{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:48:30Z","timestamp":1776127710403,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Scientific Research Item of Shenzhen Science and Technology Innovation Committee","award":["JCYJ20140414170821262"],"award-info":[{"award-number":["JCYJ20140414170821262"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Australas Phys Eng Sci Med"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s13246-015-0406-x","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T13:22:58Z","timestamp":1449580978000},"page":"785-791","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Homocysteine-lowering therapy and early functional outcomes of ischemic patients with H-type hypertension: a retrospective analysis of CNSR"],"prefix":"10.1007","volume":"38","author":[{"given":"Shiyu","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingquan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,12,7]]},"reference":[{"key":"406_CR1","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1161\/01.ATV.20.7.1704","volume":"20","author":"SH Mudd","year":"2002","unstructured":"Mudd SH, Finkelstein JD, Refsum H et al (2002) Homocysteine and its disulfide derivatives: a suggested consensus terminology. Arterioscler Thromb Vasc Biol 20:1704\u20131706","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"406_CR2","first-page":"111","volume":"56","author":"KS McCully","year":"1969","unstructured":"McCully KS (1969) Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 56(1):111\u2013128","journal-title":"Am J Pathol"},{"issue":"14","key":"406_CR3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-14-6","volume":"10","author":"P Ganguly","year":"2015","unstructured":"Ganguly P, Alam SF (2015) Role of homocysteine in the development of cardiovascular disease. Nutr J 10(14):6","journal-title":"Nutr J"},{"key":"406_CR4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1389200052997357","volume":"6","author":"N Weiss","year":"2005","unstructured":"Weiss N (2005) Mechanisms of increased vascular oxidant stress in hyperhomocys-teinemia and its impact on endothelial function. Curr Drug Metab 6:27\u201336","journal-title":"Curr Drug Metab"},{"key":"406_CR5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.arcmed.2007.01.004","volume":"38","author":"TN Abahji","year":"2007","unstructured":"Abahji TN, Nill L, Ide N, Keller C, Hoffmann U, Weiss N (2007) Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial dysfunction. Arch Med Res 38:411\u2013416","journal-title":"Arch Med Res"},{"issue":"22","key":"406_CR6","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1001\/jama.1997.03540460039030","volume":"277","author":"IM Graham","year":"1997","unstructured":"Graham IM, Daly LE, Refsum HM et al (1997) Plasma homocysteine as a risk factor for vascular disease: the European concerted action project. JAMA 277(22):1775\u20131781","journal-title":"JAMA"},{"issue":"3","key":"406_CR7","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1161\/STROKEAHA.113.004099","volume":"45","author":"HM Kwon","year":"2014","unstructured":"Kwon HM, Lee YS, Bae HJ (2014) Homocysteine as a predictor of early neurological deterioration in acute ischemic stroke. Stroke 45(3):871\u2013873","journal-title":"Stroke"},{"issue":"9","key":"406_CR8","doi-asserted-by":"crossref","first-page":"e107498","DOI":"10.1371\/journal.pone.0107498","volume":"9","author":"C Zhong","year":"2014","unstructured":"Zhong C, Lv L, Liu C, Zhao L, Zhou M et al (2014) High homocysteine and blood pressure related to poor outcome of acute ischemia stroke in chinese population. PLoS One 9(9):e107498. doi: 10.1371\/journal.pone.0107498","journal-title":"PLoS One"},{"key":"406_CR9","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S1474-4422(10)70038-7","volume":"9","author":"GJ Hankey","year":"2010","unstructured":"Hankey GJ, Eikelboom JW, Baker RI et al (2010) B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial. Lancet Neurol 9:855\u2013865","journal-title":"Lancet Neurol"},{"issue":"5","key":"406_CR10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jama.291.5.565","volume":"291","author":"James F Toole","year":"2004","unstructured":"Toole James F, Rene Malinow M, Chambless Lloyd E et al (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled Trial. JAMA 291(5):565\u2013575","journal-title":"JAMA"},{"issue":"4","key":"406_CR11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2796.2010.02259.x","volume":"268","author":"M Ebbing","year":"2010","unstructured":"Ebbing M, B\u00f8naa KH, Arnesen E et al (2010) Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. J Intern Med 268(4):367\u2013382","journal-title":"J Intern Med"},{"issue":"1","key":"406_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0100-879X2009007500021","volume":"43","author":"S Brustolin","year":"2010","unstructured":"Brustolin S, Giugliani R, F\u00e9lix TM (2010) Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res 43(1):1\u20137","journal-title":"Braz J Med Biol Res"},{"key":"406_CR13","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3949\/ccjm.71.9.729","volume":"71","author":"SR Lentz","year":"2004","unstructured":"Lentz SR, Haynes WG (2004) Homocysteine: it is a clinically important cardiovascular risk factor? Clevel Clin J Med 71:729\u2013734","journal-title":"Clevel Clin J Med"},{"key":"406_CR14","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1161\/STROKEAHA.112.665703","volume":"43","author":"Margherita Cavalieri","year":"2012","unstructured":"Cavalieri Margherita, Schmidt Reinhold, Chen Christopher et al (2012) B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke the VITAmins TO Prevent Stroke (VITATOPS) MRI-Substudy. Stroke 43:3266\u20133270","journal-title":"Stroke"},{"key":"406_CR15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000360153","volume":"37","author":"Amytis Towfighi","year":"2014","unstructured":"Towfighi Amytis, Arshi Baback, Markovic Daniela et al (2014) Homocysteine-lowering therapy and risk of recurrent stroke, myocardial infarction and death: the impact of age in the VISP trial. Cerebrovasc Dis 37:263\u2013267","journal-title":"Cerebrovasc Dis"},{"issue":"15","key":"406_CR16","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1212\/WNL.0b013e3182a823cc","volume":"81","author":"Y Ji","year":"2013","unstructured":"Ji Y, Tan S, Xu Y (2013) Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: a meta-analysis. Neurology 81(15):1298\u20131307","journal-title":"Neurology"},{"issue":"4","key":"406_CR17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1747-4949.2011.00584.x","volume":"6","author":"Y Wang","year":"2011","unstructured":"Wang Y, Cui L, Ji X, Dong Q et al (2011) The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics. Int J Stroke 6(4):355\u2013361","journal-title":"Int J Stroke"},{"key":"406_CR18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","volume":"24","author":"HP Adams Jr","year":"1993","unstructured":"Adams HP Jr, Bendixen BH, Kappelle LJ et al (1993) Classification of subtypes of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24:35\u201341","journal-title":"Stroke"},{"issue":"12","key":"406_CR19","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1161\/01.STR.19.12.1497","volume":"19","author":"R Bonita","year":"1988","unstructured":"Bonita R, Beaglehole R (1988) Recovery of motor function after stroke. Stroke 19(12):1497\u20131500","journal-title":"Stroke"},{"issue":"15","key":"406_CR20","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","volume":"354","author":"E Lonn","year":"2006","unstructured":"Lonn E, Yusuf S, Arnold MJ et al (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 354(15):1567\u20131577","journal-title":"N Engl J Med"},{"issue":"3","key":"406_CR21","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/STROKEAHA.114.006927","volume":"46","author":"B Arshi","year":"2015","unstructured":"Arshi B, Ovbiagele B, Markovic D et al (2015) Differential effect of B-vitamin therapy by antiplatelet use on risk of recurrent vascular events after stroke. Stroke 46(3):870\u2013873","journal-title":"Stroke"},{"key":"406_CR22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.CIR.99.1.178","volume":"99","author":"MR Malinow","year":"1999","unstructured":"Malinow MR, Bostom AG, Krauss RM (1999) Homocyst(e)ine, diet, and cardiovascular diseases:a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 99:178\u2013182","journal-title":"Circulation"},{"issue":"2","key":"406_CR23","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/01.STR.0000199147.30016.74","volume":"37","author":"RL Sacco","year":"2006","unstructured":"Sacco RL, Adams R, Albers G et al (2006) Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association\/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Stroke 37(2):577\u2013617","journal-title":"Stroke"},{"issue":"6","key":"406_CR24","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/STROKEAHA.109.573410","volume":"41","author":"M Lee","year":"2010","unstructured":"Lee M, Hong KS, Chang SC et al (2010) Efficacy of homocysteine-lowering therapy with folic Acid in stroke prevention: a meta-analysis. Stroke 41(6):1205\u20131212","journal-title":"Stroke"},{"issue":"1","key":"406_CR25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/ajcn\/69.1.99","volume":"69","author":"IA Brouwer","year":"1999","unstructured":"Brouwer IA, van Dusseldorp M, Thomas CM et al (1999) Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. Am J Clin Nutr 69(1):99\u2013104","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"406_CR26","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/ijs.12017","volume":"10","author":"X Liu","year":"2015","unstructured":"Liu X, Shi M, Xia F (2015) The China Stroke Secondary Prevention Trial (CSSPT) protocol: a double-blinded, randomized, controlled trial of combined folic acid and B vitamins for secondary prevention of stroke. Int J Stroke 10(2):264\u2013268","journal-title":"Int J Stroke"},{"key":"406_CR27","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.1038\/srep05663","volume":"4","author":"T Okura","year":"2014","unstructured":"Okura T, Miyoshi KI, Irita J et al (2014) Hyperhomocysteinemia is one of the risk factors associated with cerebrovascular stiffness in hypertensive patients, especially elderly males. Sci Rep 4:5663. doi: 10.1038\/srep05663","journal-title":"Sci Rep"}],"container-title":["Australasian Physical &amp; Engineering Sciences in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13246-015-0406-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13246-015-0406-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13246-015-0406-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T03:32:45Z","timestamp":1567395165000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13246-015-0406-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["406"],"URL":"https:\/\/doi.org\/10.1007\/s13246-015-0406-x","relation":{},"ISSN":["0158-9938","1879-5447"],"issn-type":[{"value":"0158-9938","type":"print"},{"value":"1879-5447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}