_CR34","doi-asserted-by":"crossref","first-page":"16870","DOI":"10.1073\/pnas.0606509103","volume":"103","author":"Y Hu","year":"2006","unstructured":"Hu, Y., Swerdlow, S., Duffy, T.M., Weinmann, R., Lee, F.Y., and Li, S. (2006). Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci U S A 103, 16870\u201316875.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2115_CR35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrc1592","volume":"5","author":"BJ Huntly","year":"2005","unstructured":"Huntly, B.J., and Gilliland, D.G. (2005). Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer 5, 311\u2013321.","journal-title":"Nat Rev Cancer"},{"key":"2115_CR36","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ccr.2004.10.015","volume":"6","author":"BJ Huntly","year":"2004","unstructured":"Huntly, B.J., Shigematsu, H., Deguchi, K., Lee, B.H., Mizuno, S., Duclos, N., Rowan, R., Amaral, S., Curley, D., Williams, I.R., et al. (2004). MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 6, 587\u2013596.","journal-title":"Cancer Cell"},{"key":"2115_CR37","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1084\/jem.20110304","volume":"208","author":"C Hurtz","year":"2011","unstructured":"Hurtz, C., Hatzi, K., Cerchietti, L., Braig, M., Park, E., Kim, Y.M., Herzog, S., Ramezani-Rad, P., Jumaa, H., Muller, M.C., et al. (2011). BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med 208, 2163\u20132174.","journal-title":"J Exp Med"},{"key":"2115_CR38","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.2882","volume":"18","author":"K Ito","year":"2012","unstructured":"Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D.E., Schafer, Z.T., Evans, R.M., Suda, T., Lee, C.H., et al. (2012). A PML-PPARdelta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med 18, 1350\u20131358.","journal-title":"Nat Med"},{"key":"2115_CR39","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1056\/NEJMoa055104","volume":"354","author":"H Kantarjian","year":"2006","unstructured":"Kantarjian, H., Giles, F., Wunderle, L., Bhalla, K., O\u2019Brien, S., Wassmann, B., Tanaka, C., Manley, P., Rae, P., Mietlowski, W., et al. (2006). Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 354, 2542\u20132551.","journal-title":"N Engl J Med"},{"key":"2115_CR40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.cell.2007.04.019","volume":"129","author":"B Keith","year":"2007","unstructured":"Keith, B., and Simon, M.C. (2007). Hypoxia-inducible factors, stem cells, and cancer. Cell 129, 465\u2013472.","journal-title":"Cell"},{"key":"2115_CR41","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2005.03.032","volume":"121","author":"CF Kim","year":"2005","unstructured":"Kim, C.F., Jackson, E.L., Woolfenden, A.E., Lawrence, S., Babar, I., Vogel, S., Crowley, D., Bronson, R.T., and Jacks, T. (2005). Identi-fication of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121, 823\u2013835.","journal-title":"Cell"},{"key":"2115_CR42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/bbrc.1999.1704","volume":"266","author":"YC Kim","year":"1999","unstructured":"Kim, Y.C., and Ntambi, J.M. (1999). Regulation of stearoyl-CoA de saturase genes: role in cellular metabolism and preadipocyte differentiation. Biochem Biophys Res Commun 266, 1\u20134.","journal-title":"Biochem Biophys Res Commun"},{"key":"2115_CR43","doi-asserted-by":"crossref","first-page":"5012","DOI":"10.1182\/blood-2009-09-243139","volume":"115","author":"M Kinder","year":"2010","unstructured":"Kinder, M., Wei, C., Shelat, S.G., Kundu, M., Zhao, L., Blair, I.A., and Pure, E. (2010). Hematopoietic stem cell function requires 12\/15-lipoxygenase-dependent fatty acid metabolism. Blood 115, 5012\u20135022.","journal-title":"Blood"},{"key":"2115_CR44","doi-asserted-by":"crossref","first-page":"9624","DOI":"10.1158\/0008-5472.CAN-08-1131","volume":"68","author":"H Konig","year":"2008","unstructured":"Konig, H., Copland, M., Chu, S., Jove, R., Holyoake, T.L., and Bhatia, R. (2008). Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells. Cancer Res 68, 9624\u20139633.","journal-title":"Cancer Res"},{"key":"2115_CR45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nature01572","volume":"423","author":"J Lessard","year":"2003","unstructured":"Lessard, J., and Sauvageau, G. (2003). Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423, 255\u2013260.","journal-title":"Nature"},{"key":"2115_CR46","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1158\/0008-5472.CAN-06-2030","volume":"67","author":"C Li","year":"2007","unstructured":"Li, C., Heidt, D.G., Dalerba, P., Burant, C.F., Zhang, L., Adsay, V., Wicha, M., Clarke, M.F., and Simeone, D.M. (2007). Identification of pancreatic cancer stem cells. Cancer Res 67, 1030\u20131037.","journal-title":"Cancer Res"},{"key":"2115_CR47","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1021\/jm049486a","volume":"47","author":"LJ Lombardo","year":"2004","unstructured":"Lombardo, L.J., Lee, F.Y., Chen, P., Norris, D., Barrish, J.C., Behnia, K., Castaneda, S., Cornelius, L.A., Das, J., Doweyko, A.M., et al. (2004). Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src\/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 47, 6658\u20136661.","journal-title":"J Med Chem"},{"key":"2115_CR48","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1182\/blood-2002-01-0109","volume":"100","author":"M Mayerhofer","year":"2002","unstructured":"Mayerhofer, M., Valent, P., Sperr, W.R., Griffin, J.D., and Sillaber, C. (2002). BCR\/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood 100, 3767\u20133775.","journal-title":"Blood"},{"key":"2115_CR49","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrc2147","volume":"7","author":"JV Melo","year":"2007","unstructured":"Melo, J.V., and Barnes, D.J. (2007). Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer 7, 441\u2013453.","journal-title":"Nat Rev Cancer"},{"key":"2115_CR50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1476-4598-9-133","volume":"9","author":"O Mendez","year":"2010","unstructured":"Mendez, O., Zavadil, J., Esencay, M., Lukyanov, Y., Santovasi, D., Wang, S.C., Newcomb, E.W., and Zagzag, D. (2010). Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres. Mol Cancer 9, 133.","journal-title":"Mol Cancer"},{"key":"2115_CR51","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1084\/jem.185.9.1661","volume":"185","author":"F Meng","year":"1997","unstructured":"Meng, F., and Lowell, C.A. (1997). Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med 185, 1661\u20131670.","journal-title":"J Exp Med"},{"key":"2115_CR52","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nature08734","volume":"463","author":"K Naka","year":"2010","unstructured":"Naka, K., Hoshii, T., Muraguchi, T., Tadokoro, Y., Ooshio, T., Kondo, Y., Nakao, S., Motoyama, N., and Hirao, A. (2010). TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 463, 676\u2013680.","journal-title":"Nature"},{"key":"2115_CR53","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1128\/MCB.20.4.1179-1186.2000","volume":"20","author":"MS Neshat","year":"2000","unstructured":"Neshat, M.S., Raitano, A.B., Wang, H.G., Reed, J.C., and Sawyers, C.L. (2000). The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf. Mol Cell Biol 20, 1179\u20131186.","journal-title":"Mol Cell Biol"},{"key":"2115_CR54","first-page":"1497","volume":"132","author":"PC Nowell","year":"1960","unstructured":"Nowell P.C., and Hungerford, H.D. (1960). A minute chromosome in human chronic granulocytic leukemia. Science 132, 1497.","journal-title":"Science"},{"key":"2115_CR55","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00041433-200306000-00005","volume":"14","author":"JM Ntambi","year":"2003","unstructured":"Ntambi, J.M., and Miyazaki, M. (2003). Recent insights into stearoyl-CoA desaturase-1. Curr Opin Lipidol 14, 255\u2013261.","journal-title":"Curr Opin Lipidol"},{"key":"2115_CR56","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1182\/blood-2007-03-066936","volume":"110","author":"T O\u2019Hare","year":"2007","unstructured":"O\u2019Hare, T., Eide, C.A., and Deininger, M.W. (2007). Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood 110, 2242\u20132249.","journal-title":"Blood"},{"key":"2115_CR57","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1182\/blood-2007-02-073528","volume":"110","author":"O Ottmann","year":"2007","unstructured":"Ottmann, O., Dombret, H., Martinelli, G., Simonsson, B., Guilhot, F., Larson, R.A., Rege-Cambrin, G., Radich, J., Hochhaus, A., Apanovitch, A.M., et al. (2007). Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 110, 2309\u20132315.","journal-title":"Blood"},{"key":"2115_CR58","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature01587","volume":"423","author":"IK Park","year":"2003","unstructured":"Park, I.K., Qian, D., Kiel, M., Becker, M.W., Pihalja, M., Weissman, I.L., Morrison, S.J., and Clarke, M.F. (2003). Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423, 302\u2013305.","journal-title":"Nature"},{"key":"2115_CR59","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1182\/blood-2009-06-228130","volume":"115","author":"C Peng","year":"2010","unstructured":"Peng, C., Chen, Y., Yang, Z., Zhang, H., Osterby, L., Rosmarin, A.G., and Li, S. (2010). PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice. Blood 115, 626\u2013635.","journal-title":"Blood"},{"key":"2115_CR60","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nature03147","volume":"432","author":"RT Phan","year":"2004","unstructured":"Phan, R.T., and Dalla-Favera, R. (2004). The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432, 635\u2013639.","journal-title":"Nature"},{"key":"2115_CR61","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/sj.leu.2403928","volume":"19","author":"RG Piazza","year":"2005","unstructured":"Piazza, R.G., Magistroni, V., Andreoni, F., Franceschino, A., Tornaghi, L., Varella-Garcia, M., Bungaro, S., Colnaghi, F., Corneo, G., Pogliani, E.M., et al. (2005). Imatinib dose increase up to 1200 mg daily can induce new durable complete cytogenetic remissions in relapsed Ph+ chronic myeloid leukemia patients. Leukemia 19, 1985\u20131987.","journal-title":"Leukemia"},{"key":"2115_CR62","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/j.1460-2075.1994.tb06319.x","volume":"13","author":"L Puil","year":"1994","unstructured":"Puil, L., Liu, J., Gish, G., Mbamalu, G., Bowtell, D., Pelicci, P.G., Arlinghaus, R., and Pawson, T. (1994). Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J 13, 764\u2013773.","journal-title":"EMBO J"},{"key":"2115_CR63","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrd2324","volume":"6","author":"A Quintas-Cardama","year":"2007","unstructured":"Quintas-Cardama, A., Kantarjian, H., and Cortes, J. (2007). Flying under the radar: the new wave of BCR-ABL inhibitors. Nat Rev Drug Discov 6, 834\u2013848.","journal-title":"Nat Rev Drug Discov"},{"key":"2115_CR64","doi-asserted-by":"crossref","first-page":"11110","DOI":"10.1073\/pnas.1934571100","volume":"100","author":"SM Rahman","year":"2003","unstructured":"Rahman, S.M., Dobrzyn, A., Dobrzyn, P., Lee, S.H., Miyazaki, M., and Ntambi, J.M. (2003). Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates proteintyrosine phosphatase 1B in muscle. Proc Natl Acad Sci U S A 100, 11110\u201311115.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2115_CR65","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nrc1567","volume":"5","author":"R Ren","year":"2005","unstructured":"Ren, R. (2005). Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer 5, 172\u2013183.","journal-title":"Nat Rev Cancer"},{"key":"2115_CR66","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","volume":"414","author":"T Reya","year":"2001","unstructured":"Reya, T., Morrison, S.J., Clarke, M.F., and Weissman, I.L. (2001). Stem cells, cancer, and cancer stem cells. Nature 414, 105\u2013111.","journal-title":"Nature"},{"key":"2115_CR67","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ccr.2011.10.012","volume":"20","author":"D Reynaud","year":"2011","unstructured":"Reynaud, D., Pietras, E., Barry-Holson, K., Mir, A., Binnewies, M., Jeanne, M., Sala-Torra, O., Radich, J.P., and Passegue, E. (2011). IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell 20, 661\u2013673.","journal-title":"Cancer Cell"},{"key":"2115_CR68","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature05384","volume":"445","author":"L Ricci-Vitiani","year":"2007","unstructured":"Ricci-Vitiani, L., Lombardi, D.G., Pilozzi, E., Biffoni, M., Todaro, M., Peschle, C., and De Maria, R. (2007). Identification and expansion of human colon-cancer-initiating cells. Nature 445, 111\u2013115.","journal-title":"Nature"},{"key":"2115_CR69","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/ni893","volume":"4","author":"K Saijo","year":"2003","unstructured":"Saijo, K., Schmedt, C., Su, I.H., Karasuyama, H., Lowell, C.A., Reth, M., Adachi, T., Patke, A., Santana, A., and Tarakhovsky, A. (2003). Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol 4, 274\u2013279.","journal-title":"Nat Immunol"},{"key":"2115_CR70","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1749-6632.2011.06303.x","volume":"1243","author":"H Sampath","year":"2011","unstructured":"Sampath, H., and Ntambi, J.M. (2011). The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation. Ann N Y Acad Sci 1243, 47\u201353.","journal-title":"Ann N Y Acad Sci"},{"key":"2115_CR71","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrc2368","volume":"8","author":"M Savona","year":"2008","unstructured":"Savona, M., and Talpaz, M. (2008). Getting to the stem of chronic myeloid leukaemia. Nat Rev Cancer 8, 341\u2013350.","journal-title":"Nat Rev Cancer"},{"key":"2115_CR72","doi-asserted-by":"crossref","first-page":"e 6812","DOI":"10.1371\/journal.pone.0006812","volume":"4","author":"N Scaglia","year":"2009","unstructured":"Scaglia, N., Chisholm, J.W., and Igal, R.A. (2009). Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PLoS One 4, e 6812.","journal-title":"PLoS One"},{"key":"2115_CR73","doi-asserted-by":"crossref","first-page":"25339","DOI":"10.1074\/jbc.M501159200","volume":"280","author":"N Scaglia","year":"2005","unstructured":"Scaglia, N., and Igal, R.A. (2005). Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells. J Biol Chem 280, 25339\u201325349.","journal-title":"J Biol Chem"},{"key":"2115_CR74","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1126\/science.289.5486.1938","volume":"289","author":"T Schindler","year":"2000","unstructured":"Schindler, T., Bornmann, W., Pellicena, P., Miller, W.T., Clarkson, B., and Kuriyan, J. (2000). Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 289, 1938\u20131942.","journal-title":"Science"},{"key":"2115_CR75","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","volume":"3","author":"GL Semenza","year":"2003","unstructured":"Semenza, G.L. (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3, 721\u2013732.","journal-title":"Nat Rev Cancer"},{"key":"2115_CR76","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.1099480","volume":"305","author":"NP Shah","year":"2004","unstructured":"Shah, N.P., Tran, C., Lee, F.Y., Chen, P., Norris, D., and Sawyers, C.L. (2004). Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305, 399\u2013401.","journal-title":"Science"},{"key":"2115_CR77","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm2354","volume":"9","author":"MC Simon","year":"2008","unstructured":"Simon, M.C., and Keith, B. (2008). The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol 9, 285\u2013296.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2115_CR78","first-page":"5821","volume":"63","author":"SK Singh","year":"2003","unstructured":"Singh, S.K., Clarke, I.D., Terasaki, M., Bonn, V.E., Hawkins, C., Squire, J., and Dirks, P.B. (2003). Identification of a cancer stem cell in human brain tumors. Cancer Res 63, 5821\u20135828.","journal-title":"Cancer Res"},{"key":"2115_CR79","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1038\/onc.2009.252","volume":"28","author":"A Soeda","year":"2009","unstructured":"Soeda, A., Park, M., Lee, D., Mintz, A., Androutsellis-Theotokis, A., McKay, R.D., Engh, J., Iwama, T., Kunisada, T., Kassam, A.B., et al. (2009). Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene 28, 3949\u20133959.","journal-title":"Oncogene"},{"key":"2115_CR80","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1056\/NEJMoa055229","volume":"354","author":"M Talpaz","year":"2006","unstructured":"Talpaz, M., Shah, N.P., Kantarjian, H., Donato, N., Nicoll, J., Paquette, R., Cortes, J., O\u2019Brien, S., Nicaise, C., Bleickardt, E., et al. (2006). Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 354, 2531\u20132541.","journal-title":"N Engl J Med"},{"key":"2115_CR81","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1128\/MCB.20.4.1227-1233.2000","volume":"20","author":"G Texido","year":"2000","unstructured":"Texido, G., Su, I.H., Mecklenbrauker, I., Saijo, K., Malek, S.N., Desiderio, S., Rajewsky, K., and Tarakhovsky, A. (2000). The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. Mol Cell Biol 20, 1227\u20131233.","journal-title":"Mol Cell Biol"},{"key":"2115_CR82","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrc2499","volume":"8","author":"JE Visvader","year":"2008","unstructured":"Visvader, J.E., and Lindeman, G.J. (2008). Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8, 755\u2013768.","journal-title":"Nat Rev Cancer"},{"key":"2115_CR83","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.tcb.2005.07.004","volume":"15","author":"JC Wang","year":"2005","unstructured":"Wang, J.C., and Dick, J.E. (2005). Cancer stem cells: lessons from leukemia. Trends Cell Biol 15, 494\u2013501.","journal-title":"Trends Cell Biol"},{"key":"2115_CR84","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.stem.2011.02.006","volume":"8","author":"Y Wang","year":"2011","unstructured":"Wang, Y., Liu, Y., Malek, S.N., Zheng, P., and Liu, Y. (2011). Targeting HIF1a eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8, 399\u2013411.","journal-title":"Cell Stem Cell"},{"key":"2115_CR85","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ccr.2010.01.020","volume":"17","author":"PS Ward","year":"2010","unstructured":"Ward, P.S., Patel, J., Wise, D.R., Abdel-Wahab, O., Bennett, B.D., Coller, H.A., Cross, J.R., Fantin, V.R., Hedvat, C.V., Perl, A.E., et al. (2010). The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alphaketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225\u2013234.","journal-title":"Cancer Cell"},{"key":"2115_CR86","doi-asserted-by":"crossref","first-page":"33260","DOI":"10.1074\/jbc.272.52.33260","volume":"272","author":"M Warmuth","year":"1997","unstructured":"Warmuth, M., Bergmann, M., Priess, A., Hauslmann, K., Emmerich, B., and Hallek, M. (1997). The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr. J Biol Chem 272, 33260\u201333270.","journal-title":"J Biol Chem"},{"key":"2115_CR87","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ccr.2005.01.007","volume":"7","author":"E Weisberg","year":"2005","unstructured":"Weisberg, E., Manley, P.W., Breitenstein, W., Bruggen, J., Cowan-Jacob, S.W., Ray, A., Huntly, B., Fabbro, D., Fendrich, G., Hall-Meyers, E., et al. (2005). Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 7, 129\u2013141.","journal-title":"Cancer Cell"},{"key":"2115_CR88","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.immunol.22.012703.104753","volume":"22","author":"S Wong","year":"2004","unstructured":"Wong, S., and Witte, O.N. (2004). The BCR-ABL story: bench to bedside and back. Annu Rev Immunol 22, 247\u2013306.","journal-title":"Annu Rev Immunol"},{"key":"2115_CR89","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1182\/blood-2007-08-109330","volume":"111","author":"J Wu","year":"2008","unstructured":"Wu, J., Meng, F., Lu, H., Kong, L., Bornmann, W., Peng, Z., Talpaz, M., and Donato, N.J. (2008). Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. Blood 111, 3821\u20133829.","journal-title":"Blood"},{"key":"2115_CR90","first-page":"924","volume":"118","author":"W Xiao","year":"2008","unstructured":"Xiao, W., Hong, H., Kawakami, Y., Lowell, C.A., and Kawakami, T. (2008). Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn\/Hck, SHIP, and Stat5. J Clin Invest 118, 924\u2013934.","journal-title":"J Clin Invest"},{"key":"2115_CR91","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1128\/MCB.05672-11","volume":"32","author":"H Zhang","year":"2012","unstructured":"Zhang, H., Li, H., Ho, N., Li, D., and Li, S. (2012a). Scd1 plays a tumorsuppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia. Mol Cell Biol 32, 1776\u20131787.","journal-title":"Mol Cell Biol"},{"key":"2115_CR92","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1182\/blood-2011-10-387381","volume":"119","author":"H Zhang","year":"2012","unstructured":"Zhang, H., Li, H., Xi, H.S., and Li, S. (2012b). HIF1alpha is required for survival maintenance of chronic myeloid leukemia stem cells. Blood 119, 2595\u20132607.","journal-title":"Blood"},{"key":"2115_CR93","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ng.2350","volume":"44","author":"H Zhang","year":"2012","unstructured":"Zhang, H., Peng, C., Hu, Y., Li, H., Sheng, Z., Chen, Y., Sullivan, C., Cerny, J., Hutchinson, L., Higgins, A., et al. (2012c). The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nat Genet 44, 861\u2013871.","journal-title":"Nat Genet"},{"key":"2115_CR94","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature08675","volume":"463","author":"J Zhang","year":"2011","unstructured":"Zhang, J., Adrian, F.J., Jahnke, W., Cowan-Jacob, S.W., Li, A.G., Iacob, R.E., Sim, T., Powers, J., Dierks, C., Sun, F., et al. (2011). Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature 463, 501\u2013506.","journal-title":"Nature"},{"key":"2115_CR95","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ccr.2007.11.003","volume":"12","author":"C Zhao","year":"2007","unstructured":"Zhao, C., Blum, J., Chen, A., Kwon, H.Y., Jung, S.H., Cook, J.M., Lagoo, A., and Reya, T. (2007). Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 12, 528\u2013541.","journal-title":"Cancer Cell"},{"key":"2115_CR96","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nature07737","volume":"458","author":"C Zhao","year":"2009","unstructured":"Zhao, C., Chen, A., Jamieson, C.H., Fereshteh, M., Abrahamsson, A., Blum, J., Kwon, H.Y., Kim, J., Chute, J.P., Rizzieri, D., et al. (2009). Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 458, 776\u2013779.","journal-title":"Nature"},{"key":"2115_CR97","first-page":"1541","volume":"60","author":"H Zhong","year":"2000","unstructured":"Zhong, H., Chiles, K., Feldser, D., Laughner, E., Hanrahan, C., Georgescu, M.M., Simons, J.W., and Semenza, G.L. (2000). Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor\/phosphatidylinositol 3-kinase\/PTEN\/AKT\/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60, 1541\u20131545.","journal-title":"Cancer Res"}],"container-title":["Protein & Cell"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13238-013-2115-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13238-013-2115-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13238-013-2115-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:41:13Z","timestamp":1676374873000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/article\/4\/3\/186\/6874330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":97,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["2115"],"URL":"https:\/\/doi.org\/10.1007\/s13238-013-2115-0","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}