{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:43:48Z","timestamp":1790657028687,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Key Scientific and Technological Project of Meizhou People\u2019s Hospital","award":["MPHKSTP-20170101"],"award-info":[{"award-number":["MPHKSTP-20170101"]}]},{"name":"Key Scientific and Technological Project of Meizhou People\u2019s Hospital","award":["MPHKSTP-20180101"],"award-info":[{"award-number":["MPHKSTP-20180101"]}]},{"name":"Science and Technology Program of Meizhou","award":["2018B027"],"award-info":[{"award-number":["2018B027"]}]},{"name":"the Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population","award":["2018B030322003"],"award-info":[{"award-number":["2018B030322003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s13258-021-01110-2","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T05:04:19Z","timestamp":1620709459000},"page":"19-28","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characterization of the B cell receptor repertoire of patients with acute coronary syndrome"],"prefix":"10.1007","volume":"44","author":[{"given":"Ruiqiang","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"1110_CR1","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1084\/jem.20100155","volume":"207","author":"H Ait-Oufella","year":"2010","unstructured":"Ait-Oufella H, Herbin O, Bouaziz JD, Binder CJ, Uyttenhove C, Laurans L, Taleb S, Van Vr\u00e9 E, Esposito B, Vilar J et al (2010) B cell depletion reduces the development of atherosclerosis in mice. J Exp Med 207:1579\u20131587","journal-title":"J Exp Med"},{"key":"1110_CR2","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1161\/CIRCULATIONAHA.112.000412","volume":"127","author":"GM Allan","year":"2013","unstructured":"Allan GM, Nouri F, Korownyk C, Kolber MR, Vandermeer B, McCormack J (2013) Agreement among cardiovascular disease risk calculators. Circulation 127:1948\u20131956","journal-title":"Circulation"},{"key":"1110_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/imm.12927","volume":"155","author":"RJM Bashford-Rogers","year":"2018","unstructured":"Bashford-Rogers RJM, Smith KGC, Thomas DC (2018) Antibody repertoire analysis in polygenic autoimmune diseases. Immunology 155:3\u201317","journal-title":"Immunology"},{"key":"1110_CR4","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1093\/brain\/awu205","volume":"137","author":"E Beltr\u00e1n","year":"2014","unstructured":"Beltr\u00e1n E, Obermeier B, Moser M, Coret F, Sim\u00f3-Castell\u00f3 M, Bosc\u00e1 I, P\u00e9rez-Miralles F, Villar LM, Senel M, Tumani H et al (2014) Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation. Brain 137:2703\u20132714","journal-title":"Brain"},{"key":"1110_CR5","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nmeth.3364","volume":"12","author":"DA Bolotin","year":"2015","unstructured":"Bolotin DA, Poslavsky S, Mitrophanov I, Mamedov IZ, Putintseva EV, Chudakov DM, Shugay M (2015) MiXCR: software for comprehensive adaptive immunity profiling. Nat Methods 12:380\u2013381","journal-title":"Nat Methods"},{"key":"1110_CR6","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1172\/JCI7272","volume":"109","author":"G Caligiuri","year":"2002","unstructured":"Caligiuri G, Nicoletti A, Poirier B, Hansson GK (2002) Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest 109:745\u2013753","journal-title":"J Clin Invest"},{"key":"1110_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2012.07.064","volume":"61","author":"F Crea","year":"2013","unstructured":"Crea F, Liuzzo G (2013) Pathogenesis of acute coronary syndromes. J Am Coll Cardiol 61:1\u201311","journal-title":"J Am Coll Cardiol"},{"key":"1110_CR8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s12471-016-0939-y","volume":"25","author":"P Damman","year":"2017","unstructured":"Damman P, van \u2018t Hof AW, Ten Berg JM, Jukema JW, Appelman Y, Liem AH, de Winter RJ (2017) 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: comments from the Dutch ACS working group. Neth Heart J 25:181\u2013185","journal-title":"Neth Heart J"},{"key":"1110_CR9","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1161\/STROKEAHA.109.558742","volume":"41","author":"R Fiskesund","year":"2010","unstructured":"Fiskesund R, Stegmayr B, Hallmans G, Vikstr\u00f6m M, Weinehall L, de Faire U, Frosteg\u00e5rd J (2010) Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden. Stroke 41:607\u2013612","journal-title":"Stroke"},{"key":"1110_CR10","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/nbt.2782","volume":"32","author":"G Georgiou","year":"2014","unstructured":"Georgiou G, Ippolito GC, Beausang J, Busse CE, Wardemann H, Quake SR (2014) The promise and challenge of high-throughput sequencing of the antibody repertoire. Nat Biotechnol 32:158\u2013168","journal-title":"Nat Biotechnol"},{"key":"1110_CR11","first-page":"716","volume":"2011","author":"V Giudicelli","year":"2011","unstructured":"Giudicelli V, Lefranc MP (2011) IMGT\/junctionanalysis: IMGT standardized analysis of the V-J and V-D-J junctions of the rearranged immunoglobulins (IG) and T cell receptors (TR). Cold Spring Harb Protoc 2011:716\u2013725","journal-title":"Cold Spring Harb Protoc"},{"key":"1110_CR12","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.clim.2012.01.002","volume":"142","author":"C Gr\u00f6nwall","year":"2012","unstructured":"Gr\u00f6nwall C, Akhter E, Oh C, Burlingame RW, Petri M, Silverman GJ (2012) IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE. Clin Immunol 142:390\u2013398","journal-title":"Clin Immunol"},{"key":"1110_CR13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3389\/fimmu.2013.00263","volume":"4","author":"KJ Jackson","year":"2013","unstructured":"Jackson KJ, Kidd MJ, Wang Y, Collins AM (2013) The shape of the lymphocyte receptor repertoire: lessons from the B cell receptor. Front Immunol 4:263","journal-title":"Front Immunol"},{"key":"1110_CR14","doi-asserted-by":"publisher","first-page":"4410","DOI":"10.4049\/jimmunol.1000033","volume":"185","author":"T Kyaw","year":"2010","unstructured":"Kyaw T, Tay C, Khan A, Dumouchel V, Cao A, To K, Kehry M, Dunn R, Agrotis A, Tipping P et al (2010) Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis. J Immunol 185:4410\u20134419","journal-title":"J Immunol"},{"key":"1110_CR15","doi-asserted-by":"publisher","first-page":"e29371","DOI":"10.1371\/journal.pone.0029371","volume":"7","author":"T Kyaw","year":"2012","unstructured":"Kyaw T, Tay C, Hosseini H, Kanellakis P, Gadowski T, MacKay F, Tipping P, Bobik A, Toh BH (2012) Depletion of B2 but not B1a B cells in BAFF receptor-deficient ApoE mice attenuates atherosclerosis by potently ameliorating arterial inflammation. PLoS One 7:e29371","journal-title":"PLoS One"},{"key":"1110_CR16","doi-asserted-by":"publisher","first-page":"e60430","DOI":"10.1371\/journal.pone.0060430","volume":"8","author":"T Kyaw","year":"2013","unstructured":"Kyaw T, Cui P, Tay C, Kanellakis P, Hosseini H, Liu E, Rolink AG, Tipping P, Bobik A, Toh BH (2013) BAFF receptor mAb treatment ameliorates development and progression of atherosclerosis in hyperlipidemic ApoE(-\/-) mice. PLoS One 8:e60430","journal-title":"PLoS One"},{"key":"1110_CR17","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.jacc.2012.11.002","volume":"60","author":"LJ Laslett","year":"2012","unstructured":"Laslett LJ, Alagona P Jr, Clark BA 3rd, Drozda JP Jr, Saldivar F, Wilson SR, Poe C, Hart M (2012) The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology. J Am Coll Cardiol 60:S1\u2013S49","journal-title":"J Am Coll Cardiol"},{"key":"1110_CR18","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1161\/ATVBAHA.110.221127","volume":"31","author":"K Ley","year":"2011","unstructured":"Ley K, Miller YI, Hedrick CC (2011) Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol 31:1506\u20131516","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1110_CR19","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1002\/hep.28116","volume":"63","author":"E Liaskou","year":"2016","unstructured":"Liaskou E, Klemsdal Henriksen EK, Holm K, Kaveh F, Hamm D, Fear J, Viken MK, Hov JR, Melum E, Robins H et al (2016) High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires. Hepatology 63:1608\u20131619","journal-title":"Hepatology"},{"key":"1110_CR20","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1056\/NEJMra1216063","volume":"368","author":"P Libby","year":"2013","unstructured":"Libby P (2013) Mechanisms of acute coronary syndromes and their implications for therapy. N Engl J Med 368:2004\u20132013","journal-title":"N Engl J Med"},{"key":"1110_CR21","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00281-013-0387-3","volume":"35","author":"P Libby","year":"2013","unstructured":"Libby P, Nahrendorf M, Swirski FK (2013) Monocyte heterogeneity in cardiovascular disease. Semin Immunopathol 35:553\u2013562","journal-title":"Semin Immunopathol"},{"key":"1110_CR22","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1161\/CIRCRESAHA.114.302699","volume":"114","author":"P Libby","year":"2014","unstructured":"Libby P, Tabas I, Fredman G, Fisher EA (2014) Inflammation and its resolution as determinants of acute coronary syndromes. Circ Res 114:1867\u20131879","journal-title":"Circ Res"},{"key":"1110_CR23","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s12872-020-01538-6","volume":"20","author":"S Liu","year":"2020","unstructured":"Liu S, Zhong Z, Zhong W, Weng R, Liu J, Gu X, Chen Y (2020) Comprehensive analysis of T-cell receptor repertoire in patients with acute coronary syndrome by high-throughput sequencing. BMC Cardiovasc Disord 20:253","journal-title":"BMC Cardiovasc Disord"},{"key":"1110_CR24","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.ijcard.2013.01.009","volume":"168","author":"G Liuzzo","year":"2013","unstructured":"Liuzzo G, Montone RA, Gabriele M, Pedicino D, Giglio AF, Trotta F, Galiffa VA, Previtero M, Severino A, Biasucci LM et al (2013) Identification of unique adaptive immune system signature in acute coronary syndromes. Int J Cardiol 168:564\u2013567","journal-title":"Int J Cardiol"},{"key":"1110_CR25","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","volume":"27","author":"T Mago\u010d","year":"2011","unstructured":"Mago\u010d T, Salzberg SL (2011) FLASH: fast length adjustment of short reads to improve genome assemblies. Bioinformatics 27:2957\u20132963","journal-title":"Bioinformatics"},{"key":"1110_CR26","first-page":"w13514","volume":"142","author":"C M\u00fcller","year":"2012","unstructured":"M\u00fcller C (2012) New ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Swiss Med Wkly 142:w13514","journal-title":"Swiss Med Wkly"},{"key":"1110_CR27","doi-asserted-by":"publisher","first-page":"185","DOI":"10.14797\/mdcj-13-4-185","volume":"13","author":"A Saeed","year":"2017","unstructured":"Saeed A, Kampangkaew J, Nambi V (2017) Prevention of Cardiovascular Disease in Women. Methodist Debakey Cardiovasc J 13:185\u2013192","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"1110_CR28","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41569-018-0106-9","volume":"16","author":"AP Sage","year":"2019","unstructured":"Sage AP, Tsiantoulas D, Binder CJ, Mallat Z (2019) The role of B cells in atherosclerosis. Nat Rev Cardiol 16:180\u2013196","journal-title":"Nat Rev Cardiol"},{"key":"1110_CR29","doi-asserted-by":"publisher","first-page":"550","DOI":"10.20452\/pamw.4076","volume":"127","author":"A S\u0142omka","year":"2017","unstructured":"S\u0142omka A, Korbal P, Pieku\u015b A, Pawliszak W, Anisimowicz L, \u017bekanowska E (2017) Plasma levels of the A subunit of factor XIII in patients undergoing off-pump coronary artery bypass surgery. Pol Arch Intern Med 127:550\u2013553","journal-title":"Pol Arch Intern Med"},{"key":"1110_CR30","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1177\/0003319717706616","volume":"69","author":"A S\u0142omka","year":"2018","unstructured":"S\u0142omka A, Pieku\u015b A, Kowalewski M, Pawliszak W, Anisimowicz L, \u017bekanowska E (2018) Assessment of the Procoagulant Activity of Microparticles and the Protein Z System in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery. Angiology 69:347\u2013357","journal-title":"Angiology"},{"key":"1110_CR31","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1161\/CIR.0b013e318267e99f","volume":"126","author":"SC Smith Jr","year":"2012","unstructured":"Smith SC Jr, Collins A, Ferrari R, Holmes DR Jr, Logstrup S, McGhie DV, Ralston J, Sacco RL, Stam H, Taubert K et al (2012) Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke). Circulation 126:2769\u20132775","journal-title":"Circulation"},{"key":"1110_CR32","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/ni.3175","volume":"16","author":"CM Tipton","year":"2015","unstructured":"Tipton CM, Fucile CF, Darce J, Chida A, Ichikawa T, Gregoretti I, Schieferl S, Hom J, Jenks S, Feldman RJ et al (2015) Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus. Nat Immunol 16:755\u2013765","journal-title":"Nat Immunol"},{"key":"1110_CR33","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1161\/CIRCRESAHA.113.301145","volume":"114","author":"D Tsiantoulas","year":"2014","unstructured":"Tsiantoulas D, Diehl CJ, Witztum JL, Binder CJ (2014) B cells and humoral immunity in atherosclerosis. Circ Res 114:1743\u20131756","journal-title":"Circ Res"},{"key":"1110_CR34","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1016\/j.jacc.2012.08.979","volume":"60","author":"S Tsimikas","year":"2012","unstructured":"Tsimikas S, Willeit P, Willeit J, Santer P, Mayr M, Xu Q, Mayr A, Witztum JL, Kiechl S (2012) Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events. J Am Coll Cardiol 60:2218\u20132229","journal-title":"J Am Coll Cardiol"},{"key":"1110_CR35","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1534\/genetics.115.176735","volume":"201","author":"W Zhang","year":"2015","unstructured":"Zhang W, Du Y, Su Z, Wang C, Zeng X, Zhang R, Hong X, Nie C, Wu J, Cao H et al. (2015) IMonitor: A Robust Pipeline for TCR and BCR Repertoire Analysis. Genetics 201:459-472","journal-title":"Genetics"},{"key":"1110_CR36","doi-asserted-by":"publisher","first-page":"104256","DOI":"10.1016\/j.cellimm.2020.104256","volume":"360","author":"S Zhang","year":"2021","unstructured":"Zhang S, Zhang S, Lin Z, Zhang X, Dou X, Zhou X, Wang X, Wang Z, Zhang Q (2021) Deep sequencing reveals\n10\nthe skewed B-cell receptor repertoire in plaques and the association between pathogens and atherosclerosis. Cell Immunol 360:104256","journal-title":"Cell Immunol"}],"container-title":["Genes &amp; Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-021-01110-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-021-01110-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-021-01110-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:44:27Z","timestamp":1641343467000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-021-01110-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,11]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["1110"],"URL":"https:\/\/doi.org\/10.1007\/s13258-021-01110-2","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,11]]},"assertion":[{"value":"20 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in accordance with the declaration of Helsinki. This study was conducted with approval from the Ethics Committee of the Meizhou People\u2019s Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou 514031, P. R. China (No.: MPH-HEC 2016-A-43).\u00a0Written informed consent was obtained from each patient..","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}