{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:35:13Z","timestamp":1782142513905,"version":"3.54.5"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103289"],"award-info":[{"award-number":["82103289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s13258-023-01476-5","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T06:02:19Z","timestamp":1702015339000},"page":"713-731","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Downregulated CDH3 is correlated with a better prognosis for LUAD and decreases proliferation and migration of lung cancer cells"],"prefix":"10.1007","volume":"46","author":[{"given":"Wanru","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"issue":"8","key":"1476_CR1","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1177\/1060028015586218","volume":"49","author":"MS Barbee","year":"2015","unstructured":"Barbee MS, Ogunniyi A, Horvat TZ, Dang TO (2015) Current status and future directions of the immune checkpoint inhibitors ipilimumab, pembrolizumab, and nivolumab in oncology. Ann Pharmacother 49(8):907\u2013937","journal-title":"Ann Pharmacother"},{"issue":"21","key":"1476_CR2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.233189","volume":"132","author":"M Le Borgne-Rochet","year":"2019","unstructured":"Le Borgne-Rochet M, Angevin L, Bazellieres E, Ordas L, Comunale F, Denisov EV et al (2019) P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration. J Cell Sci 132(21):233189","journal-title":"J Cell Sci"},{"issue":"7791","key":"1476_CR3","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/d41586-019-03943-0","volume":"577","author":"TC Bruno","year":"2020","unstructured":"Bruno TC (2020) New predictors for immunotherapy responses sharpen our view of the tumour microenvironment. Nature 577(7791):474\u2013476","journal-title":"Nature"},{"issue":"2","key":"1476_CR4","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nrc1276","volume":"4","author":"U Cavallaro","year":"2004","unstructured":"Cavallaro U, Christofori G (2004) Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4(2):118\u2013132","journal-title":"Nat Rev Cancer"},{"issue":"9","key":"1476_CR5","doi-asserted-by":"publisher","first-page":"736","DOI":"10.7150\/jca.7734","volume":"4","author":"K Domvri","year":"2013","unstructured":"Domvri K, Zarogoulidis P, Darwiche K, Browning RF, Li Q, Turner JF et al (2013) Molecular targeted drugs and biomarkers in NSCLC, the evolving role of individualized therapy. J Cancer 4(9):736\u2013754","journal-title":"J Cancer"},{"issue":"9","key":"1476_CR6","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1158\/0008-5472.CAN-11-3687","volume":"72","author":"A Facciabene","year":"2012","unstructured":"Facciabene A, Motz GT, Coukos G (2012) T-regulatory cells: key players in tumor immune escape and angiogenesis. Can Res 72(9):2162\u20132171","journal-title":"Can Res"},{"issue":"4","key":"1476_CR7","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00428-018-2406-1","volume":"473","author":"C Ferreira","year":"2018","unstructured":"Ferreira C, Lobo J, Antunes L, Lopes P, Jeronimo C, Henrique R (2018) Differential expression of E-cadherin and P-cadherin in pT3 prostate cancer: correlation with clinical and pathological features. Virchows Arch 473(4):443\u2013452","journal-title":"Virchows Arch"},{"key":"1476_CR8","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baz046","author":"O Franzen","year":"2019","unstructured":"Franzen O, Gan LM, Bjorkegren JLM (2019) PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data. Database (oxford). https:\/\/doi.org\/10.1093\/database\/baz046","journal-title":"Database (oxford)."},{"issue":"269","key":"1476_CR9","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO et al (2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6(269):pl1","journal-title":"Sci Signal."},{"issue":"7","key":"1476_CR10","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1164\/rccm.201309-1611OC","volume":"189","author":"C Germain","year":"2014","unstructured":"Germain C, Gnjatic S, Tamzalit F, Knockaert S, Remark R, Goc J et al (2014) Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer. Am J Respir Crit Care Med 189(7):832\u2013844","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"1476_CR11","doi-asserted-by":"publisher","first-page":"8687","DOI":"10.18632\/oncotarget.3478","volume":"6","author":"K He","year":"2015","unstructured":"He K, Lv W, Zheng D, Cheng F, Zhou T, Ye S et al (2015) The stromal genome heterogeneity between breast and prostate tumors revealed by a comparative transcriptomic analysis. Oncotarget 6(11):8687\u20138697","journal-title":"Oncotarget"},{"issue":"13","key":"1476_CR12","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1056\/NEJMra0802714","volume":"359","author":"RS Herbst","year":"2008","unstructured":"Herbst RS, Heymach JV, Lippman SM (2008) Lung cancer. N Engl J Med 359(13):1367\u20131380","journal-title":"N Engl J Med"},{"key":"1476_CR13","doi-asserted-by":"publisher","first-page":"3220","DOI":"10.1158\/1078-0432.CCR-19-3972","volume":"26","author":"TF Hsiao","year":"2020","unstructured":"Hsiao TF, Wang CL, Wu YC, Feng HP, Chiu YC, Lin HY et al (2020) Integrative omics analysis reveals soluble cadherin-3 as a survival predictor and an early monitoring marker of EGFR tyrosine kinase inhibitor therapy in lung cancer. Clin Cancer Res 26:3220\u20133229","journal-title":"Clin Cancer Res"},{"issue":"3","key":"1476_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120852","volume":"10","author":"KH Hsu","year":"2015","unstructured":"Hsu KH, Ho CC, Hsia TC, Tseng JS, Su KY, Wu MF et al (2015) Identification of five driver gene mutations in patients with treatment-Naive lung adenocarcinoma in Taiwan. PLoS ONE 10(3):e0120852","journal-title":"PLoS ONE"},{"issue":"7","key":"1476_CR15","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1200\/JCO.1998.16.7.2468","volume":"16","author":"DJ Kwiatkowski","year":"1998","unstructured":"Kwiatkowski DJ, Harpole DH Jr, Godleski J, Herndon JE 2nd, Shieh DB, Richards W et al (1998) Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: clinical implications. J Clin Oncol 16(7):2468\u20132477","journal-title":"J Clin Oncol"},{"issue":"21","key":"1476_CR16","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","volume":"77","author":"T Li","year":"2017","unstructured":"Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS et al (2017) TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Can Res 77(21):e108\u2013e110","journal-title":"Can Res"},{"key":"1476_CR17","first-page":"9644466","volume":"2022","author":"F Li","year":"2022","unstructured":"Li F, Wan B, Li XQ (2022) Expression profile and prognostic values of CDH family members in lung adenocarcinoma. Dis Markers 2022:9644466","journal-title":"Dis Markers"},{"key":"1476_CR18","doi-asserted-by":"publisher","first-page":"37606","DOI":"10.1038\/srep37606","volume":"6","author":"P Liu","year":"2016","unstructured":"Liu P, Weng Y, Sui Z, Wu Y, Meng X, Wu M et al (2016) Quantitative secretomic analysis of pancreatic cancer cells in serum-containing conditioned medium. Sci Rep 6:37606","journal-title":"Sci Rep"},{"key":"1476_CR19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1755-8794-2-18","volume":"2","author":"H Mizuno","year":"2009","unstructured":"Mizuno H, Kitada K, Nakai K, Sarai A (2009) PrognoScan: a new database for meta-analysis of the prognostic value of genes. BMC Med Genomics 2:18","journal-title":"BMC Med Genomics"},{"key":"1476_CR20","first-page":"4","volume":"7","author":"H Ohtani","year":"2007","unstructured":"Ohtani H (2007) Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer. Cancer Immun 7:4","journal-title":"Cancer Immun"},{"key":"1476_CR21","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fimmu.2019.00006","volume":"10","author":"JH Pan","year":"2019","unstructured":"Pan JH, Zhou H, Cooper L, Huang JL, Zhu SB, Zhao XX et al (2019) LAYN is a prognostic biomarker and correlated with immune infiltrates in gastric and colon cancers. Front Immunol 10:6","journal-title":"Front Immunol"},{"issue":"16","key":"1476_CR22","doi-asserted-by":"publisher","first-page":"5869","DOI":"10.1158\/1078-0432.CCR-05-0059","volume":"11","author":"J Paredes","year":"2005","unstructured":"Paredes J, Albergaria A, Oliveira JT, Jeronimo C, Milanezi F, Schmitt FC (2005) P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation. Clin Cancer Res 11(16):5869\u20135877","journal-title":"Clin Cancer Res"},{"issue":"5","key":"1476_CR23","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/bcr1774","volume":"9","author":"J Paredes","year":"2007","unstructured":"Paredes J, Correia AL, Ribeiro AS, Albergaria A, Milanezi F, Schmitt FC (2007) P-cadherin expression in breast cancer: a review. Breast Cancer Res 9(5):214","journal-title":"Breast Cancer Res"},{"issue":"7","key":"1476_CR24","first-page":"1263","volume":"86","author":"A Peralta Soler","year":"1999","unstructured":"Peralta Soler A, Knudsen KA, Salazar H, Han AC, Keshgegian AA (1999) P-cadherin expression in breast carcinoma indicates poor survival. Cancer-Am Cancer Soc 86(7):1263\u20131272","journal-title":"Cancer-Am Cancer Soc"},{"issue":"6797","key":"1476_CR25","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"CM Perou","year":"2000","unstructured":"Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA et al (2000) Molecular portraits of human breast tumours. Nature 406(6797):747\u2013752","journal-title":"Nature"},{"issue":"1\u20132","key":"1476_CR26","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0248-4900(01)01125-X","volume":"93","author":"C Peyssonnaux","year":"2001","unstructured":"Peyssonnaux C, Eychene A (2001) The Raf\/MEK\/ERK pathway: new concepts of activation. Biol Cell 93(1\u20132):53\u201362","journal-title":"Biol Cell"},{"issue":"2","key":"1476_CR27","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1593\/neo.07112","volume":"9","author":"DR Rhodes","year":"2007","unstructured":"Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB et al (2007) Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 9(2):166\u2013180","journal-title":"Neoplasia"},{"issue":"15","key":"1476_CR28","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1056\/NEJM198710083171504","volume":"317","author":"S Rodenhuis","year":"1987","unstructured":"Rodenhuis S, van de Wetering ML, Mooi WJ, Evers SG, van Zandwijk N, Bos JL (1987) Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung. N Engl J Med 317(15):929\u2013935","journal-title":"N Engl J Med"},{"issue":"20","key":"1476_CR29","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1093\/bioinformatics\/btz210","volume":"35","author":"B Ru","year":"2019","unstructured":"Ru B, Wong CN, Tong Y, Zhong JY, Zhong SSW, Wu WC et al (2019) TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics 35(20):4200\u20134202","journal-title":"Bioinformatics"},{"issue":"11","key":"1476_CR30","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1101\/gr.145144.112","volume":"22","author":"JS Seo","year":"2012","unstructured":"Seo JS, Ju YS, Lee WC, Shin JY, Lee JK, Bleazard T et al (2012) The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res 22(11):2109\u20132119","journal-title":"Genome Res"},{"issue":"7","key":"1476_CR31","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1158\/1535-7163.MCT-20-0708","volume":"20","author":"Q Sheng","year":"2021","unstructured":"Sheng Q, D\u2019Alessio JA, Menezes DL, Karim C, Tang Y, Tam A et al (2021) PCA062, a P-cadherin targeting antibody-drug conjugate, displays potent antitumor activity against P-cadherin-expressing Malignancies. Mol Cancer Ther 20(7):1270\u20131282","journal-title":"Mol Cancer Ther"},{"issue":"1","key":"1476_CR32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/COH.0000000000000326","volume":"12","author":"K Sigel","year":"2017","unstructured":"Sigel K, Makinson A, Thaler J (2017) Lung cancer in persons with HIV. Curr Opin HIV AIDS 12(1):31\u201338","journal-title":"Curr Opin HIV AIDS"},{"issue":"7153","key":"1476_CR33","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nature05945","volume":"448","author":"M Soda","year":"2007","unstructured":"Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S et al (2007) Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448(7153):561\u2013566","journal-title":"Nature"},{"issue":"3","key":"1476_CR34","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nm.2658","volume":"18","author":"K Takeuchi","year":"2012","unstructured":"Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S et al (2012) RET, ROS1 and ALK fusions in lung cancer. Nat Med 18(3):378\u2013381","journal-title":"Nat Med"},{"issue":"W1","key":"1476_CR35","doi-asserted-by":"publisher","first-page":"W98","DOI":"10.1093\/nar\/gkx247","volume":"45","author":"Z Tang","year":"2017","unstructured":"Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z (2017) GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res 45(W1):W98\u2013W102","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"1476_CR36","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1158\/0008.5472.CAN-04-3646","volume":"65","author":"K Taniuchi","year":"2005","unstructured":"Taniuchi K, Nakagawa H, Hosokawa M, Nakamura T, Eguchi H, Ohigashi H et al (2005) Overexpressed P-cadherin\/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases. Can Res 65(8):3092\u20133099","journal-title":"Can Res"},{"issue":"2","key":"1476_CR37","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","volume":"65","author":"LA Torre","year":"2015","unstructured":"Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65(2):87\u2013108","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"1476_CR38","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00005-017-0463-9","volume":"65","author":"D Waniczek","year":"2017","unstructured":"Waniczek D, Lorenc Z, Snietura M, Wesecki M, Kopec A, Muc-Wierzgon M (2017) Tumor-associated macrophages and regulatory T cells infiltration and the clinical outcome in colorectal cancer. Arch Immunol Ther Exp (warsz) 65(5):445\u2013454","journal-title":"Arch Immunol Ther Exp (warsz)"},{"issue":"3","key":"1476_CR39","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1023\/A:1022978932215","volume":"20","author":"J Yokota","year":"2003","unstructured":"Yokota J, Nishioka M, Tani M, Kohno T (2003) Genetic alterations responsible for metastatic phenotypes of lung cancer cells. Clin Exp Metastasis 20(3):189\u2013193","journal-title":"Clin Exp Metastasis"},{"issue":"8","key":"1476_CR40","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s00262-011-1186-0","volume":"61","author":"H Yoshioka","year":"2012","unstructured":"Yoshioka H, Yamamoto S, Hanaoka H, Iida Y, Paudyal P, Higuchi T et al (2012) In vivo therapeutic effect of CDH3\/P-cadherin-targeting radioimmunotherapy. Cancer Immunol Immunotherapy CII 61(8):1211\u20131220","journal-title":"Cancer Immunol Immunotherapy CII"},{"issue":"2","key":"1476_CR41","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/SLA.0000000000002058","volume":"267","author":"H Zhang","year":"2018","unstructured":"Zhang H, Liu H, Shen Z, Lin C, Wang X, Qin J et al (2018) Tumor-infiltrating neutrophils is prognostic and predictive for postoperative adjuvant chemotherapy benefit in patients with gastric cancer. Ann Surg 267(2):311\u2013318","journal-title":"Ann Surg"},{"issue":"6","key":"1476_CR42","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1016\/j.jtcvs.2018.07.054","volume":"156","author":"ZR Zhao","year":"2018","unstructured":"Zhao ZR, Lau RWH, Long H, Mok TSK, Chen GG, Underwood MJ et al (2018) Novel method for rapid identification of micropapillary or solid components in early-stage lung adenocarcinoma. J Thorac Cardiovasc Surg 156(6):2310\u20132318","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-023-01476-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-023-01476-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-023-01476-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T05:17:36Z","timestamp":1716009456000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-023-01476-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,8]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["1476"],"URL":"https:\/\/doi.org\/10.1007\/s13258-023-01476-5","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,8]]},"assertion":[{"value":"4 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}