{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:23:09Z","timestamp":1784798589408,"version":"3.55.0"},"reference-count":129,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002649","name":"Yeungnam University","doi-asserted-by":"publisher","award":["Yeungnam University"],"award-info":[{"award-number":["Yeungnam University"]}],"id":[{"id":"10.13039\/501100002649","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s13258-024-01565-z","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T17:02:38Z","timestamp":1726246958000},"page":"1345-1361","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Recent advances in anticancer mechanisms of molecular glue degraders: focus on RBM39-dgrading synthetic sulfonamide such as indisulam, E7820, tasisulam, and chloroquinoxaline sulfonamide"],"prefix":"10.1007","volume":"46","author":[{"given":"Ji Hoon","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3934-2035","authenticated-orcid":false,"given":"Tae-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"1565_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.molstruc.2016.03.066","volume":"1117","author":"A Abbas","year":"2016","unstructured":"Abbas A, Murtaza S, Tahir MN, Shamim S, Sirajuddin M, Rana UA, Naseem K, Rafique H (2016) Synthesis, antioxidant, enzyme inhibition and DNA binding studies of novel N-benzylated derivatives of sulfonamide. J Mol Struct 1117:269\u2013275","journal-title":"J Mol Struct"},{"key":"1565_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.bmcl.2003.09.062","volume":"14","author":"F Abbate","year":"2004","unstructured":"Abbate F, Casini A, Owa T, Scozzafava A, Supuran CT (2004) Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett 14:217\u2013223","journal-title":"Bioorg Med Chem Lett"},{"key":"1565_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.gendis.2018.12.003","volume":"6","author":"V Adorno-Cruz","year":"2019","unstructured":"Adorno-Cruz V, Liu H (2019) Regulation and functions of integrin \u03b12 in cell adhesion and disease. Genes Dis 6:16\u201324","journal-title":"Genes Dis"},{"key":"1565_CR4","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ejmech.2018.08.002","volume":"157","author":"S Ahmad","year":"2018","unstructured":"Ahmad S, Alam O, Naim MJ, Shaquiquzzaman M, Alam MM, Iqbal M (2018) Pyrrole: an insight into recent pharmacological advances with structure activity relationship. Eur J Med Chem 157:527\u2013561","journal-title":"Eur J Med Chem"},{"key":"1565_CR5","doi-asserted-by":"publisher","first-page":"104640","DOI":"10.1016\/j.bioorg.2021.104640","volume":"107","author":"GH Al-Ansary","year":"2021","unstructured":"Al-Ansary GH, Nasr T, Taha H, Fayad W, Mahgoub S (2021) Biphenylurea\/thiourea derivatives tagged with heteroarylsulfonamide motifs as novel VEGFR2 inhibitors; design, synthesis and anti-angiogenic activity. Bioorg Chem 107:104640","journal-title":"Bioorg Chem"},{"key":"1565_CR6","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.bmcl.2017.03.018","volume":"27","author":"S Alaoui","year":"2017","unstructured":"Alaoui S, Dufies M, Driowya M, Demange L, Bougrin K, Robert G, Auberger P, Pag\u00e8s G, Benhida R (2017) Synthesis and anti-cancer activities of new sulfonamides 4-substituted-triazolyl nucleosides. Bioorg Med Chem Lett 27:1989\u20131992","journal-title":"Bioorg Med Chem Lett"},{"key":"1565_CR7","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1185\/03007997309111720","volume":"1","author":"HB Allen","year":"1973","unstructured":"Allen HB, Lee DA (1973) A general practice assessment of mefruside (\u2018Baycaron\u2019) in the treatment of oedema and hypertension. Curr Med Res Opin 1:547\u2013553","journal-title":"Curr Med Res Opin"},{"key":"1565_CR8","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1002\/cncr.31398","volume":"124","author":"R Assi","year":"2018","unstructured":"Assi R, Kantarjian HM, Kadia TM, Pemmaraju N, Jabbour E, Jain N, Daver N, Estrov Z, Uehara T, Owa T et al (2018) Final results of a phase 2, open-label study of indisulam, idarubicin, and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome. Cancer 124:2758\u20132765","journal-title":"Cancer"},{"key":"1565_CR9","doi-asserted-by":"publisher","first-page":"e202200831","DOI":"10.1002\/cbdv.202200831","volume":"19","author":"H Azevedo-Barbosa","year":"2022","unstructured":"Azevedo-Barbosa H, Ferreira-Silva G, do Vale BP, Hawkes JA, Ionta M, Carvalho DT (2022) Synthesis and structure-activity relationship studies of Novel Aryl sulfonamides and their activity against human breast Cancer cell lines. Chem Biodivers 19:e202200831","journal-title":"Chem Biodivers"},{"key":"1565_CR10","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.bmcl.2014.12.006","volume":"25","author":"S Bag","year":"2015","unstructured":"Bag S, Tulsan R, Sood A, Cho H, Redjeb H, Zhou W, LeVine H 3rd, T\u00f6r\u00f6k B, T\u00f6r\u00f6k M (2015) Sulfonamides as multifunctional agents for Alzheimer\u2019s disease. Bioorg Med Chem Lett 25:626\u2013630","journal-title":"Bioorg Med Chem Lett"},{"key":"1565_CR11","doi-asserted-by":"publisher","first-page":"10709","DOI":"10.1021\/acs.jmedchem.1c01855","volume":"65","author":"SK Baidya","year":"2022","unstructured":"Baidya SK, Banerjee S, Adhikari N, Jha T (2022) Selective inhibitors of medium-size S1\u2019 Pocket Matrix metalloproteinases: a Stepping Stone of Future Drug Discovery. J Med Chem 65:10709\u201310754","journal-title":"J Med Chem"},{"key":"1565_CR12","doi-asserted-by":"publisher","first-page":"5763","DOI":"10.1016\/j.ejmech.2011.08.015","volume":"46","author":"S Bano","year":"2011","unstructured":"Bano S, Javed K, Ahmad S, Rathish IG, Singh S, Alam MS (2011) Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents. Eur J Med Chem 46:5763\u20135768","journal-title":"Eur J Med Chem"},{"key":"1565_CR13","doi-asserted-by":"publisher","first-page":"112904","DOI":"10.1016\/j.ejmech.2020.112904","volume":"209","author":"AKA Bass","year":"2021","unstructured":"Bass AKA, El-Zoghbi MS, Nageeb EM, Mohamed MFA, Badr M, Abuo-Rahma GEA (2021) Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors. Eur J Med Chem 209:112904","journal-title":"Eur J Med Chem"},{"key":"1565_CR14","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1038\/s41375-023-02050-4","volume":"37","author":"JP Bewersdorf","year":"2023","unstructured":"Bewersdorf JP, Stahl M, Taylor J, Mi X, Chandhok NS, Watts J, Derkach A, Wysocki M, Lu SX, Bourcier J et al (2023) E7820, an anti-cancer sulfonamide, degrades RBM39 in patients with splicing factor mutant myeloid malignancies: a phase II clinical trial. Leukemia 37:2512\u20132516","journal-title":"Leukemia"},{"key":"1565_CR15","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1039\/D1CB00011J","volume":"2","author":"MJ Bond","year":"2021","unstructured":"Bond MJ, Crews CM (2021) Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation. RSC Chem Biol 2:725\u2013742","journal-title":"RSC Chem Biol"},{"key":"1565_CR16","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1016\/0006-2952(89)90123-8","volume":"38","author":"RF Branda","year":"1989","unstructured":"Branda RF, Moore AL, McCormack JJ (1989) Immunosuppressive properties of chloroquinoxaline sulfonamide. Biochem Pharmacol 38:3521\u20133526","journal-title":"Biochem Pharmacol"},{"key":"1565_CR17","doi-asserted-by":"publisher","first-page":"11269","DOI":"10.1021\/acs.chemrev.7b00077","volume":"117","author":"GM Burslem","year":"2017","unstructured":"Burslem GM, Crews CM (2017) Small-molecule modulation of protein homeostasis. Chem Rev 117:11269\u201311301","journal-title":"Chem Rev"},{"key":"1565_CR18","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.4155\/fmc.14.68","volume":"6","author":"F Carta","year":"2014","unstructured":"Carta F, Supuran CT, Scozzafava A (2014) Sulfonamides and their isosters as carbonic anhydrase inhibitors. Future Med Chem 6:1149\u20131165","journal-title":"Future Med Chem"},{"key":"1565_CR21","doi-asserted-by":"publisher","first-page":"6311","DOI":"10.1007\/s13277-014-1819-y","volume":"35","author":"Y Chai","year":"2014","unstructured":"Chai Y, Liu X, Dai L, Li Y, Liu M, Zhang JY (2014) Overexpression of HCC1\/CAPER\u03b1 may play a role in lung cancer carcinogenesis. Tumour Biol 35:6311\u20136317","journal-title":"Tumour Biol"},{"key":"1565_CR20","doi-asserted-by":"publisher","first-page":"4288","DOI":"10.1038\/s41467-021-24498-7","volume":"12","author":"WC Chen","year":"2021","unstructured":"Chen WC, To MD, Westcott PMK, Delrosario R, Kim IJ, Philips M, Tran Q, Bollam SR, Goodarzi H, Bayani N et al (2021) Targeting KRAS4A splicing through the RBM39\/DCAF15 pathway inhibits cancer stem cells. Nat Commun 12:4288","journal-title":"Nat Commun"},{"key":"1565_CR19","doi-asserted-by":"publisher","first-page":"115706","DOI":"10.1016\/j.ejmech.2023.115706","volume":"259","author":"P Chen","year":"2023","unstructured":"Chen P, Yang J, Zhou Y, Li X, Zou Y, Zheng Z, Guo M, Chen Z, Cho WJ, Chattipakorn N et al (2023) Design, synthesis, and bioactivity evaluation of novel amide\/sulfonamide derivatives as potential anti-inflammatory agents against acute lung injury and ulcerative colitis. Eur J Med Chem 259:115706","journal-title":"Eur J Med Chem"},{"key":"1565_CR22","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1124\/jpet.110.167270","volume":"334","author":"F Cianchi","year":"2010","unstructured":"Cianchi F, Vinci MC, Supuran CT, Peruzzi B, De Giuli P, Fasolis G, Perigli G, Pastorekova S, Papucci L, Pini A et al (2010) Selective inhibition of carbonic anhydrase IX decreases cell proliferation and induces ceramide-mediated apoptosis in human cancer cells. J Pharmacol Exp Ther 334:710\u2013719","journal-title":"J Pharmacol Exp Ther"},{"key":"1565_CR23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/BF00685641","volume":"37","author":"BA Conley","year":"1995","unstructured":"Conley BA, O\u2019Hara S, Wu S, Melink TJ, Parnes H, Pardoe E, Egorin MJ, Van Echo DA (1995) Phase I trial of chloroguinoxaline sulfonamide, with correlation of its pharmacokinetics and pharmacodynamics. Cancer Chemother Pharmacol 37:139\u2013149","journal-title":"Cancer Chemother Pharmacol"},{"key":"1565_CR24","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1158\/1541-7786.MCR-22-0541","volume":"21","author":"S Coomar","year":"2023","unstructured":"Coomar S, Mota P, Penson A, Schwaller J, Abdel-Wahab O, Gillingham D (2023) Overlaid transcriptional and proteome analyses identify mitotic kinesins as important targets of arylsulfonamide-mediated RBM39 degradation. Mol Cancer Res 21:768\u2013778","journal-title":"Mol Cancer Res"},{"key":"1565_CR25","doi-asserted-by":"crossref","unstructured":"Das R, Tambe G, Shard A (2023) Sulfonamides as tyrosine kinase modulators \u2013 A promising class of anticancer agents. Results Chem 5","DOI":"10.1016\/j.rechem.2023.100950"},{"key":"1565_CR26","first-page":"5195","volume":"9","author":"C Dittrich","year":"2003","unstructured":"Dittrich C, Dumez H, Calvert H, Hanauske A, Faber M, Wanders J, Yule M, Ravic M, Fumoleau P (2003) Phase I and pharmacokinetic study of E7070, a chloroindolyl-sulfonamide anticancer agent, administered on a weekly schedule to patients with solid tumors. Clin Cancer Res 9:5195\u20135204","journal-title":"Clin Cancer Res"},{"key":"1565_CR27","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1021\/acschemneuro.6b00146","volume":"7","author":"S Diwakarla","year":"2016","unstructured":"Diwakarla S, Nylander E, Gr\u00f6nbladh A, Vanga SR, Shamsudin Y, Guti\u00e9rrez-de-Ter\u00e1n H, S\u00e4vmarker J, Ng L, Pham V, Lundb\u00e4ck T et al (2016) Aryl Sulfonamide inhibitors of insulin-regulated aminopeptidase enhance spine density in primary hippocampal neuron cultures. ACS Chem Neurosci 7:1383\u20131392","journal-title":"ACS Chem Neurosci"},{"key":"1565_CR28","doi-asserted-by":"publisher","first-page":"10606","DOI":"10.1021\/acs.jmedchem.1c00895","volume":"1264","author":"G Dong","year":"2021","unstructured":"Dong G, Ding Y, He S, Sheng C (2021) Molecular glues for targeted protein degradation: from serendipity to rational Discovery. J Med Chem 1264:10606\u201310620","journal-title":"J Med Chem"},{"key":"1565_CR29","doi-asserted-by":"publisher","first-page":"e38430","DOI":"10.7554\/eLife.38430","volume":"7","author":"KA Donovan","year":"2018","unstructured":"Donovan KA, An J, Nowak RP, Yuan JC, Fink EC, Berry BC, Ebert BL, Fischer ES (2018) Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. Elife 7:e38430","journal-title":"Elife"},{"key":"1565_CR30","first-page":"2922","volume":"13","author":"Z Dou","year":"2023","unstructured":"Dou Z, Zhang X, Su W, Zhang T, Ye F, Zhao D, Chen X, Li Q, Zhang H, Di C (2023) Indisulam exerts anticancer effects via modulation of transcription, translation and alternative splicing on human cervical cancer cells. Am J Cancer Res 13:2922\u20132937","journal-title":"Am J Cancer Res"},{"key":"1565_CR31","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.molcel.2004.12.025","volume":"17","author":"DH Dowhan","year":"2005","unstructured":"Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O\u2019Malley BW (2005) Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta. Mol Cell 17:429\u2013439","journal-title":"Mol Cell"},{"key":"1565_CR32","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.str.2019.10.005","volume":"27","author":"X Du","year":"2019","unstructured":"Du X, Volkov OA, Czerwinski RM, Tan H, Huerta C, Morton ER, Rizzi JP, Wehn PM, Xu R, Nijhawan D et al (2019) Structural basis and kinetic pathway of RBM39 recruitment to DCAF15 by a Sulfonamide Molecular glue E7820. Structure 27:1625\u20131633e1623","journal-title":"Structure"},{"key":"1565_CR33","doi-asserted-by":"publisher","first-page":"10792","DOI":"10.1128\/JVI.00903-08","volume":"82","author":"J Dutta","year":"2008","unstructured":"Dutta J, Fan G, G\u00e9linas C (2008) CAPERalpha is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel\/NF-kappaB oncoprotein v-Rel. J Virol 82:10792\u201310802","journal-title":"J Virol"},{"key":"1565_CR34","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41589-019-0378-3","volume":"16","author":"TB Faust","year":"2020","unstructured":"Faust TB, Yoon H, Nowak RP, Donovan KA, Li Z, Cai Q, Eleuteri NA, Zhang T, Gray NS, Fischer ES (2020) Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat Chem Biol 16:7\u201314","journal-title":"Nat Chem Biol"},{"key":"1565_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00873904","volume":"11","author":"JS Fisherman","year":"1993","unstructured":"Fisherman JS, Osborn BL, Chun HG, Plowman J, Smith AC, Christian MC, Zaharko DS, Shoemaker RH (1993) Chloroquinoxaline sulfonamide: a sulfanilamide antitumor agent entering clinical trials. Invest New Drugs 11:1\u20139","journal-title":"Invest New Drugs"},{"key":"1565_CR36","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1023\/A:1010608317361","volume":"19","author":"K Fukuoka","year":"2001","unstructured":"Fukuoka K, Usuda J, Iwamoto Y, Fukumoto H, Nakamura T, Yoneda T, Narita N, Saijo N, Nishio K (2001) Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells. Invest New Drugs 19:219\u2013227","journal-title":"Invest New Drugs"},{"key":"1565_CR37","first-page":"6116","volume":"62","author":"Y Funahashi","year":"2002","unstructured":"Funahashi Y, Sugi NH, Semba T, Yamamoto Y, Hamaoka S, Tsukahara-Tamai N, Ozawa Y, Tsuruoka A, Nara K, Takahashi K et al (2002) Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. Cancer Res 62:6116\u20136123","journal-title":"Cancer Res"},{"key":"1565_CR38","first-page":"5937","volume":"60","author":"H Gao","year":"2000","unstructured":"Gao H, Yamasaki EF, Chan KK, Shen LL, Snapka RM (2000) Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha\/beta poison. Cancer Res 60:5937\u20135940","journal-title":"Cancer Res"},{"key":"1565_CR39","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1124\/mol.63.6.1382","volume":"63","author":"H Gao","year":"2003","unstructured":"Gao H, Yamasaki EF, Chan KK, Shen LL, Snapka RM (2003) DNA sequence specificity for topoisomerase II poisoning by the quinoxaline anticancer drugs XK469 and CQS. Mol Pharmacol 63:1382\u20131388","journal-title":"Mol Pharmacol"},{"key":"1565_CR40","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1248\/cpb.c16-00614","volume":"64","author":"MM Ghorab","year":"2016","unstructured":"Ghorab MM, Alsaid MS, Nissan YM, Ashour AE, Al-Mishari AA, Kumar A, Ahmed SF (2016) Novel sulfonamide derivatives carrying a biologically active 3,4-Dimethoxyphenyl Moiety as VEGFR-2 inhibitors. Chem Pharm Bull (Tokyo) 64:1747\u20131754","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"1565_CR41","doi-asserted-by":"publisher","first-page":"B197","DOI":"10.1158\/1535-7163.TARG-09-B197","volume":"8","author":"M Gordon","year":"2009","unstructured":"Gordon M, McMeekin DS, Temkin S, Tew W, Yapp S, Scambia G, Streltsova O, Kaiser C, Ilaria R, Look K (2009) Abstract B197: phase II, single-arm study of tasisulam\u2010sodium (LY573636\u2010sodium) as 2nd\u20134th line therapy for platinum resistant ovarian cancer. Mol Cancer Ther 8:B197\u2013B197","journal-title":"Mol Cancer Ther"},{"key":"1565_CR42","doi-asserted-by":"publisher","first-page":"5990","DOI":"10.1021\/acs.jmedchem.6b01850","volume":"60","author":"RF Graceffa","year":"2017","unstructured":"Graceffa RF, Boezio AA, Able J, Altmann S, Berry LM, Boezio C, Butler JR, Chu-Moyer M, Cooke M, DiMauro EF et al (2017) Sulfonamides as selective na(V)1.7 inhibitors: optimizing potency, Pharmacokinetics, and metabolic properties to obtain Atropisomeric Quinolinone (AM-0466) that affords robust in vivo activity. J Med Chem 60:5990\u20136017","journal-title":"J Med Chem"},{"key":"1565_CR43","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.bmcl.2019.02.023","volume":"29","author":"Z Guo","year":"2019","unstructured":"Guo Z, Xu Y, Peng Y, Haroon Ur R, Quan W, Xie P, Wu L, Jiang J, Wang L, Liu X (2019) Design, synthesis and evaluation of novel (S)-tryptamine derivatives containing an allyl group and an aryl sulfonamide unit as anticancer agents. Bioorg Med Chem Lett 29:1133\u20131137","journal-title":"Bioorg Med Chem Lett"},{"key":"1565_CR44","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1215\/15228517-2007-065","volume":"10","author":"J Haapasalo","year":"2008","unstructured":"Haapasalo J, Hilvo M, Nordfors K, Haapasalo H, Parkkila S, Hyrskyluoto A, Rantala I, Waheed A, Sly WS, Pastorekova S et al (2008) Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas. Neuro Oncol 10:131\u2013138","journal-title":"Neuro Oncol"},{"key":"1565_CR46","doi-asserted-by":"publisher","first-page":"4680","DOI":"10.1158\/1078-0432.CCR-04-0229","volume":"10","author":"RI Haddad","year":"2004","unstructured":"Haddad RI, Weinstein LJ, Wieczorek TJ, Bhattacharya N, Raftopoulos H, Oster MW, Zhang X, Latham VM Jr., Costello R, Faucher J et al (2004) A phase II clinical and pharmacodynamic study of E7070 in patients with metastatic, recurrent, or refractory squamous cell carcinoma of the head and neck: modulation of retinoblastoma protein phosphorylation by a novel chloroindolyl sulfonamide cell cycle inhibitor. Clin Cancer Res 10:4680\u20134687","journal-title":"Clin Cancer Res"},{"key":"1565_CR45","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S1470-2045(13)70011-1","volume":"14","author":"R Haddad","year":"2013","unstructured":"Haddad R, O\u2019Neill A, Rabinowits G, Tishler R, Khuri F, Adkins D, Clark J, Sarlis N, Lorch J, Beitler JJ et al (2013) Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial. Lancet Oncol 14:257\u2013264","journal-title":"Lancet Oncol"},{"key":"1565_CR47","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1002\/cncr.28635","volume":"120","author":"O Hamid","year":"2014","unstructured":"Hamid O, Ilaria R Jr., Garbe C, Wolter P, Maio M, Hutson TE, Arance A, Lorigan P, Lee J, Hauschild A et al (2014) A randomized, open-label clinical trial of tasisulam sodium versus paclitaxel as second-line treatment in patients with metastatic melanoma. Cancer 120:2016\u20132024","journal-title":"Cancer"},{"key":"1565_CR48","doi-asserted-by":"publisher","first-page":"eaal3755","DOI":"10.1126\/science.aal3755","volume":"356","author":"T Han","year":"2017","unstructured":"Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D (2017) Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science 356:eaal3755","journal-title":"Science"},{"key":"1565_CR49","first-page":"1237","volume":"20","author":"T Haritunians","year":"2008","unstructured":"Haritunians T, Gueller S, O\u2019Kelly J, Ilaria R Jr., Koeffler HP (2008) Novel acyl sulfonamide LY573636-sodium: effect on hematopoietic malignant cells. Oncol Rep 20:1237\u20131242","journal-title":"Oncol Rep"},{"key":"1565_CR50","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1185\/030079904125003313","volume":"20","author":"H Hasegawa","year":"2004","unstructured":"Hasegawa H (2004) Utilization of zonisamide in patients with chronic pain or epilepsy refractory to other treatments: a retrospective, open label, uncontrolled study in a VA hospital. Curr Med Res Opin 20:577\u2013580","journal-title":"Curr Med Res Opin"},{"key":"1565_CR51","doi-asserted-by":"publisher","first-page":"12460","DOI":"10.1021\/acs.jmedchem.0c00830","volume":"63","author":"TCS Ho","year":"2020","unstructured":"Ho TCS, Chan AHY, Ganesan A (2020) Thirty years of HDAC inhibitors: 2020 insight and Hindsight. J Med Chem 63:12460\u201312484","journal-title":"J Med Chem"},{"key":"1565_CR52","doi-asserted-by":"publisher","first-page":"116259","DOI":"10.1016\/j.biopha.2024.116259","volume":"172","author":"C Hou","year":"2024","unstructured":"Hou C, Wu X, Shi R, Xing X, Tian S, El\u00e9ou\u00ebt M, Qiao C, Ma J, Xu G (2024) Subtle structural alteration in indisulam switches the molecular mechanisms for the inhibitory effect on the migration of gastric cancer cells. Biomed Pharmacother 172:116259","journal-title":"Biomed Pharmacother"},{"key":"1565_CR53","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1002\/cncr.26488","volume":"118","author":"G Huang","year":"2011","unstructured":"Huang G, Zhou Z, Wang H, Kleinerman ES (2012) CAPER-\u03b1 alternative splicing regulates the expression of vascular endothelial growth factor165 in Ewing sarcoma cells. Cancer 2 118:2106\u20132116","journal-title":"Cancer 2"},{"key":"1565_CR54","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1186\/s12885-021-08301-w","volume":"21","author":"MD H\u00fclskamp","year":"2021","unstructured":"H\u00fclskamp MD, Kronenberg D, Stange R (2021) The small-molecule protein ligand interface stabiliser E7820 induces differential cell line specific responses of integrin \u03b12 expression. BMC Cancer 21:571","journal-title":"BMC Cancer"},{"key":"1565_CR55","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1172\/JCI116848","volume":"92","author":"H Imai","year":"1993","unstructured":"Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (1993) Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma. J Clin Invest 92:2419\u20132426","journal-title":"J Clin Invest"},{"key":"1565_CR56","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1126\/science.1177319","volume":"327","author":"T Ito","year":"2010","unstructured":"Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, Yamaguchi Y, Handa H (2010) Identification of a primary target of thalidomide teratogenicity. Science 327:1345\u20131350","journal-title":"Science"},{"key":"1565_CR57","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1074\/jbc.M110417200","volume":"277","author":"DJ Jung","year":"2002","unstructured":"Jung DJ, Na SY, Na DS, Lee JW (2002) Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. J Biol Chem 277:1229\u20131234","journal-title":"J Biol Chem"},{"key":"1565_CR58","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ejmech.2013.01.034","volume":"62","author":"A Kamal","year":"2013","unstructured":"Kamal A, Swapna P, Shetti RV, Shaik AB, Narasimha Rao MP, Gupta S (2013) Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents. Eur J Med Chem 62:661\u2013669","journal-title":"Eur J Med Chem"},{"key":"1565_CR59","doi-asserted-by":"publisher","first-page":"e1005116","DOI":"10.1371\/journal.pgen.1005116","volume":"11","author":"YK Kang","year":"2015","unstructured":"Kang YK, Putluri N, Maity S, Tsimelzon A, Ilkayeva O, Mo Q, Lonard D, Michailidis G, Sreekumar A, Newgard CB et al (2015) CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-\u03b1-Gabpa and stress-induced adaptive responses via NF-\u03baB-cMYC. PLoS Genet 11:e1005116","journal-title":"PLoS Genet"},{"key":"1565_CR60","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1208\/s12248-011-9260-2","volume":"13","author":"RJ Keizer","year":"2011","unstructured":"Keizer RJ, Funahashi Y, Semba T, Wanders J, Beijnen JH, Schellens JH, Huitema AD (2011) Evaluation of \u03b12-integrin expression as a biomarker for tumor growth inhibition for the investigational integrin inhibitor E7820 in preclinical and clinical studies. Aaps j 13:230\u2013239","journal-title":"Aaps j"},{"key":"1565_CR61","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.1016\/S0968-0896(01)00200-0","volume":"9","author":"DK Kim","year":"2001","unstructured":"Kim DK, Lee JY, Lee N, Ryu DH, Kim JS, Lee S, Choi JY, Ryu JH, Kim NH, Im GJ et al (2001) Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5\u2019-sulfonamide moiety of a phenyl ring. Bioorg Med Chem 9:3013\u20133021","journal-title":"Bioorg Med Chem"},{"key":"1565_CR62","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.chembiol.2023.02.008","volume":"30","author":"EA King","year":"2023","unstructured":"King EA, Cho Y, Hsu NS, Dovala D, McKenna JM, Tallarico JA, Schirle M, Nomura DK (2023) Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-\u03baB. Cell Chem Biol 30:394\u2013402e9","journal-title":"Cell Chem Biol"},{"key":"1565_CR63","doi-asserted-by":"publisher","first-page":"4732","DOI":"10.1002\/cncr.26068","volume":"117","author":"JM Kirkwood","year":"2011","unstructured":"Kirkwood JM, Gonzalez R, Reintgen D, Clingan PR, McWilliams RR, de Alwis DP, Zimmermann A, Brown MP, Ilaria RL Jr., Millward MJ (2011) A phase 2 study of tasisulam sodium (LY573636 sodium) as second-line treatment for patients with unresectable or metastatic melanoma. Cancer 117:4732\u20134739","journal-title":"Cancer"},{"key":"1565_CR64","doi-asserted-by":"publisher","first-page":"7749","DOI":"10.1021\/acs.jmedchem.5b00764","volume":"58","author":"Y Kwon","year":"2015","unstructured":"Kwon Y, Song J, Lee H, Kim EY, Lee K, Lee SK, Kim S (2015) Design, synthesis, and Biological Activity of Sulfonamide analogues of Antofine and Cryptopleurine as Potent and orally active Antitumor agents. J Med Chem 58:7749\u20137762","journal-title":"J Med Chem"},{"key":"1565_CR65","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1038\/s41418-020-0541-0","volume":"27","author":"N Lalaoui","year":"2020","unstructured":"Lalaoui N, Merino D, Giner G, Vaillant F, Chau D, Liu L, Kratina T, Pal B, Whittle JR, Etemadi N, Berthelet J, Gr\u00e4sel J, Hall C, Ritchie ME, Ernst M, Smyth GK, Vaux DL, Visvader JE, Lindeman GJ, Silke J (2020) Targeting triple-negative breast cancers with the Smac-mimetic birinapant. Cell Death Differ 27:2768\u20132780","journal-title":"Cell Death Differ"},{"key":"1565_CR66","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13059-020-1940-8","volume":"21","author":"MT Lau","year":"2020","unstructured":"Lau MT, Ghazanfar S, Parkin A, Chou A, Rouaen JR, Littleboy JB, Nessem D, Khuong TM, Nevoltris D, Schofield P et al (2020) Systematic functional identification of cancer multi-drug resistance genes. Genome Biol 21:27","journal-title":"Genome Biol"},{"key":"1565_CR67","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.bmcl.2009.11.104","volume":"20","author":"MY Lee","year":"2010","unstructured":"Lee MY, Kim MH, Kim J, Kim SH, Kim BT, Jeong IH, Chang S, Kim SH, Chang SY (2010) Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents. Bioorg Med Chem Lett 20:541\u2013545","journal-title":"Bioorg Med Chem Lett"},{"key":"1565_CR69","doi-asserted-by":"crossref","unstructured":"Li Y, Seto E (2016) HDACs and HDAC inhibitors in Cancer Development and Therapy. Cold Spring Harb Perspect Med 6","DOI":"10.1101\/cshperspect.a026831"},{"key":"1565_CR68","doi-asserted-by":"publisher","first-page":"576946","DOI":"10.3389\/fcell.2020.576946","volume":"8","author":"G Li","year":"2020","unstructured":"Li G, Tian Y, Zhu WG (2020) The roles of histone deacetylases and their inhibitors in Cancer Therapy. Front Cell Dev Biol 8:576946","journal-title":"Front Cell Dev Biol"},{"key":"1565_CR70","doi-asserted-by":"publisher","first-page":"5367","DOI":"10.1021\/jm030594r","volume":"47","author":"KL Lobb","year":"2004","unstructured":"Lobb KL, Hipskind PA, Aikins JA, Alvarez E, Cheung YY, Considine EL, De Dios A, Durst GL, Ferritto R, Grossman CS et al (2004) Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem 47:5367\u20135380","journal-title":"J Med Chem"},{"key":"1565_CR71","doi-asserted-by":"publisher","first-page":"17325","DOI":"10.1074\/jbc.M114.558825","volume":"289","author":"S Loerch","year":"2014","unstructured":"Loerch S, Maucuer A, Manceau V, Green MR, Kielkopf CL (2014) Cancer-relevant splicing factor CAPER\u03b1 engages the essential splicing factor SF3b155 in a specific ternary complex. J Biol Chem 289:17325\u201317337","journal-title":"J Biol Chem"},{"key":"1565_CR72","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1126\/science.1244917","volume":"343","author":"G Lu","year":"2014","unstructured":"Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, Wong KK, Bradner JE, Kaelin WG Jr (2014) The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science 343:305\u2013309","journal-title":"Science"},{"key":"1565_CR76","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1016\/j.bmcl.2016.06.037","volume":"26","author":"XY Lu","year":"2016","unstructured":"Lu XY, Wang ZC, Ren SZ, Shen FQ, Man RJ, Zhu HL (2016) Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis. Bioorg Med Chem Lett 26:3491\u20133498","journal-title":"Bioorg Med Chem Lett"},{"key":"1565_CR73","doi-asserted-by":"publisher","first-page":"4462","DOI":"10.1021\/acs.jproteome.1c00437","volume":"20","author":"J Lu","year":"2021","unstructured":"Lu J, Jiang H, Li D, Chen T, Wang Y, Pu Z, Xu G (2021) Proximity labeling, quantitative proteomics, and biochemical studies revealed the molecular mechanism for the Inhibitory Effect of Indisulam on the proliferation of gastric Cancer cells. J Proteome Res 20:4462\u20134474","journal-title":"J Proteome Res"},{"key":"1565_CR75","doi-asserted-by":"publisher","first-page":"4032","DOI":"10.1016\/j.cell.2021.05.038","volume":"184","author":"SX Lu","year":"2021","unstructured":"Lu SX, De Neef E, Thomas JD, Sabio E, Rousseau B, Gigoux M, Knorr DA, Greenbaum B, Elhanati Y, Hogg SJ et al (2021) Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell 184:4032\u20134047e4031","journal-title":"Cell"},{"key":"1565_CR74","doi-asserted-by":"publisher","first-page":"103025","DOI":"10.1016\/j.jbc.2023.103025","volume":"299","author":"J Lu","year":"2023","unstructured":"Lu J, Li D, Jiang H, Li Y, Lu C, Chen T, Wang Y, Wang X, Sun W, Pu Z et al (2023) The aryl sulfonamide indisulam inhibits gastric cancer cell migration by promoting the ubiquitination and degradation of the transcription factor ZEB1. J Biol Chem 299:103025","journal-title":"J Biol Chem"},{"key":"1565_CR77","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.bbagrm.2016.06.007","volume":"1859","author":"S Mai","year":"2016","unstructured":"Mai S, Qu X, Li P, Ma Q, Cao C, Liu X (2016) Global regulation of alternative RNA splicing by the SR-rich protein RBM39. Biochim Biophys Acta 1859:1014\u20131024","journal-title":"Biochim Biophys Acta"},{"key":"1565_CR78","doi-asserted-by":"publisher","first-page":"12603","DOI":"10.1021\/acs.jmedchem.1c00497","volume":"64","author":"M Marcinkowska","year":"2021","unstructured":"Marcinkowska M, Bucki A, Sniecikowska J, Zag\u00f3rska A, Fajkis-Zaj\u0105czkowska N, Siwek A, Gluch-Lutwin M, \u017bmudzki P, Jastrzebska-Wiesek M, Partyka A et al (2021) Multifunctional arylsulfone and arylsulfonamide-based ligands with Prominent Mood-modulating activity and Benign Safety Profile, targeting neuropsychiatric symptoms of Dementia. J Med Chem 64:12603\u201312629","journal-title":"J Med Chem"},{"key":"1565_CR79","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/ijc.23131","volume":"122","author":"J Matsui","year":"2008","unstructured":"Matsui J, Yamamoto Y, Funahashi Y, Tsuruoka A, Watanabe T, Wakabayashi T, Uenaka T, Asada M (2008) E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer 122:664\u2013671","journal-title":"Int J Cancer"},{"key":"1565_CR80","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1038\/s41589-020-0594-x","volume":"16","author":"C Mayor-Ruiz","year":"2020","unstructured":"Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, M\u00fcller AC, Zuber J, Geyer M, Thom\u00e4 NH, Kubicek S, Winter GE (2020) Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol 16:1199\u20131207","journal-title":"Nat Chem Biol"},{"key":"1565_CR81","doi-asserted-by":"crossref","unstructured":"Mboge MY, Mahon BP, McKenna R, Frost SC (2018) Carbonic anhydrases: role in pH control and Cancer. Metabolites 8","DOI":"10.3390\/metabo8010019"},{"key":"1565_CR82","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1158\/1535-7163.MCT-11-0323","volume":"10","author":"T Meier","year":"2011","unstructured":"Meier T, Uhlik M, Chintharlapalli S, Dowless M, Van Horn R, Stewart J, Blosser W, Cook J, Young D, Ye X et al (2011) Tasisulam sodium, an antitumor agent that inhibits mitotic progression and induces vascular normalization. Mol Cancer Ther 10:2168\u20132178","journal-title":"Mol Cancer Ther"},{"key":"1565_CR83","doi-asserted-by":"publisher","first-page":"115712","DOI":"10.1016\/j.bmc.2020.115712","volume":"28","author":"JE Melnyk","year":"2020","unstructured":"Melnyk JE, Steri V, Nguyen HG, Hann B, Feng FY, Shokat KM (2020) The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells. Bioorg Med Chem 28:115712","journal-title":"Bioorg Med Chem"},{"key":"1565_CR84","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.4161\/cc.28156","volume":"13","author":"I Mercier","year":"2014","unstructured":"Mercier I, Gonzales DM, Quann K, Pestell TG, Molchansky A, Sotgia F, Hulit J, Gandara R, Wang C, Pestell RG, Lisanti MP, Jasmin JF (2014) CAPER, a novel regulator of human breast cancer progression. Cell Cycle 13:1256\u20131264","journal-title":"Cell Cycle"},{"key":"1565_CR85","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.jacc.2010.07.053","volume":"57","author":"FH Messerli","year":"2011","unstructured":"Messerli FH, Makani H, Benjo A, Romero J, Alviar C, Bangalore S (2011) Antihypertensive efficacy of hydrochlorothiazide as evaluated by ambulatory blood pressure monitoring: a meta-analysis of randomized trials. J Am Coll Cardiol 57:590\u2013600","journal-title":"J Am Coll Cardiol"},{"key":"1565_CR86","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ejps.2014.08.013","volume":"65","author":"R Mikl\u00e1\u0161","year":"2014","unstructured":"Mikl\u00e1\u0161 R, Mikl\u00e1\u0161ov\u00e1 N, Bukovsk\u00fd M, Horv\u00e1th B, Kubincov\u00e1 J, Dev\u00ednsky F (2014) Synthesis, surface and antimicrobial properties of some quaternary ammonium homochiral camphor sulfonamides. Eur J Pharm Sci 65:29\u201337","journal-title":"Eur J Pharm Sci"},{"key":"1565_CR87","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1158\/1078-0432.CCR-10-0010","volume":"17","author":"M Mita","year":"2011","unstructured":"Mita M, Kelly KR, Mita A, Ricart AD, Romero O, Tolcher A, Hook L, Okereke C, Krivelevich I, Rossignol DP et al (2011) Phase I study of E7820, an oral inhibitor of integrin alpha-2 expression with antiangiogenic properties, in patients with advanced malignancies. Clin Cancer Res 17:193\u2013200","journal-title":"Clin Cancer Res"},{"key":"1565_CR88","doi-asserted-by":"crossref","unstructured":"Mon\u00e7\u00e3o CCD, Scrideli CA, Andrade AF, Viapiano MS, Carlotti CG, Moreno DA, Baroni M, Tone LG, Teixeira SA (2022) Indisulam reduces viability and regulates apoptotic gene expression in Pediatric High-Grade Glioma cells. Biomedicines 11","DOI":"10.3390\/biomedicines11010068"},{"key":"1565_CR89","doi-asserted-by":"publisher","first-page":"5068","DOI":"10.1016\/j.cell.2023.09.011","volume":"186","author":"D Mossmann","year":"2023","unstructured":"Mossmann D, M\u00fcller C, Park S, Ryback B, Colombi M, Ritter N, Wei\u00dfenberger D, Dazert E, Coto-Llerena M, Nuciforo S et al (2023) Arginine reprograms metabolism in liver cancer via RBM39. Cell 186:5068\u20135083e5023","journal-title":"Cell"},{"key":"1565_CR90","doi-asserted-by":"publisher","first-page":"4979","DOI":"10.1021\/jm0496234","volume":"47","author":"A Natarajan","year":"2004","unstructured":"Natarajan A, Guo Y, Harbinski F, Fan YH, Chen H, Luus L, Diercks J, Aktas H, Chorev M, Halperin JA (2004) Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation. J Med Chem 47:4979\u20134982","journal-title":"J Med Chem"},{"key":"1565_CR91","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1038\/s41467-022-28907-3","volume":"13","author":"A Nijhuis","year":"2022","unstructured":"Nijhuis A, Sikka A, Yogev O, Herendi L, Balcells C, Ma Y, Poon E, Eckold C, Valbuena GN, Xu Y et al (2022) Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma. Nat Commun 13:1380","journal-title":"Nat Commun"},{"key":"1565_CR92","doi-asserted-by":"publisher","first-page":"5589","DOI":"10.1016\/j.bmc.2013.05.043","volume":"21","author":"X Ning","year":"2013","unstructured":"Ning X, Guo Y, Ma X, Zhu R, Tian C, Zhang Z, Wang X, Ma Z, Liu J (2013) Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury. Bioorg Med Chem 21:5589\u20135597","journal-title":"Bioorg Med Chem"},{"key":"1565_CR93","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1021\/ac026196y","volume":"75","author":"Y Oda","year":"2003","unstructured":"Oda Y, Owa T, Sato T, Boucher B, Daniels S, Yamanaka H, Shinohara Y, Yokoi A, Kuromitsu J, Nagasu T (2003) Quantitative chemical proteomics for identifying candidate drug targets. Anal Chem 75:2159\u20132165","journal-title":"Anal Chem"},{"key":"1565_CR94","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.3390\/12051125","volume":"12","author":"S Oh","year":"2007","unstructured":"Oh S, Moon HI, Son IH, Jung JC, Avery MA (2007) Synthesis of sulfonamides and evaluation of their histone deacetylase (HDAC) activity. Molecules 12:1125\u20131135","journal-title":"Molecules"},{"key":"1565_CR95","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1021\/jm9902638","volume":"42","author":"T Owa","year":"1999","unstructured":"Owa T, Yoshino H, Okauchi T, Yoshimatsu K, Ozawa Y, Sugi NH, Nagasu T, Koyanagi N, Kitoh K (1999) Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle. J Med Chem 42:3789\u20133799","journal-title":"J Med Chem"},{"key":"1565_CR96","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10555-019-09799-0","volume":"38","author":"S Pastorekova","year":"2019","unstructured":"Pastorekova S, Gillies RJ (2019) The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond. Cancer Metastasis Rev 38:65\u201377","journal-title":"Cancer Metastasis Rev"},{"key":"1565_CR97","doi-asserted-by":"crossref","unstructured":"Pogacar Z, Groot K, Jochems F, Dos Santos Dias M, Mulero-S\u00e1nchez A, Morris B, Roosen M, Wardak L, De Conti G, Velds A et al (2022a) Genetic and compound screens uncover factors modulating cancer cell response to indisulam. Life Sci Alliance 5","DOI":"10.26508\/lsa.202101348"},{"key":"1565_CR98","doi-asserted-by":"publisher","first-page":"e0273182","DOI":"10.1371\/journal.pone.0273182","volume":"17","author":"Z Pogacar","year":"2022","unstructured":"Pogacar Z, Johnson JL, Krenning L, De Conti G, Jochems F, Lieftink C, Velds A, Wardak L, Groot K, Schepers A et al (2022b) Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity. PLoS ONE 17:e0273182","journal-title":"PLoS ONE"},{"key":"1565_CR99","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1093\/neuonc\/nos216","volume":"14","author":"MA Proescholdt","year":"2012","unstructured":"Proescholdt MA, Merrill MJ, Stoerr EM, Lohmeier A, Pohl F, Brawanski A (2012) Function of carbonic anhydrase IX in glioblastoma multiforme. Neuro Oncol 14:1357\u20131366","journal-title":"Neuro Oncol"},{"key":"1565_CR100","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1023\/A:1012287111922","volume":"12","author":"CJ Punt","year":"2001","unstructured":"Punt CJ, Fumoleau P, van de Walle B, Faber MN, Ravic M, Campone M (2001) Phase I and pharmacokinetic study of E7070, a novel sulfonamide, given at a daily times five schedule in patients with solid tumors. A study by the EORTC-early clinical studies group (ECSG). Ann Oncol 12:1289\u20131293","journal-title":"Ann Oncol"},{"key":"1565_CR101","doi-asserted-by":"publisher","first-page":"488","DOI":"10.2174\/1871520617666171103140749","volume":"18","author":"KP Rakesh","year":"2018","unstructured":"Rakesh KP, Wang SM, Leng J, Ravindar L, Asiri AM, Marwani HM, Qin HL (2018) Recent development of Sulfonyl or Sulfonamide hybrids as potential Anticancer agents: a key review. Anticancer Agents Med Chem 18:488\u2013505","journal-title":"Anticancer Agents Med Chem"},{"key":"1565_CR102","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.1200\/JCO.2002.09.030","volume":"20","author":"E Raymond","year":"2002","unstructured":"Raymond E, ten Bokkel Huinink WW, Ta\u00efeb J, Beijnen JH, Faivre S, Wanders J, Ravic M, Fumoleau P, Armand JP, Schellens JH (2002) Phase I and pharmacokinetic study of E7070, a novel chloroindolyl sulfonamide cell-cycle inhibitor, administered as a one-hour infusion every three weeks in patients with advanced cancer. J Clin Oncol 20:3508\u20133521","journal-title":"J Clin Oncol"},{"key":"1565_CR104","first-page":"6619","volume":"52","author":"JR Rigas","year":"1992","unstructured":"Rigas JR, Tong WP, Kris MG, Orazem JP, Young CW, Warrell RP Jr. (1992) Phase I clinical and pharmacological study of chloroquinoxaline sulfonamide. Cancer Res 52:6619\u20136623","journal-title":"Cancer Res"},{"key":"1565_CR103","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/BF00686832","volume":"35","author":"JR Rigas","year":"1995","unstructured":"Rigas JR, Francis PA, Miller VA, Tong WP, Roistacher N, Kris MG, Orazem JP, Young CW, Warrell RP Jr. (1995) Clinical and pharmacology study of chloroquinoxaline sulfonamide given on a weekly schedule. Cancer Chemother Pharmacol 35:483\u2013488","journal-title":"Cancer Chemother Pharmacol"},{"key":"1565_CR105","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s10637-012-9819-5","volume":"31","author":"CW Ryan","year":"2013","unstructured":"Ryan CW, Matias C, Agulnik M, Lopez-Pousa A, Williams C, de Alwis DP, Kaiser C, Miller MA, Ermisch S, Ilaria R Jr. et al (2013) A phase II study of tasisulam sodium (LY573636 sodium) as second-line or third-line treatment for patients with unresectable or metastatic soft tissue sarcoma. Invest New Drugs 31:145\u2013151","journal-title":"Invest New Drugs"},{"key":"1565_CR106","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1021\/acs.biochem.2c00245","volume":"62","author":"JM Sasso","year":"2023","unstructured":"Sasso JM, Tenchov R, Wang D, Johnson LS, Wang X, Zhou QA (2023) Molecular glues: the Adhesive connecting targeted protein degradation to the clinic. Biochemistry 62:601\u2013623","journal-title":"Biochemistry"},{"key":"1565_CR107","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.cell.2020.12.020","volume":"184","author":"SL Schreiber","year":"2021","unstructured":"Schreiber SL (2021) The rise of Molecular glues. Cell 184:3\u20139","journal-title":"Cell"},{"key":"1565_CR108","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1527-3466.2001.tb00065.x","volume":"19","author":"C Serradeil-Le Gal","year":"2001","unstructured":"Serradeil-Le Gal C (2001) An overview of SR121463, a selective non-peptide vasopressin V(2) receptor antagonist. Cardiovasc Drug Rev 19:201\u2013214","journal-title":"Cardiovasc Drug Rev"},{"key":"1565_CR109","doi-asserted-by":"publisher","first-page":"208","DOI":"10.2174\/1568026616666160530152546","volume":"17","author":"PC Sharma","year":"2017","unstructured":"Sharma PC, Bansal KK, Deep A, Pathak M (2017) Benzothiazole Derivatives as potential anti-infective agents. Curr Top Med Chem 17:208\u2013237","journal-title":"Curr Top Med Chem"},{"key":"1565_CR110","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1111\/j.1742-4658.2010.07771.x","volume":"277","author":"CH Shen","year":"2010","unstructured":"Shen CH, Wang YF, Kovalevsky AY, Harrison RW, Weber IT (2010) Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters. Febs j 277:3699\u20133714","journal-title":"Febs j"},{"key":"1565_CR111","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1038\/sj.bjc.6604300","volume":"98","author":"WS Siegel-Lakhai","year":"2008","unstructured":"Siegel-Lakhai WS, Zandvliet AS, Huitema AD, Tibben MM, Milano G, Girre V, Di\u00e9ras V, King A, Richmond E, Wanders J et al (2008) A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours. Br J Cancer 98:1320\u20131326","journal-title":"Br J Cancer"},{"key":"1565_CR112","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s00280-011-1593-0","volume":"68","author":"GR Simon","year":"2011","unstructured":"Simon GR, Ilaria RL Jr., Sovak MA, Williams CC, Haura EB, Cleverly AL, Sykes AK, Wagner MM, de Alwis DP, Slapak CA et al (2011) A phase I study of tasisulam sodium (LY573636 sodium), a novel anticancer compound in patients with refractory solid tumors. Cancer Chemother Pharmacol 68:1233\u20131241","journal-title":"Cancer Chemother Pharmacol"},{"key":"1565_CR115","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1039\/C5MB00003C","volume":"11","author":"T Singh","year":"2015","unstructured":"Singh T, Adekoya OA, Jayaram B (2015) Understanding the binding of inhibitors of matrix metalloproteinases by molecular docking, quantum mechanical calculations, molecular dynamics simulations, and a MMGBSA\/MMBappl study. Mol Biosyst 11:1041\u20131051","journal-title":"Mol Biosyst"},{"key":"1565_CR113","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fmolb.2015.00019","volume":"2","author":"D Singh","year":"2015","unstructured":"Singh D, Srivastava SK, Chaudhuri TK, Upadhyay G (2015) Multifaceted role of matrix metalloproteinases (MMPs). Front Mol Biosci 2:19","journal-title":"Front Mol Biosci"},{"key":"1565_CR114","doi-asserted-by":"publisher","first-page":"eabj5405","DOI":"10.1126\/sciadv.abj5405","volume":"7","author":"S Singh","year":"2021","unstructured":"Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J (2021) Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv 7:eabj5405","journal-title":"Sci Adv"},{"key":"1565_CR116","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1200\/jco.2007.25.18_suppl.2542","volume":"25","author":"CA Slapak","year":"2007","unstructured":"Slapak CA, LoRusso PM, Mendelson D, Sykes AK, Alwis DPD, Wagner MM Jr, Gordon RLI MS (2007) Phase I study of LY573636-sodium, an acylsulfonamide anti-cancer compound with a novel mechanism of action, administered as 24-hour continuous infusion in patients with advanced solid tumors. J Clin Oncol 25:2542\u20132542","journal-title":"J Clin Oncol"},{"key":"1565_CR117","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1093\/annonc\/mdi016","volume":"16","author":"JF Smyth","year":"2005","unstructured":"Smyth JF, Aamdal S, Awada A, Dittrich C, Caponigro F, Sch\u00f6ffski P, Gore M, Lesimple T, Djurasinovic N, Baron B et al (2005) Phase II study of E7070 in patients with metastatic melanoma. Ann Oncol 16:158\u2013161","journal-title":"Ann Oncol"},{"key":"1565_CR118","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1107\/S2059798316001248","volume":"72","author":"GA Stepanyuk","year":"2016","unstructured":"Stepanyuk GA, Serrano P, Peralta E, Farr CL, Axelrod HL, Geralt M, Das D, Chiu HJ, Jaroszewski L, Deacon AM et al (2016) UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex. Acta Crystallogr D Struct Biol 72:497\u2013511","journal-title":"Acta Crystallogr D Struct Biol"},{"key":"1565_CR119","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1158\/1078-0432.CCR-06-0249","volume":"13","author":"DC Talbot","year":"2007","unstructured":"Talbot DC, von Pawel J, Cattell E, Yule SM, Johnston C, Zandvliet AS, Huitema AD, Norbury CJ, Ellis P, Bosquee L et al (2007) A randomized phase II pharmacokinetic and pharmacodynamic study of indisulam as second-line therapy in patients with advanced non-small cell lung cancer. Clin Cancer Res 13:1816\u20131822","journal-title":"Clin Cancer Res"},{"key":"1565_CR120","doi-asserted-by":"publisher","first-page":"4520","DOI":"10.1007\/s12035-021-02437-3","volume":"58","author":"SA Teixeira","year":"2021","unstructured":"Teixeira SA, Viapiano MS, Andrade AF, Nandhu MS, Pezuk JA, Bidinotto LT, Suazo VK, Neder L, Carlotti CG, Becker AP et al (2021) The carbonic anhydrase inhibitor E7070 sensitizes Glioblastoma cells to radio- and chemotherapy and reduces Tumor Growth. Mol Neurobiol 58:4520\u20134534","journal-title":"Mol Neurobiol"},{"key":"1565_CR121","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/S0959-8049(03)00128-X","volume":"39","author":"C Terret","year":"2003","unstructured":"Terret C, Zanetta S, Roch\u00e9 H, Schellens JH, Faber MN, Wanders J, Ravic M, Droz JP (2003) Phase I clinical and pharmacokinetic study of E7070, a novel sulfonamide given as a 5-day continuous infusion repeated every 3 weeks in patients with solid tumours. A study by the EORTC Early Clinical Study Group (ECSG). Eur J Cancer 39:1097\u20131104","journal-title":"Eur J Cancer"},{"key":"1565_CR122","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/nchembio.2363","volume":"13","author":"T Uehara","year":"2017","unstructured":"Uehara T, Minoshima Y, Sagane K, Sugi NH, Mitsuhashi KO, Yamamoto N, Kamiyama H, Takahashi K, Kotake Y, Uesugi M et al (2017) Selective degradation of splicing factor CAPER\u03b1 by anticancer sulfonamides. Nat Chem Biol 13:675\u2013680","journal-title":"Nat Chem Biol"},{"key":"1565_CR123","doi-asserted-by":"publisher","first-page":"4521","DOI":"10.1016\/j.bmc.2013.05.042","volume":"21","author":"D Vullo","year":"2013","unstructured":"Vullo D, De Luca V, Scozzafava A, Carginale V, Rossi M, Supuran CT, Capasso C (2013) The extremo-\u03b1-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium azorense is highly inhibited by sulfonamides. Bioorg Med Chem 21:4521\u20134525","journal-title":"Bioorg Med Chem"},{"key":"1565_CR124","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ccell.2019.01.010","volume":"35","author":"E Wang","year":"2019","unstructured":"Wang E, Lu SX, Pastore A, Chen X, Imig J, Chun-Wei Lee S, Hockemeyer K, Ghebrechristos YE, Yoshimi A, Inoue D, Ki M, Cho H, Bitner L, Kloetgen A, Lin KT, Uehara T, Owa T, Tibes R, Krainer AR, Abdel-Wahab O, Aifantis I (2019) Targeting an RNA-Binding protein network in Acute myeloid leukemia. Cancer Cell 35:369\u2013384e7","journal-title":"Cancer Cell"},{"key":"1565_CR125","doi-asserted-by":"publisher","first-page":"e0299019","DOI":"10.1371\/journal.pone.0299019","volume":"19","author":"C Wu","year":"2024","unstructured":"Wu C, Wu C, Liu J, Jia M, Zeng X, Fu Z, He Z, Xu W, Yan H (2024) Indisulam synergizes with melphalan to inhibit multiple myeloma malignancy via targeting TOP2A. PLoS ONE 19:e0299019","journal-title":"PLoS ONE"},{"key":"1565_CR126","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/s41420-021-00598-7","volume":"7","author":"C Xu","year":"2021","unstructured":"Xu C, Chen X, Zhang X, Zhao D, Dou Z, Xie X, Li H, Yang H, Li Q, Zhang H, Di C (2021) RNA-binding protein 39: a promising therapeutic target for cancer. Cell Death Discov 7:214","journal-title":"Cell Death Discov"},{"key":"1565_CR127","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1111\/bph.15331","volume":"179","author":"Y Xu","year":"2022","unstructured":"Xu Y, Nijhuis A, Keun HC (2022) RNA-binding motif protein 39 (RBM39): an emerging cancer target. Br J Pharmacol 179:2795\u20132812","journal-title":"Br J Pharmacol"},{"key":"1565_CR128","doi-asserted-by":"publisher","first-page":"113307","DOI":"10.1016\/j.celrep.2023.113307","volume":"42","author":"Y Xu","year":"2023","unstructured":"Xu Y, Spear S, Ma Y, Lorentzen MP, Gruet M, McKinney F, Xu Y, Wickremesinghe C, Shepherd MR, McNeish I et al (2023) Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma. Cell Rep 42:113307","journal-title":"Cell Rep"},{"key":"1565_CR129","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ejmech.2017.04.077","volume":"136","author":"HZ Zhang","year":"2017","unstructured":"Zhang HZ, He SC, Peng YJ, Zhang HJ, Gopala L, Tangadanchu VKR, Gan LL, Zhou CH (2017) Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues. Eur J Med Chem 136:165\u2013183","journal-title":"Eur J Med Chem"}],"container-title":["Genes &amp; Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-024-01565-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-024-01565-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-024-01565-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T18:05:28Z","timestamp":1732817128000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-024-01565-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":129,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1565"],"URL":"https:\/\/doi.org\/10.1007\/s13258-024-01565-z","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,13]]},"assertion":[{"value":"11 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}