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Transcatheter heart valve prostheses (THV) are inserted into the aortic valve, creating a new area between the native and artificial leaflets. This area, known as neo-sinus, increases the thrombogenicity of THVs. But there is a lack of testing methods that evaluate thrombogenicity in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To analyze the flow field within the native sinus and the neo-sinus, Particle Image Velocimetry (PIV) was performed with a thrombosis tester. Additionally, a comparative study was conducted with porcine blood on two polycarbonate urethane valves, with and without neo-sinus, respectively. Blood samples collected every hour were analyzed for platelet count, coagulation via ROTEM parameters, and plasma-free hemoglobin. Thrombus formation was detected optically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PIV measurements yield a physiological flow field in the aortic root that were consistent with those reported in literature. The analyzed blood parameters reveal no obvious difference between the valve with neo-sinus and the valve without. A higher amount of thrombus material for the valve with neo-sinus was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The visualized flow field shows low velocities and stagnation zones due to the presence of native leaflets. Clot formation at the heart valve prostheses are in accordance with in-vivo findings. The benchmark of the two valves indicates an increased thrombogenic potential due to the neo-sinus. The thrombosis tester simulates the natural environment after TAVR. Thereby, newly developed THVs can be evaluated in vitro and consequently optimized regarding their thrombogenicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s13239-025-00792-z","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T18:17:37Z","timestamp":1752517057000},"page":"537-550","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of Neo-Sinus on Thrombogenicity of Aortic Valve Prostheses: Experimental Proof-of-Concept Study"],"prefix":"10.1007","volume":"16","author":[{"given":"Saskia","family":"Thoenissen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Mager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio A.","family":"Luisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Mous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schmitz-Rode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Steinseifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-2391","authenticated-orcid":false,"given":"Johanna C.","family":"Clauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"792_CR1","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","volume":"380","author":"JJ Popma","year":"2019","unstructured":"Popma JJ, Deeb GM, Yakubov SJ, Mumtaz M, Gada H, O\u2019Hair D, et al. 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