{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:05:32Z","timestamp":1777568732276,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Australas Phys Eng Sci Med"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s13246-018-0661-8","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T08:17:48Z","timestamp":1529914668000},"page":"657-667","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Biomechanical behavior of Hoffa\u2019s fat pad in healthy and osteoarthritic conditions: histological and mechanical investigations"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-9842","authenticated-orcid":false,"given":"Chiara Giulia","family":"Fontanella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Macchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele Luigi","family":"Carniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Frigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Porzionato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgardo Enrico Edoardo","family":"Picardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Favero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Ruggieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"de Caro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo N.","family":"Natali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"661_CR1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1001\/jama.1904.92500120002h","volume":"43","author":"A Hoffa","year":"1904","unstructured":"Hoffa A (1904) The influence of the adipose tissue with regard to the pathology of the knee joint. J Am Med Assoc 43:795\u2013796","journal-title":"J Am Med Assoc"},{"key":"661_CR2","volume-title":"Atlas van de anatomie","author":"W Platzer","year":"1999","unstructured":"Platzer W (1999) Atlas van de anatomie, 7th edn. Intro, Baarn","edition":"7"},{"key":"661_CR3","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.joca.2008.11.002","volume":"17","author":"KM Clements","year":"2009","unstructured":"Clements KM, Ball AD, Jones HB, Brickmann S, Read SJ, Murray F (2009) Cellular and histopathological changes in the infrapatellar fat pad in the monoiodoacetate model of osteoarthritis pain. Osteoarthr Cartil 17:805\u2013812","journal-title":"Osteoarthr Cartil"},{"key":"661_CR4","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.joca.2010.03.014","volume":"18","author":"S Clockaerts","year":"2010","unstructured":"Clockaerts S, Bastiaansen-Jenniskens YM, Runhaar J, Van Osch GJVM, Van Offel J:F, Verhaar JAN, De Clerck LS, Somville J (2010) The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review. Osteoarthr Cartil 18:876\u2013882","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"661_CR5","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/ar4422","volume":"15","author":"A Ioan-Facsinay","year":"2013","unstructured":"Ioan-Facsinay A, Kloppenburg M (2013) An emerging player in knee osteoarthritis: the infrapatellar fat pad. Arthritis Res Ther 15(6):225","journal-title":"Arthritis Res Ther"},{"key":"661_CR6","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1002\/jcp.21258","volume":"213","author":"MB Goldring","year":"2007","unstructured":"Goldring MB, Goldring SR (2007) Osteoarthritis. J Cell Physiol 213:626\u2013634","journal-title":"J Cell Physiol"},{"key":"661_CR7","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1159\/000442876","volume":"201","author":"V Macchi","year":"2016","unstructured":"Macchi V, Porzionato A, Sarasin G, Petrelli L, Guidolin D, Rossato M, Fontanella CG, Natali A, De Caro R (2016) The infrapatellar adipose body: an histotopographic study. Cell Tissue Organs 201:220\u2013231","journal-title":"Cell Tissue Organs"},{"issue":"4","key":"661_CR8","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1002\/jbm.a.35974","volume":"105","author":"B Gurumurthy","year":"2017","unstructured":"Gurumurthy B, Bierdeman P, Janorkar AV (2017) Spheroid model for osteogenic evaluation of human adipose derived stem cells. J Biomed Mat Res A 105(4):1230\u20131236","journal-title":"J Biomed Mat Res A"},{"issue":"10","key":"661_CR9","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1093\/rheumatology\/kex287","volume":"56","author":"M Favero","year":"2017","unstructured":"Favero M, El Hadi H, Belluzzi E, Granzotto M, Porzionato A, Sarasin G, Iacobellis C, Cigolotti A, Fontanella CG, Natali AN, Ramonda R, Ruggieri P, De Caro R, Rossato M, Macchi V (2017) Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study. Rheumatology 56(10):1784\u20131793","journal-title":"Rheumatology"},{"key":"661_CR10","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s11517-015-1356-x","volume":"54","author":"CG Fontanella","year":"2016","unstructured":"Fontanella CG, Nalesso F, Carniel EL, Natali AN (2016) Biomechanical behavior of plantar fat pad in healthy and degenerative foot conditions. Med Biol Eng Comput 54:653\u2013661","journal-title":"Med Biol Eng Comput"},{"key":"661_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jmbbm.2016.11.024","volume":"67","author":"CG Fontanella","year":"2017","unstructured":"Fontanella CG, Carniel EL, Frigo A, Macchi V, Porzionato A, Sarasin G, Rossato M, De Caro R, Natali AN (2017) Investigation of biomechanical response of Hoffa\u2019s fat pad and comparative characterization. J Mech Beh Biomed Mater 67:1\u20139","journal-title":"J Mech Beh Biomed Mater"},{"key":"661_CR12","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jmbbm.2011.08.025","volume":"5","author":"AN Natali","year":"2012","unstructured":"Natali AN, Fontanella CG, Carniel EL (2012) A numerical model for investigating the mechanics of calcaneal fat pad region. J Mech Behav Biomed 5:216\u2013223","journal-title":"J Mech Behav Biomed"},{"issue":"8","key":"661_CR13","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3113\/FAI.2011.0802","volume":"32","author":"Y-N Wang","year":"2011","unstructured":"Wang Y-N, Lee K, Ledoux WR (2011) Histomorphological evaluation of diabetic and non-diabetic plantar soft tissue. Foot Ankle Int 32(8):802\u2013810","journal-title":"Foot Ankle Int"},{"key":"661_CR14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/ase.69","volume":"2","author":"R Caro De","year":"2009","unstructured":"De Caro R, Macchi V, Porzionato A (2009) Promotion of body donation and use of cadavers in anatomical education at the University of Padova. Anat Sci Educ 2:91\u201392","journal-title":"Anat Sci Educ"},{"key":"661_CR15","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/ase.1285","volume":"5","author":"A Porzionato","year":"2012","unstructured":"Porzionato A, Macchi V, Stecco C, Mazzi A, Rambaldo A, Sarasin G, Parenti A, Scipioni A, De Caro R (2012) Quality management of body donation program at the University of Padova. Anat Sci Educ 5:264\u2013272","journal-title":"Anat Sci Educ"},{"key":"661_CR16","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1006\/jsre.1996.0138","volume":"61","author":"PB Dobrin","year":"1996","unstructured":"Dobrin PB (1996) Effect of histologic preparation on the cross-sectional area of arterial rings. J Surg Res 61:413\u2013415","journal-title":"J Surg Res"},{"key":"661_CR17","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.ijsolstr.2010.07.001","volume":"47","author":"K Comley","year":"2010","unstructured":"Comley K, Fleck NA (2010) A micromechanical model for the Young\u2019s modulus of adipose tissue. Int J Solids Struct 47:2982\u20132990","journal-title":"Int J Solids Struct"},{"key":"661_CR18","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/S0021-9290(02)00090-8","volume":"35","author":"JE Miller Young","year":"2002","unstructured":"Miller Young JE, Duncan NA, Baroud G (2002) Material properties of the human calcaneal fat pad in compression: experiment and theory. J Biomech 35:1523\u20131531","journal-title":"J Biomech"},{"key":"661_CR19","doi-asserted-by":"publisher","first-page":"9036","DOI":"10.1016\/j.actbio.2013.06.011","volume":"9","author":"G Sommer","year":"2013","unstructured":"Sommer G, Eder M, Kovacs L, Pathak H, Bonitz L, Mueller C, Regitnig P, Holzapfel GA (2013) Multiaxial mechanical properties and constitutive modeling of human adipose tissue: a basis for preoperative simulations in plastic and reconstructive surgery. Acta Biomater 9:9036\u20139048","journal-title":"Acta Biomater"},{"key":"661_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijimpeng.2011.12.009","volume":"46","author":"K Comley","year":"2012","unstructured":"Comley K, Fleck NA (2012) The compressive response of porcine adipose tissue from low to high strain rate. Int J Impact Eng 46:1\u201310","journal-title":"Int J Impact Eng"},{"issue":"6","key":"661_CR21","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3233\/BIR-2008-0517","volume":"45","author":"M Geerlings","year":"2008","unstructured":"Geerlings M, Peters GWM, Ackermans PAJ, Oomens CWJ, Baaijens FPT (2008) Linear viscoelastic response of adipose tissue. Biorheology 45(6):677\u2013688","journal-title":"Biorheology"},{"key":"661_CR22","first-page":"15","volume":"122","author":"JR Funk","year":"2000","unstructured":"Funk JR, Hall GW, Crandall JR, Pilkey WD (2000) Linear and quasi-linear visco-elastic characterization of ankle ligament. J Biomed Eng 122:15\u201322","journal-title":"J Biomed Eng"},{"key":"661_CR23","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/j.biomaterials.2008.11.038","volume":"30","author":"H Liao","year":"2009","unstructured":"Liao H, Zakhaleva J, Chen W (2009) Cells and tissue interactions with glycated collagen and their relevance to delayed diabetic wound healing. Biomaterials 30:1689\u20131696","journal-title":"Biomaterials"},{"key":"661_CR24","doi-asserted-by":"publisher","first-page":"614329","DOI":"10.1117\/12.654301","volume":"6143","author":"K Stevenson","year":"2006","unstructured":"Stevenson K, Schweitzer M, Hamarneh G (2006) Multi-Angle deformation analysis if Hoffa\u2019s fat pad. Proc. of SPIE 6143:614329","journal-title":"Proc. of SPIE"},{"issue":"2","key":"661_CR25","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.jbiomech.2011.10.021","volume":"45","author":"S Pai","year":"2012","unstructured":"Pai S, Ledoux WR (2012) The shear mechanical properties of diabetic and non-diabetic plantar soft tissue. J Biomech 45(2):364\u2013370","journal-title":"J Biomech"},{"issue":"4","key":"661_CR26","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/srt.12139","volume":"20","author":"CG Fontanella","year":"2014","unstructured":"Fontanella CG, Carniel EL, Forestiero A, Natali AN (2014) Investigation of the mechanical behaviour of the foot skin. Skin Res Technol 20(4):445\u2013452","journal-title":"Skin Res Technol"},{"key":"661_CR27","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.joca.2007.01.013","volume":"15","author":"EB Dam","year":"2007","unstructured":"Dam EB, Folkesson J, Pettersen MD, Christiansen C (2007) Automatic morphometric cartilage quantification in the medial tibial plateau from MRI for osteoarthritis grading. Osteoarthr Cartil 15:808\u2013818","journal-title":"Osteoarthr Cartil"},{"key":"661_CR28","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.joca.2009.04.001","volume":"17","author":"DJ Hunter","year":"2009","unstructured":"Hunter DJ, Buck R, Vignon E, Eckstein F, Brand K, Mazzuca AS, Wyman BT, Otterness I, Hellio MP, Le Graverand MPH (2009) Relation of regional articular cartilage morphometry and meniscal position by MRI to joint space width in knee radiographs. Osteoarthr Cartil 17:1170\u20131176","journal-title":"Osteoarthr Cartil"},{"key":"661_CR29","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3389\/fbioe.2014.00054","volume":"2","author":"F Galbusera","year":"2014","unstructured":"Galbusera F, Freutel M, DUrselen L, D\u2019aiuto M, Croce D, Villa T, Sansone V, Innocenti B (2014) Material models and properties in the finite ligament analysis of knee ligaments: a literature review. Front Bioeng Biotechnol 2:54","journal-title":"Front Bioeng Biotechnol"},{"issue":"2","key":"661_CR30","first-page":"158","volume":"100","author":"AN Natali","year":"2010","unstructured":"Natali AN, Carniel EL, Pavan PG (2010) Modelling of mandibole bone properties in the numerical analysis of oral implant biomechanics. Comput Methods Biomech Biomed Eng 100(2):158\u2013165","journal-title":"Comput Methods Biomech Biomed Eng"},{"issue":"4","key":"661_CR31","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1080\/10255842.2012.688105","volume":"14","author":"A Forestiero","year":"2014","unstructured":"Forestiero A, Carniel EL, Natali AN (2014) Biomechanical behaviour of ankle ligaments: constitutive formulation and numerical modelling. Comput Methods Biomech Biomed Eng 14(4):395\u2013404","journal-title":"Comput Methods Biomech Biomed Eng"},{"key":"661_CR32","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.medengphy.2012.06.008","volume":"35","author":"CG Fontanella","year":"2013","unstructured":"Fontanella CG, Forestiero A, Carniel EL, Natali AN (2013) Analysis of heel pad tissues mechanics at the heel strike in bare and shod conditions. Med Eng Phys 35:441\u2013447","journal-title":"Med Eng Phys"},{"key":"661_CR33","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1148\/radiographics.17.3.9153705","volume":"17","author":"JA Jacobson","year":"1997","unstructured":"Jacobson JA, Lenchik L, Ruhoy MK, Schweitzer ME, Resnick D (1997) MR Imaging of the infrapatellar fat pad of Hoffa. Radiographics 17:675\u2013691","journal-title":"Radiographics"},{"key":"661_CR34","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1007\/s00264-014-2427-6","volume":"38","author":"R Moverley","year":"2014","unstructured":"Moverley R, Williams D, Bardakos N, Field R (2014) Removal of the infrapatella fat pad during total knee arthroplasty: does it affect patient outcomes? Int Orthop 38:2483\u20132487","journal-title":"Int Orthop"},{"key":"661_CR35","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s11999-013-3321-z","volume":"472","author":"P Pinsornsak","year":"2014","unstructured":"Pinsornsak P, Naratrikun K, Chumchuen S (2014) The effect of infrapatellar fat pad excision on complications after minimally invasive TKA: a randomized controlled trial. Clin Orthop Relat Res 472:695\u2013701","journal-title":"Clin Orthop Relat Res"},{"issue":"10","key":"661_CR36","doi-asserted-by":"publisher","first-page":"e0163515","DOI":"10.1371\/journal.pone.0163515","volume":"11","author":"C Ye","year":"2016","unstructured":"Ye C, Zhang W, Wu W, Xu M, Nonso NS, He R (2016) Influence of the infrapatellar fat pad resection during total knee arthroplasty: a systematic review and meta-analysis. PLoS ONE 11(10):e0163515","journal-title":"PLoS ONE"},{"key":"661_CR37","volume-title":"Biomechanics: mechanical properties of living tissues","author":"YC Fung","year":"2013","unstructured":"Fung YC (2013) Biomechanics: mechanical properties of living tissues. Springer, New York"},{"key":"661_CR38","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.medengphy.2016.06.001","volume":"38","author":"HN Beidokhti","year":"2016","unstructured":"Beidokhti HN, Janssen D, Khoshgoftar M, Sprenders A, Perdahcioglu ES, Van den Boogaard T, Verdonschot N (2016) A comparison between dynamic implicit and explicit finite element simulations of the native knee joint. Med Eng Phys 38:1123\u20131130","journal-title":"Med Eng Phys"},{"key":"661_CR39","doi-asserted-by":"publisher","first-page":"011002","DOI":"10.1115\/1.4025692","volume":"136","author":"A Kiapour","year":"2014","unstructured":"Kiapour A, Kiapour AM, Kaul V, Quatman CE, Wordeman SC, Hewett TE, Demetropoulos CK, Goel VK (2014) Finite element model of the knee for investigation of injury mechanisms: development and validation. J Biomech Eng 136:011002","journal-title":"J Biomech Eng"}],"container-title":["Australasian Physical & Engineering Sciences in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13246-018-0661-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13246-018-0661-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13246-018-0661-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T06:49:50Z","timestamp":1604472590000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13246-018-0661-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,25]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["661"],"URL":"https:\/\/doi.org\/10.1007\/s13246-018-0661-8","relation":{},"ISSN":["0158-9938","1879-5447"],"issn-type":[{"value":"0158-9938","type":"print"},{"value":"1879-5447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,25]]},"assertion":[{"value":"14 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}