{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T05:19:40Z","timestamp":1792905580049,"version":"4.5.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Protein Cell"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s13238-017-0479-2","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T20:37:36Z","timestamp":1508791056000},"page":"823-833","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease"],"prefix":"10.1093","volume":"8","author":[{"given":"Rui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"issue":"6","key":"479_CR1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(04)00140-0","volume":"41","author":"TE Anthony","year":"2004","unstructured":"Anthony TE, Klein C, Fishell G, Heintz N (2004) Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron 41(6):881\u2013890","journal-title":"Neuron"},{"issue":"4","key":"479_CR2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.stem.2016.12.007","volume":"20","author":"M Bershteyn","year":"2017","unstructured":"Bershteyn M et al (2017) Human iPSC-derived cerebral organoids model cellular features of lissencephaly and reveal prolonged mitosis of outer radial glia. Cell Stem Cell 20(4):435\u2013449","journal-title":"Cell Stem Cell"},{"issue":"2","key":"479_CR3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng995","volume":"32","author":"J Bond","year":"2002","unstructured":"Bond J et al (2002) ASPM is a major determinant of cerebral cortical size. Nat Genet 32(2):316\u2013320","journal-title":"Nat Genet"},{"issue":"5","key":"479_CR4","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1086\/379085","volume":"73","author":"J Bond","year":"2003","unstructured":"Bond J et al (2003) Protein-truncating mutations in ASPM cause variable reduction in brain size. Am J Hum Genet 73(5):1170\u20131177","journal-title":"Am J Hum Genet"},{"issue":"7","key":"479_CR5","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/dneu.22013","volume":"72","author":"V Borrell","year":"2012","unstructured":"Borrell V, Reillo I (2012) Emerging roles of neural stem cells in cerebral cortex development and evolution. Dev Neurobiol 72(7):955\u2013971","journal-title":"Dev Neurobiol"},{"issue":"51","key":"479_CR6","doi-asserted-by":"crossref","first-page":"15672","DOI":"10.1073\/pnas.1520760112","volume":"112","author":"JG Camp","year":"2015","unstructured":"Camp JG et al (2015) Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc Natl Acad Sci USA 112(51):15672\u201315677","journal-title":"Proc Natl Acad Sci USA"},{"key":"479_CR7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.ne.01.030178.001501","volume":"1","author":"VS Caviness Jr","year":"1978","unstructured":"Caviness VS Jr, Rakic P (1978) Mechanisms of cortical development: a view from mutations in mice. Annu Rev Neurosci 1:297\u2013326","journal-title":"Annu Rev Neurosci"},{"issue":"7606","key":"479_CR8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature18296","volume":"534","author":"FR Cugola","year":"2016","unstructured":"Cugola FR et al (2016) The Brazilian Zika virus strain causes birth defects in experimental models. Nature 534(7606):267\u2013271","journal-title":"Nature"},{"issue":"1","key":"479_CR9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yebeh.2005.09.005","volume":"8","author":"G D\u2019Arcangelo","year":"2006","unstructured":"D\u2019Arcangelo G (2006) Reelin mouse mutants as models of cortical development disorders. Epilepsy Behav 8(1):81\u201390","journal-title":"Epilepsy Behav"},{"issue":"4","key":"479_CR10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.earlhumdev.2005.10.013","volume":"82","author":"VB Graaf-Peters de","year":"2006","unstructured":"de Graaf-Peters VB, Hadders-Algra M (2006) Ontogeny of the human central nervous system: what is happening when? Early Hum Dev 82(4):257\u2013266","journal-title":"Early Hum Dev"},{"issue":"6","key":"479_CR11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nrn2097","volume":"8","author":"C Dehay","year":"2007","unstructured":"Dehay C, Kennedy H (2007) Cell-cycle control and cortical development. Nat Rev Neurosci 8(6):438\u2013450","journal-title":"Nat Rev Neurosci"},{"key":"479_CR12","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.neuro.27.070203.144152","volume":"27","author":"RJ Douglas","year":"2004","unstructured":"Douglas RJ, Martin KA (2004) Neuronal circuits of the neocortex. Annu Rev Neurosci 27:419\u2013451","journal-title":"Annu Rev Neurosci"},{"issue":"5","key":"479_CR13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.stem.2008.09.002","volume":"3","author":"M Eiraku","year":"2008","unstructured":"Eiraku M et al (2008) Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell 3(5):519\u2013532","journal-title":"Cell Stem Cell"},{"issue":"7341","key":"479_CR14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature09941","volume":"472","author":"M Eiraku","year":"2011","unstructured":"Eiraku M et al (2011) Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 472(7341):51\u201356","journal-title":"Nature"},{"issue":"Suppl 1","key":"479_CR15","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1755-8794-8-S1-S4","volume":"8","author":"M Faheem","year":"2015","unstructured":"Faheem M et al (2015) Molecular genetics of human primary microcephaly: an overview. BMC Med Genom 8(Suppl 1):S4","journal-title":"BMC Med Genom"},{"issue":"1","key":"479_CR16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.conb.2010.10.002","volume":"21","author":"SA Fietz","year":"2011","unstructured":"Fietz SA, Huttner WB (2011) Cortical progenitor expansion, self-renewal and neurogenesis-a polarized perspective. Curr Opin Neurobiol 21(1):23\u201335","journal-title":"Curr Opin Neurobiol"},{"issue":"1","key":"479_CR17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0959-4388(03)00013-8","volume":"13","author":"G Fishell","year":"2003","unstructured":"Fishell G, Kriegstein AR (2003) Neurons from radial glia: the consequences of asymmetric inheritance. Curr Opin Neurobiol 13(1):34\u201341","journal-title":"Curr Opin Neurobiol"},{"issue":"13","key":"479_CR19","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1242\/dev.087668","volume":"140","author":"P Gao","year":"2013","unstructured":"Gao P, Sultan KT, Zhang XJ, Shi SH (2013) Lineage-dependent circuit assembly in the neocortex. Development 140(13):2645\u20132655","journal-title":"Development"},{"issue":"6287","key":"479_CR20","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.aaf6116","volume":"352","author":"PP Garcez","year":"2016","unstructured":"Garcez PP et al (2016) Zika virus impairs growth in human neurospheres and brain organoids. Science 352(6287):816\u2013818","journal-title":"Science"},{"issue":"2","key":"479_CR21","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/cercor\/bhr312","volume":"22","author":"F Garcia-Moreno","year":"2012","unstructured":"Garcia-Moreno F, Vasistha NA, Trevia N, Bourne JA, Molnar Z (2012) Compartmentalization of cerebral cortical germinal zones in a lissencephalic primate and gyrencephalic rodent. Cereb Cortex 22(2):482\u2013492","journal-title":"Cereb Cortex"},{"issue":"7","key":"479_CR22","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1523\/JNEUROSCI.2645-13.2014","volume":"34","author":"CC Gertz","year":"2014","unstructured":"Gertz CC, Lui JH, LaMonica BE, Wang X, Kriegstein AR (2014) Diverse behaviors of outer radial glia in developing ferret and human cortex. J Neurosci 34(7):2559\u20132570","journal-title":"J Neurosci"},{"issue":"10","key":"479_CR23","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrm1739","volume":"6","author":"M Gotz","year":"2005","unstructured":"Gotz M, Huttner WB (2005) The cell biology of neurogenesis. Nat Rev 6(10):777\u2013788","journal-title":"Nat Rev"},{"issue":"7288","key":"479_CR24","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nature08845","volume":"464","author":"DV Hansen","year":"2010","unstructured":"Hansen DV, Lui JH, Parker PR, Kriegstein AR (2010) Neurogenic radial glia in the outer subventricular zone of human neocortex. Nature 464(7288):554\u2013561","journal-title":"Nature"},{"issue":"1","key":"479_CR25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/dbio.2000.9962","volume":"229","author":"E Hartfuss","year":"2001","unstructured":"Hartfuss E, Galli R, Heins N, Gotz M (2001) Characterization of CNS precursor subtypes and radial glia. Dev Biol 229(1):15\u201330","journal-title":"Dev Biol"},{"issue":"6","key":"479_CR27","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.ceb.2005.10.005","volume":"17","author":"WB Huttner","year":"2005","unstructured":"Huttner WB, Kosodo Y (2005) Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system. Curr Opin Cell Biol 17(6):648\u2013657","journal-title":"Curr Opin Cell Biol"},{"issue":"50","key":"479_CR28","doi-asserted-by":"crossref","first-page":"20284","DOI":"10.1073\/pnas.1315710110","volume":"110","author":"T Kadoshima","year":"2013","unstructured":"Kadoshima T et al (2013) Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex. Proc Natl Acad Sci USA 110(50):20284\u201320289","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"479_CR29","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nrn2008","volume":"7","author":"A Kriegstein","year":"2006","unstructured":"Kriegstein A, Noctor S, Martinez-Cerdeno V (2006) Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion. Nat Rev Neurosci 7(11):883\u2013890","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"479_CR30","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.conb.2012.03.006","volume":"22","author":"BE LaMonica","year":"2012","unstructured":"LaMonica BE, Lui JH, Wang X, Kriegstein AR (2012) OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease. Curr Opin Neurobiol 22(5):747\u2013753","journal-title":"Curr Opin Neurobiol"},{"issue":"7467","key":"479_CR31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","volume":"501","author":"MA Lancaster","year":"2013","unstructured":"Lancaster MA et al (2013) Cerebral organoids model human brain development and microcephaly. Nature 501(7467):373\u2013379","journal-title":"Nature"},{"issue":"3","key":"479_CR33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.stem.2016.11.017","volume":"20","author":"Y Li","year":"2017","unstructured":"Li Y et al (2017) Induction of expansion and folding in human cerebral organoids. Cell stem cell 20(3):385\u2013396","journal-title":"Cell stem cell"},{"issue":"1","key":"479_CR34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cell.2011.06.030","volume":"146","author":"JH Lui","year":"2011","unstructured":"Lui JH, Hansen DV, Kriegstein AR (2011) Development and evolution of the human neocortex. Cell 146(1):18\u201336","journal-title":"Cell"},{"issue":"12","key":"479_CR35","doi-asserted-by":"crossref","first-page":"e53024","DOI":"10.1371\/journal.pone.0053024","volume":"7","author":"M Nasu","year":"2012","unstructured":"Nasu M et al (2012) Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture. PloS ONE 7(12):e53024","journal-title":"PloS ONE"},{"issue":"6821","key":"479_CR36","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/35055553","volume":"409","author":"SC Noctor","year":"2001","unstructured":"Noctor SC, Flint AC, Weissman TA, Dammerman RS, Kriegstein AR (2001) Neurons derived from radial glial cells establish radial units in neocortex. Nature 409(6821):714\u2013720","journal-title":"Nature"},{"issue":"8","key":"479_CR37","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1523\/JNEUROSCI.22-08-03161.2002","volume":"22","author":"SC Noctor","year":"2002","unstructured":"Noctor SC et al (2002) Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia. J Neurosci 22(8):3161\u20133173","journal-title":"J Neurosci"},{"issue":"13","key":"479_CR38","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1038\/emboj.2013.96","volume":"32","author":"M Nonaka-Kinoshita","year":"2013","unstructured":"Nonaka-Kinoshita M et al (2013) Regulation of cerebral cortex size and folding by expansion of basal progenitors. EMBO J 32(13):1817\u20131828","journal-title":"EMBO J"},{"issue":"5","key":"479_CR39","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stem.2016.03.012","volume":"18","author":"TJ Nowakowski","year":"2016","unstructured":"Nowakowski TJ et al (2016) Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells. Cell Stem Cell 18(5):591\u2013596","journal-title":"Cell Stem Cell"},{"issue":"7151","key":"479_CR40","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature05934","volume":"448","author":"K Okita","year":"2007","unstructured":"Okita K, Ichisaka T, Yamanaka S (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448(7151):313\u2013317","journal-title":"Nature"},{"issue":"3","key":"479_CR41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.celrep.2014.06.058","volume":"8","author":"BE Ostrem","year":"2014","unstructured":"Ostrem BE, Lui JH, Gertz CC, Kriegstein AR (2014) Control of outer radial glial stem cell mitosis in the human brain. Cell Rep 8(3):656\u2013664","journal-title":"Cell Rep"},{"issue":"7","key":"479_CR42","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.3415","volume":"12","author":"AM Pasca","year":"2015","unstructured":"Pasca AM et al (2015) Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods 12(7):671\u2013678","journal-title":"Nat Methods"},{"key":"479_CR43","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1038\/ncomms3125","volume":"4","author":"GA Pilz","year":"2013","unstructured":"Pilz GA et al (2013) Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type. Nat Commun 4:2125","journal-title":"Nat Commun"},{"issue":"1\u20133","key":"479_CR44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000109848","volume":"30","author":"A Pontious","year":"2008","unstructured":"Pontious A, Kowalczyk T, Englund C, Hevner RF (2008) Role of intermediate progenitor cells in cerebral cortex development. Dev Neurosci 30(1\u20133):24\u201332","journal-title":"Dev Neurosci"},{"issue":"38","key":"479_CR45","doi-asserted-by":"crossref","first-page":"16595","DOI":"10.1073\/pnas.1010494107","volume":"107","author":"JN Pulvers","year":"2010","unstructured":"Pulvers JN et al (2010) Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Proc Natl Acad Sci USA 107(38):16595\u201316600","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"479_CR46","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.cell.2016.04.032","volume":"165","author":"X Qian","year":"2016","unstructured":"Qian X et al (2016) Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell 165(5):1238\u20131254","journal-title":"Cell"},{"issue":"10","key":"479_CR47","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nrn2719","volume":"10","author":"P Rakic","year":"2009","unstructured":"Rakic P (2009) Evolution of the neocortex: a perspective from developmental biology. Nat Rev Neurosc 10(10):724\u2013735","journal-title":"Nat Rev Neurosc"},{"issue":"7","key":"479_CR48","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/cercor\/bhq238","volume":"21","author":"I Reillo","year":"2011","unstructured":"Reillo I, de Juan Romero C, Garcia-Cabezas MA, Borrell V (2011) A role for intermediate radial glia in the tangential expansion of the mammalian cerebral cortex. Cereb Cortex 21(7):1674\u20131694","journal-title":"Cereb Cortex"},{"issue":"11","key":"479_CR49","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ncb2858","volume":"15","author":"MA Rujano","year":"2013","unstructured":"Rujano MA, Sanchez-Pulido L, Pennetier C, le Dez G, Basto R (2013) The microcephaly protein Asp regulates neuroepithelium morphogenesis by controlling the spatial distribution of myosin II. Nat Cell Biol 15(11):1294\u20131306","journal-title":"Nat Cell Biol"},{"issue":"9","key":"479_CR51","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1136\/jmg.2004.027706","volume":"42","author":"J Shen","year":"2005","unstructured":"Shen J et al (2005) ASPM mutations identified in patients with primary microcephaly and seizures. J Med Genet 42(9):725\u2013729","journal-title":"J Med Genet"},{"issue":"7375","key":"479_CR53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature10637","volume":"480","author":"H Suga","year":"2011","unstructured":"Suga H et al (2011) Self-formation of functional adenohypophysis in three-dimensional culture. Nature 480(7375):57\u201362","journal-title":"Nature"},{"issue":"4","key":"479_CR54","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663\u2013676","journal-title":"Cell"},{"issue":"5","key":"479_CR55","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.stem.2016.02.016","volume":"18","author":"H Tang","year":"2016","unstructured":"Tang H et al (2016) Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell 18(5):587\u2013590","journal-title":"Cell Stem Cell"},{"issue":"6","key":"479_CR56","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.neuron.2010.08.027","volume":"67","author":"E Taverna","year":"2010","unstructured":"Taverna E, Huttner WB (2010) Neural progenitor nuclei in motion. Neuron 67(6):906\u2013914","journal-title":"Neuron"},{"issue":"5","key":"479_CR57","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nn.2807","volume":"14","author":"X Wang","year":"2011","unstructured":"Wang X, Tsai JW, LaMonica B, Kriegstein AR (2011) A new subtype of progenitor cell in the mouse embryonic neocortex. Nat Neurosci 14(5):555\u2013561","journal-title":"Nat Neurosci"},{"issue":"5","key":"479_CR58","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1086\/429930","volume":"76","author":"CG Woods","year":"2005","unstructured":"Woods CG, Bond J, Enard W (2005) Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings. Am J Hum Genet 76(5):717\u2013728","journal-title":"Am J Hum Genet"},{"issue":"10","key":"479_CR59","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nm.4184","volume":"22","author":"M Xu","year":"2016","unstructured":"Xu M et al (2016) Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med 22(10):1101\u20131107","journal-title":"Nat Med"}],"container-title":["Protein & Cell"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13238-017-0479-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13238-017-0479-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13238-017-0479-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:44:42Z","timestamp":1676375082000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/proteincell\/article\/8\/11\/823\/6765120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["479"],"URL":"https:\/\/doi.org\/10.1007\/s13238-017-0479-2","relation":{},"ISSN":["1674-800X","1674-8018"],"issn-type":[{"value":"1674-800X","type":"print"},{"value":"1674-8018","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}