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A Millar pressure catheter and force transducers (\u201cC-gauges\u201d) were used to acquire the data. Strut chordal force was recorded simultaneously with the marginal chordal force, to serve as a verification of the employed equipment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The marginal chordal force in porcine and human averaged to 0.012 N\u2009\u00b1\u20090.008 N and 0.006 N\u2009\u00b1\u20090.008 N respectively at peak systolic pressure of 120\u00a0mmHg. Additionally, a simplified finite element study was conducted and supports low marginal forces relative to intermediary chords.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion &amp; Conclusion<\/jats:title>\n                    <jats:p>This low force calls into question the traditionally-described role of the marginal chordae in preventing mitral prolapse at closure. The chords do, however, still show signs of assisting with the leaflets\u2019 positioning. The relationship between marginal chordal forces and transvalvular pressure varies significantly across experiments, further obfuscating their role in normal valvular function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s13239-026-00857-7","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:22:33Z","timestamp":1788452553000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human and Porcine Marginal Chordal Forces in a Vacuum Based Physiological In Vitro Mitral Valve Model"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1938-7770","authenticated-orcid":false,"given":"Mads V.","family":"Ancker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-9523","authenticated-orcid":false,"given":"Sam E.","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2486-9865","authenticated-orcid":false,"given":"Justin T.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6180-610X","authenticated-orcid":false,"given":"Neil B.","family":"Ingels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-9914","authenticated-orcid":false,"given":"Jonathan F.","family":"Wenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2352-853X","authenticated-orcid":false,"given":"S\u00f8ren N.","family":"Skov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra K.","family":"Chawla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit. 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