{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:16:49Z","timestamp":1778671009646,"version":"3.51.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s13258-017-0605-9","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:54:33Z","timestamp":1503968073000},"page":"17-24","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of rs1057035polymorphism in microRNA biogenesis pathway gene (DICER1) with azoospermia among Iranian population"],"prefix":"10.1007","volume":"40","author":[{"given":"Sahar","family":"Moghbelinejad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Najafipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdolmabood","family":"Momeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"605_CR1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","volume":"431","author":"V Ambros","year":"2004","unstructured":"Ambros V ((2004) The functions of animal microRNAs. Nature 431:350\u2013355","journal-title":"Nature"},{"key":"605_CR2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cell.2005.07.031","volume":"122","author":"S Bagga","year":"2005","unstructured":"Bagga S, Bracht J, Hunter S, Massirer K, Holtz J, Eachus R, Pasquinelli AE (2005) Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122:553\u2013563","journal-title":"Cell"},{"key":"605_CR3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281\u2013297","journal-title":"Cell"},{"key":"605_CR4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136:215\u2013233","journal-title":"Cell"},{"key":"605_CR5","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1242\/dev.050955","volume":"137","author":"JK Bj\u00f6rk","year":"2010","unstructured":"Bj\u00f6rk JK, Sandqvist A, Elsing AN, Kotaja N, Sistonen L ((2010) MiR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis. Development 137:3177\u20133184","journal-title":"Development"},{"key":"605_CR6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1261\/rna.1963810","volume":"16","author":"F Bouhallier","year":"2010","unstructured":"Bouhallier F, Allioli N, Lavial F, Chalmel F, Perrard MH, Durand P, Samarut J, Pain B, Rouault JP ((2010) Role of miR-34c microRNA in the late steps of spermatogenesis. RNA 16:720\u2013731","journal-title":"RNA"},{"key":"605_CR7","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1261\/rna.7135204","volume":"10","author":"X Cai","year":"2004","unstructured":"Cai X, Hagedorn CH, Cullen BR, Hagedorn Cullen (2004) Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10:1957\u20131966","journal-title":"RNA"},{"key":"605_CR8","first-page":"0131125","volume":"6","author":"SH Cho","year":"2015","unstructured":"Cho SH, Ko JJ, Kim JO, Jeon YJ, Yoo JK, Oh J, Oh D, Kim JW, Kim NK (2015) 3\u2032-UTR polymorphisms in the miRNA machiner genes DROSHA, DICER1, RAN, and XPO5 are associated with colorectal cancer risk in a korean population. PLoS ONE 6:e 0131125","journal-title":"PLoS ONE"},{"key":"605_CR9","doi-asserted-by":"crossref","first-page":"e25241","DOI":"10.1371\/journal.pone.0025241","volume":"6","author":"RP Da","year":"2011","unstructured":"Da RP, Ros M, Chalmel F, Zimmermann C, Toppari J, Nef S, Kotaja N (2011) DICER regulates the formation and maintenance of cell-cell junctions in the mouse seminiferous epithelium. PLoS ONE 6:e25241","journal-title":"PLoS ONE"},{"key":"605_CR10","first-page":"720","volume":"9","author":"R Dada","year":"2007","unstructured":"Dada R, Kumar R, Shamsi MB, Kumar R, Kucheria K, Sharma RK, Gupta SK, Gupta NP (2007) Higher frequency of Yq microdeletions in sperm DNA as compared to DNA isolated from blood. Asian. J Androl 9:720\u2013722","journal-title":"J Androl"},{"key":"605_CR11","first-page":"3443","volume":"84","author":"DM Kretser De","year":"1999","unstructured":"De Kretser DM, Baker HW (1999) Infertility in men: recent advances and continuing controversies. J Clin Endocrinol Metab 84:3443\u20133450","journal-title":"J Clin Endocrinol Metab"},{"key":"605_CR12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.eururo.2005.06.002","volume":"48","author":"GR Dohle","year":"2005","unstructured":"Dohle GR, Colpi GM, Hargreave TB, Papp GK, Jungwirth A, Weidner W (2005) EAU guidelines on male infertility. Eur Urol 48:703\u2013711","journal-title":"Eur Urol"},{"key":"605_CR13","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbagrm.2008.08.005","volume":"1779","author":"M Faller","year":"2008","unstructured":"Faller M, Guo F, Guo (2008) MicroRNA biogenesis: there\u2019s more than one way to skin a cat. Biochim Biophys Acta 1779:663\u2013667","journal-title":"Biochim Biophys Acta"},{"key":"605_CR14","first-page":"365","volume":"33","author":"M Fu","year":"2016","unstructured":"Fu M, Xu K, Ye J, Xu W ((2016) Association of polymorphisms of miRNA biogenesis related genes DICER and DROSHA with azoospermia. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 33:365\u2013368","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"605_CR15","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJMoa003005","volume":"345","author":"DS Guzick","year":"2001","unstructured":"Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, Carson SA, Cisneros P, Steinkampf MP, Hill JA et al (2001) Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 345:1388\u20131393","journal-title":"N Engl J Med"},{"key":"605_CR16","doi-asserted-by":"crossref","first-page":"e1738","DOI":"10.1371\/journal.pone.0001738","volume":"3","author":"K Hayashi","year":"2008","unstructured":"Hayashi K, Chuva de Sousa Lopes SM, Kaneda M, Tang F, Hajkova P, Lao K, O\u2019Carroll D, Das PP, Tarakhovsky A, Miska EA et al (2008) MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS ONE 3:e1738","journal-title":"PLoS ONE"},{"key":"605_CR17","doi-asserted-by":"crossref","unstructured":"Jie L, Xiansheng Zh, Hui T, Ning L, Yong W, Chaozhao L, Xin, Li,Fei S (2009)Altered microRNA expression in patients with non-obstructive azoospermia. Reprod Biol Endocrinol 7:13","DOI":"10.1186\/1477-7827-7-13"},{"key":"605_CR18","doi-asserted-by":"crossref","first-page":"e0118905","DOI":"10.1371\/journal.pone.0118905","volume":"10","author":"YW Jung","year":"2015","unstructured":"Jung YW, Jeon YJ, Rah H, Kim JH, Shin JE, Choi DH, Cha SH, Kim NK ((2015) Genetic variants in microRNA machinery genes are associated [corrected] with idiopathic recurrent pregnancy loss risk. PLoS ONE 10:e0118905","journal-title":"PLoS ONE"},{"key":"605_CR19","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1093\/humrep\/dep194","volume":"24","author":"N Khazamipour","year":"2009","unstructured":"Khazamipour N, Noruzinia M, Fatehmanesh P, Keyhanee M, Pujol P (2009) MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility. Hum Reprod 24:2361\u20132364","journal-title":"Hum Reprod"},{"key":"605_CR100","doi-asserted-by":"crossref","unstructured":"Kim G-J, Georg I, Scherthan H, Merkenschlager M, Guillou F, Scherer G, Barrionuevo F (2010) Dicer is required for Sertoli cell function and survival. Int J Dev Biol 54(5):867\u2013875","DOI":"10.1387\/ijdb.092874gk"},{"key":"605_CR20","doi-asserted-by":"crossref","first-page":"e25241","DOI":"10.1371\/journal.pone.0025241","volume":"6","author":"HM Korhonen","year":"2011","unstructured":"Korhonen HM., Yadav RP, Da Ros M., Chalmel F., Zimmermann C., Toppari J., Nef S., Kotaja N (2011) DICER regulates the formation and maintenance of cell-cell junctions in the mouse seminiferous epithelium. PLoS ONE 6:e25241","journal-title":"PLoS ONE"},{"key":"605_CR22","first-page":"415","volume":"425","author":"Y Lee","year":"2003","unstructured":"Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, R\u00e5dmark O, Kim S, Kim VN ((2003) The nuclear RNase III Drosha initiates. microRNA Process Nat 425:415\u2013419","journal-title":"microRNA Process Nat"},{"key":"605_CR23","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","volume":"23","author":"Y Lee","year":"2004","unstructured":"Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, Kim VN, Kim H, Yeom L, Baek K (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23:4051\u20134060","journal-title":"EMBO J"},{"key":"605_CR24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03315","volume":"433","author":"LP Lim","year":"2005","unstructured":"Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433:769\u2013773","journal-title":"Nature"},{"key":"605_CR101","doi-asserted-by":"crossref","unstructured":"Liu D, Li L, Fu H, Li S, Li J (2012) Inactivation of Dicer1 has a severe cumulative impact on the formation of mature germ cells in mouse testes. Biochem Biophys Res Commun 422(1):114\u2013120","DOI":"10.1016\/j.bbrc.2012.04.118"},{"key":"605_CR25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1095\/biolreprod.108.067827","volume":"79","author":"DM Maatouk","year":"2008","unstructured":"Maatouk DM, Loveland KL, McManus MT, Moore K, Harfe BD (2008) Dicer1 is required for differentiation of the mouse male germline. Biol Reprod 79:696\u2013703","journal-title":"Biol Reprod"},{"key":"605_CR26","first-page":"e81524","volume":"28","author":"I Martin-Guerrero","year":"2013","unstructured":"Martin-Guerrero I, Gutierrez-Camino A, Lopez-Lopez E, Bilbao-Aldaiturriaga N, Pombar-Gomez M, Ardanaz M, Garcia-Orad A (2013) Genetic variants in miRNA processing genes and pre-miRNAs are associated with the risk of chronic lymphocytic leukemia. PLoS ONE 28:e81524","journal-title":"PLoS ONE"},{"key":"605_CR27","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/leu.2014.351","volume":"29","author":"K Musilova","year":"2014","unstructured":"Musilova K, Mraz M (2014) MicroRNAs in B cell lymphomas: how a complex biology gets more complex. Leukemia 29:1004\u20131017","journal-title":"Leukemia"},{"key":"605_CR28","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/and.12537","volume":"48","author":"R Najafipour","year":"2016","unstructured":"Najafipour R, Rashvand Z, Alizadeh S, Aleyasin A, Moghbelinejad S (2016) Association of (rs222859) polymorphism in exon 1 of YBX2 gene with azoospermia, among the Iranian infertile male. Andrologia 48:956\u2013960","journal-title":"Andrologia"},{"key":"605_CR29","doi-asserted-by":"crossref","unstructured":"Osuch Wojcikiewicz E, Bruzgielewicz A, Niemczyk K, Sieniawska-Buccella O, Nowak A, Walczak A, Majsterek I (2015) Association of polymorphic variants of miRNA processing genes with larynx cancer risk in a polish population. Biomed Research International Epub","DOI":"10.1155\/2015\/298378"},{"key":"605_CR30","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1172\/JCI33680","volume":"118","author":"M Otsuka","year":"2008","unstructured":"Otsuka M, Zheng M, Hayashi M, Lee JD, Yoshino O, Lin S, Han J ((2008) Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest 118:1944\u20131954","journal-title":"J Clin Invest"},{"key":"605_CR31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ydbio.2008.11.011","volume":"326","author":"MD Papaioannou","year":"2009","unstructured":"Papaioannou MD, Pitetti JL, Ro S, Park C, Aubry F, Schaad O, Vejnar CE, K\u00fchne F, Descombes P, Zdobnov EM et al (2009) Sertoli cell DICER1 is essential for spermatogenesis in mice. Dev Biol 326:250\u2013259","journal-title":"Dev Biol"},{"key":"605_CR32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature10198","volume":"475","author":"JE Park","year":"2011","unstructured":"Park JE, Heo I, Tian Y, Simanshu DK, Chang H, Jee D, Patel DJ, Kim VN (2011) Dicer recognizes the 5\u2032 end of RNA for efficient and accuratprocessing. Nature 475:201\u2013205","journal-title":"Nature"},{"key":"605_CR33","first-page":"45461","volume":"24","author":"Y Qin","year":"2012","unstructured":"Qin Y, Xia Y, Wu W, Han X, Lu C, Ji G, Chen D, Wang H, Song L, Wang S et al (2012) Genetic variants in microRNA biogenesis pathway genes are associated with semen quality in a Han-Chinese population. Reprod Biomed Online 24:454\u201361","journal-title":"Reprod Biomed Online"},{"key":"605_CR34","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1101\/gr.2722704","volume":"14","author":"A Rodriguez","year":"2004","unstructured":"Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A (2004) Identification of mammalian microRNA host genes and transcription units. Genome Res 14:1902\u20131910","journal-title":"Genome Res"},{"key":"605_CR35","doi-asserted-by":"crossref","unstructured":"Romero Y, Meikar O, Papaioannou MD, Conne B, Grey C, Weier M, Pralong F, De Massy B, Kaessmann H, Vassalli JD, Kotaja N, Nef S (2011) Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects. PLoS One 6(10):e25241","DOI":"10.1371\/journal.pone.0025241"},{"key":"605_CR36","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C (T) method. Nat Protoc 3:1101\u20131108","journal-title":"Nat Protoc"},{"key":"605_CR37","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1289\/ehp.00108961","volume":"108","author":"SH Swan","year":"2000","unstructured":"Swan SH, Elkin EP, Fenster L ((2000) The question of declining sperm density revisited: an analysis of 101 studies published 1934\u20131996. Environ Health Perspect 108:961\u2013966","journal-title":"Environ Health Perspect"},{"key":"605_CR38","first-page":"40813","volume":"35","author":"X Tian","year":"2014","unstructured":"Tian X, Zhang B, Li X, Zhai K, Xu J, Chang J, Qiao Y, Zhou Y, Huang L, Chen J (2014) Association of microRNA-related genes (DROSHA, DICER1 and GEMIN4) polymorphisms with T-cell lymphoma prognosis. Zhonghua Xue Ye Xue Za Zhi 35:408\u201313","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"605_CR39","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s10815-012-9798-7","volume":"29","author":"M Totonchi","year":"2012","unstructured":"Totonchi M, Mohseni Meybodi A, Borjian Boroujeni P, SedighiGilani M, Almadani N, Gourabi H (2012) Clinical data for 185 infertileIranian men with Y-chromosome microdeletion. J Assist Reprod Genet 29:847\u2013853","journal-title":"J Assist Reprod Genet"},{"key":"605_CR40","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ygeno.2009.12.003","volume":"95","author":"MA Varela","year":"2010","unstructured":"Varela MA, Amos W (2010) Heterogeneous distribution of SNPs in the human genome: microsatellites as predictors of nucleotide diversity and divergence. Genomics 95:151\u2013159","journal-title":"Genomics"},{"key":"605_CR41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1055\/s-0029-1202301","volume":"27","author":"TJ Walsh","year":"2009","unstructured":"Walsh TJ, Pera RR, Turek PJ ((2009) The genetics of male infertility. Semin Reprod Med 27:124\u2013136","journal-title":"Semin Reprod Med"},{"key":"605_CR42","volume-title":"World health Organization DoRHaR. WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"WHO","year":"2010","unstructured":"WHO (2010) World health Organization DoRHaR. WHO Laboratory Manual for the Examination and Processing of Human Semen. WHO Press, Geneva"},{"key":"605_CR43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1745-7262.2006.00121.x","volume":"8","author":"Y Yang","year":"2006","unstructured":"Yang Y, Xiao CY, Zhou-Cun A, Zhang SZ, Li X, Zhang SX (2006) DAZ1\/DAZ2 cluster deletion mediated by gr\/gr recombination per se may not be sufficient for spermatogenesis impairment: a study of Chinese normozoospermic men. Asian J Androl 8:183\u2013187","journal-title":"Asian J Androl"},{"key":"605_CR44","doi-asserted-by":"crossref","first-page":"119","DOI":"10.7314\/APJCP.2015.16.1.119","volume":"16","author":"YY Yu","year":"2015","unstructured":"Yu YY, Kuang D, Yin XX (2015) Association between the DICER rs1057035 polymorphism and cancer risk: evidence from a meta-analysis of 1,2675 individuals. Asian. Pac J Cancer Prev 16:119\u201324","journal-title":"Pac J Cancer Prev"},{"key":"605_CR45","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1387\/ijdb.092874gk","volume":"54","author":"L Yuan","year":"2010","unstructured":"Yuan L, Chu H, Wang M, Gu X, Shi D, Ma L, Zhong D, Du M, Li P, Tong N et al (2010) Genetic variation in DROSHA 3\u2032UTR regulated by hsa-miR-27b is associated with bladder cancer risk. Int J Dev Biol 54:867\u2013875","journal-title":"Int J Dev Biol"},{"key":"605_CR46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fertnstert.2011.04.053","volume":"96","author":"H Zhang","year":"2011","unstructured":"Zhang H, Liu Y, Su D, Yang Y, Bai G, Tao D et al (2011) A single nucleotide polymorphism in a miR-1302 binding site in CGA increases the risk of idiopathic male infertility. Fertil Steril 96:34\u201339","journal-title":"Fertil Steril"},{"key":"605_CR47","doi-asserted-by":"crossref","unstructured":"Zhou X, Ruan J, Wang G, Zhang W, Zhang RW (2007) Characterization and identification of microRNA core promoters in four model species\u201d. PLoS Comput Biol 3:e37","DOI":"10.1371\/journal.pcbi.0030037"},{"issue":"9","key":"605_CR48","doi-asserted-by":"crossref","first-page":"e107023","DOI":"10.1371\/journal.pone.0107023","volume":"9","author":"C Zimmermann","year":"2014","unstructured":"Zimmermann C, Romero Y, Warnefors M, Bilican A., Borel C, Smith LB, Kotaja N, Kaessmann H, Nef S (2014) Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility. PLoS ONE 9(9):e107023","journal-title":"PLoS ONE"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13258-017-0605-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-017-0605-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-017-0605-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T17:42:42Z","timestamp":1570038162000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13258-017-0605-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["605"],"URL":"https:\/\/doi.org\/10.1007\/s13258-017-0605-9","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]}}}