{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:54:17Z","timestamp":1791244457970,"version":"4.1.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Phys Eng Sci Med"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s13246-026-01778-4","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:57:00Z","timestamp":1784725020000},"page":"1747-1756","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinguishing model- and environment-related effects in knowledge-based planning of moderately hypofractionated prostate VMAT"],"prefix":"10.1007","volume":"49","author":[{"given":"Yuto","family":"Yamaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9561-0287","authenticated-orcid":false,"given":"Motoharu","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kamomae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kanazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Sakuragawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ikushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"issue":"3","key":"1778_CR1","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/S1470-2045(14)70482-6","volume":"16","author":"S Aluwini","year":"2015","unstructured":"Aluwini S, Pos F, Schimmel E et al (2015) Hypofractionated versus conventionally fractionated radiotherapy for patients with prostate cancer (HYPRO): acute toxicity results from a randomised non-inferiority phase 3 trial. Lancet Oncol 16(3):274\u2013283","journal-title":"Lancet Oncol"},{"issue":"8","key":"1778_CR2","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/S1470-2045(16)30102-4","volume":"17","author":"D Dearnaley","year":"2016","unstructured":"Dearnaley D, Syndikus I, Mossop H et al (2016) Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial. Lancet Oncol 17(8):1047\u20131060","journal-title":"Lancet Oncol"},{"issue":"8","key":"1778_CR3","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/S1470-2045(16)30070-5","volume":"17","author":"L Incrocci","year":"2016","unstructured":"Incrocci L, Wortel RC, Alemayehu WG et al (2016) Hypofractionated versus conventionally fractionated radiotherapy for patients with localised prostate cancer (HYPRO): final efficacy results from a randomised, multicentre, open-label, phase 3 trial. Lancet Oncol 17(8):1061\u20131069","journal-title":"Lancet Oncol"},{"issue":"3","key":"1778_CR4","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/S0022-5347(05)65855-7","volume":"166","author":"MJ Zelefsky","year":"2001","unstructured":"Zelefsky MJ, Fuks Z, Hunt M et al (2001) High dose radiation delivered by intensity modulated conformal radiotherapy improves the outcome of localized prostate cancer. J Urol 166(3):876\u2013881","journal-title":"J Urol"},{"issue":"5","key":"1778_CR5","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S0360-3016(02)02857-2","volume":"53","author":"MJ Zelefsky","year":"2002","unstructured":"Zelefsky MJ, Fuks Z, Hunt M et al (2002) High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys 53(5):1111\u20131116","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1778_CR6","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) (2024) Prostate Cancer. Version 4"},{"issue":"3","key":"1778_CR7","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.radonc.2014.11.009","volume":"113","author":"A Fogliata","year":"2014","unstructured":"Fogliata A, Belosi F, Clivio A et al (2014) On the pre-clinical validation of a commercial model-based optimisation engine: application to volumetric modulated arc therapy for patients with lung or prostate cancer. Radiother Oncol 113(3):385\u2013391","journal-title":"Radiother Oncol"},{"issue":"3","key":"1778_CR8","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.ijrobp.2014.11.014","volume":"91","author":"JP Tol","year":"2015","unstructured":"Tol JP, Delaney AR, Dahele M et al (2015) Evaluation of a knowledge-based planning solution for head and neck cancer. Int J Radiat Oncol Biol Phys 91(3):612\u2013620","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"1778_CR9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.meddos.2024.02.002","volume":"49","author":"M Sasaki","year":"2024","unstructured":"Sasaki M, Nakaguchi Y, Kamomae T et al (2024) Comparative analysis of two dose-volume histogram prediction tools for treatment planning in volumetric-modulated arc therapy: a multi-planner study. Med Dosim 49(3):271\u2013275","journal-title":"Med Dosim"},{"issue":"1","key":"1778_CR10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s13014-017-0808-x","volume":"12","author":"A Fogliata","year":"2017","unstructured":"Fogliata A, Reggiori G, Stravato A et al (2017) RapidPlan head and neck model: the objectives and possible clinical benefit. Radiat Oncol 12(1):73","journal-title":"Radiat Oncol"},{"issue":"3","key":"1778_CR11","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.radonc.2016.06.022","volume":"120","author":"M Hussein","year":"2016","unstructured":"Hussein M, South CP, Barry MA et al (2016) Clinical validation and benchmarking of knowledge-based IMRT and VMAT treatment planning in pelvic anatomy. Radiother Oncol 120(3):473\u2013479","journal-title":"Radiother Oncol"},{"issue":"2","key":"1778_CR12","doi-asserted-by":"publisher","first-page":"e218","DOI":"10.1016\/j.prro.2018.11.007","volume":"9","author":"JA Kavanaugh","year":"2019","unstructured":"Kavanaugh JA, Holler S, DeWees TA et al (2019) Multi-institutional validation of a knowledge-based planning model for patients enrolled in RTOG 0617: implications for plan quality controls in cooperative group trials. Pract Radiat Oncol 9(2):e218\u2013e227","journal-title":"Pract Radiat Oncol"},{"issue":"9","key":"1778_CR13","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s11604-017-0661-8","volume":"35","author":"M Sasaki","year":"2017","unstructured":"Sasaki M, Tominaga M, Kamomae T et al (2017) Influence of multi-leaf collimator leaf transmission on head and neck intensity-modulated radiation therapy and volumetric-modulated arc therapy planning. Jpn J Radiol 35(9):511\u2013525","journal-title":"Jpn J Radiol"},{"issue":"4","key":"1778_CR14","doi-asserted-by":"publisher","first-page":"462","DOI":"10.5603\/rpor.106490","volume":"30","author":"M Sasaki","year":"2025","unstructured":"Sasaki M, Nakaguchi Y, Kamomae T et al (2025) Linear accelerator selection: impact on feasibility dose-volume histograms and practicality in dose reduction for organs at risk during prostate volumetric-modulated arc therapy. Rep Pract Oncol Radiother 30(4):462\u2013473","journal-title":"Rep Pract Oncol Radiother"},{"key":"1778_CR15","doi-asserted-by":"publisher","first-page":"825","DOI":"10.6009\/jjrt.2012_JSRT_68.7.825","volume":"68","author":"S Fujimoto","year":"2012","unstructured":"Fujimoto S, Ono K, Furukawa K et al (2012) Influence of high-definition multileaf collimator for three-dimensional conformal radiotherapy and intensity-modulated radiotherapy of prostate cancer. Jpn J Radiol Technol 68:825\u2013834","journal-title":"Jpn J Radiol Technol"},{"issue":"12","key":"1778_CR16","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s11604-015-0481-7","volume":"33","author":"M Sasaki","year":"2015","unstructured":"Sasaki M, Ikushima H, Tominaga M, Kamomae T, Kishi T, Oita M, Harada M (2015) Dose impact of rectal gas on prostatic IMRT and VMAT. Jpn J Radiol 33(12):723\u2013733","journal-title":"Jpn J Radiol"},{"issue":"1","key":"1778_CR17","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s12194-023-00759-6","volume":"17","author":"N Masumoto","year":"2024","unstructured":"Masumoto N, Sasaki M, Nakaguchi Y et al (2024) Knowledge-based model building for treatment planning for prostate cancer using commercial treatment planning quality assurance software tools. Radiol Phys Technol 17(1):337\u2013345","journal-title":"Radiol Phys Technol"},{"issue":"7","key":"1778_CR18","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/acm2.13316","volume":"22","author":"H Hirashima","year":"2021","unstructured":"Hirashima H, Nakamura M, Mukumoto N et al (2021) Reducing variability among treatment machines using knowledge-based planning for head and neck, pancreatic, and rectal cancer. J Appl Clin Med Phys 22(7):245\u2013254","journal-title":"J Appl Clin Med Phys"},{"issue":"2","key":"1778_CR19","doi-asserted-by":"publisher","first-page":"e14168","DOI":"10.1002\/acm2.14168","volume":"25","author":"R Kaderka","year":"2024","unstructured":"Kaderka R, Dogan N, Jin W et al (2024) Effects of model size and composition on quality of head-and-neck knowledge-based plans. J Appl Clin Med Phys 25(2):e14168","journal-title":"J Appl Clin Med Phys"},{"issue":"1","key":"1778_CR20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.meddos.2025.08.002","volume":"51","author":"Y Sakuka","year":"2026","unstructured":"Sakuka Y, Sasaki M, Nakaguchi Y et al (2026) Effect of inter-planner variability on knowledge-based treatment planning in moderately hypofractionated prostate cancer. Med Dosim 51(1):84\u201390","journal-title":"Med Dosim"},{"key":"1778_CR21","doi-asserted-by":"publisher","first-page":"100297","DOI":"10.1016\/j.tipsro.2024.100297","volume":"33","author":"S Nakano","year":"2024","unstructured":"Nakano S, Sasaki M, Nakaguchi Y et al (2024) Comparative evaluation of two dose-volume histogram prediction tools for treatment planning: treatment planning quality and dose verification accuracy. Tech Innov Patient Support Radiat Oncol 33:100297","journal-title":"Tech Innov Patient Support Radiat Oncol"}],"container-title":["Physical and Engineering Sciences in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13246-026-01778-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13246-026-01778-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13246-026-01778-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:06:07Z","timestamp":1791241567000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13246-026-01778-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["1778"],"URL":"https:\/\/doi.org\/10.1007\/s13246-026-01778-4","relation":{},"ISSN":["2662-4729","2662-4737"],"issn-type":[{"value":"2662-4729","type":"print"},{"value":"2662-4737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"28 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Yuji Nakaguchi is an employee of Toyo-MedicCo., Ltd.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Tokushima University Institutional Review Board for Biomedical Research (approval no. 3434). Written informed consent was obtained from all patients prior to their inclusion in the study. The study was conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}