{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:14:20Z","timestamp":1771528460908,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s13258-024-01578-8","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T02:52:04Z","timestamp":1731379924000},"page":"1495-1506","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Granzyme mRNA-miRNA interaction and its implication to functional impact"],"prefix":"10.1007","volume":"46","author":[{"given":"Hyeon-Young","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0896-718X","authenticated-orcid":false,"given":"Young Kee","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"1578_CR1","doi-asserted-by":"publisher","first-page":"677707","DOI":"10.3389\/fimmu.2021.677707","volume":"12","author":"AC Bouwman","year":"2021","unstructured":"Bouwman AC, van Daalen KR, Crnko S, Ten Broeke T, Bovenschen N (2021) Intracellular and extracellular roles of granzyme K. Front Immunol 12:677707. https:\/\/doi.org\/10.3389\/fimmu.2021.677707","journal-title":"Front Immunol"},{"key":"1578_CR2","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1073\/pnas.0307323101","volume":"101","author":"GA Calin","year":"2004","unstructured":"Calin GA, Sevignani C, Dumitru CD et al (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 101:2999\u20133004. https:\/\/doi.org\/10.1073\/pnas.0307323101","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"1578_CR3","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.3390\/genes14071375","volume":"14","author":"A Chakrabortty","year":"2023","unstructured":"Chakrabortty A, Patton DJ, Smith BF, Agarwal P (2023) miRNAs: potential as biomarkers and therapeutic targets for cancer. Genes (Basel) 14(7):1375. https:\/\/doi.org\/10.3390\/genes14071375","journal-title":"Genes (Basel)"},{"issue":"1","key":"1578_CR4","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s12943-023-01807-w","volume":"22","author":"M Chehelgerdi","year":"2023","unstructured":"Chehelgerdi M, Chehelgerdi M (2023) The use of RNA-based treatments in the field of cancer immunotherapy. Mol Cancer 22(1):106. https:\/\/doi.org\/10.1186\/s12943-023-01807-w","journal-title":"Mol Cancer"},{"key":"1578_CR5","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1146\/annurev.immunol.26.021607.090404","volume":"26","author":"D Chowdhury","year":"2008","unstructured":"Chowdhury D, Lieberman J (2008) Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol 26:389\u2013420. https:\/\/doi.org\/10.1146\/annurev.immunol.26.021607.090404","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"1578_CR6","doi-asserted-by":"publisher","first-page":"6171","DOI":"10.4049\/jimmunol.1100835","volume":"187","author":"F Cichocki","year":"2011","unstructured":"Cichocki F, Felices M, McCullar V, Presnell SR, Al-Attar A, Lutz CT, Miller JS (2011) Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol 187(12):6171\u20136175. https:\/\/doi.org\/10.4049\/jimmunol.1100835","journal-title":"J Immunol"},{"issue":"2","key":"1578_CR7","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1161\/STROKEAHA.118.023739","volume":"50","author":"C Diaz-Ca\u00f1estro","year":"2019","unstructured":"Diaz-Ca\u00f1estro C, Reiner MF, Bonetti NR et al (2019) AP-1 (Activated Protein-1) transcription factor JunD regulates ischemia\/reperfusion brain damage via IL-1\u03b2 (Interleukin-1\u03b2). Stroke 50(2):469\u2013477. https:\/\/doi.org\/10.1161\/STROKEAHA.118.023739","journal-title":"Stroke"},{"issue":"5","key":"1578_CR8","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.gendis.2020.08.006","volume":"8","author":"F Gao","year":"2021","unstructured":"Gao F, He S, Jin A (2021) MiRNAs and lncRNAs in NK cell biology and NK\/T-cell lymphoma. Genes Dis 8(5):590\u2013602. https:\/\/doi.org\/10.1016\/j.gendis.2020.08.006","journal-title":"Genes Dis"},{"issue":"5","key":"1578_CR9","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/s0952-7915(03)00099-2","volume":"15","author":"WJ Grossman","year":"2003","unstructured":"Grossman WJ, Revell PA, Lu ZH, Johnson H, Bredemeyer AJ, Ley TJ (2003) The orphan granzymes of humans and mice. Curr Opin Immunol 15(5):544\u2013552. https:\/\/doi.org\/10.1016\/s0952-7915(03)00099-2","journal-title":"Curr Opin Immunol"},{"issue":"3","key":"1578_CR10","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.3390\/ijms23031833","volume":"23","author":"ZLZ Hay","year":"2022","unstructured":"Hay ZLZ, Slansky JE (2022) Granzymes: the molecular executors of immune-mediated cytotoxicity. Int J Mol Sci 23(3):1833. https:\/\/doi.org\/10.3390\/ijms23031833","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1578_CR11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3390\/jcm5030036","volume":"5","author":"K Inamura","year":"2016","unstructured":"Inamura K, Ishikawa Y (2016) MicroRNA in lung cancer: novel biomarkers and potential tools for treatment. J Clin Med 5(3):36. https:\/\/doi.org\/10.3390\/jcm5030036","journal-title":"J Clin Med"},{"key":"1578_CR12","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgae037","author":"Y Jin","year":"2024","unstructured":"Jin Y, Dai Y, Qiao O, Hu P, Han J (2024) miR-1972 inhibits hepatocellular carcinoma proliferation by targeting GZMH-mediated DNA replication in the cell cycle. J Pharm Pharmacy. https:\/\/doi.org\/10.1093\/jpp\/rgae037","journal-title":"J Pharm Pharmacy"},{"key":"1578_CR13","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/cdd.2009.169","volume":"17","author":"D Kaiserman","year":"2010","unstructured":"Kaiserman D, Bird P (2010) Control of granzymes by serpins. Cell Death Differ 17:586\u2013595. https:\/\/doi.org\/10.1038\/cdd.2009.169","journal-title":"Cell Death Differ"},{"issue":"20","key":"1578_CR14","doi-asserted-by":"publisher","first-page":"5476","DOI":"10.1182\/blood-2011-04-347526","volume":"118","author":"TD Kim","year":"2011","unstructured":"Kim TD, Lee SU, Yun S et al (2011) Human microRNA-27a targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity. Blood 118(20):5476\u20135486. https:\/\/doi.org\/10.1182\/blood-2011-04-347526","journal-title":"Blood"},{"issue":"7","key":"1578_CR15","doi-asserted-by":"publisher","first-page":"465","DOI":"10.14348\/molcells.2022.2158","volume":"45","author":"WR Kim","year":"2022","unstructured":"Kim WR, Park EG, Lee HE et al (2022) Hsa-miR-422a Originated from short interspersed nuclear element increases ARID5B expression by collaborating with NF-E2. Mol Cells 45(7):465\u2013478. https:\/\/doi.org\/10.14348\/molcells.2022.2158","journal-title":"Mol Cells"},{"key":"1578_CR16","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1038\/s41598-021-82735-x","volume":"11","author":"HE Lee","year":"2021","unstructured":"Lee HE, Park SJ, Huh JW et al (2021) The enhancer activity of long interspersed nuclear element derived microRNA 625 induced by NF-\u03baB. Sci Rep 11:3139. https:\/\/doi.org\/10.1038\/s41598-021-82735-x","journal-title":"Sci Rep"},{"issue":"10","key":"1578_CR17","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1002\/eji.201444798","volume":"44","author":"JW Leong","year":"2014","unstructured":"Leong JW, Sullivan RP, Fehniger TA (2014) microRNA management of NK-cell developmental and functional programs. Eur J Immunol 44(10):2862\u20132868. https:\/\/doi.org\/10.1002\/eji.201444798","journal-title":"Eur J Immunol"},{"issue":"5","key":"1578_CR18","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/cmi.2015.52","volume":"13","author":"S Liu","year":"2016","unstructured":"Liu S, Chen L, Zeng Y, Si L, Guo X, Zhou J, Fang D, Zeng G, Jiang L (2016) Suppressed expression of miR-378 targeting gzmb in NK cells is required to control dengue virus infection. Cell Mol Immunol 13(5):700\u2013708. https:\/\/doi.org\/10.1038\/cmi.2015.52","journal-title":"Cell Mol Immunol"},{"key":"1578_CR19","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s10238-024-01334-y","volume":"24","author":"E Nalbant","year":"2024","unstructured":"Nalbant E, Akkaya-Ulum YZ (2024) Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases. Clin Exp Med 24:142. https:\/\/doi.org\/10.1007\/s10238-024-01334-y","journal-title":"Clin Exp Med"},{"key":"1578_CR20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","volume":"9","author":"J O'Brien","year":"2018","unstructured":"O\u2019Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402. https:\/\/doi.org\/10.3389\/fendo.2018.00402","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"1578_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.4331\/wjbc.v8.i1.45","volume":"8","author":"S Oliveto","year":"2017","unstructured":"Oliveto S, Mancino M, Manfrini N, Biffo S (2017) Role of microRNAs in translation regulation and cancer. World J Biol Chem. 8(1):45\u201356. https:\/\/doi.org\/10.4331\/wjbc.v8.i1.45","journal-title":"World J Biol Chem."},{"key":"1578_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-024-01207-0","author":"L Peng","year":"2024","unstructured":"Peng L, Sferruzza G, Yang L et al (2024) CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors. Cell Mol Immunol. https:\/\/doi.org\/10.1038\/s41423-024-01207-0","journal-title":"Cell Mol Immunol"},{"issue":"9","key":"1578_CR23","doi-asserted-by":"publisher","first-page":"16526","DOI":"10.1002\/jcp.28323","volume":"234","author":"Z Qi","year":"2019","unstructured":"Qi Z, Li S, Su Y, Zhang J, Kang Y, Huang Y, Jin F, Xing Q (2019) Role of microRNA-145 in protection against myocardial ischemia\/reperfusion injury in mice by regulating expression of GZMK with the treatment of sevoflurane. J Cell Physiol 234(9):16526\u201316539. https:\/\/doi.org\/10.1002\/jcp.28323","journal-title":"J Cell Physiol"},{"issue":"13","key":"1578_CR24","doi-asserted-by":"publisher","first-page":"e124985","DOI":"10.1172\/jci.insight.124985","volume":"6","author":"EJ Ruiz","year":"2021","unstructured":"Ruiz EJ, Lan L, Diefenbacher ME et al (2021) JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. JCI Insight 6(13):e124985. https:\/\/doi.org\/10.1172\/jci.insight.124985","journal-title":"JCI Insight"},{"issue":"2","key":"1578_CR25","doi-asserted-by":"publisher","first-page":"e32262","DOI":"10.1371\/journal.pone.0032262","volume":"7","author":"SM Ruppert","year":"2012","unstructured":"Ruppert SM, Chehtane M, Zhang G et al (2012) JunD\/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction. PLoS ONE 7(2):e32262. https:\/\/doi.org\/10.1371\/journal.pone.0032262","journal-title":"PLoS ONE"},{"key":"1578_CR26","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.biocel.2014.01.003","volume":"49","author":"D Sanchez-Mart\u00ednez","year":"2014","unstructured":"Sanchez-Mart\u00ednez D, Krzywinska E, Rathore MG et al (2014) All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity. Int J Biochem Cell Biol 49:42\u201352. https:\/\/doi.org\/10.1016\/j.biocel.2014.01.003","journal-title":"Int J Biochem Cell Biol"},{"key":"1578_CR27","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1038\/s41467-022-29691-w","volume":"13","author":"JI Scott","year":"2022","unstructured":"Scott JI, Mendive-Tapia L, Gordon D et al (2022) A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies. Nat Commun 13:2366. https:\/\/doi.org\/10.1038\/s41467-022-29691-w","journal-title":"Nat Commun"},{"key":"1578_CR28","doi-asserted-by":"publisher","DOI":"10.1088\/2057-1976\/ac9fd9","author":"Z Shi","year":"2022","unstructured":"Shi Z, Zhao M, Lin T, Chen J, Qian X (2022) A novel Granzymes and miRNA nanocapsules co-delivery system for tumor suppression. Biomed Phys Eng Express. https:\/\/doi.org\/10.1088\/2057-1976\/ac9fd9","journal-title":"Biomed Phys Eng Express"},{"issue":"3","key":"1578_CR29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin."},{"key":"1578_CR30","first-page":"391","volume":"6","author":"K Tao","year":"2014","unstructured":"Tao K, Yang J, Guo Z, Hu Y, Sheng H, Gao H, Yu H (2014) Prognostic value of miR-221-3p, miR-342-3p and miR-491-5p expression in colon cancer. Am J Transl Res 6:391\u2013401","journal-title":"Am J Transl Res"},{"key":"1578_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2001-2-12-reviews3014","author":"JA Trapani","year":"2001","unstructured":"Trapani JA (2001) Granzymes: a family of lymphocyte granule serine proteases. Genome Biol. https:\/\/doi.org\/10.1186\/gb-2001-2-12-reviews3014","journal-title":"Genome Biol"},{"key":"1578_CR32","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/nri3839","volume":"15","author":"I Voskoboinik","year":"2015","unstructured":"Voskoboinik I, Whisstock J, Trapani J (2015) Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol 15:388\u2013400. https:\/\/doi.org\/10.1038\/nri3839","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"1578_CR33","doi-asserted-by":"publisher","first-page":"211","DOI":"10.4049\/jimmunol.1200609","volume":"189","author":"P Wang","year":"2012","unstructured":"Wang P, Gu Y, Zhang Q et al (2012) Identification of resting and type I IFN-activated human NK cell miRNomes reveals microRNA-378 and microRNA-30e as negative regulators of NK cell cytotoxicity. J Immunol 189(1):211\u2013221. https:\/\/doi.org\/10.4049\/jimmunol.1200609","journal-title":"J Immunol"},{"issue":"9","key":"1578_CR34","doi-asserted-by":"publisher","first-page":"R50","DOI":"10.1186\/gb-2012-13-9-r50","volume":"13","author":"TW Whitfield","year":"2012","unstructured":"Whitfield TW, Wang J, Collins PJ, Partridge EC, Aldred SF, Trinklein ND, Myers RM, Weng Z (2012) Functional analysis of transcription factor binding sites in human promoters. Genome Biol 13(9):R50. https:\/\/doi.org\/10.1186\/gb-2012-13-9-r50","journal-title":"Genome Biol"},{"issue":"9","key":"1578_CR35","doi-asserted-by":"publisher","first-page":"761","DOI":"10.2217\/bmm-2017-0144","volume":"11","author":"Y Yan","year":"2017","unstructured":"Yan Y, Song X, Li Z et al (2017) Elevated levels of granzyme B correlated with miR-874-3p downregulation in patients with acute myocardial infarction. Biomark Med 11(9):761\u2013767. https:\/\/doi.org\/10.2217\/bmm-2017-0144","journal-title":"Biomark Med"},{"issue":"10","key":"1578_CR36","doi-asserted-by":"publisher","first-page":"e108913","DOI":"10.1371\/journal.pone.0108913","volume":"9","author":"S Yun","year":"2014","unstructured":"Yun S, Lee SU, Kim JM et al (2014) Integrated mRNA-microRNA profiling of human NK cell differentiation identifies MiR-583 as a negative regulator of IL2R\u03b3 expression. PLoS ONE 9(10):e108913. https:\/\/doi.org\/10.1371\/journal.pone.0108913","journal-title":"PLoS ONE"},{"issue":"12","key":"1578_CR37","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1093\/carcin\/bgy128","volume":"39","author":"MT Zhou","year":"2018","unstructured":"Zhou MT, Zhao C, Chen X et al (2018) MicroRNA-34a promotes MICB expression in hepatocytes. Carcinogenesis 39(12):1477\u20131487. https:\/\/doi.org\/10.1093\/carcin\/bgy128","journal-title":"Carcinogenesis"}],"container-title":["Genes &amp; Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-024-01578-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-024-01578-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-024-01578-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T17:09:54Z","timestamp":1732813794000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-024-01578-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1578"],"URL":"https:\/\/doi.org\/10.1007\/s13258-024-01578-8","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"14 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}