{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:48:26Z","timestamp":1790146106770,"version":"4.0.1"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2017YFB0404000"],"award-info":[{"award-number":["2017YFB0404000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31902347"],"award-info":[{"award-number":["31902347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key R&D Program of Liaoning Province","award":["2019JH2\/10200015"],"award-info":[{"award-number":["2019JH2\/10200015"]}]},{"name":"Scientific, Technological and Innovation Program of Dalian","award":["2018J12SN069"],"award-info":[{"award-number":["2018J12SN069"]}]},{"name":"Key Laboratory of Mariculture & Stock Enhancement in North China\u2019s Sea","award":["2018-KF-13"],"award-info":[{"award-number":["2018-KF-13"]}]},{"name":"Fundamental Research Funds for the Education Department of Liaoning Province","award":["QL201706"],"award-info":[{"award-number":["QL201706"]}]},{"name":"DLOU Innovation and Entrepreneurship Training Program for College Students","award":["201810158067"],"award-info":[{"award-number":["201810158067"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s13258-019-00914-7","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T09:02:32Z","timestamp":1580288552000},"page":"425-439","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transcriptomic analyses reveal novel genes with sexually dimorphic expression in Takifugu rubripes brain during gonadal sex differentiation"],"prefix":"10.1007","volume":"42","author":[{"given":"Xufang","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-4736","authenticated-orcid":false,"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"914_CR1","doi-asserted-by":"publisher","first-page":"4873","DOI":"10.1073\/pnas.0636925100","volume":"100","author":"RJ Agate","year":"2003","unstructured":"Agate RJ, Grisham W, Wade J et al (2003) Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch. Proc Natl Acad Sci USA 100:4873\u20134878","journal-title":"Proc Natl Acad Sci USA"},{"key":"914_CR2","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/molbev\/msh027","volume":"21","author":"RJ Agate","year":"2004","unstructured":"Agate RJ, Choe M, Arnold AP (2004) Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches. Mol Biol Evol 21:384\u2013396","journal-title":"Mol Biol Evol"},{"key":"914_CR3","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1126\/science.1072104","volume":"297","author":"S Aparicio","year":"2002","unstructured":"Aparicio S, Chapman J, Stupka E et al (2002) Whole genome shotgun assembly and analysis of the genome of Fugu rubripes. Science 297:1301\u20131310","journal-title":"Science"},{"key":"914_CR4","doi-asserted-by":"publisher","first-page":"9791","DOI":"10.1021\/es0509937","volume":"39","author":"A Arukwe","year":"2005","unstructured":"Arukwe A (2005) Modulation of brain steroidogenesis by affecting transcriptional changes of steroidogenic acute regulatory (StAR) protein and cholesterol side chain cleavage (P450scc) in juvenile Atlantic salmon (Salmo salar) is a novel aspect of nonylphenol toxicity. Environ Sci Technol 39:9791\u20139798","journal-title":"Environ Sci Technol"},{"key":"914_CR5","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1002\/etc.5620161220","volume":"16","author":"A Arukwe","year":"1997","unstructured":"Arukwe A, F\u00f6rlin L, Goks\u00f8yr A (1997) Xenobiotic and steroid biotransformation enzymes in Atlantic salmon (salmo salar) liver treated with an estrogenic compound, 4-nonylphenol. Environ Toxicol Chem 16:2576\u20132583","journal-title":"Environ Toxicol Chem"},{"key":"914_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1023\/A:1013923308125","volume":"32","author":"IA Barannikova","year":"2002","unstructured":"Barannikova IA, Dyubin VP, Bayunova LV, Semenkova TB (2002) Steroids in the control of reproductive function in fish. Neurosci Behav Physiol 32:141\u2013148","journal-title":"Neurosci Behav Physiol"},{"key":"914_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0074-7742(01)46057-0","volume":"46","author":"EE Baulieu","year":"2001","unstructured":"Baulieu EE, Robel P, Schumacher M (2001) Neurosteroids: beginning of the story. Int Rev Neurobiol 46:1\u201332","journal-title":"Int Rev Neurobiol"},{"key":"914_CR8","first-page":"669","volume":"118","author":"J Benoit","year":"1935","unstructured":"Benoit J (1935) Le role des yeux dans l\u2019action stimulante de la lumiere sure le developpement testiulaire chez le canard. CR Soc Biol (Paris) 118:669\u2013671","journal-title":"CR Soc Biol (Paris)"},{"key":"914_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1080\/10408440601123529","volume":"37","author":"ML Blanton","year":"2007","unstructured":"Blanton ML, Specker JL (2007) The hypothalamic-pituitary-thyroid (HPT) axis in fish and its role in fish development and reproduction. Crit Rev Toxicol 37:97\u2013115","journal-title":"Crit Rev Toxicol"},{"key":"914_CR10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/onc.2013.527","volume":"34","author":"S Busch","year":"2015","unstructured":"Busch S, Acar A, Magnusson Y, Gregersson P, Ryd\u00e9n L, Landberg G (2015) TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer. Oncogene 34:27\u201338","journal-title":"Oncogene"},{"key":"914_CR11","doi-asserted-by":"publisher","first-page":"7730","DOI":"10.1073\/pnas.0408350102","volume":"102","author":"X Chen","year":"2005","unstructured":"Chen X, Agate RJ, Itoh Y, Arnold AP (2005) Sexually dimorphic expression of trkB, a Z-linked gene, in early posthatch zebra finch brain. Proc Natl Acad Sci USA 102:7730\u20137735","journal-title":"Proc Natl Acad Sci USA"},{"key":"914_CR12","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1152\/physrev.00003.2012","volume":"93","author":"J Cherfils","year":"2013","unstructured":"Cherfils J, Zeghouf M (2013) Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev 93:269\u2013309","journal-title":"Physiol Rev"},{"key":"914_CR13","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","volume":"21","author":"A Conesa","year":"2005","unstructured":"Conesa A, G\u00f6tz S, Garc\u00eda-G\u00f3mez JM, Terol J, Tal\u00f3n M, Robles M (2005) Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics 21:3674\u20133676","journal-title":"Bioinformatics"},{"key":"914_CR14","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.neuroscience.2005.06.018","volume":"138","author":"BM Cooke","year":"2006","unstructured":"Cooke BM (2006) Steroid-dependent plasticity in the medial amygdala. Neuroscience 138:997\u20131005","journal-title":"Neuroscience"},{"key":"914_CR15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.brainres.2006.09.105","volume":"1126","author":"W Davies","year":"2006","unstructured":"Davies W, Wilkinson LS (2006) It is not all hormones: alternative explanations for sexual differentiation of the brain. Brain Res 1126:36\u201345","journal-title":"Brain Res"},{"key":"914_CR16","first-page":"1489","volume":"10","author":"DM Dean","year":"1996","unstructured":"Dean DM, Sanders MM (1996) Ten years after: reclassification of steroid-responsive genes. Mol Endocrinol 10:1489\u20131495","journal-title":"Mol Endocrinol"},{"key":"914_CR17","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/427390a","volume":"427","author":"C Dennis","year":"2004","unstructured":"Dennis C (2004) Brain development: the most important sexual organ. Nature 427:390\u2013392","journal-title":"Nature"},{"key":"914_CR18","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0044-8486(02)00057-1","volume":"208","author":"RH Devlin","year":"2002","unstructured":"Devlin RH, Nagahama Y (2002) Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences. Aquaculture 208:191\u2013364","journal-title":"Aquaculture"},{"key":"914_CR19","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/S0169-328X(03)00339-5","volume":"118","author":"P Dewing","year":"2003","unstructured":"Dewing P, Shi T, Horvath S, Vilain E (2003) Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. Mol Brain Res 118:82\u201390","journal-title":"Mol Brain Res"},{"key":"914_CR20","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.cub.2006.01.017","volume":"16","author":"P Dewing","year":"2006","unstructured":"Dewing P, Chiang CW, Sinchak K et al (2006) Direct regulation of adult brain function by the male specific factor SRY. Curr Biol 16:415\u2013420","journal-title":"Curr Biol"},{"key":"914_CR21","volume-title":"China fisheries statistic yearbook","author":"DOF (Department of Fisheries)","year":"2014","unstructured":"DOF (Department of Fisheries) (2014) China fisheries statistic yearbook. China Agricul-ture Press, Beijing"},{"key":"914_CR22","first-page":"143","volume-title":"Handbook of behavioral neurobiology","author":"NG Forger","year":"2001","unstructured":"Forger NG (2001) Development of sex differences in the nervous system. In: Blass E (ed) Handbook of behavioral neurobiology, vol 13. Kluwer Academic (Plenum Publishers), New York, pp 143\u2013198"},{"key":"914_CR23","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.neuroscience.2005.07.006","volume":"138","author":"NG Forger","year":"2006","unstructured":"Forger NG (2006) Cell death and sexual differentiation of the nervous system. Neuroscience 138:929\u2013938","journal-title":"Neuroscience"},{"key":"914_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/417445","volume":"67","author":"RC Francis","year":"1992","unstructured":"Francis RC (1992) Sexual lability in teleosts: developmental factors. Quart Rev Biol 67:1\u201318","journal-title":"Quart Rev Biol"},{"key":"914_CR25","doi-asserted-by":"publisher","first-page":"10673","DOI":"10.1073\/pnas.90.22.10673","volume":"90","author":"RC Francis","year":"1993","unstructured":"Francis RC, Barlow GW (1993) Social control of primary sex differentiation in the Midas cichlid. Proc Natl Acad Sci USA 90:10673\u201310675","journal-title":"Proc Natl Acad Sci USA"},{"key":"914_CR26","first-page":"79","volume":"24","author":"T Fujiyama","year":"2018","unstructured":"Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S (2018) Forebrain Ptf1a is required for sexual differentiation of the brain. Cell Res 24:79\u201394","journal-title":"Cell Res"},{"key":"914_CR27","doi-asserted-by":"publisher","first-page":"7959","DOI":"10.1073\/pnas.1335934100","volume":"100","author":"M Gahr","year":"2003","unstructured":"Gahr M (2003) Male Japanese quails with female brains do not show male sexual behaviors. Proc Natl Acad Sci USA 100:7959\u20137964","journal-title":"Proc Natl Acad Sci USA"},{"key":"914_CR28","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0006-8993(78)90723-0","volume":"148","author":"RA Gorski","year":"1978","unstructured":"Gorski RA, Gordon JH, Shryne JE, Southam AM (1978) Evidence for a morphological sex difference within the medial preoptic area of the rat brain. Brain Res 148:333\u2013346","journal-title":"Brain Res"},{"key":"914_CR29","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1002\/cne.901930214","volume":"193","author":"RA Gorski","year":"1980","unstructured":"Gorski RA, Harlan RE, Jacobson CD, Shryne JE, Southam AM (1980) Evidence for the existence of a sexually dimorphic nucleus in the preoptic area of the rat. J Comp Neurol 193:529\u2013539","journal-title":"J Comp Neurol"},{"key":"914_CR30","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.ygcen.2009.03.002","volume":"165","author":"Y Guiguen","year":"2010","unstructured":"Guiguen Y, Fostier A, Piferrer F, Chang CF (2010) Ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish. Gen Comp Endocrinol 165:352\u2013366","journal-title":"Gen Comp Endocrinol"},{"key":"914_CR31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1476-5926-4-2","volume":"4","author":"L Hasselberg","year":"2005","unstructured":"Hasselberg L, Gr\u00f8svik BE, Goks\u00f8yr A, Celander MC (2005) Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua). Comp Hepatol 4:2\u201317","journal-title":"Comp Hepatol"},{"key":"914_CR32","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1073\/pnas.1018392109","volume":"109","author":"RS Hattori","year":"2012","unstructured":"Hattori RS, Murai Y, Oura M, Masuda S, Majhi SK, Sakamoto T (2012) A Y-linked anti-M\u00fcllerian hormone duplication takes over a critical role in sex determination. Proc Natl Acad Sci USA 109:2955\u20132959","journal-title":"Proc Natl Acad Sci USA"},{"key":"914_CR33","first-page":"85","volume-title":"Biological rhythms and their central mechanism","author":"K Homma","year":"1979","unstructured":"Homma K, Ohta M, Sakakibara Y (1979) Photoinducible phase of the Japanese quail detected by direct stimulation of the brain. In: Suda M, Hayaishi O, Nakagawa H (eds) Biological rhythms and their central mechanism. Elsevier, Amsterdam, pp 85\u201394"},{"key":"914_CR34","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.mcn.2017.01.007","volume":"80","author":"GH Huang","year":"2017","unstructured":"Huang GH, Sun ZL, Li HJ et al (2017) Rho GTPase-activating proteins: regulators of Rho GTPase activity in neuronal development and CNS diseases. Mol Cell Neurosci 80:18\u201331","journal-title":"Mol Cell Neurosci"},{"key":"914_CR35","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/mrd.22642","volume":"83","author":"DN Jiang","year":"2016","unstructured":"Jiang DN, Yang HH, Li MH, Shi HJ, Zhang XB, Wang DS (2016) Gsdf is a downstream gene of dmrt1 that functions in the male sex determination pathway of the Nile tilapia. Mol Reprod Dev 83:497\u2013508","journal-title":"Mol Reprod Dev"},{"key":"914_CR36","doi-asserted-by":"publisher","first-page":"e1002798","DOI":"10.1371\/journal.pgen.1002798","volume":"8","author":"T Kamiya","year":"2012","unstructured":"Kamiya T, Kai W, Tasumi S, Oka A, Matsunaga T, Mizuno N (2012) A transspecies missense SNP in Amhr2 is associated with sex determination in the tiger pufferfish, Takifugu rubripes (fugu). PLoS Genet 8:e1002798","journal-title":"PLoS Genet"},{"key":"914_CR37","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1534\/genetics.106.069278","volume":"175","author":"K Kikuchi","year":"2007","unstructured":"Kikuchi K, Kai W, Hosokawa A, Mizuno N, Suetake H, Asahina K (2007) The sex-determining locus in the tiger pufferfish, Takifugu rubripes. Genetics 175:2039\u20132042","journal-title":"Genetics"},{"key":"914_CR38","doi-asserted-by":"publisher","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","volume":"14","author":"D Kim","year":"2013","unstructured":"Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL (2013) TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol 14:R36","journal-title":"Genome Biol"},{"key":"914_CR39","doi-asserted-by":"publisher","first-page":"10613","DOI":"10.1523\/JNEUROSCI.22-24-10613.2002","volume":"22","author":"SR King","year":"2002","unstructured":"King SR, Manna PR, Ishii T, Syapin PJ, Ginsberg SD, Wilson K (2002) An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J Neurosci 22:10613\u201310620","journal-title":"J Neurosci"},{"key":"914_CR40","doi-asserted-by":"publisher","first-page":"639","DOI":"10.2108\/zsj.26.639","volume":"26","author":"KH Lee","year":"2009","unstructured":"Lee KH, Yamaguchi A, Rashid H, Kadomura K, Yasumoto S, Matsuyama M (2009a) Estradiol-17beta treatment induces intersexual gonadal development in the pufferfish, Takifugu rubripes. Zool Sci 26:639\u2013645","journal-title":"Zool Sci"},{"key":"914_CR41","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000228723","volume":"3","author":"KH Lee","year":"2009","unstructured":"Lee KH, Yamaguchi A, Rashid H, Kadomura K, Yasumoto S, Matsuyama M (2009b) Germ cell degeneration in high temperature treated pufferfish, Takifugu rubripes. Sex Dev 3:225\u2013232","journal-title":"Sex Dev"},{"key":"914_CR42","doi-asserted-by":"publisher","first-page":"e1005678","DOI":"10.1371\/journal.pgen.1005678","volume":"11","author":"M Li","year":"2015","unstructured":"Li M, Sun Y, Zhao J et al (2015) A tandem duplicate of anti-mullerian hormone with a missense SNP on the Y chromosome is essential for male sex determination in Nile Tilapia, Oreochromis niloticus. PLoS Genet 11:e1005678","journal-title":"PLoS Genet"},{"key":"914_CR43","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s10126-015-9650-z","volume":"17","author":"J Lu","year":"2005","unstructured":"Lu J, Zheng M, Zheng J et al (2005) Transcriptomic analyses reveal novel genes with sexually dimorphic expression in yellow catfish (Pelteobagrus fulvidraco). Brain Mar Biotechnol 17:613\u2013623","journal-title":"Brain Mar Biotechnol"},{"key":"914_CR44","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.bbrc.2014.01.131","volume":"445","author":"S Maehiro","year":"2014","unstructured":"Maehiro S, Takeuchi A, Yamashita J et al (2014) Sexually dimorphic expression of the sex chromosome linked genes cntfa and pdlim3a in the medaka brain. Biochem Biophys Res Commun 445:113\u2013119","journal-title":"Biochem Biophys Res Commun"},{"key":"914_CR45","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/1471-2164-9-148","volume":"9","author":"JE Mank","year":"2008","unstructured":"Mank JE, Hultin-Rosenberg L, Webster MT, Ellegren H (2008) The unique genomic properties of sex-biased genes: insights from avian microarray data. BMC Genom 9:148","journal-title":"BMC Genom"},{"key":"914_CR46","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1186\/1471-2164-15-655","volume":"15","author":"T Manousaki","year":"2014","unstructured":"Manousaki T, Tsakogiannis A, Lagnel J et al (2014) The sex-specific transcriptome of the hermaphrodite sparid sharpsnout seabream (Diplodus puntazzo). BMC Genom 15:655","journal-title":"BMC Genom"},{"key":"914_CR47","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s12562-014-0768-0","volume":"80","author":"T Matsunaga","year":"2014","unstructured":"Matsunaga T, Ieda R, Hosoya S et al (2014) An efficient molecular technique for sexing tiger pufferfish (fugu) and the occurrence of sex reversal in a hatchery population. Fish Sci 80:933\u2013942","journal-title":"Fish Sci"},{"key":"914_CR48","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-12-803592-4.00091-2","volume-title":"Hormones, brain, and behavior","author":"MM McCarthy","year":"2017","unstructured":"McCarthy MM, De Vries GJ, Forger NG (2017) Sexual differentiation of the brain: a fresh look at mode, mechanisms, and meaning. In: Pfaff DW, Jo\u00ebls M (eds) Hormones, brain, and behavior, 3rd edn. Academic Press, Oxford, pp 3\u201332","edition":"3"},{"key":"914_CR49","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.ygcen.2006.11.013","volume":"150","author":"S Mukhi","year":"2007","unstructured":"Mukhi S, Torres L, Pati\u00f1o R (2007) Effects of larval\u2013juvenile treatment with perchlorate and co-treatment with thyroxine on zebrafish sex ratios. Gen Comp Endocrinol 150:486\u2013494","journal-title":"Gen Comp Endocrinol"},{"key":"914_CR50","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.tree.2005.10.020","volume":"21","author":"PL Munday","year":"2006","unstructured":"Munday PL, Buston PM, Warner RR (2006) Diversity and flexibility of sex change strategies in animals. Trends Ecol Evol 21:89\u201395","journal-title":"Trends Ecol Evol"},{"key":"914_CR51","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1534\/genetics.111.137497","volume":"191","author":"T Myosho","year":"2012","unstructured":"Myosho T, Otake H, Masuyama H, Matsuda M, Kuroki Y, Fujiyama A et al (2012) Tracing the emergence of a novel sex-determining gene in medaka, Oryzias luzonensis. Genetics 191:163\u2013170","journal-title":"Genetics"},{"key":"914_CR52","doi-asserted-by":"publisher","first-page":"15264","DOI":"10.1073\/pnas.1006393107","volume":"107","author":"Y Nakane","year":"2010","unstructured":"Nakane Y, Ikegami K, Ono H et al (2010) A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds. Proc Natl Acad Sci USA 107:15264\u201315268","journal-title":"Proc Natl Acad Sci USA"},{"key":"914_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00008571-199602000-00002","volume":"6","author":"DR Nelson","year":"1996","unstructured":"Nelson DR, Koymans L, Kamataki T et al (1996) P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6:1\u201342","journal-title":"Pharmacogenetics"},{"key":"914_CR54","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1007\/BF01955346","volume":"38","author":"J Oliver","year":"1982","unstructured":"Oliver J, Bayle JD (1982) Brain photoreceptors for the photoinduced testicular response in birds. Experientia 38:1020\u20131029","journal-title":"Experientia"},{"key":"914_CR55","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/S0306-4522(01)00153-1","volume":"104","author":"IS Parhar","year":"2001","unstructured":"Parhar IS, Tosaki H, Sakuma Y, Kobayashi M (2001) Sex differences in the brain of goldfish: gonadotropin-releasing hormone and vasotocinergic neurons. Neuroscience 104:1099\u20131110","journal-title":"Neuroscience"},{"key":"914_CR56","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1159\/000108935","volume":"1","author":"H Rashid","year":"2007","unstructured":"Rashid H, Kitano H, Lee KH et al (2007) Fugu (Takifugu rubripes) sexual differentiation: CYP19 regulation and aromatase inhibitor induced testicular development. Sex Dev 1:311\u2013322","journal-title":"Sex Dev"},{"key":"914_CR57","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.cell.2015.10.071","volume":"163","author":"K Reichwald","year":"2015","unstructured":"Reichwald K, Petzold A, Koch P et al (2015) Insights into sex chromosome evolution and aging from the genome of a short-lived fish. Cell 163:1527\u20131538","journal-title":"Cell"},{"key":"914_CR58","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.abb.2005.06.023","volume":"445","author":"J Ruf","year":"2006","unstructured":"Ruf J, Carayon P (2006) Structural and functional aspects of thyroid peroxidase. Arch Biochem Biophys 445:269\u2013277","journal-title":"Arch Biochem Biophys"},{"key":"914_CR59","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.cbpa.2008.01.010","volume":"149","author":"EM Santos","year":"2008","unstructured":"Santos EM, Kille P, Workman VL, Paull GC, Tyler CR (2008) Sexually dimorphic gene expression in the brains of mature zebrafish. Comp Biochem Physiol Part A Mol Integrat Physiol 149:314\u2013324","journal-title":"Comp Biochem Physiol Part A Mol Integrat Physiol"},{"key":"914_CR60","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1159\/000111391","volume":"18","author":"M Schumacher","year":"1996","unstructured":"Schumacher M, Robel P, Baulieu EE (1996) Development and regeneration of the nervous system: a role for neurosteroids. Dev Neurosci 18:6\u201321","journal-title":"Dev Neurosci"},{"key":"914_CR61","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s10126-015-9613-4","volume":"17","author":"MJ Sellars","year":"2015","unstructured":"Sellars MJ, Trewin C, Mcwilliam SM, Glaves RSE, Hertzler PL (2015) Transcriptome profiles of Penaeus (Marsupenaeus) japonicus animal and vegetal half-embryos: identification of sex determination, germ line, mesoderm, and other developmental genes. Mar Biotechnol 17:252\u2013265","journal-title":"Mar Biotechnol"},{"key":"914_CR62","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ygcen.2012.12.018","volume":"184","author":"P Sharma","year":"2013","unstructured":"Sharma P, Pati\u00f1o R (2013) Regulation of gonadal sex ratios and pubertal development by the thyroid endocrine system in zebrafish (Danio rerio). Gen Comp Endocrinol 184:111\u2013119","journal-title":"Gen Comp Endocrinol"},{"key":"914_CR63","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ygcen.2016.05.028","volume":"235","author":"P Sharma","year":"2016","unstructured":"Sharma P, Tang S, Mayer GD, Pati\u00f1o R (2016) Effects of thyroid endocrine manipulation on sex-related gene expression and population sex ratios in Zebrafish. Gen Comp Endocrinol 235:38\u201347","journal-title":"Gen Comp Endocrinol"},{"key":"914_CR64","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.3382\/ps.0532035","volume":"53","author":"TD Siopes","year":"1974","unstructured":"Siopes TD, Wilson WO (1974) Extraocular modification of photoreception in intact and pinealectomized coturnix. Poult Sci 53:2035\u20132041","journal-title":"Poult Sci"},{"key":"914_CR65","doi-asserted-by":"publisher","first-page":"e1791","DOI":"10.1371\/journal.pone.0001791","volume":"3","author":"R Sreenivasan","year":"2008","unstructured":"Sreenivasan R, Cai M, Bartfai R, Wang X, Christoffels A, Orban L (2008) Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. PLoS One 3:e1791","journal-title":"PLoS One"},{"key":"914_CR66","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/S0014-5793(03)01212-2","volume":"554","author":"EE Tarttelin","year":"2003","unstructured":"Tarttelin EE, Bellingham J, Hankins MW, Foster RG, Lucas RJ (2003) Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. FEBS Lett 554:410\u2013416","journal-title":"FEBS Lett"},{"key":"914_CR67","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ygcen.2018.04.023","volume":"265","author":"A Tovo-Neto","year":"2018","unstructured":"Tovo-Neto A, da Silva Rodrigues M, Habibi HR, N\u00f3brega RH (2018) Thyroid hormone actions on male reproductive system of teleost fish. Gen Comp Endocrinol 265:230\u2013236","journal-title":"Gen Comp Endocrinol"},{"key":"914_CR68","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0960-0760(92)90350-R","volume":"41","author":"M Truss","year":"1992","unstructured":"Truss M, Chalepakis G, Pi\u00f1a B et al (1992) Transcriptional control by steroid hormones. J Steroid Biochem Mol Biol 41:241\u2013248","journal-title":"J Steroid Biochem Mol Biol"},{"key":"914_CR69","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1515\/hsz-2016-0275","volume":"398","author":"A Ulc","year":"2017","unstructured":"Ulc A, Gottschling C, Sch\u00e4fer I et al (2017) Involvement of the guanine nucleotide exchange factor Vav3 in central nervous system development and plasticity. Biol Chem 398:663\u2013675","journal-title":"Biol Chem"},{"key":"914_CR70","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ygcen.2010.10.009","volume":"170","author":"D Vizziano-Cantonnet","year":"2001","unstructured":"Vizziano-Cantonnet D, Anglade I, Pellegrini E et al (2001) Sexual dimorphism in the brain aromatase expression and activity, and in the central expression of other steroidogenic enzymes during the period of sex differentiation in monosex rainbow trout populations. Gen Comp Endocrinol 170:346\u2013355","journal-title":"Gen Comp Endocrinol"},{"key":"914_CR71","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1677\/JOE-08-0218","volume":"199","author":"MS Wagner","year":"2008","unstructured":"Wagner MS, Wajner SM, Maia AL (2008) The role of thyroid hormone in testicular development and function. J Endocrinol 199:351\u2013365","journal-title":"J Endocrinol"},{"key":"914_CR72","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.3390\/ijms17091402","volume":"17","author":"P Wang","year":"2016","unstructured":"Wang P, Zheng M, Liu J, Liu Y, Lu J, Su X (2016) Sexually dimorphic gene expression associated with growth and reproduction of tongue sole (Cynoglossus semilaevis) revealed by brain transcriptome analysis. Int J Mol Sci 17:1402","journal-title":"Int J Mol Sci"},{"key":"914_CR73","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1093\/hmg\/11.12.1409","volume":"11","author":"J Xu","year":"2002","unstructured":"Xu J, Burgoyne PS, Arnold AP (2002) Sex differences in sex chromosome gene expression in mouse brain. Hum Mol Genet 11:1409\u20131419","journal-title":"Hum Mol Genet"},{"key":"914_CR74","doi-asserted-by":"publisher","first-page":"4521","DOI":"10.1523\/JNEUROSCI.5382-07.2008","volume":"28","author":"J Xu","year":"2008","unstructured":"Xu J, Deng X, Watkins R, Disteche CM (2008) Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons. J Neurosci 28:4521\u20134527","journal-title":"J Neurosci"},{"key":"914_CR75","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s10126-012-9480-1","volume":"15","author":"D Xu","year":"2013","unstructured":"Xu D, Lou B, Xu H, Li S, Geng Z (2013) Isolation and characterization of male-specific DNA markers in the rock bream Oplegnathus fasciatus. Mar Biotechnol 15:221\u2013229","journal-title":"Mar Biotechnol"},{"key":"914_CR76","first-page":"59","volume":"1","author":"A Yamaguchi","year":"2006","unstructured":"Yamaguchi A, Lee KH, Fujimoto H, Kadomura K, Yasumoto S, Matsuyama M (2006) Expression of the DMRT gene and its roles in early gonadal development of the Japanese pufferfish Takifugu rubripes. Comp Biochem Physiol Part D Genom Proteom 1:59\u201368","journal-title":"Comp Biochem Physiol Part D Genom Proteom"},{"key":"914_CR77","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1007\/s10695-018-0519-8","volume":"44","author":"H Yan","year":"2018","unstructured":"Yan H, Shen X, Cui X et al (2018) Identification of genes involved in gonadal sex differentiation and the dimorphic expression pattern in takifugu rubripes, gonad at the early stage of sex differentiation. Fish Physiol Biochem 44:1275\u20131290","journal-title":"Fish Physiol Biochem"},{"key":"914_CR78","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1101\/gr.5217506","volume":"16","author":"X Yang","year":"2006","unstructured":"Yang X, Schadt EE, Wang S et al (2006) Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res 16:995\u20131004","journal-title":"Genome Res"},{"key":"914_CR79","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s10126-013-9546-8","volume":"16","author":"A Yano","year":"2014","unstructured":"Yano A, Nicol B, Jouanno E, Guiguen Y (2014) Heritable targeted inactivation of the rainbow trout (Oncorhynchus mykiss) master sex determining gene using zinc-finger nucleases. Mar Biotechnol 16:243\u2013250","journal-title":"Mar Biotechnol"},{"key":"914_CR80","doi-asserted-by":"publisher","first-page":"3747","DOI":"10.1210\/en.2015-1039","volume":"156","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Lau SW, Zhang L, Ge W (2015a) Disruption of zebrafish follicle-stimulating hormone receptor (fshr) but not luteinizing hormone receptor (lhcgr) gene by TALEN leads to failed follicle activation in females followed by sexual reversal to males. Endocrinology 156:3747\u20133762","journal-title":"Endocrinology"},{"key":"914_CR81","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1210\/me.2014-1256","volume":"29","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Zhu B, Ge W (2015b) Genetic analysis of zebrafish gonadotropin (FSH and LH) functions by TALEN-mediated gene disruption. Mol Endocrinol 29:76\u201398","journal-title":"Mol Endocrinol"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-019-00914-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-019-00914-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-019-00914-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T13:30:18Z","timestamp":1650202218000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-019-00914-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,29]]},"references-count":81,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["914"],"URL":"https:\/\/doi.org\/10.1007\/s13258-019-00914-7","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,29]]},"assertion":[{"value":"5 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal work in our study were approved by the lab animal protection regulations and guidelines of People\u2019s Republic of China (Order of the State Council of the People\u2019s Republic of China No. 676) and Liaoning Province (Order No. 143rd of the people\u2019s government of Liaoning province). And the animal protocols were approved according to the regulations established by Fishery Resources Enhancement Laboratory at Dalian Ocean University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}