{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:09:24Z","timestamp":1790687364479,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T00:00:00Z","timestamp":1435795200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Protein Cell"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s13238-015-0185-x","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T05:17:46Z","timestamp":1435727866000},"page":"628-637","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":330,"title":["Functional metabolomics: from biomarker discovery to metabolome reprogramming"],"prefix":"10.1093","volume":"6","author":[{"given":"Bo","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan-Xian","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,7,2]]},"reference":[{"key":"185_CR1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/gm333","volume":"4","author":"J Adamski","year":"2012","unstructured":"Adamski J (2012) Genome-wide association studies with metabolomics. Genome Med 4:34","journal-title":"Genome Med"},{"key":"185_CR2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.copbio.2012.10.003","volume":"224","author":"J Adamski","year":"2013","unstructured":"Adamski J, Suhre K (2013) Metabolomics platforms for genome wide association studies\u2014linking the genome to the metabolome. Curr Opin Biotechnol 224:39\u201347","journal-title":"Curr Opin Biotechnol"},{"key":"185_CR3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cmet.2015.01.012","volume":"21","author":"P Bhargava","year":"2015","unstructured":"Bhargava P, Collins JJ (2015) Boosting bacterial metabolism to combat antibiotic resistance. Cell Metab 21:154\u2013155","journal-title":"Cell Metab"},{"key":"185_CR4","first-page":"805","volume":"5","author":"M Bielecka","year":"2014","unstructured":"Bielecka M, Watanabe M, Morcuende R, Scheible WR, Hawkesford MJ, Hesse H, Hoefgen R (2014) Transcriptome and metabolome analysis of plant sulphate starvation and resupply provides novel information on transcriptional regulation of metabolism associated with sulphur, nitrogen and phosphorus nutritional responses in Arabidopsis. Front Plant Sci 5:805","journal-title":"Front Plant Sci"},{"key":"185_CR5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pnmrs.2014.09.001","volume":"83","author":"L Brennan","year":"2014","unstructured":"Brennan L (2014) NMR-based metabolomics: from sample preparation to applications in nutrition research. Prog Nucl Magn Reson Spectrosc 83:42\u201349","journal-title":"Prog Nucl Magn Reson Spectrosc"},{"key":"185_CR6","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/ijc.29152","volume":"136","author":"J Budczies","year":"2015","unstructured":"Budczies J, Pfitzner BM, Gy\u00f6rffy B, Winzer KJ, Radke C, Dietel M, Fiehn O, Denkert C (2015) Glutamate enrichment as new diagnostic opportunity in breast cancer. Inter J Cancer 136:1619\u20131628","journal-title":"Inter J Cancer"},{"key":"185_CR7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature13981","volume":"518","author":"BW Carey","year":"2015","unstructured":"Carey BW, Finley LW, Cross JR, Allis CD, Thompson CB (2015) Intracellular \u03b1-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 518:413\u2013416","journal-title":"Nature"},{"key":"185_CR8","first-page":"279","volume":"33","author":"P Castro-Santos","year":"2015","unstructured":"Castro-Santos P, Laborde CM, Diaz-Pena R (2015) Genomics, proteomics and metabolomics: their emerging roles in the discovery and validation of rheumatoid arthritis biomarkers. Clin Exp Rheumatol 33:279\u2013286","journal-title":"Clin Exp Rheumatol"},{"key":"185_CR9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.fsi.2014.08.008","volume":"40","author":"ZX Cheng","year":"2014","unstructured":"Cheng ZX, Ma YM, Li H, Peng XX (2014) N-acetylglucosamine enhances survival ability of tilapias infected by Streptococcus iniae. Fish Shellfish Immunol 40:524\u2013530","journal-title":"Fish Shellfish Immunol"},{"key":"185_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5936\/csbj.201301007","volume":"4","author":"M Commisso","year":"2013","unstructured":"Commisso M, Strazzer P, Toffali K, Stocchero M, Guzzo F (2013) Untargeted metabolomics: an emerging approach to determine the composition of herbal products. Comput Struct Biotechnol J 4:1\u20137","journal-title":"Comput Struct Biotechnol J"},{"key":"185_CR11","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1021\/pr501130a","volume":"14","author":"KT Do","year":"2015","unstructured":"Do KT, Kastenmuller G, Mook-Kanamori DO, Yousri NA, Theis FJ, Suhre K, Krumsiek J (2015) Network-based approach for analyzing intra- and interfluid metabolite associations in human blood, urine, and saliva. J Proteome Res 14:1183\u20131194","journal-title":"J Proteome Res"},{"key":"185_CR12","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1128\/AAC.03104-14","volume":"58","author":"K D\u00f6rries","year":"2014","unstructured":"D\u00f6rries K, Schlueter R, Lalk M (2014) Impact of antibiotics with various target sites on the metabolome of Staphylococcus aureus. Antimicrob Agents Chemother 58:7151\u20137163","journal-title":"Antimicrob Agents Chemother"},{"key":"185_CR13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.envint.2014.03.015","volume":"68","author":"I Dudka","year":"2014","unstructured":"Dudka I, Kossowska B, Senhadri H, Latajka R, Hajek J, Andrzejak R, Antonowicz-Juchniewicz J, Gancarz R (2014) Metabonomic analysis of serum of workers occupationally exposed to arsenic, cadmium and lead for biomarker research: a preliminary study. Environ Int 68:71\u201381","journal-title":"Environ Int"},{"key":"185_CR14","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1039\/c2mb25167a","volume":"8","author":"ME Dumas","year":"2012","unstructured":"Dumas ME (2012) Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes. Mol Biosyst 8:2494\u20132502","journal-title":"Mol Biosyst"},{"key":"185_CR15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2013.11.001","volume":"146","author":"ME Dumas","year":"2014","unstructured":"Dumas ME, Kinross J, Nicholson JK (2014) Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease. Gastroenterol 146:46\u201362","journal-title":"Gastroenterol"},{"key":"185_CR17","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s00216-014-8432-1","volume":"407","author":"MA Farag","year":"2015","unstructured":"Farag MA, Porzel A, Mahrous EA, El-Massry MM, Wessjohann LA (2015) Integrated comparative metabolite profiling via MS and NMR techniques for Senna drug quality control analysis. Anal Bioanal Chem 407:1937\u20131949","journal-title":"Anal Bioanal Chem"},{"key":"185_CR18","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1038\/ncomms7528","volume":"6","author":"Q Feng","year":"2015","unstructured":"Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z, Zhang D et al (2015) Gut microbiome development along the colorectal adenoma\u2013carcinoma sequence. Nat Commun 6:6528","journal-title":"Nat Commun"},{"key":"185_CR19","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1038\/ijo.2014.39","volume":"38","author":"A Floegel","year":"2014","unstructured":"Floegel A, Wientzek A, Bachlechner U, Jacobs S, Drogan D, Prehn C, Adamski J, Krumsiek J, Schulze M, Pischon T (2014) Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study. Int J Obes (Lond) 38:1388\u20131396","journal-title":"Int J Obes (Lond)"},{"key":"185_CR20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.copbio.2014.08.006","volume":"31","author":"T Fuhrer","year":"2015","unstructured":"Fuhrer T, Zamboni N (2015) High-throughput discovery metabolomics. Curr Opin Biotechnol 31:73\u201378","journal-title":"Curr Opin Biotechnol"},{"key":"185_CR21","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00216-014-8127-7","volume":"407","author":"P Gao","year":"2015","unstructured":"Gao P, Xu G (2015) Mass-spectrometry-based microbial metabolomics: recent developments and applications. Anal Bioanal Chem 407:669\u2013680","journal-title":"Anal Bioanal Chem"},{"key":"185_CR22","doi-asserted-by":"crossref","first-page":"776-e1","DOI":"10.1016\/j.ajog.2015.03.052","volume":"212","author":"J Ghartey","year":"2015","unstructured":"Ghartey J, Bastek JA, Brown AG, Anglim L, Elovitz MA (2015) Women with preterm birth have a distinct cervicovaginal metabolome. Am J Obstet Gynecol 212:776-e1","journal-title":"Am J Obstet Gynecol"},{"key":"185_CR23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/MOL.0000000000000140","volume":"26","author":"H Gibbons","year":"2015","unstructured":"Gibbons H, O\u2019Gorman A, Brennan L (2015) Metabolomics as a tool in nutritional research. Curr Opin Lipidol 26:30\u201334","journal-title":"Curr Opin Lipidol"},{"key":"185_CR24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/tra.12280","volume":"16","author":"JB Helms","year":"2015","unstructured":"Helms JB, Kaloyanova DV, Strating JR, van Hellemond JJ, van der Schaar HM, Tielens AG, van Kuppeveld FJ, Brouwers JF (2015) Targeting of the hydrophobic metabolome by pathogens. Traffic 16:439\u2013460","journal-title":"Traffic"},{"key":"185_CR25","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2008.08.026","volume":"134","author":"E Holmes","year":"2008","unstructured":"Holmes E, Wilson ID, Nicholson JK (2008) Metabolic phenotyping in health and disease. Cell 134:714\u2013717","journal-title":"Cell"},{"key":"185_CR26","doi-asserted-by":"crossref","unstructured":"Jorge TF, Rodrigues JA, Caldana C, Schmidt R, van Dongen JT, Thomas\u2010Oates J, Ant\u00f3nio C (2015). Mass spectrometry\u2010based plant metabolomics: Metabolite responses to abiotic stress. Mass Spectrom Rev. doi: 10.1002\/mas.21449","DOI":"10.1002\/mas.21449"},{"key":"185_CR27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature14363","volume":"520","author":"D Kim","year":"2015","unstructured":"Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y et al (2015) SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 520:363\u2013367","journal-title":"Nature"},{"key":"185_CR28","unstructured":"Kl\u00e4hn S, Orf, Schwarz D, Matthiessen JK, Kopka J, Hess WR, Hagemann M (2015). Integrated transcriptomic and metabolomic characterization of the low-carbon response using an ndhR mutant of Synechocystis sp. PCC 6803. Plant Physiol, 144"},{"key":"185_CR29","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1039\/c3np70127a","volume":"31","author":"D Krug","year":"2014","unstructured":"Krug D, M\u00fcller R (2014) Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products. Nat Prod Rep 31:768\u2013783","journal-title":"Nat Prod Rep"},{"key":"185_CR30","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.pharep.2014.06.010","volume":"66","author":"B Kumar","year":"2014","unstructured":"Kumar B, Prakash A, Ruhela RK, Medhi B (2014) Potential of metabolomics in preclinical and clinical drug development. Pharmacol Rep 66:956\u2013963","journal-title":"Pharmacol Rep"},{"key":"185_CR31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.plantsci.2014.12.009","volume":"232","author":"H Kusuda","year":"2015","unstructured":"Kusuda H, Koga W, Kusano M, Oikawa A, Saito K, Hirai MY, Yoshida KT (2015) Ectopic expression of myo-inositol 3-phosphate synthase induces a wide range of metabolic changes and confers salt tolerance in rice. Plant Sci 232:49\u201356","journal-title":"Plant Sci"},{"key":"185_CR32","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1016\/j.jprot.2012.03.006","volume":"75","author":"PP Li","year":"2012","unstructured":"Li PP, Liu XJ, Li H, Peng XX (2012) Downregulation of Na (+)\u2013NQR complex is essential for Vibrio alginolyticus in resistance to balofloxacin. J Proteomics 75:2638\u20132648","journal-title":"J Proteomics"},{"key":"185_CR33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jprot.2013.12.024","volume":"98","author":"XM Lin","year":"2014","unstructured":"Lin XM, Yang MJ, Li H, Wang C, Peng XX (2014) Decreased expression of LamB and Odp1 complex is crucial for antibiotic resistance in Escherichia coli. J Proteomics 98:244\u2013253","journal-title":"J Proteomics"},{"key":"185_CR34","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/CAD.0000000000000096","volume":"25","author":"X Liu","year":"2014","unstructured":"Liu X, Zhang CC, Liu Z, Wei L, Liu YJ, Yu J, Sun LX (2014) LC-based targeted metabolomics analysis of nucleotides and identification of biomarkers associated with chemotherapeutic drugs in cultured cell models. Anti Cancer Drugs 25:690\u2013703","journal-title":"Anti Cancer Drugs"},{"key":"185_CR35","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.fsi.2015.04.037","volume":"45","author":"YM Ma","year":"2015","unstructured":"Ma YM, Yang MJ, Wang S, Li H, Peng XX (2015) Liver functional metabolomics discloses an action of l-leucine against Streptococcus iniae infection intilapias. Fish Shellfish Immunol 45:414\u2013421","journal-title":"Fish Shellfish Immunol"},{"key":"185_CR36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jare.2014.10.003","volume":"6","author":"EA Mahrous","year":"2015","unstructured":"Mahrous EA, Farag MA (2015) Two dimensional NMR spectroscopic approaches for exploring plant metabolome: A review. J Adv Res 6:3\u201315","journal-title":"J Adv Res"},{"key":"185_CR37","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.2174\/1568026614666141215124956","volume":"14","author":"A Mastrangelo","year":"2014","unstructured":"Mastrangelo A, Armitage EG, Garc\u00eda A, Barbas C (2014) Metabolomics as a tool for drug discovery and personalised medicine. A review. Curr Top Med Chem 14:2627\u20132636","journal-title":"Curr Top Med Chem"},{"key":"185_CR38","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jchromb.2013.11.043","volume":"966","author":"R Matsuda","year":"2014","unstructured":"Matsuda R, Bi C, Anguizola J, Sobansky M, Rodriguez E, Badilla JV, Zheng X, Hage B, Hage DS (2014) Studies of metabolite\u2013protein interactions: a review. J Chromatogr B Analyt Technol Biomed Life Sci 966:48\u201358","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"185_CR39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pbi.2015.01.003","volume":"24","author":"R Nakabayashi","year":"2015","unstructured":"Nakabayashi R, Saito K (2015) Integrated metabolomics for abiotic stress responses in plants. Curr Opin Plant Biol 24:10\u201316","journal-title":"Curr Opin Plant Biol"},{"key":"185_CR40","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1111\/1462-2920.12554","volume":"16","author":"T Osanai","year":"2014","unstructured":"Osanai T, Oikawa A, Iijima H, Kuwahara A, Asayama M, Tanaka K, Ikeuchi M, Saito K, Hirai MY (2014) Metabolomic analysis reveals rewiring of Synechocystis sp. PCC 6803 primary metabolism by ntcA overexpression. Environ Microbiol 16:3304\u20133317","journal-title":"Environ Microbiol"},{"key":"185_CR41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jpba.2014.12.020","volume":"107","author":"S Patel","year":"2015","unstructured":"Patel S, Ahmed S (2015) Emerging field of metabolomics: big promise for cancer biomarker identification and drug discovery. J Pharm Biomed Anal 107:63\u201374","journal-title":"J Pharm Biomed Anal"},{"key":"185_CR42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dci.2012.03.017","volume":"39","author":"XX Peng","year":"2013","unstructured":"Peng XX (2013) Proteomics and its applications to aquaculture in China: Infection, immunity, and interaction of aquaculture hosts with pathogens. Dev Comp Immunol 39:63\u201371","journal-title":"Dev Comp Immunol"},{"key":"185_CR43","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cmet.2015.01.008","volume":"21","author":"B Peng","year":"2015","unstructured":"Peng B, Su YB, Li H, Han Y, Guo C, Tian YM, Peng XX (2015a) Exogenous alanine and\/or glucose plus kanamycin kills antibiotic-resistant bacteria. Cell Metab 21:249\u2013261","journal-title":"Cell Metab"},{"key":"185_CR44","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1021\/pr5011857","volume":"14","author":"S Peng","year":"2015","unstructured":"Peng S, Zhang J, Liu L, Zhang X, Huang Q, Alamdar A, Tian M, Shen H (2015b) Newborn meconium and urinary metabolome response to maternal gestational diabetes mellitus: a preliminary case\u2013control study. J Proteome Res 14:1799\u20131809","journal-title":"J Proteome Res"},{"key":"185_CR45","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/elps.201400388","volume":"36","author":"R Ramautar","year":"2015","unstructured":"Ramautar R, Somsen GW, de Jong GJ (2015) CE-MS for metabolomics: developments and applications in the period 2012\u20132014. Electrophoresis 36:212\u2013224","journal-title":"Electrophoresis"},{"key":"185_CR46","doi-asserted-by":"crossref","unstructured":"Rojo D, Gosalbes MJ, Ferrari R, P\u00e9rez-Cobas AE, Hern\u00e1ndez E, Oltra R, Buesa J, Latorre A, Barbas C, Ferrer M (2015). Clostridium difficile heterogeneously impacts intestinal community architecture but drives stable metabolome responses. ISME J.\u00a0doi: 10.1038\/ismej.2015.32","DOI":"10.1038\/ismej.2015.32"},{"key":"185_CR47","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1021\/pr501285f","volume":"14","author":"YB Su","year":"2015","unstructured":"Su YB, Peng B, Han Y, Li H, Peng XX (2015) Fructose restores susceptibility of multidrug-resistant Edwardsiella tarda to kanamycin. J Proteome Res 14:1612\u20131620","journal-title":"J Proteome Res"},{"key":"185_CR48","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nature10354","volume":"477","author":"K Suhre","year":"2011","unstructured":"Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, W\u00e4gele B, Altmaier E, Deloukas P, Erdmann J, Grundberg E (2011) Human metabolic individuality in biomedical and pharmaceutical research. Nature 477:54\u201360","journal-title":"Nature"},{"key":"185_CR49","doi-asserted-by":"crossref","unstructured":"Sun CX, Li MQ, Gao XX, Liu LN, Wu XF, Zhou JH (2015). Metabolic response of maize plants to multi-factorial abiotic stresses. Plant Biol (Stuttg).\u00a0doi: 10.1111\/plb.12305","DOI":"10.1111\/plb.12305"},{"key":"185_CR50","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","volume":"496","author":"GM Tannahill","year":"2013","unstructured":"Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C et al (2013) Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1. Nature 496:238\u2013242","journal-title":"Nature"},{"key":"185_CR51","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1021\/pr5007894","volume":"14","author":"R V\u00e1zquez-Fresno","year":"2014","unstructured":"V\u00e1zquez-Fresno R, Llorach R, Urpi-Sarda M, Lupianez-Barbero A, Estruch R, Corella D, Fit\u00f3 M, Ar\u00f3s F, Ruiz-Canela M, Salas-Salvad\u00f3 J (2014) Metabolomic pattern analysis after mediterranean diet intervention in a nondiabetic population: a 1-and 3-year follow-up in the PREDIMED study. J Proteome Res 14:531\u2013540","journal-title":"J Proteome Res"},{"key":"185_CR52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1086\/679637","volume":"88","author":"ND Wagner","year":"2015","unstructured":"Wagner ND, Lankadurai BP, Simpson MJ, Simpson AJ, Frost PC (2015) Metabolomic differentiation of nutritional stress in an aquatic invertebrate. Physiol Biochem Zool 88:43\u201352","journal-title":"Physiol Biochem Zool"},{"key":"185_CR53","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1039\/C5MT00002E","volume":"7","author":"X Wang","year":"2015","unstructured":"Wang X, Mu X, Zhang J, Huang Q, Alamdar A, Tian M, Liu L, Shen H (2015) Serum metabolomics reveals that arsenic exposure disrupted lipid and amino acid metabolism in rats: a step forward in understanding chronic arsenic toxicity. Metallomics 7:544\u2013552","journal-title":"Metallomics"},{"key":"185_CR54","doi-asserted-by":"crossref","first-page":"e481","DOI":"10.1038\/tp.2014.119","volume":"4","author":"K Weckmann","year":"2014","unstructured":"Weckmann K, Labermaier C, Asara J, M\u00fcller M, Turck C (2014) Time-dependent metabolomic profiling of Ketamine drug action reveals hippocampal pathway alterations and biomarker candidates. Transl Psychiatry 4:e481","journal-title":"Transl Psychiatry"},{"key":"185_CR55","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.chroma.2014.10.091","volume":"1382","author":"JL Wolfender","year":"2015","unstructured":"Wolfender JL, Marti G, Thomas A, Bertrand S (2015) Current approaches and challenges for the metabolite profiling of complex natural extracts. J Chromatogr A 1382:136\u2013164","journal-title":"J Chromatogr A"},{"key":"185_CR56","doi-asserted-by":"crossref","first-page":"fnv040","DOI":"10.1093\/femsle\/fnv040","volume":"362","author":"CW Wu","year":"2015","unstructured":"Wu CW, Zhao XL, Wu XJ, Wen C, Li H, Chen XH, Peng XX (2015) Exogenous glycine and serine promote growth and antifungal activity of Penicillium citrinum W1 from the Southwest Indian Ocean. FEMS Microbiol Lett 362:fnv040","journal-title":"FEMS Microbiol Lett"},{"key":"185_CR57","doi-asserted-by":"crossref","first-page":"12265","DOI":"10.1021\/es503659w","volume":"48","author":"J Zhang","year":"2014","unstructured":"Zhang J, Shen H, Xu W, Xia Y, Barr DB, Mu X, Wang X, Liu L, Huang Q, Tian M (2014) Urinary metabolomics revealed arsenic internal dose-related metabolic alterations: a proof-of-concept study in a Chinese male cohort. Environ Sci Technol 48:12265\u201312274","journal-title":"Environ Sci Technol"},{"key":"185_CR58","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1021\/pr5011263","volume":"14","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Zhao F, Deng Y, Zhao Y, Ren H (2015) Metagenomic and metabolomic analysis of the toxic effects of trichloroacetamide-induced gut microbiome and urine metabolome perturbations in mice. J Proteome Res 14:1752\u20131761","journal-title":"J Proteome Res"},{"key":"185_CR59","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1021\/pr500592x","volume":"13","author":"XL Zhao","year":"2014","unstructured":"Zhao XL, Wu CW, Peng XX, Li H (2014) Interferon-\u03b12b against microbes through promoting biosynthesis of unsaturated fatty acids. J Proteome Res 13:4155\u20134163","journal-title":"J Proteome Res"},{"key":"185_CR60","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fsi.2015.01.025","volume":"44","author":"XL Zhao","year":"2015","unstructured":"Zhao XL, Han Y, Ren ST, Ma YM, Li H, Peng XX (2015) l-proline increases survival of tilapias infected by Streptococcus agalactiae in higher water temperature. Fish Shellfish Immunol 44:33\u201342","journal-title":"Fish Shellfish Immunol"},{"key":"185_CR61","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cub.2014.11.018","volume":"25","author":"H Zheng","year":"2015","unstructured":"Zheng H, Kim J, Liew M, Yan JK, Herrera O, Bok JW, Kelleher NL, Keller NP, Wang Y (2015) Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in aspergillus. Curr Biol 25:29\u201337","journal-title":"Curr Biol"}],"container-title":["Protein & Cell"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13238-015-0185-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13238-015-0185-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13238-015-0185-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T06:42:58Z","timestamp":1676356978000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/article\/6\/9\/628\/6803385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,2]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["185"],"URL":"https:\/\/doi.org\/10.1007\/s13238-015-0185-x","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,2]]}}}