{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:46:27Z","timestamp":1791960387316,"version":"4.3.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Eng Tech"],"DOI":"10.1007\/s13239-026-00864-8","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:47:38Z","timestamp":1791928058000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biventricular Assist Devices Versus Total Artificial Heart as Bridge-to-Transplantation Strategies: A Systematic Review and Meta-analysis"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3242-2127","authenticated-orcid":false,"given":"Obay J. I.","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8600-6866","authenticated-orcid":false,"given":"Moaz J. I.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9645-6851","authenticated-orcid":false,"given":"Moustafa Mahmoud","family":"Aboutabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0344-4930","authenticated-orcid":false,"given":"Mariam","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8619-515X","authenticated-orcid":false,"given":"Mohamed","family":"Elserougi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-2873","authenticated-orcid":false,"given":"Khaled Ashraf","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2413-4065","authenticated-orcid":false,"given":"Tamer","family":"Ghazy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7449-9455","authenticated-orcid":false,"given":"Diyar","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5451-4504","authenticated-orcid":false,"given":"Ahmed","family":"Abdelsamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"864_CR1","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1007\/s10439-011-0348-8","volume":"39","author":"SD Gregory","year":"2011","unstructured":"Gregory, S. D., D. Timms, N. Gaddum, et al. Biventricular assist devices: a technical review. Ann. Biomed. Eng. 39:2313\u20132328, 2011.","journal-title":"Ann. Biomed. Eng."},{"key":"864_CR2","first-page":"493","volume":"56","author":"A Nguyen","year":"2015","unstructured":"Nguyen, A., M. Pozzi, C. Mastroianni, et al. Bridge to transplantation using paracorporeal biventricular assist devices or the syncardia temporary total artificial heart: is there a difference? J Cardiovasc Surg (Torino). 56:493\u2013502, 2015.","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"864_CR3","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/jocs.12823","volume":"31","author":"A Cheng","year":"2016","unstructured":"Cheng, A., J. R. Trivedi, V. H. Van Berkel, et al. Comparison of total artificial heart and biventricular assist device support as bridge-to-transplantation. J Card Surg. 31:648\u2013653, 2016. https:\/\/doi.org\/10.1111\/jocs.12823.","journal-title":"J Card Surg"},{"key":"864_CR4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.21037\/ACS.2020.03.07","volume":"9","author":"EJ Maynes","year":"2020","unstructured":"Maynes, E. J., T. J. Omalley, J. G. Y. Luc, et al. Comparison of SynCardia total artificial heart and HeartWare HVAD biventricular support for management of biventricular heart failure: A systematic review and meta-analysis. Ann Cardiothorac Surg. 9:69\u201380, 2020. https:\/\/doi.org\/10.21037\/ACS.2020.03.07.","journal-title":"Ann Cardiothorac Surg"},{"key":"864_CR5","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page, M. J., J. E. McKenzie, P. M. Bossuyt, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 372:n71, 2021.","journal-title":"BMJ"},{"key":"864_CR6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1080\/02763869.2019.1588072","volume":"38","author":"JH Schiavo","year":"2019","unstructured":"Schiavo, J. H. PROSPERO: an international register of systematic review protocols. Med. Ref. Serv. Q. 38:171\u2013180, 2019.","journal-title":"Med. Ref. Serv. Q."},{"issue":"14","key":"864_CR7","doi-asserted-by":"publisher","first-page":"142","DOI":"10.56645\/jmde.v6i14.284","volume":"6","author":"M Tarsilla","year":"2010","unstructured":"Tarsilla, M. Cochrane handbook for systematic reviews of interventions. J Multidiscip Eval. 6(14):142\u2013148, 2010. https:\/\/doi.org\/10.56645\/jmde.v6i14.284.","journal-title":"J Multidiscip Eval"},{"key":"864_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-7-16","author":"C Schardt","year":"2007","unstructured":"Schardt, C., M. B. Adams, T. Owens, et al. Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Mak. 2007. https:\/\/doi.org\/10.1186\/1472-6947-7-16.","journal-title":"BMC Med Inform Decis Mak"},{"key":"864_CR9","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.healun.2011.11.024","volume":"31","author":"M Kirsch","year":"2012","unstructured":"Kirsch, M., J. P. Mazzucotelli, J. C. Roussel, et al. Survival after biventricular mechanical circulatory support: does the type of device matter? J Heart Lung Transpl. 31:501\u2013508, 2012. https:\/\/doi.org\/10.1016\/j.healun.2011.11.024.","journal-title":"J Heart Lung Transpl"},{"key":"864_CR10","unstructured":"Higgins JP, Li T, Deeks JJ (editors). Chapter 6: Choosing effect measures and computing estimates of effect [last updated August 2023]. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 6.5. Cochrane, 2024. Available from cochrane.org\/handbook."},{"key":"864_CR11","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1097\/MAT.0000000000001900","volume":"69","author":"M Satish","year":"2023","unstructured":"Satish, M., A. Anyanwu, N. Moss, et al. HeartMate-3 ventricular assist devices versus the total artificial heart for biventricular support: a single-center series. ASAIO J. 69:544\u2013551, 2023. https:\/\/doi.org\/10.1097\/MAT.0000000000001900.","journal-title":"ASAIO J"},{"key":"864_CR12","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1177\/0962280219889080","volume":"29","author":"S McGrath","year":"2020","unstructured":"McGrath, S., X. F. Zhao, R. Steele, et al. Estimating the sample mean and standard deviation from commonly reported quantiles in meta-analysis. Stat Methods Med Res. 29:2520\u20132537, 2020. https:\/\/doi.org\/10.1177\/0962280219889080.","journal-title":"Stat Methods Med Res"},{"key":"864_CR13","unstructured":"Review Manager (RevMan). 5.4. The Cochrane Collaboration. 2020. Available from: https:\/\/revman.cochrane.org\/"},{"key":"864_CR14","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R Dersimonian","year":"1986","unstructured":"Dersimonian, R., and N. Laird. Meta-analysis in clinical trials. Control Clin Trials. 7:177\u2013188, 1986.","journal-title":"Control Clin Trials"},{"key":"864_CR15","unstructured":"Wells G, Shea B, O\u2019Connell D, et al The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. In: Ottawa Hospital Research Institute. Available from https:\/\/ohri.ca\/en\/who-we-are\/core-facilities-and-platforms\/ottawa-methods-centre\/newcastle-ottawa-scale. Accessed 26 Feb 2026."},{"key":"864_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2023.101484","author":"M Prasad","year":"2024","unstructured":"Prasad, M. Introduction to the GRADE tool for rating certainty in evidence and recommendations. Clin Epidemiol Glob Health. 2024. https:\/\/doi.org\/10.1016\/j.cegh.2023.101484.","journal-title":"Clin Epidemiol Glob Health"},{"key":"864_CR17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008","author":"BJ Shea","year":"2017","unstructured":"Shea, B. J., B. C. Reeves, G. Wells, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017. https:\/\/doi.org\/10.1136\/bmj.j4008.","journal-title":"BMJ"},{"key":"864_CR18","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1012054","author":"A EI-Banayosy","year":"1999","unstructured":"EI-Banayosy, A., R. Korfer, L. Arusoglu, et al. Bridging to cardiac transplantation with the thoratec ventricular assist device. Thorac Cardiovasc Surg. 1999. https:\/\/doi.org\/10.1055\/s-2007-1012054.","journal-title":"Thorac Cardiovasc Surg"},{"key":"864_CR19","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/aor.14884","volume":"49","author":"J Ferrall","year":"2025","unstructured":"Ferrall, J., A. S. Vaidya, E. S. Kawaguchi, et al. Comparison of waitlist and post-transplant outcomes in patients supported with total artificial heart versus continuous biventricular assist devices. Artif Organs. 49:281\u2013291, 2025. https:\/\/doi.org\/10.1111\/aor.14884.","journal-title":"Artif Organs"},{"key":"864_CR20","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0003-4975(93)90540-x","volume":"55","author":"WE Pae","year":"1993","unstructured":"Pae, W. E. Ventricular assist devices and total artificial hearts: a combined registry experience. Ann Thorac Surg. 55:295\u2013298, 1993. https:\/\/doi.org\/10.1016\/0003-4975(93)90540-x.","journal-title":"Ann Thorac Surg"},{"key":"864_CR21","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/S1010-7940(96)01044-5","volume":"11","author":"E Quaini","year":"1997","unstructured":"Quaini, E., A. Pavie, S. Chieco, and B. Mambrito. The Concerted Action \u201cHeart\u201d European registry on clinical application of mechanical circulatory support systems: bridge to transplant. Eur J Cardio-thoracic Surg. 11:182\u2013188, 1997.","journal-title":"Eur J Cardio-thoracic Surg"},{"key":"864_CR22","doi-asserted-by":"publisher","DOI":"10.1111\/aor.70047","author":"D Rahimov","year":"2025","unstructured":"Rahimov, D., N. Nasher, T. Sakata, et al. Impact of 2018 donor heart allocation policy change on patients on biventricular support: a UNOS database analysis. Artif Organs. 2025. https:\/\/doi.org\/10.1111\/aor.70047.","journal-title":"Artif Organs"},{"key":"864_CR23","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/MAT.0000000000000395","volume":"62","author":"MF Swartz","year":"2016","unstructured":"Swartz, M. F., R. Angona, K. Smith, et al. Costs and outcomes in the care of bi-ventricular support as a bridge to cardiac transplant. ASAIO J. 62:513\u2013517, 2016.","journal-title":"ASAIO J"},{"key":"864_CR24","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bpa.2012.03.004","volume":"26","author":"G Loor","year":"2012","unstructured":"Loor, G., and G. Gonzalez-Stawinski. Pulsatile vs. continuous flow in ventricular assist device therapy. Best Pract. Res. Clin. Anaesthesiol. 26:105\u2013115, 2012.","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"864_CR25","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1177\/0267659109351330","volume":"24","author":"A Platis","year":"2009","unstructured":"Platis, A., and D. F. Larson. CardioWest temporary total artificial heart. Perfusion. 24:341\u2013347, 2009. https:\/\/doi.org\/10.1177\/0267659109351330.","journal-title":"Perfusion"},{"key":"864_CR26","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1097\/MAT.0b013e3181e5de0a","volume":"56","author":"S Crow","year":"2010","unstructured":"Crow, S., C. Milano, L. Joyce, et al. Comparative analysis of von willebrand factor profiles in pulsatile and continuous left ventricular assist device recipients. ASAIO J. 56:441\u2013445, 2010. https:\/\/doi.org\/10.1097\/MAT.0b013e3181e5de0a.","journal-title":"ASAIO J"},{"key":"864_CR27","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/j.jacc.2009.02.048","volume":"53","author":"J Klovaite","year":"2009","unstructured":"Klovaite, J., F. Gustafsson, S. A. Mortensen, et al. Severely impaired von Willebrand factor-dependent platelet aggregation in patients with a continuous-flow left ventricular assist device (HeartMate II). J Am Coll Cardiol. 53:2162\u20132167, 2009. https:\/\/doi.org\/10.1016\/j.jacc.2009.02.048.","journal-title":"J Am Coll Cardiol"},{"key":"864_CR28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1055\/s-0030-1248726","volume":"36","author":"Z Zhou","year":"2010","unstructured":"Zhou, Z., T. C. Nguyen, P. Guchhait, and J. F. Dong. Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura. Semin. Thromb. Hemost. 36:71\u201381, 2010.","journal-title":"Semin. Thromb. Hemost."},{"key":"864_CR29","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1182\/blood.V83.8.2171.2171","volume":"83","author":"H-M Tsai","year":"1994","unstructured":"Tsai, H.-M., I. I. Sussman, and R. L. Nagel. Shear stress enhances the proteolysis of von Willebrand factor in normal plasma. Blood. 83:2171\u20132179, 1994.","journal-title":"Blood"},{"key":"864_CR30","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jtcvs.2014.09.031","volume":"149","author":"CR Bartoli","year":"2015","unstructured":"Bartoli, C. R., D. J. Restle, D. M. Zhang, et al. Pathologic von Willebrand factor degradation with a left ventricular assist device occurs via two distinct mechanisms: mechanical demolition and enzymatic cleavage. J Thoracic Cardiovasc Surg. 149:281\u2013289, 2015. https:\/\/doi.org\/10.1016\/j.jtcvs.2014.09.031.","journal-title":"J Thoracic Cardiovasc Surg"},{"key":"864_CR31","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3390\/biomedicines11030757","volume":"11","author":"F Khalil","year":"2023","unstructured":"Khalil, F., R. Asleh, R. K. Perue, et al. Vascular function in continuous flow LVADs: implications for clinical practice. Biomedicines. 11:757, 2023.","journal-title":"Biomedicines"},{"key":"864_CR32","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1161\/CIRCULATIONAHA.111.040246","volume":"125","author":"PM Eckman","year":"2012","unstructured":"Eckman, P. M., and R. John. Bleeding and thrombosis in patients with continuous-flow ventricular assist devices. Circulation. 125:3038\u20133047, 2012. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.040246.","journal-title":"Circulation"},{"key":"864_CR33","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1161\/CIRCHEARTFAILURE.111.962613","volume":"4","author":"J Suarez","year":"2011","unstructured":"Suarez, J., C. B. Patel, G. M. Felker, et al. Mechanisms of bleeding and approach to patients with axial-flow left ventricular assist devices. Circ Heart Fail. 4:779\u2013784, 2011. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.111.962613.","journal-title":"Circ Heart Fail"},{"key":"864_CR34","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/joa.13675","volume":"242","author":"G Malone","year":"2023","unstructured":"Malone, G., G. Abdelsayed, F. Bligh, et al. Advancements in left ventricular assist devices to prevent pump thrombosis and blood coagulopathy. J. Anat. 242:29\u201349, 2023.","journal-title":"J. Anat."},{"key":"864_CR35","doi-asserted-by":"publisher","first-page":"311","DOI":"10.21037\/acs-2021-cfmcs-34","volume":"10","author":"J Farag","year":"2021","unstructured":"Farag, J., K. Woldendorp, N. McNamara, et al. Contemporary outcomes of continuous-flow biventricular assist devices. Ann Cardiothorac Surg. 10:311\u2013328, 2021. https:\/\/doi.org\/10.21037\/acs-2021-cfmcs-34.","journal-title":"Ann Cardiothorac Surg"},{"key":"864_CR36","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/aor.13675","volume":"44","author":"EJ Maynes","year":"2020","unstructured":"Maynes, E. J., T. J. O\u2019Malley, P. Patel, et al. Right atrial versus right ventricular HeartWare HVAD position in patients on biventricular HeartWare HVAD support: a systematic review. Artif Organs. 44:926\u2013934, 2020. https:\/\/doi.org\/10.1111\/aor.13675.","journal-title":"Artif Organs"},{"key":"864_CR37","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.atssr.2022.09.007","volume":"1","author":"JN Schroder","year":"2023","unstructured":"Schroder, J. N., S. L. McCartney, P. Jansen, et al. The first autoregulated total artificial heart implant in the United States. Ann Thoracic Surg Short Rep. 1:185\u2013187, 2023. https:\/\/doi.org\/10.1016\/j.atssr.2022.09.007.","journal-title":"Ann Thoracic Surg Short Rep"},{"key":"864_CR38","doi-asserted-by":"publisher","first-page":"6743","DOI":"10.1097\/js9.0000000000002879","volume":"111","author":"S Wang","year":"2025","unstructured":"Wang, S., Y. Wang, J. Zhang, et al. Implantation of integrated magnetically levitated biventricular assist devices (DuoCor)\u2014a single-center clinical experience. Int J Surg. 111:6743\u20136754, 2025. https:\/\/doi.org\/10.1097\/js9.0000000000002879.","journal-title":"Int J Surg"},{"key":"864_CR39","doi-asserted-by":"publisher","DOI":"10.1111\/aor.70064","author":"JD Schmitto","year":"2026","unstructured":"Schmitto, J. D., J. S. Hanke, S. Knigge, et al. A novel biventricular assist device with a single driveline: a report on the first patient treated. Artif Organs. 2026. https:\/\/doi.org\/10.1111\/aor.70064.","journal-title":"Artif Organs"}],"container-title":["Cardiovascular Engineering and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13239-026-00864-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13239-026-00864-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13239-026-00864-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:03:11Z","timestamp":1791957791000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13239-026-00864-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":39,"alternative-id":["864"],"URL":"https:\/\/doi.org\/10.1007\/s13239-026-00864-8","relation":{},"ISSN":["1869-408X","1869-4098"],"issn-type":[{"value":"1869-408X","type":"print"},{"value":"1869-4098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"7 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study did not require approval from an institutional review board (IRB) or local ethics committee, as it is a systematic review and meta-analysis.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"As this study involved a secondary analysis of already published data, consent was not required.","order":3,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}