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As precision technologies advance, quantitative data to inform the planned accuracy of surgical margins is increasingly important. This study assesses two novel computational methods (M2, M3) to support the co-registration of 2D histologic images within 3D radiological volumes. Replicated evaluation of an established method (M1) is also performed with new data. M2 suits concave bisected sections by assuming a different orientation during tissue bandsaw than M1. M3 handles freeform geometries by using a third measurement to constrain 2D histology images within 3D space without need for geometric bandsaw assumptions. Three computed distances across 38 canine specimen dissections from each method were compared with three corresponding physical measurements collected during laboratory processing. M1 produced a mean error of 0.12 (\u00b1 1.7)\u00a0mm, M2 produced a mean error of 0.06 (\u00b1 1.9)\u00a0mm, while M3 produced a mean error of 0.02 (\u00b1 1.5)\u00a0mm. Mean errors for each method were of similar magnitude to 3D registration error reported in histology co-registration frameworks for other tissues. This study supports a simple low cost opportunity for use of digital histology images to support bone sarcoma radiology interpretation and treatment planning.<\/jats:p>","DOI":"10.1007\/s13246-026-01764-w","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:41:47Z","timestamp":1785159707000},"page":"1551-1559","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expanded methods for geometric location of 2D bone histology co-registration in 3D radiology volumes"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8485-0054","authenticated-orcid":false,"given":"Jaime","family":"Uy De Baron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"1764_CR1","doi-asserted-by":"publisher","unstructured":"Gerrand C, Athanasou N, Brennan B, Grimer R, Morland JI, Peake B, Seddon D, Whelan B, J (2016) On behalf of the british sarcoma group. uk guidelines for the management of bone sarcomas. 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The Otago University Ethics Committee confirmed that animal ethics was not required prior to the study commencing.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This work, unless stated otherwise through referencing, was obtained originally by the authors.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}