{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:07:00Z","timestamp":1790827620944,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T00:00:00Z","timestamp":1493164800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Protein Cell"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s13238-017-0405-7","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T06:35:39Z","timestamp":1493188539000},"page":"590-600","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection"],"prefix":"10.1093","volume":"8","author":[{"given":"Xuyuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihe","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"405_CR1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","volume":"66","author":"PD Adams","year":"2010","unstructured":"Adams PD, Afonine PV, Bunkoczi G, Chen VB, Davis IW, Echols N, Headd JJ, Hung LW, Kapral GJ, Grosse-Kunstleve RW et al (2010) PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr Sect D 66:213\u2013221","journal-title":"Acta Crystallogr Sect D"},{"key":"405_CR2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nri3515","volume":"13","author":"J Canton","year":"2013","unstructured":"Canton J, Neculai D, Grinstein S (2013) Scavenger receptors in homeostasis and immunity. Nat Rev Immunol 13:621\u2013634","journal-title":"Nat Rev Immunol"},{"key":"405_CR3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3201\/eid1301.020112","volume":"9","author":"KP Chan","year":"2003","unstructured":"Chan KP, Goh KT, Chong CY, Teo ES, Lau G, Ling AE (2003) Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore. Emerg Infect Dis 9:78\u201385","journal-title":"Emerg Infect Dis"},{"key":"405_CR4","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1074\/jbc.M111.301622","volume":"287","author":"P Chen","year":"2012","unstructured":"Chen P, Song Z, Qi Y, Feng X, Xu N, Sun Y, Wu X, Yao X, Mao Q, Li X et al (2012) Molecular determinants of enterovirus 71 viral entry: cleft around GLN-172 on VP1 protein interacts with variable region on scavenge receptor B 2. J Biol Chem 287:6406\u20136420","journal-title":"J Biol Chem"},{"key":"405_CR5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3345\/kjp.2010.53.5.639","volume":"53","author":"HK Cho","year":"2010","unstructured":"Cho HK, Lee NY, Lee H, Kim HS, Seo JW, Hong YM, Lee SJ, Lee SW, Cheon DS, Hong JY et al (2010) Enterovirus 71-associated hand, foot and mouth diseases with neurologic symptoms, a university hospital experience in Korea, 2009. Korean J Pediatr 53:639\u2013643","journal-title":"Korean J Pediatr"},{"key":"405_CR6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12250-011-3195-8","volume":"26","author":"KB Chua","year":"2011","unstructured":"Chua KB, Kasri AR (2011) Hand foot and mouth disease due to enterovirus 71 in Malaysia. Virol Sin 26:221\u2013228","journal-title":"Virol Sin"},{"key":"405_CR7","first-page":"69","volume":"29","author":"KB Chua","year":"2007","unstructured":"Chua KB, Chua BH, Lee CS, Chem YK, Ismail N, Kiyu A, Kumarasamy V (2007) Genetic diversity of enterovirus 71 isolated from cases of hand, foot and mouth disease in the 1997, 2000 and 2005 outbreaks, Peninsular Malaysia. Malays J Pathol 29:69\u201378","journal-title":"Malays J Pathol"},{"key":"405_CR8","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s13238-014-0087-3","volume":"5","author":"M Dang","year":"2014","unstructured":"Dang M, Wang X, Wang Q, Wang Y, Lin J, Sun Y, Li X, Zhang L, Lou Z, Wang J et al (2014) Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71. Protein Cell 5:692\u2013703","journal-title":"Protein Cell"},{"key":"405_CR9","unstructured":"DeLano, W.L. (2002). The PyMOL molecular graphics system."},{"key":"405_CR10","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"P Emsley","year":"2004","unstructured":"Emsley P, Cowtan K (2004) Coot: model-building tools for molecular graphics. Acta Crystallogr Sect D 60:2126\u20132132","journal-title":"Acta Crystallogr Sect D"},{"key":"405_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11262-012-0814-x","volume":"46","author":"X Fan","year":"2013","unstructured":"Fan X, Jiang J, Liu Y, Huang X, Wang P, Liu L, Wang J, Chen W, Wu W, Xu B (2013) Detection of human enterovirus 71 and Coxsackievirus A16 in an outbreak of hand, foot, and mouth disease in Henan Province, China in 2009. Virus Genes 46:1\u20139","journal-title":"Virus Genes"},{"key":"405_CR12","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1073\/pnas.1217563110","volume":"110","author":"K Fujii","year":"2013","unstructured":"Fujii K, Nagata N, Sato Y, Ong KC, Wong KT, Yamayoshi S, Shimanuki M, Shitara H, Taya C, Koike S (2013) Transgenic mouse model for the study of enterovirus 71 neuropathogenesis. Proc Natl Acad Sci USA 110:14753\u201314758","journal-title":"Proc Natl Acad Sci USA"},{"key":"405_CR13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.antiviral.2014.03.009","volume":"106","author":"M Gao","year":"2014","unstructured":"Gao M, Duan H, Liu J, Zhang H, Wang X, Zhu M, Guo J, Zhao Z, Meng L, Peng Y (2014) The multi-targeted kinase inhibitor sorafenib inhibits enterovirus 71 replication by regulating IRES-dependent translation of viral proteins. Antivir Res 106:80\u201385","journal-title":"Antivir Res"},{"key":"405_CR14","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","volume":"341","author":"M Ho","year":"1999","unstructured":"Ho M, Chen ER, Hsu KH, Twu SJ, Chen KT, Tsai SF, Wang JR, Shih SR (1999) An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med 341:929\u2013935","journal-title":"N Engl J Med"},{"key":"405_CR15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/01.inf.0000227959.89339.c3","volume":"25","author":"M Hosoya","year":"2006","unstructured":"Hosoya M, Kawasaki Y, Sato M, Honzumi K, Kato A, Hiroshima T, Ishiko H, Suzuki H (2006) Genetic diversity of enterovirus 71 associated with hand, foot and mouth disease epidemics in Japan from 1983 to 2003. Pediatr Infect Dis J 25:691\u2013694","journal-title":"Pediatr Infect Dis J"},{"key":"405_CR16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3346\/jkms.2013.28.1.120","volume":"28","author":"SJ Kim","year":"2013","unstructured":"Kim SJ, Kim JH, Kang JH, Kim DS, Kim KH, Kim KH, Kim YH, Chung JY, Bin JH, Jung DE et al (2013) Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009. J Korean Med Sci 28:120\u2013127","journal-title":"J Korean Med Sci"},{"key":"405_CR17","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3346\/jkms.2016.31.4.561","volume":"31","author":"KY Lee","year":"2016","unstructured":"Lee KY, Lee MS, Kim DB (2016) Neurologic manifestations of enterovirus 71 infection in Korea. J Korean Med Sci 31:561\u2013567","journal-title":"J Korean Med Sci"},{"key":"405_CR18","doi-asserted-by":"crossref","first-page":"e30507","DOI":"10.1371\/journal.pone.0030507","volume":"7","author":"YW Lin","year":"2012","unstructured":"Lin YW, Lin HY, Tsou YL, Chitra E, Hsiao KN, Shao HY, Liu CC, Sia C, Chong P, Chow YH (2012) Human SCARB2-mediated entry and endocytosis of EV71. PLoS ONE 7:e30507","journal-title":"PLoS ONE"},{"key":"405_CR19","doi-asserted-by":"crossref","first-page":"e57591","DOI":"10.1371\/journal.pone.0057591","volume":"8","author":"YW Lin","year":"2013","unstructured":"Lin YW, Yu SL, Shao HY, Lin HY, Liu CC, Hsiao KN, Chitra E, Tsou YL, Chang HW, Sia C et al (2013) Human SCARB2 transgenic mice as an infectious animal model for enterovirus 71. PLoS ONE 8:e57591","journal-title":"PLoS ONE"},{"key":"405_CR20","doi-asserted-by":"crossref","first-page":"e25287","DOI":"10.1371\/journal.pone.0025287","volume":"6","author":"MY Liu","year":"2011","unstructured":"Liu MY, Liu W, Luo J, Liu Y, Zhu Y, Berman H, Wu J (2011) Characterization of an outbreak of hand, foot, and mouth disease in Nanchang, China in 2010. PLoS ONE 6:e25287","journal-title":"PLoS ONE"},{"key":"405_CR21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0022-2836(68)90205-2","volume":"33","author":"BW Matthews","year":"1968","unstructured":"Matthews BW (1968) Solvent content of protein crystals. J Mol Biol 33:491\u2013497","journal-title":"J Mol Biol"},{"key":"405_CR22","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"AJ McCoy","year":"2007","unstructured":"McCoy AJ, Grosse-Kunstleve RW, Adams PD, Winn MD, Storoni LC, Read RJ (2007) Phaser crystallographic software. J Appl Crystallogr 40:658\u2013674","journal-title":"J Appl Crystallogr"},{"key":"405_CR23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1574-6976.2002.tb00601.x","volume":"26","author":"PC McMinn","year":"2002","unstructured":"McMinn PC (2002) An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev 26:91\u2013107","journal-title":"FEMS Microbiol Rev"},{"key":"405_CR24","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1099\/jmm.0.079699-0","volume":"63","author":"K Mizuta","year":"2014","unstructured":"Mizuta K, Aoki Y, Matoba Y, Yahagi K, Itagaki T, Katsushima F, Katsushima Y, Ito S, Hongo S, Matsuzaki Y (2014) Molecular epidemiology of enterovirus 71 strains isolated from children in Yamagata, Japan, between 1990 and 2013. J Med Microbiol 63:1356\u20131362","journal-title":"J Med Microbiol"},{"key":"405_CR25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nature12684","volume":"504","author":"D Neculai","year":"2013","unstructured":"Neculai D, Schwake M, Ravichandran M, Zunke F, Collins RF, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC et al (2013) Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature 504:172\u2013176","journal-title":"Nature"},{"key":"405_CR26","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1128\/JCM.40.10.3666-3670.2002","volume":"40","author":"M Nijhuis","year":"2002","unstructured":"Nijhuis M, van Maarseveen N, Schuurman R, Verkuijlen S, de Vos M, Hendriksen K, van Loon AM (2002) Rapid and sensitive routine detection of all members of the genus enterovirus in different clinical specimens by real-time PCR. J Clin Microbiol 40:3666\u20133670","journal-title":"J Clin Microbiol"},{"key":"405_CR27","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1086\/511073","volume":"44","author":"MH Ooi","year":"2007","unstructured":"Ooi MH, Wong SC, Podin Y, Akin W, del Sel S, Mohan A, Chieng CH, Perera D, Clear D, Wong D et al (2007) Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study. Clin Infect Dis 44:646\u2013656","journal-title":"Clin Infect Dis"},{"key":"405_CR28","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","volume":"9","author":"MH Ooi","year":"2010","unstructured":"Ooi MH, Wong SC, Lewthwaite P, Cardosa MJ, Solomon T (2010) Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol 9:1097\u20131105","journal-title":"Lancet Neurol"},{"key":"405_CR29","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Z Otwinowski","year":"1997","unstructured":"Otwinowski Z, Minor W (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276:307\u2013326","journal-title":"Methods Enzymol"},{"key":"405_CR30","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00705-005-0684-9","volume":"151","author":"SA Sanders","year":"2006","unstructured":"Sanders SA, Herrero LJ, McPhie K, Chow SS, Craig ME, Dwyer DE, Rawlinson W, McMinn PC (2006) Molecular epidemiology of enterovirus 71 over two decades in an Australian urban community. Arch Virol 151:1003\u20131013","journal-title":"Arch Virol"},{"key":"405_CR31","doi-asserted-by":"crossref","first-page":"348","DOI":"10.7883\/yoken.JJID.2006.348","volume":"59","author":"C Sato","year":"2006","unstructured":"Sato C, Syoji M, Ueki Y, Sato Y, Okimura Y, Saito N, Kikuchi N, Yagi T, Numakura H (2006) Isolation of enterovirus 71 from patients with hand, foot and mouth disease in a local epidemic on March 2006, in Miyagi prefecture, Japan. Jpn J Infect Dis 59:348","journal-title":"Jpn J Infect Dis"},{"key":"405_CR32","doi-asserted-by":"crossref","first-page":"16269","DOI":"10.1016\/S0021-9258(18)55288-1","volume":"266","author":"MA Vega","year":"1991","unstructured":"Vega MA, Rodriguez F, Segui B, Cales C, Alcalde J, Sandoval IV (1991a) Targeting of lysosomal integral membrane protein LIMP II. The tyrosine-lacking carboxyl cytoplasmic tail of LIMP II is sufficient for direct targeting to lysosomes. J Biol Chem 266:16269\u201316272","journal-title":"J Biol Chem"},{"key":"405_CR33","doi-asserted-by":"crossref","first-page":"16818","DOI":"10.1016\/S0021-9258(18)55375-8","volume":"266","author":"MA Vega","year":"1991","unstructured":"Vega MA, Segui-Real B, Garcia JA, Cales C, Rodriguez F, Vanderkerckhove J, Sandoval IV (1991b) Cloning, sequencing, and expression of a cDNA encoding rat LIMP II, a novel 74-kDa lysosomal membrane protein related to the surface adhesion protein CD36. J Biol Chem 266:16818\u201316824","journal-title":"J Biol Chem"},{"key":"405_CR34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12985-015-0308-2","volume":"12","author":"Y Wang","year":"2015","unstructured":"Wang Y, Zou G, Xia A, Wang X, Cai J, Gao Q, Yuan S, He G, Zhang S, Zeng M et al (2015) Enterovirus 71 infection in children with hand, foot, and mouth disease in Shanghai, China: epidemiology, clinical feature and diagnosis. Virol J 12:83","journal-title":"Virol J"},{"key":"405_CR35","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1073\/pnas.1616502114","volume":"114","author":"X Wang","year":"2017","unstructured":"Wang X, Zhu L, Dang M, Hu Z, Gao Q, Yuan S, Sun Y, Zhang B, Ren J, Kotecha A et al (2017) Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site. Proc Natl Acad Sci USA 114:770\u2013775","journal-title":"Proc Natl Acad Sci USA"},{"key":"405_CR36","doi-asserted-by":"crossref","first-page":"e1076","DOI":"10.1016\/j.ijid.2010.07.006","volume":"14","author":"Y Wu","year":"2010","unstructured":"Wu Y, Yeo A, Phoon MC, Tan EL, Poh CL, Quak SH, Chow VT (2010) The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int J Infect Dis 14:e1076\u20131081","journal-title":"Int J Infect Dis"},{"key":"405_CR37","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1128\/JVI.02358-10","volume":"85","author":"S Yamayoshi","year":"2011","unstructured":"Yamayoshi S, Koike S (2011) Identification of a human SCARB2 region that is important for enterovirus 71 binding and infection. J Virol 85:4937\u20134946","journal-title":"J Virol"},{"key":"405_CR38","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nm.1992","volume":"15","author":"S Yamayoshi","year":"2009","unstructured":"Yamayoshi S, Yamashita Y, Li J, Hanagata N, Minowa T, Takemura T, Koike S (2009) Scavenger receptor B2 is a cellular receptor for enterovirus 71. Nat Med 15:798\u2013801","journal-title":"Nat Med"},{"key":"405_CR39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fmicb.2012.00032","volume":"3","author":"S Yamayoshi","year":"2012","unstructured":"Yamayoshi S, Fujii K, Koike S (2012) Scavenger receptor b2 as a receptor for hand, foot, and mouth disease and severe neurological diseases. Front Microbiol 3:32","journal-title":"Front Microbiol"},{"key":"405_CR40","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1128\/JVI.02070-12","volume":"87","author":"S Yamayoshi","year":"2013","unstructured":"Yamayoshi S, Ohka S, Fujii K, Koike S (2013) Functional comparison of SCARB2 and PSGL1 as receptors for enterovirus 71. J Virol 87:3335\u20133347","journal-title":"J Virol"},{"key":"405_CR41","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1038\/emi.2014.49","volume":"3","author":"S Yamayoshi","year":"2014","unstructured":"Yamayoshi S, Fujii K, Koike S (2014) Receptors for enterovirus 71. Emerg Microbes Infect 3:e53","journal-title":"Emerg Microbes Infect"},{"key":"405_CR42","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/INF.0000000000000194","volume":"33","author":"Q Zhang","year":"2014","unstructured":"Zhang Q, MacDonald NE, Smith JC, Cai K, Yu H, Li H, Lei C (2014) Severe enterovirus type 71 nervous system infections in children in the Shanghai region of China: clinical manifestations and implications for prevention and care. Pediatr Infect Dis J 33:482\u2013487","journal-title":"Pediatr Infect Dis J"},{"key":"405_CR43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.7883\/yoken.66.149","volume":"66","author":"X Zhou","year":"2013","unstructured":"Zhou X, Fan G, Xia W, He F, Hu M, Ni X, Zhang Y, Chen H (2013) Molecular epidemiology of human enterovirus 71 strains in the Nanchang region of China in 2011. Jpn J Infect Dis 66:149\u2013150","journal-title":"Jpn J Infect Dis"},{"key":"405_CR44","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1016\/j.vaccine.2016.04.029","volume":"34","author":"S Zhou","year":"2016","unstructured":"Zhou S, Liu Q, Wu X, Chen P, Wu X, Guo Y, Liu S, Liang Z, Fan C, Wang Y (2016) A safe and sensitive enterovirus A71 infection model based on human SCARB2 knock-in mice. Vaccine 34:2729\u20132736","journal-title":"Vaccine"},{"key":"405_CR45","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.bjid.2012.08.001","volume":"16","author":"XN Zou","year":"2012","unstructured":"Zou XN, Zhang XZ, Wang B, Qiu YT (2012) Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases. Braz J Infect Dis 16:457\u2013465","journal-title":"Braz J Infect Dis"}],"container-title":["Protein & Cell"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13238-017-0405-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13238-017-0405-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13238-017-0405-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T19:46:23Z","timestamp":1719171983000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/article\/8\/8\/590\/6765121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,26]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["405"],"URL":"https:\/\/doi.org\/10.1007\/s13238-017-0405-7","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,26]]}}}