{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T03:02:56Z","timestamp":1763348576983,"version":"build-2065373602"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s13258-023-01426-1","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T12:02:11Z","timestamp":1691409731000},"page":"1489-1508","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Proteome based analysis of circulating SARS-CoV-2 variants: approach to a universal vaccine candidate"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9646-5122","authenticated-orcid":false,"given":"Elijah Kolawole","family":"Oladipo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiwo Ooreoluwa","family":"Ojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seun Elijah","family":"Olufemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boluwatife Ayobami","family":"Irewolede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Adewole","family":"Adediran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asegunloluwa Grace","family":"Abiala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwaseun Samuel","family":"Hezekiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akindele Felix","family":"Idowu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinmi Gabriel","family":"Oladeji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Omotoyinbo","family":"Ikuomola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adenike Titilayo","family":"Olayinka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon Oluwamayowa","family":"Akanbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usman Abiodun","family":"Idowu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odunola Abimbola","family":"Olubodun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folusho Daniel","family":"Odunlami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Akinwumi","family":"Ogunniran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omodamola Paulina","family":"Akinro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadijat Motunrayo","family":"Adegoke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Oluwatoyin","family":"Folakanmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temitope Aishat","family":"Usman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Folakemi","family":"Oladokun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glory Jesudara","family":"Oluwasanya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hezekiah Oluwajoba","family":"Awobiyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry Ayobami","family":"Oluwasegun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Adebowale","family":"Akintibubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther Moradeyo","family":"Jimah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"1426_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/6718083","volume":"2018","author":"UK Adhikari","year":"2018","unstructured":"Adhikari UK, Tayebi M, Rahman MM (2018) Immunoinformatics approach for epitope-based peptide vaccine design and active site prediction against polyprotein of emerging oropouche virus. J Immunol Res 2018:1\u201322","journal-title":"J Immunol Res"},{"issue":"7","key":"1426_CR2","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1089\/vim.2020.0306","volume":"34","author":"NS Ali","year":"2022","unstructured":"Ali NS, Ahmad HZ, Qasim M, Suleman M, Ali S, Khan A, Wei DQ (2022) Computational modeling of immune response triggering immunogenic peptide vaccine against the human papillomaviruses to induce immunity against Cervical Cancer. Viral Immunol 34(7):457\u2013469. https:\/\/doi.org\/10.1089\/vim.2020.0306","journal-title":"Viral Immunol"},{"key":"1426_CR3","doi-asserted-by":"publisher","first-page":"738","DOI":"10.3339\/fmicb.2019.007387","volume":"10","author":"MI Anasir","year":"2016","unstructured":"Anasir MI, Poh CL (2016) structural vaccinolody for viral vaccine design. Front Microbiol 10:738. https:\/\/doi.org\/10.3339\/fmicb.2019.007387","journal-title":"Front Microbiol"},{"key":"1426_CR4","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/prot.20530","volume":"689","author":"RJ Anderson","year":"2005","unstructured":"Anderson RJ, Weng Z, Campbell RK, Jiang X (2005) Main-chain conformational tendencies of amino acids. Proteins 689:679\u2013689. https:\/\/doi.org\/10.1002\/prot.20530","journal-title":"Proteins"},{"key":"1426_CR40","doi-asserted-by":"publisher","unstructured":"Bassaganya-Riera J, Hontecillas R (2016) Chapter 1 - Introduction to Computational Immunology. In J Bassaganya-Riera (ed), Computational Immunology (pp 1\u20138). Academic Press. https:\/\/doi.org\/10.1016\/B978-0-12-803697-6.00001-1","DOI":"10.1016\/B978-0-12-803697-6.00001-1"},{"key":"1426_CR59","doi-asserted-by":"publisher","unstructured":"Bibi S, Ullah I, Zhu B, Adnan M, Liaqat R, Kong WB, Niu S (2021) In silico analysis of epitope-based vaccine candidate against tuberculosis using reverse vaccinology. Sci Rep 11(1):1249. https:\/\/doi.org\/10.1038\/s41598-020-80899-6. PMID: 33441913; PMCID: PMC7807040","DOI":"10.1038\/s41598-020-80899-6"},{"key":"1426_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2021.646972","volume":"12","author":"F Castiglione","year":"2021","unstructured":"Castiglione F, Deb D, Srivastava AP, Li\u00f2 P (2021) From infection to immunity: understanding the response to SARS-CoV2 through in-silico modeling. Front Immunol 12:1\u201316. https:\/\/doi.org\/10.3389\/fimmu.2021.646972","journal-title":"Front Immunol"},{"key":"1426_CR6","volume-title":"Textbook of microbiology and immunology","author":"SP Chandra","year":"2012","unstructured":"Chandra SP (2012) Textbook of microbiology and immunology, 2nd edn. Elsevier Inc.","edition":"2"},{"key":"1426_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40249-020-00713-3","volume":"9","author":"H Chen","year":"2020","unstructured":"Chen H, Tang L, Yu X, Zhou J, Chang Y, Wu X (2020a) Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2. Infect Dis Poverty 9:1\u201310","journal-title":"Infect Dis Poverty"},{"issue":"4","key":"1426_CR8","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/jmv.252681","volume":"92","author":"Y Chen","year":"2020","unstructured":"Chen Y, Liu Q, Guo D (2020b) Emerging coronaviruses: genome structure, replication and pathogenesis. J Med Virol 92(4):418\u2013423. https:\/\/doi.org\/10.1002\/jmv.252681","journal-title":"J Med Virol"},{"key":"1426_CR9","doi-asserted-by":"publisher","first-page":"0","DOI":"10.1186\/1471-2105-14-346","volume":"14","author":"DB Craig","year":"2013","unstructured":"Craig DB, Dombkowski AA (2013) Disulfide by Design 2.0: a web-based tool for disulfide engineering in proteins Disulfide by Design 2.0: a web-based tool for disulfide engineering in proteins. BMC Bioinformatics 14:0\u20136","journal-title":"BMC Bioinformatics"},{"issue":"9","key":"1426_CR10","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.str.2020.06.006","volume":"28","author":"IT Desta","year":"2020","unstructured":"Desta IT, Porter KA, Xia B, Kozakov D, Vajda S, Desta IT, Porter KA, Xia B, Kozakov D, Vajda S (2020) Resource performance and its limits in rigid body protein- protein docking. Structure\/folding Des 28(9):1071-1081.e3. https:\/\/doi.org\/10.1016\/j.str.2020.06.006","journal-title":"Structure\/folding Des"},{"key":"1426_CR11","doi-asserted-by":"publisher","first-page":"22","DOI":"10.2174\/1875035400801010022","volume":"1","author":"IA Doytchinova","year":"2008","unstructured":"Doytchinova IA, Flower DR (2008) Bioinformatic approach for identifying parasite and fungal candidate subunit vaccines. Open Vaccine J. 1:22\u201326","journal-title":"Open Vaccine J."},{"key":"1426_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-019-09940-1","author":"M Ebrahimi","year":"2019","unstructured":"Ebrahimi M, Javad S, Mohammad S, Ranjbar M, Tahvildar F (2019) Designing and modeling of multi - epitope proteins for diagnosis of toxocara canis infection. Int J Pept Res Ther. https:\/\/doi.org\/10.1007\/s10989-019-09940-1","journal-title":"Int J Pept Res Ther"},{"key":"1426_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99227-7","author":"AO Fadaka","year":"2021","unstructured":"Fadaka AO, Remaliah N, Sibuyi S, Martin DR, Goboza M, Klein A, Madiehe AM, Meyer M (2021) Immunoinformatics design of a novel epitope - based vaccine candidate against dengue virus. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-021-99227-7","journal-title":"Sci Rep"},{"key":"1426_CR14","doi-asserted-by":"publisher","first-page":"100500","DOI":"10.1016\/j.imu.2020.100500","volume":"22","author":"S Hossain","year":"2021","unstructured":"Hossain S, Imran M, Mizan S, Tayab A, Sultana A (2021) Informatics in medicine unlocked immunoinformatics approach to designing a multi-epitope vaccine against Saint Louis encephalitis virus. Inform Med Unlocked 22:100500. https:\/\/doi.org\/10.1016\/j.imu.2020.100500","journal-title":"Inform Med Unlocked"},{"key":"1426_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248061","author":"OSC Id","year":"2021","unstructured":"Id OSC, Gray CM, Fagbayi TA, Chukwuanukwu C, Oyebanji VO, Bankole TT, Adewole RA, Daniel M (2021a) Immuno-informatics design of a multimeric epitope peptide based vaccine targeting. PLoS\u00a0One. https:\/\/doi.org\/10.1371\/journal.pone.0248061","journal-title":"PLoS\u00a0One."},{"key":"1426_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253393","author":"TK Id","year":"2021","unstructured":"Id TK, Id RI, Jahan T, Id J, Mahmud A (2021b) Immunoinformatics and molecular dynamics approaches: next generation vaccine design against West Nile virus. Cdc. https:\/\/doi.org\/10.1371\/journal.pone.0253393","journal-title":"Cdc"},{"key":"1426_CR17","first-page":"497","volume":"5","author":"A Jain","year":"2014","unstructured":"Jain A, Tripathi P, Shrotriya A, Chaudhary R, Singh A (2014) In silico analysis and modeling of putative T cell epitopes for vaccine design of Toscana virus. J 3 Biotech 5:497\u2013503","journal-title":"J 3 Biotech"},{"issue":"May","key":"1426_CR18","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1093\/nar\/gkt332","volume":"41","author":"M Jamroz","year":"2013","unstructured":"Jamroz M, Kolinski A, Kmiecik S (2013) CABS-flex: server for fast simulation of protein structure fluctuations. Nucleic Acids Res 41(May):427\u2013431. https:\/\/doi.org\/10.1093\/nar\/gkt332","journal-title":"Nucleic Acids Res"},{"key":"1426_CR19","doi-asserted-by":"publisher","unstructured":"Jamroz M, Kolinski A, Kmiecik S (2014) arXiv\u202f: 1403.4954v1 [q-bio.BM] 19 Mar 2014 ensembles. https:\/\/doi.org\/10.1093\/bioinformatics\/btu184","DOI":"10.1093\/bioinformatics\/btu184"},{"key":"1426_CR20","doi-asserted-by":"publisher","unstructured":"Kozakov D, Beglov D, Bohnuud T, Mottarella SE, Xia B, Hall DR, Vajda S (2013) How good is automated protein docking? Proteins. 81(12):2159\u20132166. https:\/\/doi.org\/10.1002\/prot.24403. Epub 2013 Oct 17. PMID: 23996272; PMCID: PMC3934018","DOI":"10.1002\/prot.24403"},{"key":"1426_CR21","doi-asserted-by":"publisher","unstructured":"Kozakov D, Hall DR, Xia B, Porter KA, Padhorny D, Yueh C, Beglov D, Vajda S (2017) The ClusPro web server for protein-protein docking. Nat Protoc 12(2):255\u2013278. https:\/\/doi.org\/10.1038\/nprot.2016.169. Epub 2017 Jan 12. PMID: 28079879; PMCID: PMC5540229","DOI":"10.1038\/nprot.2016.169"},{"issue":"6","key":"1426_CR22","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/molbev\/msy096","volume":"35","author":"S Kumar","year":"2018","unstructured":"Kumar S, Stecher G, Li M, Knyaz C, Tamura K (2018) MEGA X: molecular evolutionary genetics analysis across computing platforms. Mol Biol Evol 35(6):1547\u20131549. https:\/\/doi.org\/10.1093\/molbev\/msy096","journal-title":"Mol Biol Evol"},{"key":"1426_CR23","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1093\/nar\/gky356","volume":"46","author":"A Kuriata","year":"2018","unstructured":"Kuriata A, Gierut AM, Oleniecki T, Pawe- M, Kolinski A, Kurcinski M, Kmiecik S (2018) CABS-flex 20: a web server for fast simulations of flexibility of protein structures. Nucleic Acids Res 46:338\u2013343. https:\/\/doi.org\/10.1093\/nar\/gky356","journal-title":"Nucleic Acids Res"},{"key":"1426_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97880-6","author":"T Madlala","year":"2021","unstructured":"Madlala T, Adeleke VT, Fatoba AJ, Okpeku M, Adeniyi AA, Adeleke MA (2021) Designing multiepitope - based vaccine against Eimeria from immune mapped protein 1 (IMP - 1) antigen using immunoinformatic approach. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-021-97880-6","journal-title":"Sci Rep"},{"key":"1426_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92176-1","author":"S Mahmud","year":"2021","unstructured":"Mahmud S, Rafi O, Paul GK, Promi MM, Sharmin M, Shimu S, Biswas S, Emran TB, Dhama K (2021) Designing a multi - epitope vaccine candidate to combat MERS - CoV by employing an immunoinformatics approach. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-021-92176-1","journal-title":"Sci Rep"},{"key":"1426_CR51","unstructured":"Myers J (2021) COVID-19: What you need to know about the coronavirus pandemic on 20 October. World Economic Forum. https:\/\/www.weforum.org\/agenda\/2021\/10\/covid-19-coronavirus-pandemic-20-october-2021\/"},{"key":"1426_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.00216","author":"K Nandakumar","year":"2020","unstructured":"Nandakumar K (2020) COVID-19: emergence, spread, possible treatments, and global. Front Public Health. https:\/\/doi.org\/10.3389\/fpubh.2020.00216","journal-title":"Front Public Health"},{"issue":"7","key":"1426_CR28","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.jiph.2021.04.010","volume":"14","author":"M Naveed","year":"2021","unstructured":"Naveed M, Tehreem S, Arshad S, Aniqa S (2021) Design of a novel multiple epitope-based vaccine: an immunoinformatics approach to combat SARS-CoV-2 strains. J Infect Public Health 14(7):938\u2013946. https:\/\/doi.org\/10.1016\/j.jiph.2021.04.010","journal-title":"J Infect Public Health"},{"key":"1426_CR29","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1093\/nar\/gki376","volume":"33","author":"B No","year":"2005","unstructured":"No B, Grote A, Hiller K, Scheer M, Mu R, Hempel DC, Jahn D (2005) Jcat: a novel tool to adapt codon usage of a target gene to its potential expression host. Nucleic Acids Res 33:526\u2013531. https:\/\/doi.org\/10.1093\/nar\/gki376","journal-title":"Nucleic Acids Res"},{"key":"1426_CR60","doi-asserted-by":"publisher","unstructured":"Oladipo EK, Ajayi AF, Ariyo OE, Onile SO, Jimah EM, Ezediuno LO, Adebayo OI, Adebayo ET, Odeyemi AN, Oyeleke MO, Oyewole MP, Oguntomi AS, Akindiya OE, Olamoyegun BO, Aremu VO, Arowosaye AO, Aboderin DO, Bello HB, Senbadejo TY, Awoyelu EH, Oladipo AA, Oladipo BB, Ajayi LO, Majolagbe ON, Oyawoye OM, Oloke JK (2020) Exploration of surface glycoprotein to design multi-epitope vaccine for the prevention of Covid-19. Inform Med Unlocked 21:100438. https:\/\/doi.org\/10.1016\/j.imu.2020.100438. Epub 2020 Oct 4. PMID: 33043110; PMCID: PMC7533051.","DOI":"10.1016\/j.imu.2020.100438"},{"key":"1426_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/s40203-020-00062-x","author":"EK Oladipo","year":"2021","unstructured":"Oladipo EK, Folorunsho A, Olugbenga A, Onile S, Elijah O, Jimah EM, Ezediuno LO, Adebayo OI, Adebayo ET, Odeyemi AN, Oyeleke MO, Precious M, Ayomide O, Oguntomi S, Elizabeth O (2021) Designing a conserved peptide - based subunit vaccine against SARS-CoV-2 using immunoinformatics approach. In Silico Pharmacol. https:\/\/doi.org\/10.1007\/s40203-020-00062-x","journal-title":"In Silico Pharmacol"},{"issue":"12","key":"1426_CR31","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.3390\/vaccines10122107","volume":"10","author":"EK Oladipo","year":"2022","unstructured":"Oladipo EK, Adeniyi MO, Ogunlowo MT, Irewolede BA, Adekanola VO, Oluseyi GS, Omilola JA, Udoh AF, Olufemi SE, Adediran DA, Olonade A, Idowu UA, Kolawole OM, Oloke JK, Onyeaka H (2022a) Bioinformatics designing and molecular modelling of a universal mrna vaccine for SARS-CoV-2 infection. Vaccines 10(12):2107. https:\/\/doi.org\/10.3390\/vaccines10122107","journal-title":"Vaccines"},{"issue":"2","key":"1426_CR32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00251-022-01282-5","volume":"75","author":"EK Oladipo","year":"2022","unstructured":"Oladipo EK, Akindiya OE, Oluwasanya GJ, Akanbi GM, Olufemi SE, Adediran DA, Bamigboye FO, Aremu RO, Kolapo KT, Oluwasegun JA, Awobiyi HO, Jimah EM, Irewolede BA, Folakanmi EO, Olubodun OA, Akintibubo SA, Odunlami FD, Ojo TO, Akinro OP, Hezikiah OS, Babalola MO (2022b) Bioinformatics analysis of structural protein to approach a vaccine candidate against Vibrio cholerae infection. Immunogenetics 75(2):99\u2013114. https:\/\/doi.org\/10.1007\/s00251-022-01282-5","journal-title":"Immunogenetics"},{"issue":"3","key":"1426_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nargab\/lqaa048","volume":"2","author":"OS Onile","year":"2020","unstructured":"Onile OS, Ojo GJ, Oyeyemi BF, Agbowuro GO, Fadahunsi AI (2020) Development of multiepitope subunit protein vaccines against Toxoplasma gondii using an immunoinformatics approach. NAR Genom Bioinform 2(3):1\u201311. https:\/\/doi.org\/10.1093\/nargab\/lqaa048","journal-title":"NAR Genom Bioinform"},{"issue":"1","key":"1426_CR34","doi-asserted-by":"publisher","first-page":"120139","DOI":"10.1098\/rsob.120139","volume":"3","author":"A Patronov","year":"2013","unstructured":"Patronov A, Doytchinova I (2013) t cell epitope vaccine design by immunoinformatics. Open Biol 3(1):120139. https:\/\/doi.org\/10.1098\/rsob.120139","journal-title":"Open Biol"},{"key":"1426_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-9-514","volume":"9","author":"J Ponomarenko","year":"2008","unstructured":"Ponomarenko J, Bui HH, Li W, Fusseder N, Bourne PE, Sette A, Peters B (2008) ElliPro: a new structure-based tool for the prediction of antibody epitopes. BMC Bioinformatics 9:1\u20138. https:\/\/doi.org\/10.1186\/1471-2105-9-514","journal-title":"BMC Bioinformatics"},{"key":"1426_CR36","unstructured":"Pharmacy Practice News (nd) COVID-19 Patients Don\u2019t Need \u201cJust in Case\u201d Antibiotics. Retrieved July 24, 2023, from https:\/\/www.pharmacypracticenews.com\/Covid-19\/Article\/09-20\/COVID-19-Patients-Don-t-Need-Just-in-Case-Antibiotics\/59608"},{"key":"1426_CR37","first-page":"1","volume":"9","author":"S Pyasi","year":"2021","unstructured":"Pyasi S, Sharma V, Dipti K, Jonniya NA (2021) Immunoinformatics approach to design multi-epitope- subunit vaccine against bovine ephemeral fever disease. Vacacines 9:1\u201320","journal-title":"Vacacines"},{"key":"1426_CR57","doi-asserted-by":"publisher","unstructured":"Rapin JR, Wiernsperger N (2010) Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine. Clinics (Sao Paulo) 65(6):635\u2013643. https:\/\/doi.org\/10.1590\/S1807-59322010000600012. PMID: 20613941; PMCID: PMC2898551.","DOI":"10.1590\/S1807-59322010000600012"},{"key":"1426_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-96863-x","volume":"0123456789","author":"K Rawal","year":"2021","unstructured":"Rawal K, Sinha R, Abbasi BA, Chaudhary A, Nath SK, Kumari P, Preeti P, Saraf D, Singh S, Singh P, Sood S, Subramani P, Dubey AK, Strych U (2021) Identification of vaccine targets in pathogens and design of a vaccine using computational approaches. Sci Rep 0123456789:1\u201325. https:\/\/doi.org\/10.1038\/s41598-021-96863-x","journal-title":"Sci Rep"},{"key":"1426_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/vaccines9060658","volume":"9","author":"A Rehman","year":"2021","unstructured":"Rehman A, Ahmad S, Shahid F, Albutti A, Alwashmi ASS, Aljasir MA, Alhumeed N, Qasim M, Ashfaq UA, Tahir M (2021) Integrated core proteomics, subtractive proteomics, and immunoinformatics investigation to unveil a potential multi-epitope vaccine against schistosomiasis. Vaccines 9:1\u201321","journal-title":"Vaccines"},{"key":"1426_CR27","unstructured":"Resolution GA, Others (2015) Transforming our world: the 2030 Agenda for Sustainable Development. UN Doc. A\/RES\/70\/1. https:\/\/www.itu.int\/en\/ITU-T\/Workshops-and-Seminars\/2022\/0808\/Documents\/Shailendra%20Kumar%20Mishra%20.pdf"},{"key":"1426_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/v9060153","volume":"1","author":"LK Ryan","year":"2017","unstructured":"Ryan LK, Diamond G (2017) Modulation of human \u03b2 -defensin-1 production by viruses. Viruses 1:1\u201310. https:\/\/doi.org\/10.3390\/v9060153","journal-title":"Viruses"},{"key":"1426_CR58","doi-asserted-by":"publisher","unstructured":"Samad A, Ahammad F, Nain Z, Alam R, Imon RR, Hasan M, Rahman MS (2022) Designing a multi-epitope vaccine against SARS-CoV-2: an immunoinformatics approach. J Biomol Struct Dyn 40(1):14\u201330. https:\/\/doi.org\/10.1080\/07391102.2020.1792347. Epub 2020 Jul 17. PMID: 32677533; PMCID: PMC7441805.","DOI":"10.1080\/07391102.2020.1792347"},{"key":"1426_CR42","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2299-6","author":"R Sanjua","year":"2016","unstructured":"Sanjua R (2016) Mechanisms of viral mutation. Cell Mol Life Sci. https:\/\/doi.org\/10.1007\/s00018-016-2299-6","journal-title":"Cell Mol Life Sci"},{"key":"1426_CR43","doi-asserted-by":"publisher","first-page":"100478","DOI":"10.1016\/j.imu.2020.100478","volume":"21","author":"B Sarkar","year":"2020","unstructured":"Sarkar B, Ullah A, Araf Y, Shahedur M (2020) Informatics in Medicine Unlocked Engineering a novel subunit vaccine against SARS-CoV-2 by exploring immunoinformatics approach. Inform Med Unlocked 21:100478. https:\/\/doi.org\/10.1016\/j.imu.2020.100478","journal-title":"Inform Med Unlocked"},{"key":"1426_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40833-x","author":"RA Shey","year":"2019","unstructured":"Shey RA, Ghogomu SM, Esoh KK, Nebangwa ND, Shintouo CM, Nongley NF, Asa BF, Ngale FN, Vanhamme L, Souopgui J (2019) In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-019-40833-x","journal-title":"Sci Rep"},{"key":"1426_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-73371-y","volume":"0123456789","author":"A Singh","year":"2020","unstructured":"Singh A, Thakur M, Sharma LK, Chandra K (2020) Designing a multi - epitope peptide based vaccine against SARS - CoV - 2. Sci Rep 0123456789:1\u201312. https:\/\/doi.org\/10.1038\/s41598-020-73371-y","journal-title":"Sci Rep"},{"issue":"April","key":"1426_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpubh.2020.00155","volume":"8","author":"C Sun","year":"2020","unstructured":"Sun C, Wang Y, Liu G, Liu Z (2020) Role of the eye in transmitting human coronavirus: what we know and what we do not know. Front Public Health 8(April):1\u20137. https:\/\/doi.org\/10.3389\/fpubh.2020.00155","journal-title":"Front Public Health"},{"key":"1426_CR48","doi-asserted-by":"crossref","unstructured":"Oude Munnink, B. B., & Koopmans, M. (2023). Tracking SARS-CoV-2 variants and resources [Review of Tracking SARS-CoV-2 variants and resources]. Nature Methods, 20(4), 489\u2013490. https:\/\/doi.org\/10.1038\/s41592-023-01833-y","DOI":"10.1038\/s41592-023-01833-y"},{"issue":"D1","key":"1426_CR50","doi-asserted-by":"publisher","first-page":"D405","DOI":"10.1093\/nar\/gku938","volume":"43","author":"R Vita","year":"2015","unstructured":"Vita R, Overton JA, Greenbaum JA, Ponomarenko J, Clark JD, Cantrell JR, Peters B (2015) The immune epitope database (IEDB) 3.0. Nucleic Acids Res 43(D1):D405\u2013D412. https:\/\/doi.org\/10.1093\/nar\/gku938","journal-title":"Nucleic Acids Res"},{"key":"1426_CR52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-79139-8","volume":"11","author":"Z Yang","year":"2021","unstructured":"Yang Z, Bogdan P, Nazarian S (2021) An in silico deep learning approach to multi - epitope vaccine design\u202f: a SARS - CoV - 2 case study. Sci Rep 11:1\u201321","journal-title":"Sci Rep"},{"issue":"1","key":"1426_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cmpb.2008.05.002","volume":"92","author":"W Zhang","year":"2008","unstructured":"Zhang W, Liu J, Niu YQ, Wang L, Hu X (2008) A Bayesian regression approach to the prediction of MHC-I binding affinity. Comput Methods Progr Biomed 92(1):1\u20137. https:\/\/doi.org\/10.1016\/j.cmpb.2008.05.002","journal-title":"Comput Methods Progr Biomed"},{"issue":"10","key":"1426_CR54","doi-asserted-by":"publisher","first-page":"806","DOI":"10.3855\/jidc.7207","volume":"11","author":"JW Zhao","year":"2017","unstructured":"Zhao JW, Yan M, Shi G, Zhang SL, Ming L (2017) In silico identification of cytotoxic T lymphocyte epitopes encoded by RD5 region of Mycobacterium tuberculosis. J Inf Dev Countries 11(10):806\u2013810. https:\/\/doi.org\/10.3855\/jidc.7207","journal-title":"J Inf Dev Countries"},{"key":"1426_CR55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606724113","author":"Z Zhou","year":"2016","unstructured":"Zhou Z, Dang Y, Zhou M, Li L, Yu C, Fu J, Chen S, Liu Y (2016) Codon usage is an important determinant of gene expression levels largely through its effects on transcription. Proc Natl Acad Sci. https:\/\/doi.org\/10.1073\/pnas.1606724113","journal-title":"Proc Natl Acad Sci"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-023-01426-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-023-01426-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-023-01426-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T05:30:00Z","timestamp":1701063000000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-023-01426-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,7]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["1426"],"URL":"https:\/\/doi.org\/10.1007\/s13258-023-01426-1","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"type":"print","value":"1976-9571"},{"type":"electronic","value":"2092-9293"}],"subject":[],"published":{"date-parts":[[2023,8,7]]},"assertion":[{"value":"16 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that we have no known competing financial interest or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}