{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:51:50Z","timestamp":1772754710253,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["NRF-2017R1D1A1B03030110"],"award-info":[{"award-number":["NRF-2017R1D1A1B03030110"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI18C19990200"],"award-info":[{"award-number":["HI18C19990200"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s13258-019-00835-5","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T11:02:31Z","timestamp":1559732551000},"page":"1055-1062","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of COX2 \u2212765G&gt;C promoter polymorphism and coronary artery disease in Korean population"],"prefix":"10.1007","volume":"41","author":[{"given":"In Jai","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hoon","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Wook","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Youn","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Oh","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Soo","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Sung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hoon","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Keun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"key":"835_CR1","doi-asserted-by":"publisher","first-page":"5038","DOI":"10.1074\/jbc.274.8.5038","volume":"274","author":"SR Adderley","year":"1999","unstructured":"Adderley SR, Fitzgerald DJ (1999) Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1\/2-mediated induction of cyclooxygenase-2. J Biol Chem 274:5038\u20135046","journal-title":"J Biol Chem"},{"key":"835_CR2","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1056\/NEJM199408183310709","volume":"331","author":"RW Alexander","year":"1994","unstructured":"Alexander RW (1994) Inflammation and coronary artery disease. N Engl J Med 331:468\u2013469","journal-title":"N Engl J Med"},{"key":"835_CR3","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1161\/01.ATV.19.3.646","volume":"19","author":"CS Baker","year":"1999","unstructured":"Baker CS, Hall RJ, Evans TJ, Pomerance A, Maclouf J, Creminon C, Yacoub MH, Polak JM (1999) Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages. Arterioscler Thromb Vasc Biol 19:646\u2013655","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"835_CR4","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1161\/01.CIR.102.8.840","volume":"102","author":"O Belton","year":"2000","unstructured":"Belton O, Byrne D, Kearney D, Leahy A, Fitzgerald DJ (2000) Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis. Circulation 102:840\u2013845","journal-title":"Circulation"},{"key":"835_CR5","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.yjmcc.2005.06.011","volume":"39","author":"ME Burleigh","year":"2005","unstructured":"Burleigh ME, Babaev VR, Yancey PG, Major AS, McCaleb JL, Oates JA, Morrow JD, Fazio S, Linton MF (2005) Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL\/6 mice. J Mol Cell Cardiol 39:443\u2013452","journal-title":"J Mol Cell Cardiol"},{"key":"835_CR6","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/sj.bjc.6603874","volume":"97","author":"I Cheng","year":"2007","unstructured":"Cheng I, Liu X, Plummer SJ, Krumroy LM, Casey G, Witte JS (2007) COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. Br J Cancer 97:557\u2013561","journal-title":"Br J Cancer"},{"key":"835_CR7","doi-asserted-by":"publisher","first-page":"8489","DOI":"10.1158\/0008-5472.CAN-08-0823","volume":"68","author":"SL Chiang","year":"2008","unstructured":"Chiang SL, Chen PH, Lee CH, Ko AM, Lee KW, Lin YC, Ho PS, Tu HP, Wu DC, Shieh TY et al (2008) Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G\u2009>\u2009a polymorphism reveal risk of oral cancer. Cancer Res 68:8489\u20138498","journal-title":"Cancer Res"},{"key":"835_CR8","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1161\/hc3401.093152","volume":"104","author":"F Cipollone","year":"2001","unstructured":"Cipollone F, Prontera C, Pini B, Marini M, Fazia M, De Cesare D, Iezzi A, Ucchino S, Boccoli G, Saba V et al (2001) Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability. Circulation 104:921\u2013927","journal-title":"Circulation"},{"key":"835_CR9","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1161\/01.CIR.0000043260.82447.62","volume":"107","author":"F Cipollone","year":"2003","unstructured":"Cipollone F, Fazia M, Iezzi A, Zucchelli M, Pini B, De Cesare D, Ucchino S, Spigonardo F, Bajocchi G, Bei R et al (2003) Suppression of the functionally coupled cyclooxygenase-2\/prostaglandin E synthase as a basis of simvastatin-dependent plaque stabilization in humans. Circulation 107:1479\u20131485","journal-title":"Circulation"},{"key":"835_CR10","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1001\/jama.291.18.2221","volume":"291","author":"F Cipollone","year":"2004","unstructured":"Cipollone F, Toniato E, Martinotti S, Fazia M, Iezzi A, Cuccurullo C, Pini B, Ursi S, Vitullo G, Averna M et al (2004) A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. JAMA 291:2221\u20132228","journal-title":"JAMA"},{"key":"835_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/01.mbc.0000214706.88621.da","volume":"17","author":"D Colaizzo","year":"2006","unstructured":"Colaizzo D, Fofi L, Tiscia G, Guglielmi R, Cocomazzi N, Prencipe M, Margaglione M, Toni D (2006) The COX-2 G\/C -765 polymorphism may modulate the occurrence of cerebrovascular ischemia. Blood Coagul Fibrinolysis 17:93\u201396","journal-title":"Blood Coagul Fibrinolysis"},{"key":"835_CR12","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1080\/15287390701289966","volume":"70","author":"J Gao","year":"2007","unstructured":"Gao J, Ke Q, Ma HX, Wang Y, Zhou Y, Hu ZB, Zhai XJ, Wang XC, Qing JW, Chen WS et al (2007) Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population. J Toxicol Environ Health A 70:908\u2013915","journal-title":"J Toxicol Environ Health A"},{"key":"835_CR13","first-page":"57","volume":"2","author":"N Hamajima","year":"2001","unstructured":"Hamajima N, Takezaki T, Matsuo K, Saito T, Inoue M, Hirai T, Kato T, Ozeki J, Tajima K (2001) Genotype Frequencies of Cyclooxygenease 2 (COX2) Rare Polymorphisms for Japanese with and without Colorectal Cancer. Asian Pac J Cancer Prev 2:57\u201362","journal-title":"Asian Pac J Cancer Prev"},{"key":"835_CR14","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1111\/j.1538-7836.2006.02054.x","volume":"4","author":"HH Hegener","year":"2006","unstructured":"Hegener HH, Diehl KA, Kurth T, Gaziano JM, Ridker PM, Zee RY (2006) Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach. J Thromb Haemost 4:1718\u20131722","journal-title":"J Thromb Haemost"},{"key":"835_CR15","doi-asserted-by":"publisher","first-page":"4561","DOI":"10.3748\/wjg.15.4561","volume":"15","author":"JH Hoff","year":"2009","unstructured":"Hoff JH, te Morsche RH, Roelofs HM, van der Logt EM, Nagengast FM, Peters WH (2009) COX-2 polymorphisms \u2212 765G\u2013\u2009>\u2009C and -1195A\u2013\u2009>\u2009G and colorectal cancer risk. World J Gastroenterol 15:4561\u20134565","journal-title":"World J Gastroenterol"},{"key":"835_CR16","first-page":"4243","volume":"27","author":"L Hou","year":"2007","unstructured":"Hou L, Grillo P, Zhu ZZ, Lissowska J, Yeager M, Zatonski W, Zhu G, Baccarelli A, Chanock SJ, Fraumeni JF Jr et al (2007) COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population. Anticancer Res 27:4243\u20134247","journal-title":"Anticancer Res"},{"key":"835_CR17","doi-asserted-by":"publisher","first-page":"289453","DOI":"10.1155\/2008\/289453","volume":"2008","author":"KH Huuskonen","year":"2008","unstructured":"Huuskonen KH, Kunnas TA, Tanner MM, Mikkelsson J, Ilveskoski E, Karhunen PJ, Karhunen PJ, Nikkari ST (2008) COX-2 gene promoter polymorphism and coronary artery disease in middle-aged men: the Helsinki sudden death study. Mediat Inflamm 2008:289453","journal-title":"Mediat Inflamm"},{"key":"835_CR18","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s11033-010-0151-x","volume":"38","author":"Z Ke-Xiang","year":"2011","unstructured":"Ke-Xiang Z, Yu-Min L, Xun L, Wen-Ce Z, Yong S, Tao L (2011) Study on the association of COX-2 genetic polymorphisms with risk of gastric cancer in high incidence Hexi area of Gansu province in China. Mol Biol Rep 38:649\u2013655","journal-title":"Mol Biol Rep"},{"key":"835_CR19","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1038\/sj.bjc.6601797","volume":"90","author":"WP Koh","year":"2004","unstructured":"Koh WP, Yuan JM, van den Berg D, Lee HP, Yu MC (2004) Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study. Br J Cancer 90:1760\u20131764","journal-title":"Br J Cancer"},{"key":"835_CR20","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.atherosclerosis.2007.02.010","volume":"196","author":"S Kohsaka","year":"2008","unstructured":"Kohsaka S, Volcik KA, Folsom AR, Wu KK, Ballantyne CM, Willerson JT, Boerwinkle E (2008) Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G-765C polymorphism in African\u2013Americans: the Atherosclerosis Risk in Communities Study. Atherosclerosis 196:926\u2013930","journal-title":"Atherosclerosis"},{"key":"835_CR21","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/sj.clpt.6100221","volume":"83","author":"CR Lee","year":"2008","unstructured":"Lee CR, North KE, Bray MS, Couper DJ, Heiss G, Zeldin DC (2008) Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. Clin Pharmacol Ther 83:52\u201360","journal-title":"Clin Pharmacol Ther"},{"key":"835_CR22","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.atherosclerosis.2009.06.029","volume":"207","author":"W Li","year":"2009","unstructured":"Li W, Xu J, Wang X, Chen J, Zhang C, Sun K, Hui R (2009) Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: a meta-analysis. Atherosclerosis 207:492\u2013495","journal-title":"Atherosclerosis"},{"key":"835_CR23","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.cca.2005.12.019","volume":"368","author":"J Orbe","year":"2006","unstructured":"Orbe J, Beloqui O, Rodriguez JA, Belzunce MS, Roncal C, Paramo JA (2006) Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors. Clin Chim Acta 368:138\u2013143","journal-title":"Clin Chim Acta"},{"key":"835_CR24","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1161\/01.ATV.0000030340.80207.C5","volume":"22","author":"A Papafili","year":"2002","unstructured":"Papafili A, Hill MR, Brull DJ, McAnulty RJ, Marshall RP, Humphries SE, Laurent GJ (2002) Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arterioscler Thromb Vasc Biol 22:1631\u20131636","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"835_CR25","doi-asserted-by":"publisher","first-page":"5473","DOI":"10.3748\/wjg.v12.i34.5473","volume":"12","author":"C Pereira","year":"2006","unstructured":"Pereira C, Sousa H, Ferreira P, Fragoso M, Moreira-Dias L, Lopes C, Medeiros R, Dinis-Ribeiro M (2006) 765G>C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia. World J Gastroenterol 12:5473\u20135478","journal-title":"World J Gastroenterol"},{"key":"835_CR26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s13258-018-0738-5","volume":"41","author":"CS Ryu","year":"2019","unstructured":"Ryu CS, Sakong JH, Ahn EH, Kim JO, Ko D, Kim JH, Lee WS, Kim NK (2019) Association study of the three functional polymorphisms (TAS2R46G\u2009>\u2009A, OR4C16G\u2009>\u2009A, and OR4X1A\u2009>\u2009T) with recurrent pregnancy loss. Genes Genom 41:61\u201370","journal-title":"Genes Genom"},{"key":"835_CR27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1097\/MOL.0b013e32832fa22c","volume":"20","author":"D Santovito","year":"2009","unstructured":"Santovito D, Mezzetti A, Cipollone F (2009) Cyclooxygenase and prostaglandin synthases: roles in plaque stability and instability in humans. Curr Opin Lipidol 20:402\u2013408","journal-title":"Curr Opin Lipidol"},{"key":"835_CR28","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/S0002-9440(10)65230-3","volume":"155","author":"U Sch\u00f6nbeck","year":"1999","unstructured":"Sch\u00f6nbeck U, Sukhova GK, Graber P, Coulter S, Libby P (1999) Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions. Am J Pathol 155:1281\u20131291","journal-title":"Am J Pathol"},{"key":"835_CR29","doi-asserted-by":"publisher","first-page":"10197","DOI":"10.1073\/pnas.97.18.10197","volume":"97","author":"K Shinmura","year":"2000","unstructured":"Shinmura K, Tang XL, Wang Y, Xuan YT, Liu SQ, Takano H, Bhatnagar A, Bolli R (2000) Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits. Proc Natl Acad Sci USA 97:10197\u201310202","journal-title":"Proc Natl Acad Sci USA"},{"key":"835_CR30","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1172\/JCI13271","volume":"107","author":"WL Smith","year":"2001","unstructured":"Smith WL, Langenbach R (2001) Why there are two cyclooxygenase isozymes. J Clin Invest 107:1491\u20131495","journal-title":"J Clin Invest"},{"key":"835_CR31","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1093\/carcin\/bgl242","volume":"28","author":"W Tan","year":"2007","unstructured":"Tan W, Wu J, Zhang X, Guo Y, Liu J, Sun T, Zhang B, Zhao D, Yang M, Yu D et al (2007) Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. Carcinogenesis 28:1197\u20131201","journal-title":"Carcinogenesis"},{"key":"835_CR32","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0090-6980(02)00024-2","volume":"68\u201369","author":"T Tanabe","year":"2002","unstructured":"Tanabe T, Tohnai N (2002) Cyclooxygenase isozymes and their gene structures and expression. Prostaglandins Other Lipid Mediat 68\u201369:95\u2013114","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"835_CR33","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.mrfmmm.2009.01.007","volume":"663","author":"R Upadhyay","year":"2009","unstructured":"Upadhyay R, Jain M, Kumar S, Ghoshal UC, Mittal B (2009) Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma. Mutat Res 663:52\u201359","journal-title":"Mutat Res"},{"key":"835_CR42","doi-asserted-by":"publisher","first-page":"s3","DOI":"10.1097\/00124743-199810001-00002","volume":"4","author":"SJ Vane","year":"1998","unstructured":"Vane SJ (1998) Differential inhibition of cyclooxygenase isoforms: an explanation of the action of NSAIDs. J Clin Rheumatol 4:s3\u201310","journal-title":"J Clin Rheumatol"},{"key":"835_CR34","unstructured":"Xie X, Ma YT (2009) Postacyclin synthase cyclooxygenase-2 gene polymorphism is associated with myocardial infarction in Xinjiang Uygur population study. Website Xinjiang Medical University Website. http:\/\/zhlxbxzz.yiigle.com\/CN112338200806\/592565.htm?locale=zh_CN . Accessed 05 Sept 2018"},{"key":"835_CR35","first-page":"598","volume":"29","author":"X Xie","year":"2008","unstructured":"Xie X, Ma YT, Fu ZY, Yang YN, Wang YH, Chen BD, Liu F (2008) Study on the association of cyclooxygenase-2 -765\u00a0G>C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China. Zhonghua Liu Xing Bing Xue Za Zhi 29:598\u2013603","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"835_CR36","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1515\/CCLM.2009.078","volume":"47","author":"X Xie","year":"2009","unstructured":"Xie X, Ma YT, Fu ZY, Yang YN, Ma X, Chen BD, Wang YH, Liu F (2009) Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. Clin Chem Lab Med 47:347\u2013352","journal-title":"Clin Chem Lab Med"},{"key":"835_CR37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1515\/CCLM.2011.024","volume":"49","author":"X Xie","year":"2011","unstructured":"Xie X, Ma YT, Yang YN, Fu ZY, Li XM, Huang D, Ma X, Chen BD, Liu F (2011) Interaction between COX-2 G-765C and smoking in relation to coronary artery disease in a Chinese Uighur population. Clin Chem Lab Med 49:55\u201360","journal-title":"Clin Chem Lab Med"},{"key":"835_CR38","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.3748\/wjg.14.1785","volume":"14","author":"LL Xing","year":"2008","unstructured":"Xing LL, Wang ZN, Jiang L, Zhang Y, Xu YY, Li J, Luo Y, Zhang X (2008) Cyclooxygenase 2 polymorphism and colorectal cancer: \u2212 765G>C variant modifies risk associated with smoking and body mass index. World J Gastroenterol 14:1785\u20131789","journal-title":"World J Gastroenterol"},{"key":"835_CR39","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1158\/1078-0432.CCR-07-1670","volume":"14","author":"H Yang","year":"2008","unstructured":"Yang H, Gu J, Lin X, Grossman HB, Ye Y, Dinney CP, Wu X (2008) Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition. Clin Cancer Res 14:2236\u20132244","journal-title":"Clin Cancer Res"},{"key":"835_CR40","first-page":"565","volume":"129","author":"X Zhang","year":"2005","unstructured":"Zhang X, Miao X, Tan W, Ning B, Liu Z, Hong Y, Song W, Guo Y, Zhang X, Shen Y et al (2005) Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Gastroenterology 129:565\u2013576","journal-title":"Gastroenterology"},{"key":"835_CR41","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1053\/j.gastro.2009.01.071","volume":"136","author":"D Zhao","year":"2009","unstructured":"Zhao D, Xu D, Zhang X, Wang L, Tan W, Guo Y, Yu D, Li H, Zhao P, Lin D (2009) Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin. Gastroenterology 136:1659\u20131668","journal-title":"Gastroenterology"}],"container-title":["Genes &amp; Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-019-00835-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13258-019-00835-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-019-00835-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:23:22Z","timestamp":1694931802000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13258-019-00835-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,5]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["835"],"URL":"https:\/\/doi.org\/10.1007\/s13258-019-00835-5","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,5]]},"assertion":[{"value":"10 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"I.J. Kim, S.H. Kim, D.H. Cha, S.W. Lim, J.Y. Moon, J.O. Kim, C.S. Ryu, H.S. Park, J.H. Sung, and N.K. Kim declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study had been approved by the Institutional Review Board of CHA Bundang Medical Center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}