{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:32:53Z","timestamp":1756571573566,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007924","name":"Bengbu Medical College","doi-asserted-by":"publisher","award":["BYKY1677"],"award-info":[{"award-number":["BYKY1677"]}],"id":[{"id":"10.13039\/501100007924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s13258-018-0717-x","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T10:57:59Z","timestamp":1530183479000},"page":"1101-1109","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between STAT4 polymorphisms and risk of primary biliary cholangitis: a meta-analysis"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7898-9056","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanmiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiasheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuihua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"717_CR1","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1002\/art.39504","volume":"68","author":"ME Alarcon-Riquelme","year":"2016","unstructured":"Alarcon-Riquelme ME, Ziegler JT, Molineros J, Howard TD, Moreno-Estrada A, Sanchez-Rodriguez E, Ainsworth HC, Ortiz-Tello P, Comeau ME, Rasmussen A et al (2016) Genome-wide association study in an Amerindian ancestry population reveals novel systemic lupus erythematosus risk loci and the role of European admixture. Arthritis Rheumatol 68:932\u2013943","journal-title":"Arthritis Rheumatol"},{"key":"717_CR2","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1002\/art.30171","volume":"63","author":"J Avouac","year":"2011","unstructured":"Avouac J, Furnrohr BG, Tomcik M, Palumbo K, Zerr P, Horn A, Dees C, Akhmetshina A, Beyer C, Distler O et al (2011) Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis. Arthritis Rheum 63:800\u2013809","journal-title":"Arthritis Rheum"},{"key":"717_CR3","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1002\/hep.28140","volume":"62","author":"U Beuers","year":"2015","unstructured":"Beuers U, Gershwin ME, Gish RG, Invernizzi P, Jones DE, Lindor K, Ma X, Mackay IR, Pares A, Tanaka A et al (2015) Changing nomenclature for PBC: From \u2018cirrhosis\u2019 to \u2018cholangitis\u2019. Hepatology 62:1620\u20131622","journal-title":"Hepatology"},{"key":"717_CR4","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.jhep.2011.10.025","volume":"56","author":"K Boonstra","year":"2012","unstructured":"Boonstra K, Beuers U, Ponsioen CY (2012) Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: a systematic review. J Hepatol 56:1181\u20131188","journal-title":"J Hepatol"},{"key":"717_CR5","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1155\/2015\/764684","volume":"29","author":"AC Cheung","year":"2015","unstructured":"Cheung AC, Montano-Loza A, Swain M, Vincent C, Renner E, Sherman M, Janssen HL, Mason AL (2015) Time to make the change from \u2018primary biliary cirrhosis\u2019 to \u2018primary biliary cholangitis\u2019. Can J Gastroenterol Hepatol 29:293","journal-title":"Can J Gastroenterol Hepatol"},{"key":"717_CR6","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1007\/s12016-015-8472-0","volume":"48","author":"M Dong","year":"2015","unstructured":"Dong M, Li J, Tang R, Zhu P, Qiu F, Wang C, Qiu J, Wang L, Dai Y, Xu P et al (2015) Multiple genetic variants associated with primary biliary cirrhosis in a Han Chinese population. Clin Rev Allergy Immunol 48:316\u2013321","journal-title":"Clin Rev Allergy Immunol"},{"key":"717_CR7","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1007\/s10067-017-3632-7","volume":"36","author":"D El-Lebedy","year":"2017","unstructured":"El-Lebedy D, Raslan H, Ibrahim A, Ashmawy I, El-Aziz SA, Mohammed AM (2017) Association of STAT4 rs7574865 and PTPN22 rs2476601 polymorphisms with rheumatoid arthritis and non-systemically reacting antibodies in Egyptian patients. Clin Rheumatol 36:1981\u20131987","journal-title":"Clin Rheumatol"},{"key":"717_CR8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s12016-016-8550-y","volume":"52","author":"A Goropevsek","year":"2017","unstructured":"Goropevsek A, Holcar M, Avcin T (2017) The role of STAT signaling pathways in the pathogenesis of systemic lupus erythematosus. Clin Rev Allergy Immunol 52:164\u2013181","journal-title":"Clin Rev Allergy Immunol"},{"key":"717_CR9","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1056\/NEJMoa0810440","volume":"360","author":"GM Hirschfield","year":"2009","unstructured":"Hirschfield GM, Liu X, Xu C, Lu Y, Xie G, Gu X, Walker EJ, Jing K, Juran BD, Mason AL et al (2009) Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med 360:2544\u20132555","journal-title":"N Engl J Med"},{"key":"717_CR10","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s11033-009-9553-z","volume":"37","author":"JD Ji","year":"2010","unstructured":"Ji JD, Lee WJ, Kong KA, Woo JH, Choi SJ, Lee YH, Song GG (2010) Association of STAT4 polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep 37:141\u2013147","journal-title":"Mol Biol Rep"},{"key":"717_CR11","doi-asserted-by":"publisher","first-page":"727393","DOI":"10.1155\/2014\/727393","volume":"2014","author":"S Joshita","year":"2014","unstructured":"Joshita S, Umemura T, Nakamura M, Katsuyama Y, Shibata S, Kimura T, Morita S, Komatsu M, Matsumoto A, Yoshizawa K et al (2014) STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis. Dis Markers 2014:727393","journal-title":"Dis Markers"},{"key":"717_CR12","doi-asserted-by":"publisher","first-page":"3073504","DOI":"10.1155\/2017\/3073504","volume":"2017","author":"S Joshita","year":"2017","unstructured":"Joshita S, Umemura T, Tanaka E, Ota M (2017) Genetic contribution to the pathogenesis of primary biliary cholangitis. J Immunol Res 2017:3073504","journal-title":"J Immunol Res"},{"key":"717_CR13","doi-asserted-by":"publisher","first-page":"5209","DOI":"10.1093\/hmg\/dds359","volume":"21","author":"BD Juran","year":"2012","unstructured":"Juran BD, Hirschfield GM, Invernizzi P, Atkinson EJ, Li Y, Xie G, Kosoy R, Ransom M, Sun Y, Bianchi I et al (2012) Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants. Hum Mol Genet 21:5209\u20135221","journal-title":"Hum Mol Genet"},{"key":"717_CR14","doi-asserted-by":"publisher","first-page":"e0142683","DOI":"10.1371\/journal.pone.0142683","volume":"10","author":"A Lamana","year":"2015","unstructured":"Lamana A, Lopez-Santalla M, Castillo-Gonzalez R, Ortiz AM, Martin J, Garcia-Vicuna R, Gonzalez-Alvaro I (2015) The minor allele of rs7574865 in the STAT4 gene is associated with increased mRNA and protein expression. PLoS ONE 10:e0142683","journal-title":"PLoS ONE"},{"key":"717_CR15","doi-asserted-by":"publisher","first-page":"820","DOI":"10.7326\/0003-4819-127-9-199711010-00008","volume":"127","author":"J Lau","year":"1997","unstructured":"Lau J, Ioannidis JP, Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127:820\u2013826","journal-title":"Ann Intern Med"},{"key":"717_CR16","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/hep.22906","volume":"50","author":"KD Lindor","year":"2009","unstructured":"Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ, American Association for Study of Liver D (2009) Primary biliary cirrhosis. Hepatology 50:291\u2013308","journal-title":"Hepatology"},{"key":"717_CR17","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/ng.627","volume":"42","author":"X Liu","year":"2010","unstructured":"Liu X, Invernizzi P, Lu Y, Kosoy R, Bianchi I, Podda M, Xu C, Xie G, Macciardi F, Selmi C et al (2010) Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet 42:658\u2013660","journal-title":"Nat Genet"},{"key":"717_CR18","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1038\/ng.2395","volume":"44","author":"JZ Liu","year":"2012","unstructured":"Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L, Cordell HJ, Ducker SJ, Day DB, Heneghan MA, Neuberger JM et al (2012) Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. Nat Genet 44:1137\u20131141","journal-title":"Nat Genet"},{"key":"717_CR19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/ng.789","volume":"43","author":"GF Mells","year":"2011","unstructured":"Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA, Neuberger JM, Donaldson PT, Day DB et al (2011) Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat Genet 43:329\u2013332","journal-title":"Nat Genet"},{"key":"717_CR20","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1001\/jamadermatol.2015.2","volume":"151","author":"AP Moy","year":"2015","unstructured":"Moy AP, Murali M, Kroshinsky D, Duncan LM, Nazarian RM (2015) Immunologic Overlap of Helper T-Cell Subtypes 17 and 22 in Erythrodermic Psoriasis and Atopic Dermatitis. JAMA Dermatol 151:753\u2013760","journal-title":"JAMA Dermatol"},{"key":"717_CR21","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1080\/03009742.2016.1199734","volume":"46","author":"E Myrthianou","year":"2017","unstructured":"Myrthianou E, Zervou MI, Budu-Aggrey A, Eliopoulos E, Kardassis D, Boumpas DT, Kougkas N, Barton A, Sidiropoulos P, Goulielmos GN (2017) Investigation of the genetic overlap between rheumatoid arthritis and psoriatic arthritis in a Greek population. Scand J Rheumatol 46:180\u2013186","journal-title":"Scand J Rheumatol"},{"key":"717_CR22","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.ajhg.2012.08.010","volume":"91","author":"M Nakamura","year":"2012","unstructured":"Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M et al (2012) Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet 91:721\u2013728","journal-title":"Am J Hum Genet"},{"key":"717_CR23","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.jhep.2009.11.027","volume":"52","author":"R Poupon","year":"2010","unstructured":"Poupon R (2010) Primary biliary cirrhosis: a 2010 update. J Hepatol 52:745\u2013758","journal-title":"J Hepatol"},{"key":"717_CR24","doi-asserted-by":"publisher","first-page":"14828","DOI":"10.1038\/ncomms14828","volume":"8","author":"F Qiu","year":"2017","unstructured":"Qiu F, Tang R, Zuo X, Shi X, Wei Y, Zheng X, Dai Y, Gong Y, Wang L, Xu P et al (2017) A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. Nat Commun 8:14828","journal-title":"Nat Commun"},{"key":"717_CR25","doi-asserted-by":"publisher","first-page":"144","DOI":"10.24953\/turkjped.2017.02.005","volume":"59","author":"A Salmaninejad","year":"2017","unstructured":"Salmaninejad A, Mahmoudi M, Aslani S, Poursani S, Ziaee V, Rezaei N (2017) Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients. Turk J Pediatr 59:144\u2013149","journal-title":"Turk J Pediatr"},{"key":"717_CR26","doi-asserted-by":"publisher","first-page":"g7647","DOI":"10.1136\/bmj.g7647","volume":"350","author":"L Shamseer","year":"2015","unstructured":"Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, Group P-P (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 350:g7647","journal-title":"BMJ"},{"key":"717_CR27","doi-asserted-by":"publisher","first-page":"228","DOI":"10.5114\/pdia.2017.67479","volume":"34","author":"K Skonieczna","year":"2017","unstructured":"Skonieczna K, Czajkowski R, Kaszewski S, Gawrych M, Jakubowska A, Grzybowski T (2017) Genetic similarities and differences between discoid and systemic lupus erythematosus patients within the Polish population. Postepy Dermatol Alergol 34:228\u2013232","journal-title":"Postepy Dermatol Alergol"},{"key":"717_CR28","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1136\/bmj.323.7304.101","volume":"323","author":"JA Sterne","year":"2001","unstructured":"Sterne JA, Egger M, Smith GD (2001) Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis. BMJ 323:101\u2013105","journal-title":"BMJ"},{"key":"717_CR29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jaut.2015.08.016","volume":"66","author":"GJ Webb","year":"2016","unstructured":"Webb GJ, Hirschfield GM (2016) Using GWAS to identify genetic predisposition in hepatic autoimmunity. J Autoimmun 66:25\u201339","journal-title":"J Autoimmun"},{"key":"717_CR30","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jaut.2015.07.004","volume":"64","author":"GJ Webb","year":"2015","unstructured":"Webb GJ, Siminovitch KA, Hirschfield GM (2015) The immunogenetics of primary biliary cirrhosis: A comprehensive review. J Autoimmun 64:42\u201352","journal-title":"J Autoimmun"},{"key":"717_CR31","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1111\/ijd.12839","volume":"55","author":"Y Xu","year":"2016","unstructured":"Xu Y, Wang W, Tian Y, Liu J, Yang R (2016) Polymorphisms in STAT4 and IRF5 increase the risk of systemic sclerosis: a meta-analysis. Int J Dermatol 55:408\u2013416","journal-title":"Int J Dermatol"},{"key":"717_CR32","doi-asserted-by":"publisher","first-page":"12280","DOI":"10.3390\/ijms150712280","volume":"15","author":"N Yan","year":"2014","unstructured":"Yan N, Meng S, Zhou J, Xu J, Muhali FS, Jiang W, Shi L, Shi X, Zhang J (2014) Association between STAT4 gene polymorphisms and autoimmune thyroid diseases in a Chinese population. Int J Mol Sci 15:12280\u201312293","journal-title":"Int J Mol Sci"},{"key":"717_CR33","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.humimm.2013.04.034","volume":"74","author":"J Zheng","year":"2013","unstructured":"Zheng J, Yin J, Huang R, Petersen F, Yu X (2013) Meta-analysis reveals an association of STAT4 polymorphisms with systemic autoimmune disorders and anti-dsDNA antibody. Hum Immunol 74:986\u2013992","journal-title":"Hum Immunol"}],"container-title":["Genes &amp; Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13258-018-0717-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-018-0717-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-018-0717-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T08:44:02Z","timestamp":1569228242000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13258-018-0717-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,28]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["717"],"URL":"https:\/\/doi.org\/10.1007\/s13258-018-0717-x","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"type":"print","value":"1976-9571"},{"type":"electronic","value":"2092-9293"}],"subject":[],"published":{"date-parts":[[2018,6,28]]},"assertion":[{"value":"29 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Li Zhang, Chunming Gao, Chuanmiao Liu, Jiasheng Chen and Kuihua Xu declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}