{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:25:20Z","timestamp":1789802720183,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Phys Eng Sci Med"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s13246-021-01007-0","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T08:02:59Z","timestamp":1621584179000},"page":"625-638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The first real-time intrafraction target position monitoring in pancreas SBRT on an Elekta linear accelerator"],"prefix":"10.1007","volume":"44","author":[{"given":"Sankar","family":"Arumugam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Pavey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Oar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Sidhom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"1007_CR1","first-page":"419","volume":"7","author":"S McGuire","year":"2016","unstructured":"McGuire S (2016) World cancer report 2014. Geneva, Switzerland: World Health Organization, international agency for research on cancer, WHO Press, 2015. Adv Nutr 7:419\u2013419","journal-title":"Adv Nutr"},{"key":"1007_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/00000658-199603000-00007","volume":"223","author":"KC Conlon","year":"1996","unstructured":"Conlon KC, Klimstra DS, Brennan MF (1996) Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors. Ann Surg 223:273","journal-title":"Ann Surg"},{"key":"1007_CR3","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.surg.2011.07.006","volume":"150","author":"MM Assifi","year":"2011","unstructured":"Assifi MM, Lu X, Eibl G, Reber HA, Li G, Hines OJ (2011) Neoadjuvant therapy in pancreatic adenocarcinoma: a meta-analysis of phase II trials. Surgery 150:466\u2013473","journal-title":"Surgery"},{"key":"1007_CR4","doi-asserted-by":"publisher","first-page":"e1000267","DOI":"10.1371\/journal.pmed.1000267","volume":"7","author":"S Gillen","year":"2010","unstructured":"Gillen S, Schuster T, Zum B\u00fcschenfelde CM, Friess H, Kleeff J (2010) Preoperative\/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med 7:e1000267","journal-title":"PLoS Med"},{"key":"1007_CR5","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/jso.23392","volume":"108","author":"BA Boone","year":"2013","unstructured":"Boone BA, Steve J, Krasinskas AM, Zureikat AH, Lembersky BC, Gibson MK et al (2013) Outcomes with FOLFIRINOX for borderline resectable and locally unresectable pancreatic cancer. J Surg Oncol 108:236\u2013241","journal-title":"J Surg Oncol"},{"key":"1007_CR6","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.30.15_suppl.e14613","author":"J Kharofa","year":"2012","unstructured":"Kharofa J, Kelly TR, Ritch PS, George B, Wiebe LA, Thomas JP et al (2012) 5-FU\/leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) induction followed by chemoXRT in borderline resectable pancreatic cancer. J Clin Oncol. https:\/\/doi.org\/10.1200\/jco.2012.30.15_suppl.e14613","journal-title":"J Clin Oncol"},{"key":"1007_CR7","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.ijrobp.2009.09.042","volume":"76","author":"L Potters","year":"2010","unstructured":"Potters L, Kavanagh B, Galvin JM, Hevezi JM, Janjan NA, Larson DA et al (2010) American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) practice guideline for the performance of stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys 76:326\u2013332","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1007_CR8","first-page":"223","volume":"5","author":"H Abbas","year":"2014","unstructured":"Abbas H, Chang B, Chen ZJ (2014) Motion management in gastrointestinal cancers. J Gastrointest Oncol 5:223","journal-title":"J Gastrointest Oncol"},{"key":"1007_CR9","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.ijrobp.2013.02.022","volume":"86","author":"MD Chuong","year":"2013","unstructured":"Chuong MD, Springett GM, Freilich JM, Park CK, Weber JM, Mellon EA et al (2013) Stereotactic body radiation therapy for locally advanced and borderline resectable pancreatic cancer is effective and well tolerated. Int J Radiat Oncol Biol Phys 86:516\u2013522","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1007_CR10","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/COC.0b013e31818da9e0","volume":"32","author":"AY Minn","year":"2009","unstructured":"Minn AY, Schellenberg D, Maxim P, Suh Y, McKenna S, Cox B et al (2009) Pancreatic tumor motion on a single planning 4D-CT does not correlate with intrafraction tumor motion during treatment. Am J Clin Oncol 32:364\u2013368","journal-title":"Am J Clin Oncol"},{"key":"1007_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.10.013","author":"M Suker","year":"2019","unstructured":"Suker M, Nuyttens JJ, Eskens FALM, Haberkorn BCM, Coene PPLO, van der Harst E et al (2019) Efficacy and feasibility of stereotactic radiotherapy after folfirinox in patients with locally advanced pancreatic cancer (LAPC-1 trial). EClinicalMedicine. https:\/\/doi.org\/10.1016\/j.eclinm.2019.10.013","journal-title":"EClinicalMedicine"},{"key":"1007_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.10.015","author":"TB Brunner","year":"2015","unstructured":"Brunner TB, Nestle U, Grosu AL, Partridge M (2015) SBRT in pancreatic cancer: what is the therapeutic window? Radiother Oncol. https:\/\/doi.org\/10.1016\/j.radonc.2014.10.015","journal-title":"Radiother Oncol"},{"key":"1007_CR13","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.ijrobp.2017.03.042","volume":"98","author":"M Akimoto","year":"2017","unstructured":"Akimoto M, Nakamura M, Nakamura A, Mukumoto N, Kishi T, Goto Y et al (2017) Inter-and intrafractional variation in the 3-dimensional positions of pancreatic tumors due to respiration under real-time monitoring. Int J Radiat Oncol Biol Phys 98:1204\u20131211","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1007_CR14","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/cncr.24059","volume":"115","author":"DT Chang","year":"2009","unstructured":"Chang DT, Schellenberg D, Shen J, Kim J, Goodman KA, Fisher GA et al (2009) Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas. Cancer 115:665\u2013672","journal-title":"Cancer"},{"key":"1007_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2100","author":"S Rudra","year":"2019","unstructured":"Rudra S, Jiang N, Rosenberg SA, Olsen JR, Roach MC, Wan L et al (2019) Using adaptive magnetic resonance image-guided radiation therapy for treatment of inoperable pancreatic cancer. Cancer Med. https:\/\/doi.org\/10.1002\/cam4.2100","journal-title":"Cancer Med"},{"key":"1007_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-019-1275-3","author":"L Boldrini","year":"2019","unstructured":"Boldrini L, Cusumano D, Cellini F, Azario L, Mattiucci GC, Valentini V (2019) Online adaptive magnetic resonance guided radiotherapy for pancreatic cancer: State of the art, pearls and pitfalls. Radiat Oncol. https:\/\/doi.org\/10.1186\/s13014-019-1275-3","journal-title":"Radiat Oncol"},{"key":"1007_CR17","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ijrobp.2018.08.021","volume":"103","author":"Y Vinogradskiy","year":"2019","unstructured":"Vinogradskiy Y, Goodman KA, Schefter T, Miften M, Jones BL (2019) The clinical and dosimetric impact of real-time target tracking in pancreatic SBRT. Int J Radiat Oncol Biol Phys 103:268\u2013275","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1007_CR18","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1118\/1.4940351","volume":"43","author":"S Arumugam","year":"2016","unstructured":"Arumugam S, Sidhom M, Xing A, Holloway L (2016) An online x-ray based position validation system for prostate hypofractionated radiotherapy. Med Phys 43:961\u2013974","journal-title":"Med Phys"},{"key":"1007_CR19","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ejmp.2016.12.014","volume":"33","author":"S Arumugam","year":"2017","unstructured":"Arumugam S, Sidhom M, Truant D, Xing A, Udovitch M, Holloway L (2017) Variable angle stereo imaging for rapid patient position correction in an in-house real-time position monitoring system. Phys Med 33:170\u2013178","journal-title":"Phys Med"},{"key":"1007_CR20","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.gie.2006.01.048","volume":"64","author":"AC Pishvaian","year":"2006","unstructured":"Pishvaian AC, Collins B, Gagnon G, Ahlawat S, Haddad NG (2006) EUS-guided fiducial placement for CyberKnife radiotherapy of mediastinal and abdominal malignancies. Gastrointest Endosc 64:412\u2013417","journal-title":"Gastrointest Endosc"},{"key":"1007_CR21","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1088\/0031-9155\/61\/4\/1677","volume":"61","author":"T Sothmann","year":"2016","unstructured":"Sothmann T, Blanck O, Poels K, Werner R, Gauer T (2016) Real time tracking in liver SBRT: comparison of CyberKnife and Vero by planning structure-based \u03b3-evaluation and dose-area-histograms. Phys Med Biol 61:1677","journal-title":"Phys Med Biol"},{"key":"1007_CR22","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.radonc.2014.05.017","volume":"112","author":"T Depuydt","year":"2014","unstructured":"Depuydt T, Poels K, Verellen D, Engels B, Collen C, Buleteanu M et al (2014) Treating patients with real-time tumor tracking using the vero gimbaled linac system: implementation and first review. Radiother Oncol 112:343\u2013351","journal-title":"Radiother Oncol"},{"key":"1007_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.003","author":"M Feng","year":"2009","unstructured":"Feng M, Balter JM, Normolle D, Adusumilli S, Cao Y, Chenevert TL et al (2009) Characterization of pancreatic tumor motion using cine MRI: surrogates for tumor position should be used with caution. Int J Radiat Oncol Biol Phys. https:\/\/doi.org\/10.1016\/j.ijrobp.2009.02.003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1007_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12577","author":"C Zeng","year":"2019","unstructured":"Zeng C, Xiong W, Li X, Reyngold M, Gewanter RM, Cuaron JJ et al (2019) Intrafraction tumor motion during deep inspiration breath hold pancreatic cancer treatment. J Appl Clin Med Phys. https:\/\/doi.org\/10.1002\/acm2.12577","journal-title":"J Appl Clin Med Phys"},{"key":"1007_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-018-1060-8","author":"V Batista","year":"2018","unstructured":"Batista V, Richter D, Chaudhri N, Naumann P, Herfarth K, J\u00e4kel O (2018) Significance of intra-fractional motion for pancreatic patients treated with charged particles. Radiat Oncol. https:\/\/doi.org\/10.1186\/s13014-018-1060-8","journal-title":"Radiat Oncol"},{"key":"1007_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.09.014","author":"J Ge","year":"2013","unstructured":"Ge J, Santanam L, Noel C, Parikh PJ (2013) Planning 4-dimensional computed tomography (4DCT) cannot adequately represent daily intrafractional motion of abdominal tumors. Int J Radiat Oncol Biol Phys. https:\/\/doi.org\/10.1016\/j.ijrobp.2012.09.014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1007_CR27","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/57\/5\/L1","author":"SS James","year":"2012","unstructured":"James SS, Mishra P, Hacker F, Berbeco RI, Lewis JH (2012) Quantifying ITV instabilities arising from 4DCT: a simulation study using patient data. Phys Med Biol. https:\/\/doi.org\/10.1088\/0031-9155\/57\/5\/L1","journal-title":"Phys Med Biol"},{"key":"1007_CR28","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-020-00870-7","author":"G Friend","year":"2020","unstructured":"Friend G, O\u2019Connor P, Charles P (2020) The effect of megavoltage field size on intrafraction cone-beam CT image quality. Phys Eng Sci Med. https:\/\/doi.org\/10.1007\/s13246-020-00870-7","journal-title":"Phys Eng Sci Med"},{"key":"1007_CR29","doi-asserted-by":"publisher","DOI":"10.1118\/1.4933248","author":"PR Poulsen","year":"2015","unstructured":"Poulsen PR, Jonassen J, Schmidt ML, Jensen C (2015) Improved quality of intrafraction kilovoltage images by triggered readout of unexposed frames. Med Phys. https:\/\/doi.org\/10.1118\/1.4933248","journal-title":"Med Phys"},{"key":"1007_CR30","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1118\/1.2207253","volume":"33","author":"D Ruan","year":"2006","unstructured":"Ruan D, Fessler JA, Balter JM, Sonke J (2006) Exploring breathing pattern irregularity with projection-based method. Med Phys 33:2491\u20132499","journal-title":"Med Phys"},{"key":"1007_CR31","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.ijrobp.2016.01.047","volume":"95","author":"L Rankine","year":"2016","unstructured":"Rankine L, Wan H, Parikh P, Maughan N, Poulsen P, DeWees T et al (2016) Cone-beam computed tomography internal motion tracking should be used to validate 4-dimensional computed tomography for abdominal radiation therapy patients. Int J Radiat Oncol Biol Phys 95:818\u2013826","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1007_CR32","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.ijrobp.2008.12.041","volume":"74","author":"M Hoogeman","year":"2009","unstructured":"Hoogeman M, Pr\u00e9vost J-B, Nuyttens J, P\u00f6ll J, Levendag P, Heijmen B (2009) Clinical accuracy of the respiratory tumor tracking system of the cyberknife: assessment by analysis of log files. Int J Radiat Oncol Biol Phys 74:297\u2013303","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1007_CR33","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.radonc.2009.12.022","volume":"94","author":"M Falk","year":"2010","unstructured":"Falk M, af Rosensch\u00f6ld PM, Keall P, Cattell H, Cho BC, Poulsen P et al (2010) Real-time dynamic MLC tracking for inversely optimized arc radiotherapy. Radiother Oncol 94:218\u2013223","journal-title":"Radiother Oncol"},{"key":"1007_CR34","doi-asserted-by":"publisher","first-page":"e469","DOI":"10.1016\/j.ijrobp.2012.06.005","volume":"84","author":"SH Bae","year":"2012","unstructured":"Bae SH, Kim M-S, Cho CK, Kang J-K, Lee SY, Lee K-N et al (2012) Predictor of severe gastroduodenal toxicity after stereotactic body radiotherapy for abdominopelvic malignancies. Int J Radiat Oncol Biol Phys 84:e469\u2013e474","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1007_CR35","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.radonc.2016.12.030","volume":"122","author":"V Verma","year":"2017","unstructured":"Verma V, Lazenby AJ, Zheng D, Bhirud AR, Ly QP, Are C et al (2017) Dosimetric parameters correlate with duodenal histopathologic damage after stereotactic body radiotherapy for pancreatic cancer: secondary analysis of a prospective clinical trial. Radiother Oncol 122:464\u2013469","journal-title":"Radiother Oncol"}],"container-title":["Physical and Engineering Sciences in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13246-021-01007-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13246-021-01007-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13246-021-01007-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T11:33:03Z","timestamp":1630323183000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13246-021-01007-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,21]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["1007"],"URL":"https:\/\/doi.org\/10.1007\/s13246-021-01007-0","relation":{},"ISSN":["2662-4729","2662-4737"],"issn-type":[{"value":"2662-4729","type":"print"},{"value":"2662-4737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,21]]},"assertion":[{"value":"22 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by a human research ethics committee, South Western Sydney Local Health District, Australia.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}