{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:09:31Z","timestamp":1780085371809,"version":"3.54.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Nanjing Medical Science and Technology Development Project","award":["YKK16188"],"award-info":[{"award-number":["YKK16188"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s13258-021-01153-5","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T09:04:20Z","timestamp":1629363860000},"page":"1289-1299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["RRV-induced biliary atresia in neonatal mice involves CD8\u2009+\u2009T lymphocyte killer cells and the Notch signaling pathway"],"prefix":"10.1007","volume":"43","author":[{"given":"Xinmin","family":"Si","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3975-9546","authenticated-orcid":false,"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"issue":"4","key":"1153_CR1","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1128\/JVI.02094-06","volume":"81","author":"SR Allen","year":"2007","unstructured":"Allen SR, Jafri M, Donnelly B et al (2007) Effect of rotavirus strain on the murine model of biliary atresia. J Virol 81(4):1671\u20131679","journal-title":"J Virol"},{"key":"1153_CR2","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1002\/hep.30051","volume":"68","author":"J Bednarek","year":"2018","unstructured":"Bednarek J, Traxinger B, Brigham D, Roach J, Orlicky D, Wang D, Pelanda R, Mack CL (2018) Cytokine-producing B cells promote immune-mediated bile duct injury in murine biliary atresia. Hepatology 68:1890\u20131904","journal-title":"Hepatology"},{"key":"1153_CR3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev-med-042909-093734","volume":"62","author":"K Bessho","year":"2011","unstructured":"Bessho K, Bezerra JA (2011) Biliary atresia: will blocking inflammation tame the disease. Annu Rev Med 62:171\u2013185","journal-title":"Annu Rev Med"},{"issue":"8","key":"1153_CR4","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/j.jpedsurg.2009.05.034","volume":"44","author":"AJ Bondoc","year":"2009","unstructured":"Bondoc AJ, Jafri MA, Donnelly B et al (2009) Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J Pediatr Surg 44(8):1479\u20131490","journal-title":"J Pediatr Surg"},{"issue":"2","key":"1153_CR5","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1067\/mpd.2001.111276","volume":"138","author":"C Chardot","year":"2001","unstructured":"Chardot C, Carton M, Spire-Bendelac N et al (2001) Is the Kasai operation still indicated in children older than 3 months diagnosed with biliary atresia. J Pediatr 138(2):224\u2013228","journal-title":"J Pediatr"},{"key":"1153_CR6","doi-asserted-by":"publisher","first-page":"28858","DOI":"10.1038\/srep28858","volume":"6","author":"J Chen","year":"2016","unstructured":"Chen J, Chang H, Peng X et al (2016) 3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway. Sci Rep 6:28858","journal-title":"Sci Rep"},{"key":"1153_CR7","doi-asserted-by":"crossref","unstructured":"Feng J, Yang J, Zheng S, Qiu Y, Chai C. Silencing of the rotavirus NSP4 protein decreases the incidence of biliary atresia in murine model. PLoS One. 2011. 6(8): e23655.","DOI":"10.1371\/journal.pone.0023655"},{"issue":"1","key":"1153_CR8","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/j.1399-3046.2005.00257.x","volume":"9","author":"RB Fjaer","year":"2005","unstructured":"Fjaer RB, Bruu AL, Nordb\u00f8 SA (2005) Extrahepatic bile duct atresia and viral involvement. Pediatr Transplant 9(1):68\u201373","journal-title":"Pediatr Transplant"},{"key":"1153_CR9","doi-asserted-by":"crossref","unstructured":"Harada K, Nakanuma Y. Cholangiopathy with respect to biliary innate immunity. Int J Hepatol. 2012. 2012: 793569.","DOI":"10.1155\/2012\/793569"},{"issue":"2","key":"1153_CR10","first-page":"188","volume":"6","author":"L Huang","year":"2007","unstructured":"Huang L, Gu WZ, Si XM, Wei MF, Feng JX (2007) Expression of NF-kappaB in rotavirus-induced damage to the liver and biliary tract in neonatal mice. Hepatobiliary Pancreat Dis Int 6(2):188\u2013193","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"4","key":"1153_CR11","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1055\/s-2008-1038483","volume":"18","author":"L Huang","year":"2008","unstructured":"Huang L, Wei MF, Feng JX (2008) Abnormal activation of OPN inflammation pathway in livers of children with biliary atresia and relationship to hepatic fibrosis. Eur J Pediatr Surg 18(4):224\u2013229","journal-title":"Eur J Pediatr Surg"},{"issue":"9","key":"1153_CR12","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s00383-010-2683-5","volume":"26","author":"L Huang","year":"2010","unstructured":"Huang L, Si XM, Feng JX (2010) NF-kappaB related abnormal hyper-expression of iNOS and NO correlates with the inflammation procedure in biliary atresia livers. Pediatr Surg Int 26(9):899\u2013905","journal-title":"Pediatr Surg Int"},{"issue":"9","key":"1153_CR13","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1016\/j.jpedsurg.2010.02.117","volume":"45","author":"P Laje","year":"2010","unstructured":"Laje P, Clark FH, Friedman JR, Flake AW (2010) Increased susceptibility to liver damage from pneumoperitoneum in a murine model of biliary atresia. J Pediatr Surg 45(9):1791\u20131796","journal-title":"J Pediatr Surg"},{"issue":"2","key":"1153_CR14","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/j.1872-034X.2009.00577.x","volume":"40","author":"J Leonhardt","year":"2010","unstructured":"Leonhardt J, Kuebler JF, Turowski C, Tschernig T, Geffers R, Petersen C (2010) Susceptibility to experimental biliary atresia linked to different hepatic gene expression profiles in two mouse strains. Hepatol Res 40(2):196\u2013203","journal-title":"Hepatol Res"},{"issue":"5","key":"1153_CR15","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1053\/j.gastro.2010.07.042","volume":"139","author":"BR Lu","year":"2010","unstructured":"Lu BR, Brindley SM, Tucker RM, Lambert CL, Mack CL (2010) \u03b1-enolase autoantibodies cross-reactive to viral proteins in a mouse model of biliary atresia. Gastroenterology 139(5):1753\u20131761","journal-title":"Gastroenterology"},{"issue":"3","key":"1153_CR16","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1055\/s-2007-985068","volume":"27","author":"CL Mack","year":"2007","unstructured":"Mack CL (2007) The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease. Semin Liver Dis 27(3):233\u2013242","journal-title":"Semin Liver Dis"},{"issue":"1","key":"1153_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1203\/01.PDR.0000130480.51066.FB","volume":"56","author":"CL Mack","year":"2004","unstructured":"Mack CL, Tucker RM, Sokol RJ et al (2004) Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. Pediatr Res 56(1):79\u201387","journal-title":"Pediatr Res"},{"issue":"5","key":"1153_CR18","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.jhep.2009.12.027","volume":"52","author":"AG Miethke","year":"2010","unstructured":"Miethke AG, Saxena V, Shivakumar P, Sabla GE, Simmons J, Chougnet CA (2010) Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia. J Hepatol 52(5):718\u2013726","journal-title":"J Hepatol"},{"key":"1153_CR19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1471-230X-6-14","volume":"6","author":"SK Mohanty","year":"2006","unstructured":"Mohanty SK, Shivakumar P, Sabla G, Bezerra JA (2006) Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia. BMC Gastroenterol 6:14","journal-title":"BMC Gastroenterol"},{"issue":"4","key":"1153_CR20","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1203\/PDR.0b013e3181d22a73","volume":"67","author":"SK Mohanty","year":"2010","unstructured":"Mohanty SK, Ivantes CA, Mourya R, Pacheco C, Bezerra JA (2010) Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis by Mip2\/Cxcl2. Pediatr Res 67(4):345\u2013351","journal-title":"Pediatr Res"},{"key":"1153_CR21","doi-asserted-by":"crossref","unstructured":"Oetzmann vSC, Pintelon I, Brouns I, Dreier A, Klemann C, Timmermans JP, Petersen C and Kuebler JF: Rotavirus particles in the extrahepatic bile duct in experimental biliary atresia. J Pediatr Surg 49: 520\u2013524","DOI":"10.1016\/j.jpedsurg.2013.09.064"},{"issue":"8","key":"1153_CR22","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/S0022-3468(97)90680-1","volume":"32","author":"C Petersen","year":"1997","unstructured":"Petersen C, Biermanns D, Kuske M, Sch\u00e4kel K, Meyer-Jungh\u00e4nel L, Mildenberger H (1997) New aspects in a murine model for extrahepatic biliary atresia. J Pediatr Surg 32(8):1190\u20131195","journal-title":"J Pediatr Surg"},{"issue":"4","key":"1153_CR23","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/S0168-8278(98)80283-3","volume":"28","author":"C Petersen","year":"1998","unstructured":"Petersen C, Grasshoff S, Luciano L (1998) Diverse morphology of biliary atresia in an animal model. J Hepatol 28(4):603\u2013607","journal-title":"J Hepatol"},{"issue":"1","key":"1153_CR24","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.virol.2010.10.036","volume":"410","author":"JM Ribes","year":"2011","unstructured":"Ribes JM, Ortego J, Ceriani J, Montava R, Enjuanes L, Buesa J (2011) Transmissible gastroenteritis virus (TGEV)-based vectors with engineered murine tropism express the rotavirus VP7 protein and immunize mice against rotavirus. Virology 410(1):107\u2013118","journal-title":"Virology"},{"issue":"4 Pt 1","key":"1153_CR25","first-page":"394","volume":"33","author":"M Riepenhoff-Talty","year":"1993","unstructured":"Riepenhoff-Talty M, Schaekel K, Clark HF et al (1993) Group A rotaviruses produce extrahepatic biliary obstruction in orally inoculated newborn mice. Pediatr Res 33(4 Pt 1):394\u2013399","journal-title":"Pediatr Res"},{"issue":"1","key":"1153_CR26","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1093\/infdis\/174.1.8","volume":"174","author":"M Riepenhoff-Talty","year":"1996","unstructured":"Riepenhoff-Talty M, Gouvea V, Evans MJ et al (1996) Detection of group C rotavirus in infants with extrahepatic biliary atresia. J Infect Dis 174(1):8\u201315","journal-title":"J Infect Dis"},{"issue":"102","key":"1153_CR27","doi-asserted-by":"publisher","first-page":"102ra94","DOI":"10.1126\/scitranslmed.3002069","volume":"3","author":"V Saxena","year":"2011","unstructured":"Saxena V, Shivakumar P, Sabla G, Mourya R, Chougnet C, Bezerra JA (2011) Dendritic cells regulate natural killer cell activation and epithelial injury in experimental biliary atresia. Sci Transl Med 3(102):102ra94","journal-title":"Sci Transl Med"},{"issue":"5","key":"1153_CR28","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.jpedsurg.2006.01.060","volume":"41","author":"M Shinkai","year":"2006","unstructured":"Shinkai M, Shinkai T, Puri P, Stringer MD (2006) Increased CXCR3 expression associated with CD3-positive lymphocytes in the liver and biliary remnant in biliary atresia. J Pediatr Surg 41(5):950\u2013954","journal-title":"J Pediatr Surg"},{"issue":"3","key":"1153_CR29","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1172\/JCI200421153","volume":"114","author":"P Shivakumar","year":"2004","unstructured":"Shivakumar P, Campbell KM, Sabla GE et al (2004) Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest 114(3):322\u2013329","journal-title":"J Clin Invest"},{"issue":"4","key":"1153_CR30","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1055\/s-2001-19032","volume":"21","author":"RJ Sokol","year":"2001","unstructured":"Sokol RJ, Mack C (2001) Etiopathogenesis of biliary atresia. Semin Liver Dis 21(4):517\u2013524","journal-title":"Semin Liver Dis"},{"issue":"1","key":"1153_CR31","first-page":"1","volume":"32","author":"A Srivastava","year":"2011","unstructured":"Srivastava A (2011) Biliary atresia and inflammation: from pathogenesis to prognosis. Trop Gastroenterol 32(1):1\u20133","journal-title":"Trop Gastroenterol"},{"issue":"1","key":"1153_CR32","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0022-3468(96)90333-4","volume":"31","author":"TF Tracy","year":"1996","unstructured":"Tracy TF, Dillon P, Fox ES, Minnick K, Vogler C (1996) The inflammatory response in pediatric biliary disease: macrophage phenotype and distribution. J Pediatr Surg 31(1): 121\u2013125","journal-title":"J Pediatr Surg"},{"issue":"1","key":"1153_CR33","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1089\/vim.2006.0088","volume":"20","author":"RM Tucker","year":"2007","unstructured":"Tucker RM, Hendrickson RJ, Mukaida N, Gill RG, Mack CL (2007) Progressive biliary destruction is independent of a functional tumor necrosis factor-alpha pathway in a rhesus rotavirus-induced murine model of biliary atresia. Viral Immunol 20(1):34\u201343","journal-title":"Viral Immunol"},{"issue":"6","key":"1153_CR34","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1002\/hep.510270603","volume":"27","author":"KL Tyler","year":"1998","unstructured":"Tyler KL, Sokol RJ, Oberhaus SM et al (1998) Detection of reovirus RNA in hepatobiliary tissues from patients with extrahepatic biliary atresia and choledochal cysts. Hepatology 27(6):1475\u20131482","journal-title":"Hepatology"},{"issue":"3","key":"1153_CR35","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/S0022-3468(00)90211-2","volume":"35","author":"N Urushihara","year":"2000","unstructured":"Urushihara N, Iwagaki H, Yagi T et al (2000) Elevation of serum interleukin-18 levels and activation of Kupffer cells in biliary atresia. J Pediatr Surg 35(3):446\u2013449","journal-title":"J Pediatr Surg"},{"issue":"12","key":"1153_CR36","first-page":"4009","volume":"22","author":"MM Yu","year":"2018","unstructured":"Yu MM, Zhou QM (2018) 3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition, migration and invasion in endometrial stromal cells by inhibiting the Notch signaling pathway. Eur Rev Med Pharmacol Sci 22(12):4009\u20134017","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-021-01153-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-021-01153-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-021-01153-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T04:36:44Z","timestamp":1632890204000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-021-01153-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,19]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["1153"],"URL":"https:\/\/doi.org\/10.1007\/s13258-021-01153-5","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,19]]},"assertion":[{"value":"22 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}