{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T15:34:40Z","timestamp":1769182480308,"version":"3.49.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31400153"],"award-info":[{"award-number":["31400153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Fund for the Doctoral Program of Hubei University of Technology","award":["BSQD2015004"],"award-info":[{"award-number":["BSQD2015004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s13258-018-0760-7","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T05:06:48Z","timestamp":1543468008000},"page":"343-357","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene"],"prefix":"10.1007","volume":"41","author":[{"given":"Chenguang","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanghong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caili","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"760_CR1","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1517\/17425255.2013.816285","volume":"9","author":"A Ande","year":"2013","unstructured":"Ande A, McArthur C, Kumar A, Kumar S (2013) Tobacco smoking effect on HIV-1 pathogenesis: role of cytochrome P450 isozymes. Expert Opin Drug Metab Toxicol 9:1453\u20131464","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"760_CR2","doi-asserted-by":"publisher","first-page":"3796","DOI":"10.1128\/JVI.02020-07","volume":"82","author":"A Autret","year":"2008","unstructured":"Autret A, Martin-Latil S, Brisac C, Mousson L, Colbere-Garapin F, Blondel B (2008) Early phosphatidylinositol 3-kinase\/Akt pathway activation limits poliovirus-induced JNK-mediated cell death. J Virol 82:3796\u20133802","journal-title":"J Virol"},{"key":"760_CR3","doi-asserted-by":"publisher","first-page":"11248","DOI":"10.1021\/jp204488j","volume":"115","author":"K Berka","year":"2011","unstructured":"Berka K, Hendrychova T, Anzenbacher P, Otyepka M (2011) Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site. J Phys Chem A 115:11248\u201311255","journal-title":"J Phys Chem A"},{"key":"760_CR4","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1038\/eye.2016.179","volume":"30","author":"BS Betts-Obregon","year":"2016","unstructured":"Betts-Obregon BS, Mondragon AA, Mendiola AS, LeBaron RG, Asmis R, Zou T, Gonzalez-Fernandez F, Tsin AT (2016) TGFbeta induces BIGH3 expression and human retinal pericyte apoptosis: a novel pathway of diabetic retinopathy. Eye (Lond) 30:1639\u20131647","journal-title":"Eye (Lond)"},{"key":"760_CR5","doi-asserted-by":"publisher","first-page":"5404","DOI":"10.1128\/JVI.02529-09","volume":"84","author":"S Blackham","year":"2010","unstructured":"Blackham S, Baillie A, Al-Hababi F, Remlinger K, You S, Hamatake R, McGarvey MJ (2010) Gene expression profiling indicates the roles of host oxidative stress, apoptosis, lipid metabolism, and intracellular transport genes in the replication of hepatitis C virus. J Virol 84:5404\u20135414","journal-title":"J Virol"},{"key":"760_CR6","doi-asserted-by":"publisher","first-page":"11700","DOI":"10.1073\/pnas.182372299","volume":"99","author":"LM Butler","year":"2002","unstructured":"Butler LM, Zhou X, Xu WS, Scher HI, Rifkind RA, Marks PA, Richon VM (2002) The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. Proc Natl Acad Sci USA 99:11700\u201311705","journal-title":"Proc Natl Acad Sci USA"},{"key":"760_CR7","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1080\/13550280490521032","volume":"10","author":"SC Chang","year":"2004","unstructured":"Chang SC, Lin JY, Lo LY, Li ML, Shih SR (2004) Diverse apoptotic pathways in enterovirus 71-infected cells. J Neurovirol 10:338\u2013349","journal-title":"J Neurovirol"},{"key":"760_CR8","doi-asserted-by":"publisher","first-page":"31373","DOI":"10.1074\/jbc.M111.254896","volume":"286","author":"SC Chen","year":"2011","unstructured":"Chen SC, Chang LY, Wang YW, Chen YC, Weng KF, Shih SR, Shih HM (2011) Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis. J Biol Chem 286:31373\u201331384","journal-title":"J Biol Chem"},{"key":"760_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijid.2014.07.024","volume":"28","author":"JF Chen","year":"2014","unstructured":"Chen JF, Zhang RS, Ou XH, Chen FM, Sun BC (2014) The role of enterovirus 71 and coxsackievirus A strains in a large outbreak of hand, foot, and mouth disease in 2012 in Changsha, China. Int J Infect Dis 28:17\u201325","journal-title":"Int J Infect Dis"},{"key":"760_CR10","first-page":"e135720","volume":"10","author":"F Chen","year":"2015","unstructured":"Chen F, Zhang C, Jia X, Wang S, Wang J, Chen Y, Zhao J, Tian S, Han X, Han L (2015) Transcriptome profiles of human lung epithelial cells A549 interacting with Aspergillus fumigatus by RNA-SEq. PLoS One 10:e135720","journal-title":"PLoS One"},{"key":"760_CR11","first-page":"441","volume":"38","author":"Q Chen","year":"2017","unstructured":"Chen Q, Xing XS, Wu Y, Liao QH, Liu GP, Jiang XQ, Guan XH (2017) Hand, foot and mouth disease in Hubei province, 2009\u20132015: an epidemiological and etiological study. Zhonghua Liu Xing Bing Xue Za Zhi 38:441\u2013445","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"760_CR12","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1002\/hep.29319","volume":"66","author":"T Chida","year":"2017","unstructured":"Chida T, Ito M, Nakashima K, Kanegae Y, Aoshima T, Takabayashi S, Kawata K, Nakagawa Y, Yamamoto M, Shimano H, Matsuura T, Kobayashi Y, Suda T, Suzuki T (2017) Critical role of CREBH-mediated induction of TGF-beta2 by HCV infection in fibrogenic responses in hepatic stellate cells. Hepatology 66:1430\u20131443","journal-title":"Hepatology"},{"key":"760_CR13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.lfs.2015.09.003","volume":"141","author":"MS Choi","year":"2015","unstructured":"Choi MS, Jeong HJ, Kang TH, Shin HM, Oh ST, Choi Y, Jeon S (2015) Meso-dihydroguaiaretic acid induces apoptosis and inhibits cell migration via p38 activation and EGFR\/Src\/intergrin beta3 downregulation in breast cancer cells. Life Sci 141:81\u201389","journal-title":"Life Sci"},{"key":"760_CR14","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0962-8924(00)01803-1","volume":"10","author":"S Desagher","year":"2000","unstructured":"Desagher S, Martinou JC (2000) Mitochondria as the central control point of apoptosis. Trends Cell Biol 10:369\u2013377","journal-title":"Trends Cell Biol"},{"key":"760_CR15","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1097\/MAJ.0000000000000442","volume":"349","author":"S Dong","year":"2015","unstructured":"Dong S, Geng L, Shen MD, Zheng SS (2015) Natural Killer cell activating receptor NKG2D Is involved in the immunosuppressive effects of mycophenolate mofetil and hepatitis B virus infection. Am J Med Sci 349:432\u2013437","journal-title":"Am J Med Sci"},{"key":"760_CR16","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1128\/JVI.64.2.748-756.1990","volume":"64","author":"MM Falk","year":"1990","unstructured":"Falk MM, Grigera PR, Bergmann IE, Zibert A, Multhaup G, Beck E (1990) Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3. J Virol 64:748\u2013756","journal-title":"J Virol"},{"key":"760_CR17","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1093\/nar\/gkn1004","volume":"37","author":"Z Ghosh","year":"2009","unstructured":"Ghosh Z, Mallick B, Chakrabarti J (2009) Cellular versus viral microRNAs in host-virus interaction. Nucleic Acids Res 37:1035\u20131048","journal-title":"Nucleic Acids Res"},{"key":"760_CR18","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.3892\/ol.2017.6296","volume":"14","author":"Z He","year":"2017","unstructured":"He Z, Yu Y, Nong Y, Du L, Liu C, Cao Y, Bai L, Tang H (2017) Hepatitis B virus X protein promotes hepatocellular carcinoma invasion and metastasis via upregulating thioredoxin interacting protein. Oncol Lett 14:1323\u20131332","journal-title":"Oncol Lett"},{"key":"760_CR19","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1056\/NEJM199909233411301","volume":"341","author":"M Ho","year":"1999","unstructured":"Ho M, Chen ER, Hsu KH, Twu SJ, Chen KT, Tsai SF, Wang JR, Shih SR (1999) An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med 341:929\u2013935","journal-title":"N Engl J Med"},{"key":"760_CR20","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1056\/NEJM199909233411302","volume":"341","author":"CC Huang","year":"1999","unstructured":"Huang CC, Liu CC, Chang YC, Chen CY, Wang ST, Yeh TF (1999) Neurologic complications in children with enterovirus 71 infection. N Engl J Med 341:936\u2013942","journal-title":"N Engl J Med"},{"key":"760_CR21","doi-asserted-by":"publisher","first-page":"R183","DOI":"10.1186\/gb-2007-8-9-r183","volume":"8","author":"DW Huang","year":"2007","unstructured":"Huang DW, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC, Lempicki RA (2007) The DAVID gene functional classification tool: a novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol 8:R183","journal-title":"Genome Biol"},{"key":"760_CR22","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44\u201357","journal-title":"Nat Protoc"},{"key":"760_CR23","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1038\/s41598-018-20318-z","volume":"8","author":"J Huang","year":"2018","unstructured":"Huang J, Chen S, Wu Y, Tong Y, Wang L, Zhu M, Hu S, Guan X, Wei S (2018) Quantifying the influence of temperature on hand, foot and mouth disease incidence in Wuhan, Central China. Sci Rep 8:1934","journal-title":"Sci Rep"},{"key":"760_CR24","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1099\/0022-1317-83-6-1367","volume":"83","author":"RL Kuo","year":"2002","unstructured":"Kuo RL, Kung SH, Hsu YY, Liu WT (2002) Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death. J Gen Virol 83:1367\u20131376","journal-title":"J Gen Virol"},{"key":"760_CR25","doi-asserted-by":"publisher","first-page":"3980","DOI":"10.4049\/jimmunol.1000990","volume":"185","author":"HJ Kwon","year":"2010","unstructured":"Kwon HJ, Won YS, Suh HW, Jeon JH, Shao Y, Yoon SR, Chung JW, Kim TD, Kim HM, Nam KH, Yoon WK, Kim DG, Kim JH, Kim YS, Kim DY, Kim HC, Choi I (2010) Vitamin D3 upregulated protein 1 suppresses TNF-alpha-induced NF-kappaB activation in hepatocarcinogenesis. J Immunol 185:3980\u20133989","journal-title":"J Immunol"},{"key":"760_CR26","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/j.1462-5822.2005.00644.x","volume":"8","author":"WF Leong","year":"2006","unstructured":"Leong WF, Chow VT (2006) Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Cell Microbiol 8:565\u2013580","journal-title":"Cell Microbiol"},{"key":"760_CR27","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s13238-014-0039-y","volume":"5","author":"C Li","year":"2014","unstructured":"Li C, Hu J, Hao J, Zhao B, Wu B, Sun L, Peng S, Gao GF, Meng S (2014) Competitive virus and host RNAs: the interplay of a hidden virus and host interaction. Protein Cell 5:348\u2013356","journal-title":"Protein Cell"},{"key":"760_CR28","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00705-013-1888-z","volume":"159","author":"C Liu","year":"2014","unstructured":"Liu C, Chen X (2014) A potential cellular host factor homologous to ZNF-136 can interact with truncated nonstructural protein 2 of hepatitis C virus. Arch Virol 159:785\u2013789","journal-title":"Arch Virol"},{"key":"760_CR29","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/cdd.2013.150","volume":"21","author":"S Lukic","year":"2014","unstructured":"Lukic S, Nicolas JC, Levine AJ (2014) The diversity of zinc-finger genes on human chromosome 19 provides an evolutionary mechanism for defense against inherited endogenous retroviruses. Cell Death Differ 21:381\u2013387","journal-title":"Cell Death Differ"},{"key":"760_CR30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.tox.2007.09.013","volume":"242","author":"M Lundgren","year":"2007","unstructured":"Lundgren M, Darnerud PO, Molin Y, Lilienthal H, Blomberg J, Ilback NG (2007) Coxsackievirus B3 infection and PBDE exposure causes organ-specific effects on CYP-gene expression in the mouse. Toxicology 242:91\u201399","journal-title":"Toxicology"},{"key":"760_CR31","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1586\/14760584.2016.1138862","volume":"15","author":"QY Mao","year":"2016","unstructured":"Mao QY, Wang Y, Bian L, Xu M, Liang Z (2016) EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD). Expert Rev Vaccines 15:599\u2013606","journal-title":"Expert Rev Vaccines"},{"key":"760_CR32","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1124\/jpet.117.247288","volume":"365","author":"JM McMillan","year":"2018","unstructured":"McMillan JM, Cobb DA, Lin Z, Banoub MG, Dagur RS, Branch WA, Wang W, Makarov E, Kocher T, Joshi PS, Quadros RM, Harms DW, Cohen SM, Gendelman HE, Gurumurthy CB, Gorantla S, Poluektova LY (2018) Antiretroviral drug metabolism in humanized PXR-CAR-CYP3A-NOG mice. J Pharmacol Exp Ther 365:272\u2013280","journal-title":"J Pharmacol Exp Ther"},{"key":"760_CR33","first-page":"24","volume":"1","author":"NM Midde","year":"2015","unstructured":"Midde NM, Kumar S (2015) Development of NanoART for HIV treatment: minding the cytochrome P450 (CYP) enzymes. J Pers Nanomed 1:24\u201332","journal-title":"J Pers Nanomed"},{"key":"760_CR34","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1099\/jmm.0.079699-0","volume":"63","author":"K Mizuta","year":"2014","unstructured":"Mizuta K, Aoki Y, Matoba Y, Yahagi K, Itagaki T, Katsushima F, Katsushima Y, Ito S, Hongo S, Matsuzaki Y (2014) Molecular epidemiology of enterovirus 71 strains isolated from children in Yamagata, Japan, between 1990 and 2013. J Med Microbiol 63:1356\u20131362","journal-title":"J Med Microbiol"},{"key":"760_CR35","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1093\/carcin\/bgr137","volume":"32","author":"K Nishizawa","year":"2011","unstructured":"Nishizawa K, Nishiyama H, Matsui Y, Kobayashi T, Saito R, Kotani H, Masutani H, Oishi S, Toda Y, Fujii N, Yodoi J, Ogawa O (2011) Thioredoxin-interacting protein suppresses bladder carcinogenesis. Carcinogenesis 32:1459\u20131466","journal-title":"Carcinogenesis"},{"key":"760_CR36","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s13104-016-1973-y","volume":"9","author":"C Omana-Cepeda","year":"2016","unstructured":"Omana-Cepeda C, Martinez-Valverde A, Sabater-Recolons M, Jane-Salas E, Mari-Roig A, Lopez-Lopez J (2016) A literature review and case report of hand, foot and mouth disease in an immunocompetent adult. BMC Res Notes 9:165","journal-title":"BMC Res Notes"},{"key":"760_CR37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/1471-2180-14-147","volume":"14","author":"H Peng","year":"2014","unstructured":"Peng H, Shi M, Zhang L, Li Y, Sun J, Zhang L, Wang X, Xu X, Zhang X, Mao Y, Ji Y, Jiang J, Shi W (2014) Activation of JNK1\/2 and p38 MAPK signaling pathways promotes enterovirus 71 infection in immature dendritic cells. BMC Microbiol 14:147","journal-title":"BMC Microbiol"},{"key":"760_CR38","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1086\/521895","volume":"45","author":"CM Perez-Velez","year":"2007","unstructured":"Perez-Velez CM, Anderson MS, Robinson CC, McFarland EJ, Nix WA, Pallansch MA, Oberste MS, Glode MP (2007) Outbreak of neurologic enterovirus type 71 disease: a diagnostic challenge. Clin Infect Dis 45:950\u2013957","journal-title":"Clin Infect Dis"},{"key":"760_CR39","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/gb-2010-11-1-201","volume":"11","author":"AP Roberts","year":"2010","unstructured":"Roberts AP, Jopling CL (2010) Targeting viral infection by microRNA inhibition. Genome Biol 11:201","journal-title":"Genome Biol"},{"key":"760_CR40","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/jcph.436","volume":"55","author":"JP Sabo","year":"2015","unstructured":"Sabo JP, Kort J, Ballow C, Kashuba AD, Haschke M, Battegay M, Girlich B, Ting N, Lang B, Zhang W, Cooper C, O\u2019Brien D, Seibert E, Chan TS, Tweedie D, Li Y (2015) Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: in vitro and in vivo correlation. J Clin Pharmacol 55:467\u2013477","journal-title":"J Clin Pharmacol"},{"key":"760_CR41","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1742-4690-3-68","volume":"3","author":"V Scaria","year":"2006","unstructured":"Scaria V, Hariharan M, Maiti S, Pillai B, Brahmachari SK (2006) Host-virus interaction: a new role for microRNAs. Retrovirology 3:68","journal-title":"Retrovirology"},{"key":"760_CR42","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1093\/infdis\/129.3.304","volume":"129","author":"NJ Schmidt","year":"1974","unstructured":"Schmidt NJ, Lennette EH, Ho HH (1974) An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis 129:304\u2013309","journal-title":"J Infect Dis"},{"key":"760_CR43","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/978-1-4939-6981-4_16","volume":"1604","author":"J Shao","year":"2018","unstructured":"Shao J, Liang Y, Ly H (2018) Roles of arenavirus Z protein in mediating virion budding, viral transcription-inhibition and interferon-beta suppression. Methods Mol Biol 1604:217\u2013227","journal-title":"Methods Mol Biol"},{"key":"760_CR44","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/13550280490499551","volume":"10","author":"SR Shih","year":"2004","unstructured":"Shih SR, Stollar V, Lin JY, Chang SC, Chen GW, Li ML (2004) Identification of genes involved in the host response to enterovirus 71 infection. J Neurovirol 10:293\u2013304","journal-title":"J Neurovirol"},{"key":"760_CR45","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1002\/hep.27277","volume":"60","author":"T Shirasaki","year":"2014","unstructured":"Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Okada H, Takabatake R, Tokumaru A, Sakai Y, Yamashita T, Lemon SM, Murakami S, Kaneko S (2014) Impaired interferon signaling in chronic hepatitis C patients with advanced fibrosis via the transforming growth factor beta signaling pathway. Hepatology 60:1519\u20131530","journal-title":"Hepatology"},{"key":"760_CR46","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.1016\/j.bmc.2016.05.055","volume":"24","author":"J Sun","year":"2016","unstructured":"Sun J, Niu Y, Wang C, Zhang H, Xie B, Xu F, Jin H, Peng Y, Liang L, Xu P (2016) Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents. Bioorg Med Chem 24:3472\u20133482","journal-title":"Bioorg Med Chem"},{"key":"760_CR47","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/0042-6822(90)90090-E","volume":"174","author":"M Tesar","year":"1990","unstructured":"Tesar M, Marquardt O (1990) Foot-and-mouth disease virus protease 3C inhibits cellular transcription and mediates cleavage of histone H3. Virology 174:364\u2013374","journal-title":"Virology"},{"key":"760_CR48","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S0042-6822(03)00544-0","volume":"315","author":"SR Thompson","year":"2003","unstructured":"Thompson SR, Sarnow P (2003) Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved. Virology 315:259\u2013266","journal-title":"Virology"},{"key":"760_CR49","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.cellsig.2009.09.018","volume":"22","author":"WH Tung","year":"2010","unstructured":"Tung WH, Hsieh HL, Yang CM (2010) Enterovirus 71 induces COX-2 expression via MAPKs, NF-kappaB, and AP-1 in SK-N-SH cells: Role of PGE(2) in viral replication. Cell Signal 22:234\u2013246","journal-title":"Cell Signal"},{"key":"760_CR50","doi-asserted-by":"publisher","first-page":"e1000593","DOI":"10.1371\/journal.ppat.1000593","volume":"5","author":"KF Weng","year":"2009","unstructured":"Weng KF, Li ML, Hung CT, Shih SR (2009) Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation. PLoS Pathog 5:e1000593","journal-title":"PLoS Pathog"},{"key":"760_CR51","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1099\/jgv.0.000982","volume":"99","author":"L Xie","year":"2018","unstructured":"Xie L, Lu B, Zheng Z, Miao Y, Liu Y, Zhang Y, Zheng C, Ke X, Hu Q, Wang H (2018) The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP). J Gen Virol 99:73\u201385","journal-title":"J Gen Virol"},{"key":"760_CR52","doi-asserted-by":"publisher","first-page":"e65948","DOI":"10.1371\/journal.pone.0065948","volume":"8","author":"LJ Xu","year":"2013","unstructured":"Xu LJ, Jiang T, Zhang FJ, Han JF, Liu J, Zhao H, Li XF, Liu RJ, Deng YQ, Wu XY, Zhu SY, Qin ED, Qin CF (2013) Global transcriptomic analysis of human neuroblastoma cells in response to enterovirus type 71 infection. PLoS One 8:e65948","journal-title":"PLoS One"},{"key":"760_CR53","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1128\/JCM.00563-09","volume":"47","author":"F Yang","year":"2009","unstructured":"Yang F, Ren L, Xiong Z, Li J, Xiao Y, Zhao R, He Y, Bu G, Zhou S, Wang J, Qi J (2009) Enterovirus 71 outbreak in the People\u2019s Republic of China in 2008. J Clin Microbiol 47:2351\u20132352","journal-title":"J Clin Microbiol"},{"key":"760_CR54","first-page":"e01112","volume":"1","author":"Z Yang","year":"2013","unstructured":"Yang Z, Lu S, Xian J, Ye J, Xiao L, Luo J, Zen K, Liu F (2013) Complete genome sequence of a human enterovirus 71 strain isolated in wuhan, china, in 2010. Genome Announc 1:e01112\u201313","journal-title":"Genome Announc"},{"key":"760_CR55","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12985-018-1023-6","volume":"15","author":"CG Yao","year":"2018","unstructured":"Yao CG, Xi CL, Hu KH, Gao W, Cai XF, Qin JL, Lv SY, Du CH, Wei YH (2018) Inhibition of enterovirus 71 replication and viral 3C protease by quercetin. Virology J 15:116","journal-title":"Virology J"},{"key":"760_CR56","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3389\/fimmu.2013.00514","volume":"4","author":"E Yoshihara","year":"2014","unstructured":"Yoshihara E, Masaki S, Matsuo Y, Chen Z, Tian H, Yodoi J (2014) Thioredoxin\/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases. Front Immunol 4:514","journal-title":"Front Immunol"},{"key":"760_CR57","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jcv.2011.12.025","volume":"53","author":"M Zeng","year":"2012","unstructured":"Zeng M, El KN, Tu S, Ren P, Xu S, Zhu Q, Mo X, Pu D, Wang X, Altmeyer R (2012) Seroepidemiology of Enterovirus 71 infection prior to the 2011 season in children in Shanghai. J Clin Virol 53:285\u2013289","journal-title":"J Clin Virol"},{"key":"760_CR58","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.bbrc.2014.04.021","volume":"447","author":"W Zhang","year":"2014","unstructured":"Zhang W, Zhang L, Wu Z, Tien P (2014) Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection. Biochem Biophys Res Commun 447:550\u2013555","journal-title":"Biochem Biophys Res Commun"},{"key":"760_CR59","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.mito.2012.06.004","volume":"13","author":"J Zhou","year":"2013","unstructured":"Zhou J, Chng WJ (2013) Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer. Mitochondrion 13:163\u2013169","journal-title":"Mitochondrion"},{"key":"760_CR60","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1182\/blood-2010-07-294827","volume":"118","author":"J Zhou","year":"2011","unstructured":"Zhou J, Bi C, Cheong LL, Mahara S, Liu SC, Tay KG, Koh TL, Yu Q, Chng WJ (2011) The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML. Blood 118:2830\u20132839","journal-title":"Blood"},{"key":"760_CR61","doi-asserted-by":"publisher","first-page":"10512","DOI":"10.1128\/JVI.01028-15","volume":"89","author":"L Zhou","year":"2015","unstructured":"Zhou L, He X, Gao B, Xiong S (2015) Inhibition of histone deacetylase activity aggravates coxsackievirus B3-induced myocarditis by promoting viral replication and myocardial apoptosis. J Virol 89:10512\u201310523","journal-title":"J Virol"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-018-0760-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13258-018-0760-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-018-0760-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T07:32:01Z","timestamp":1605511921000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13258-018-0760-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,29]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["760"],"URL":"https:\/\/doi.org\/10.1007\/s13258-018-0760-7","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,29]]},"assertion":[{"value":"25 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors Chenguang Yao, Kanghong Hu, Caili Xi, Ni Li and Yanhong Wei declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}}]}}