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Aspiration thrombectomy is an endovascular therapy for the removal of vessel occlusions. However, open questions regarding the hemodynamics during the intervention remain, motivating investigations of blood flow within cerebral arteries. In this study, we present a combined experimental and numerical approach to analyze hemodynamics during endovascular aspiration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We have developed an <jats:italic>in vitro<\/jats:italic> setup for investigations of hemodynamic changes during endovascular aspiration within a compliant model of patient-specific cerebral arteries. Pressures, flows, and locally resolved velocities were obtained. In addition, we established a computational fluid dynamics (CFD) model and compared the simulations during physiological conditions and in two aspiration scenarios with different occlusions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Flow redistribution within cerebral arteries after ischemic stroke is strongly dependent on the severity of the occlusion and on the volume flow extracted by endovascular aspiration. Numerical simulations exhibit an excellent correlation of <jats:italic>R<\/jats:italic>\u2009=\u20090.92 for flow rates and a good correlation of <jats:italic>R<\/jats:italic>\u2009=\u20090.73 for pressures. Further on, the local velocity field inside the basilar artery had a good agreement between CFD model and particle image velocimetry (PIV) data.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The presented setup allows for <jats:italic>in vitro<\/jats:italic> investigations of artery occlusions and endovascular aspiration techniques on arbitrary patient-specific cerebrovascular anatomies. The <jats:italic>in\u00a0silico<\/jats:italic> model provides consistent predictions of flows and pressures in several aspiration scenarios.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s13239-023-00660-8","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T17:03:06Z","timestamp":1677085386000},"page":"393-403","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Investigation of Cerebral Hemodynamics During Endovascular Aspiration: Development of an Experimental and Numerical Setup"],"prefix":"10.1007","volume":"14","author":[{"given":"C. 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