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It turns out that biomechanical research assumes an essential role in analysing the morphology and biomechanical response of the cornea, preventing pathology occurrence, and improving\/optimising treatments. In this review,\n                    <jats:italic>ex vivo, in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in silico<\/jats:italic>\n                    methods for the corneal mechanical characterization are reported. Experimental techniques are distinct in testing mode (e.g., tensile, inflation tests), samples\u2019 species (human or animal), shape and condition (e.g., healthy, treated), preservation methods, setup and test protocol (e.g., preconditioning, strain rate). The meaningful results reported in the pertinent literature are discussed, analysing differences, key features and weaknesses of the methodologies adopted. In addition, numerical techniques based on the finite element method are reported, incorporating the essential steps for the development of corneal models, such as geometry, material characterization and boundary conditions, and their application in the research field to extend the experimental results by including further relevant aspects and in the clinical field for diagnostic procedure, treatment and planning surgery. This review aims to analyse the state-of-art of the bioengineering techniques developed over the years to study the corneal biomechanics, highlighting their potentiality to improve diagnosis, treatment and healing process of the corneal tissue, and, at the same, pointing out the current limits in the experimental equipment and numerical tools that are not able to fully characterize in vivo corneal tissues non-invasively and discourage the use of finite element models in daily clinical practice for surgical planning.\n                  <\/jats:p>","DOI":"10.1007\/s13246-024-01403-2","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T08:02:12Z","timestamp":1712736132000},"page":"403-441","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ex vivo, in vivo and in silico studies of corneal biomechanics: a systematic review"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1698-9066","authenticated-orcid":false,"given":"Maria Vittoria","family":"Mascolini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4072-6597","authenticated-orcid":false,"given":"Ilaria","family":"Toniolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-2096","authenticated-orcid":false,"given":"Emanuele Luigi","family":"Carniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-9842","authenticated-orcid":false,"given":"Chiara Giulia","family":"Fontanella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"1403_CR1","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1213\/ANE.0000000000002544","volume":"126","author":"DJ Kelly","year":"2018","unstructured":"Kelly DJ, Farrell SM (2018) Physiology and role of intraocular pressure in contemporary anesthesia. 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