{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:38:16Z","timestamp":1771947496691,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Biomedical Research Institute Grant","award":["20200018"],"award-info":[{"award-number":["20200018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s13258-023-01404-7","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T13:19:48Z","timestamp":1685711988000},"page":"1013-1024","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcriptomic analysis of neutrophil apoptosis induced by diffuse large B-cell lymphoma unveils a potential role in neutropenia"],"prefix":"10.1007","volume":"45","author":[{"given":"Byeol-Eun","family":"Jeon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungwook","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Gyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Du Hyeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Su","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heui-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Jin","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"1404_CR1","unstructured":"Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002) Intracellular control of cell-cycle events. In: Molecular biology of the cell, 4th edn. Garland Science"},{"key":"1404_CR2","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1007\/s00520-020-05715-3","volume":"29","author":"A Averin","year":"2021","unstructured":"Averin A, Silvia A, Lamerato L, Richert-Boe K, Kaur M, Sundaresan D, Shah N, Hatfield M, Lawrence T, Lyman GH, Weycker D (2021) Risk of chemotherapy-induced febrile neutropenia in patients with metastatic cancer not receiving granulocyte colony-stimulating factor prophylaxis in US clinical practice. Support Care Cancer 29:2179\u20132186","journal-title":"Support Care Cancer"},{"key":"1404_CR3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B Methodol 57:289\u2013300","journal-title":"J R Stat Soc Ser B Methodol"},{"key":"1404_CR4","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.immuni.2010.11.011","volume":"33","author":"N Borregaard","year":"2010","unstructured":"Borregaard N (2010) Neutrophils, from marrow to microbes. Immunity 33:657\u2013670","journal-title":"Immunity"},{"key":"1404_CR5","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1002\/cncr.20983","volume":"103","author":"V Caggiano","year":"2005","unstructured":"Caggiano V, Weiss RV, Rickert TS, Linde-Zwirble WT (2005) Incidence, cost, and mortality of neutropenia hospitalization associated with chemotherapy. Cancer 103:1916\u20131924","journal-title":"Cancer"},{"key":"1404_CR6","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.2174\/092986709788803312","volume":"16","author":"C Carvalho","year":"2009","unstructured":"Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS, Moreira PI (2009) Doxorubicin: the good, the bad and the ugly effect. Curr Med Chem 16:3267\u20133285","journal-title":"Curr Med Chem"},{"key":"1404_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0167-5699(95)80066-2","volume":"16","author":"MA Cassatella","year":"1995","unstructured":"Cassatella MA (1995) The production of cytokines by polymorphonuclear neutrophils. Immunol Today 16:21\u201326","journal-title":"Immunol Today"},{"key":"1404_CR8","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1056\/NEJMoa011795","volume":"346","author":"B Coiffier","year":"2002","unstructured":"Coiffier B, Lepage E, Bri\u00e8re J, Herbrecht R, Tilly H, Bouabdallah R, Morel P, Van Den Neste E, Salles G, Gaulard P et al (2002) CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 346:235\u2013242","journal-title":"N Engl J Med"},{"key":"1404_CR9","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/cncr.11882","volume":"100","author":"J Crawford","year":"2004","unstructured":"Crawford J, Dale DC, Lyman GH (2004) Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management. Cancer 100:228\u2013237","journal-title":"Cancer"},{"key":"1404_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2021.101546","volume":"57","author":"DEM Duits","year":"2021","unstructured":"Duits DEM, de Visser KE (2021) Impact of cancer cell-intrinsic features on neutrophil behavior. Semin Immunol 57:101546","journal-title":"Semin Immunol"},{"key":"1404_CR11","first-page":"25","volume":"28","author":"B Fleischer","year":"2006","unstructured":"Fleischer B, Schulze-Bergkamen H, Schuchmann M, Weber A, Biesterfeld S, M\u00fcller M, Krammer PH, Galle PR (2006) Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma. Int J Oncol 28:25\u201332","journal-title":"Int J Oncol"},{"key":"1404_CR12","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1158\/0008-5472.CAN-14-1340","volume":"75","author":"JL Fox","year":"2015","unstructured":"Fox JL, Storey A (2015) BMX negatively regulates BAK function, thereby increasing apoptotic resistance to chemotherapeutic drugsBMX mediates chemoresistance through BAK inhibition. Cancer Res 75:1345\u20131355","journal-title":"Cancer Res"},{"key":"1404_CR13","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1182\/asheducation-2011.1.498","volume":"2011","author":"JW Friedberg","year":"2011","unstructured":"Friedberg JW (2011) Relapsed\/refractory diffuse large B-cell lymphoma. Hematology Am Soc Hematol Educ Program 2011:498\u2013505","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"1404_CR14","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1002\/cncr.21442","volume":"104","author":"TK Gandhi","year":"2005","unstructured":"Gandhi TK, Bartel SB, Shulman LN, Verrier D, Burdick E, Cleary A, Rothschild JM, Leape LL, Bates DW (2005) Medication safety in the ambulatory chemotherapy setting. Cancer 104:2477\u20132483","journal-title":"Cancer"},{"key":"1404_CR15","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1200\/JCO.2005.05.1003","volume":"24","author":"TM Habermann","year":"2006","unstructured":"Habermann TM, Weller EA, Morrison VA, Gascoyne RD, Cassileth PA, Cohn JB, Dakhil SR, Woda B, Fisher RI, Peterson BA, Horning SJ (2006) Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma. J Clin Oncol 24:3121\u20133127","journal-title":"J Clin Oncol"},{"key":"1404_CR16","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2021.944","author":"DY Kim","year":"2021","unstructured":"Kim DY, Nam J, Chung J-S, Jeon BE, Lee JH, Jo J-C, Kim S-W, Shin H-J (2021) Predictive parameters of febrile neutropenia and clinical significance of G-CSF receptor signaling pathway in the development of neutropenia during R-CHOP chemotherapy with prophylactic pegfilgrastim in patients with diffuse large B-cell lymphoma. Cancer Res Treat. https:\/\/doi.org\/10.4143\/crt.2021.944","journal-title":"Cancer Res Treat"},{"key":"1404_CR17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1042\/BJ20070319","volume":"405","author":"DA Kubli","year":"2007","unstructured":"Kubli DA, Ycaza JE, Gustafsson \u00c5B (2007) Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak. Biochem J 405:407\u2013415","journal-title":"Biochem J"},{"key":"1404_CR18","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1002\/cncr.21847","volume":"106","author":"NM Kuderer","year":"2006","unstructured":"Kuderer NM, Dale DC, Crawford J, Cosler LE, Lyman GH (2006) Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. Cancer 106:2258\u20132266","journal-title":"Cancer"},{"key":"1404_CR19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.8823","author":"NM Kuderer","year":"2007","unstructured":"Kuderer NM, Dale DC, Crawford J, Lyman GH (2007) Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: a systematic review. J Clin Oncol. https:\/\/doi.org\/10.1200\/JCO.2006.08.8823","journal-title":"J Clin Oncol"},{"key":"1404_CR20","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1093\/annonc\/mdx128","volume":"28","author":"A K\u00fchnl","year":"2017","unstructured":"K\u00fchnl A, Cunningham D, Counsell N, Hawkes EA, Qian W, Smith P, Chadwick N, Lawrie A, Mouncey P, Jack A et al (2017) Outcome of elderly patients with diffuse large B-cell lymphoma treated with R-CHOP: results from the UK NCRI R-CHOP14v21 trial with combined analysis of molecular characteristics with the DSHNHL RICOVER-60 trial. Ann Oncol 28:1540\u20131546","journal-title":"Ann Oncol"},{"key":"1404_CR21","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s13312-011-0055-4","volume":"48","author":"R Kumar","year":"2011","unstructured":"Kumar R, Indrayan A (2011) Receiver operating characteristic (ROC) curve for medical researchers. Indian Pediatr 48:277\u2013287","journal-title":"Indian Pediatr"},{"key":"1404_CR22","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg SL (2012) Fast gapped-read alignment with Bowtie 2. Nat Methods 9:357\u2013359","journal-title":"Nat Methods"},{"key":"1404_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13045-019-0761-2","volume":"12","author":"W Li","year":"2019","unstructured":"Li W, Gupta SK, Han W, Kundson RA, Nelson S, Knutson D, Greipp PT, Elsawa SF, Sotomayor EM, Gupta M (2019) Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and\/or BCL6 rearrangements with epigenetic bromodomain inhibitors. J Hematol Oncol 12:1\u201313","journal-title":"J Hematol Oncol"},{"key":"1404_CR24","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1080\/1042819031000119262","volume":"44","author":"GH Lyman","year":"2003","unstructured":"Lyman GH, Morrison VA, Dale DC, Crawford J, Delgado DJ, Fridman M, OPPS Working Group, ANC Study Group (2003) Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin\u2019s lymphoma receiving CHOP chemotherapy. Leuk Lymphoma 44:2069\u20132076","journal-title":"Leuk Lymphoma"},{"key":"1404_CR25","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1634\/theoncologist.10-6-427","volume":"10","author":"GH Lyman","year":"2005","unstructured":"Lyman GH, Lyman CH, Agboola O (2005) Risk models for predicting chemotherapy-induced neutropenia. Oncologist 10:427\u2013437","journal-title":"Oncologist"},{"key":"1404_CR26","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.critrevonc.2013.12.006","volume":"90","author":"GH Lyman","year":"2014","unstructured":"Lyman GH, Abella E, Pettengell R (2014) Risk factors for febrile neutropenia among patients with cancer receiving chemotherapy: a systematic review. Crit Rev Oncol Hematol 90:190\u2013199","journal-title":"Crit Rev Oncol Hematol"},{"key":"1404_CR27","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.4161\/cc.3.11.1213","volume":"3","author":"X Meng","year":"2004","unstructured":"Meng X, Lu H, Shen Z (2004) BCCIP functions through p53 to regulate the expression of p21Waf1\/Cip1. Cell Cycle 3:1457\u20131462","journal-title":"Cell Cycle"},{"key":"1404_CR28","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nmeth.1226","volume":"5","author":"A Mortazavi","year":"2008","unstructured":"Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B (2008) Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 5:621\u2013628","journal-title":"Nat Methods"},{"key":"1404_CR29","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1182\/blood.2019003959","volume":"136","author":"JC Ramos","year":"2020","unstructured":"Ramos JC, Sparano JA, Chadburn A, Reid EG, Ambinder RF, Siegel ER, Moore PC, Rubinstein PG, Durand CM, Cesarman E et al (2020) Impact of Myc in HIV-associated non-Hodgkin lymphomas treated with EPOCH and outcomes with vorinostat (AMC-075 trial). Blood 136:1284\u20131297","journal-title":"Blood"},{"key":"1404_CR30","doi-asserted-by":"publisher","first-page":"3724","DOI":"10.1182\/blood-2010-05-282632","volume":"116","author":"M Sant","year":"2010","unstructured":"Sant M, Allemani C, Tereanu C, De Angelis R, Capocaccia R, Visser O, Marcos-Gragera R, Maynadi\u00e9 M, Simonetti A, Lutz J-M, Berrino F, the HAEMACARE Working Group (2010) Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood 116:3724\u20133734","journal-title":"Blood"},{"key":"1404_CR31","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.ccr.2012.09.016","volume":"22","author":"CM Sawai","year":"2012","unstructured":"Sawai CM, Freund J, Oh P, Ndiaye-Lobry D, Bretz JC, Strikoudis A, Genesca L, Trimarchi T, Kelliher MA, Clark M et al (2012) Therapeutic targeting of the cyclin D3: CDK4\/6 complex in T cell leukemia. Cancer Cell 22:452\u2013465","journal-title":"Cancer Cell"},{"key":"1404_CR32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A (2019) Cancer statistics, 2019. CA Cancer J Clin 69:7\u201334","journal-title":"CA Cancer J Clin"},{"key":"1404_CR33","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.immuni.2005.01.011","volume":"22","author":"MA Stark","year":"2005","unstructured":"Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K (2005) Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 22:285\u2013294","journal-title":"Immunity"},{"key":"1404_CR34","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1097\/FPC.0b013e32833ffb56","volume":"21","author":"CF Thorn","year":"2011","unstructured":"Thorn CF, Oshiro C, Marsh S, Hernandez-Boussard T, McLeod H, Klein TE, Altman RB (2011) Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenet Genomics 21:440","journal-title":"Pharmacogenet Genomics"},{"key":"1404_CR35","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.2165\/00003495-200363150-00003","volume":"63","author":"CC Verstappen","year":"2003","unstructured":"Verstappen CC, Heimans JJ, Hoekman K, Postma TJ (2003) Neurotoxic complications of chemotherapy in patients with cancer: clinical signs and optimal management. Drugs 63:1549\u20131563","journal-title":"Drugs"},{"key":"1404_CR36","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1093\/bioinformatics\/btp612","volume":"26","author":"L Wang","year":"2010","unstructured":"Wang L, Feng Z, Wang X, Wang X, Zhang X (2010) DEGseq: an R package for identifying differentially expressed genes from RNA-seq data. Bioinformatics 26:136\u2013138","journal-title":"Bioinformatics"},{"key":"1404_CR37","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1007\/s00520-015-2686-9","volume":"23","author":"L Wang","year":"2015","unstructured":"Wang L, Baser O, Kutikova L, Page JH, Barron R (2015) The impact of primary prophylaxis with granulocyte colony-stimulating factors on febrile neutropenia during chemotherapy: a systematic review and meta-analysis of randomized controlled trials. Support Care Cancer 23:3131\u20133140","journal-title":"Support Care Cancer"},{"key":"1404_CR38","first-page":"84","volume":"1845","author":"F Yang","year":"2014","unstructured":"Yang F, Teves SS, Kemp CJ, Henikoff S (2014) Doxorubicin, DNA torsion, and chromatin dynamics. Biochim Biophys Acta 1845:84\u201389","journal-title":"Biochim Biophys Acta"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-023-01404-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-023-01404-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-023-01404-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T16:18:35Z","timestamp":1744215515000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-023-01404-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,2]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["1404"],"URL":"https:\/\/doi.org\/10.1007\/s13258-023-01404-7","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,2]]},"assertion":[{"value":"13 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The animal protocol used in this study was reviewed and approved by the Pusan National University-Institutional Animal Care and Use Committee (PNU-2021-3056).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}