{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:53:50Z","timestamp":1790744030341,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Science and Health Joint Project of Chongqing","award":["2020ZY013586"],"award-info":[{"award-number":["2020ZY013586"]}]},{"name":"Medical research topic of Hebei Province Health Commission","award":["20230135"],"award-info":[{"award-number":["20230135"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s13258-025-01628-9","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T07:04:28Z","timestamp":1744268668000},"page":"697-705","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["RalB promotes lymph node metastasis in tongue squamous cell carcinoma"],"prefix":"10.1007","volume":"47","author":[{"given":"Yuman","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanguang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1164-1156","authenticated-orcid":false,"given":"Xinli","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"issue":"15","key":"1628_CR1","doi-asserted-by":"publisher","first-page":"8199","DOI":"10.3390\/ijms23158199","volume":"23","author":"T Cemeli","year":"2022","unstructured":"Cemeli T, Guasch-Vall\u00e9s M, Ribes-Santolaria M, Ibars E, Navaridas R, Dolcet X, Pedraza N, Colomina N, Torres-Rosell J, Ferrezuelo F et al (2022) Antitumor effects of Ral-GTPases downregulation in glioblastoma. Int J Mol Sci 23(15):8199","journal-title":"Int J Mol Sci"},{"key":"1628_CR2","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s40265-020-01318-8","volume":"80","author":"S Dhillon","year":"2020","unstructured":"Dhillon S (2020) Tirabrutinib: first approval. Drugs 80:835\u2013840","journal-title":"Drugs"},{"key":"1628_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.630942","volume":"9","author":"HY Estupi\u00f1\u00e1n","year":"2021","unstructured":"Estupi\u00f1\u00e1n HY, Bergl\u00f6f A, Zain R, Smith CIE (2021) Comparative analysis of BTK inhibitors and mechanisms underlying adverse effects. Front Cell Dev Biol 9:630942","journal-title":"Front Cell Dev Biol"},{"key":"1628_CR4","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1177\/0022034519860828","volume":"98","author":"P Gao","year":"2019","unstructured":"Gao P, Liu S, Yoshida R, Shi CY, Yoshimachi S, Sakata N, Goto K, Kimura T, Shirakawa R, Nakayama H et al (2019) Ral GTPase activation by downregulation of RalGAP enhances oral squamous cell carcinoma progression. J Dent Res 98:1011\u20131019","journal-title":"J Dent Res"},{"key":"1628_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2022.151987","volume":"125","author":"Y Gao","year":"2023","unstructured":"Gao Y, Gong Y, Liu Y, Xue Y, Zheng K, Guo Y, Hao L, Peng Q, Shi X (2023) Integrated analysis of transcriptomics and metabolomics in human hepatocellular carcinoma HepG2215 cells after YAP1 knockdown. Acta Histochem 125:151987","journal-title":"Acta Histochem"},{"key":"1628_CR6","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s12350-014-9908-2","volume":"21","author":"B George","year":"2014","unstructured":"George B, Seals S, Aban I (2014) Survival analysis and regression models. J Nucl Cardiol 21:686\u2013694","journal-title":"J Nucl Cardiol"},{"key":"1628_CR7","doi-asserted-by":"crossref","unstructured":"Ghoroghi S, Mary B, Larnicol A, Asokan N, Klein A, Osmani N, Busnelli I, Delalande F, Paul N, Halary S, et al. (2021) Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes. Elife 10","DOI":"10.7554\/eLife.61539"},{"key":"1628_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.997138","volume":"13","author":"G Huang","year":"2022","unstructured":"Huang G, Xu X, Ju C, Zhong N, He J, Tang XX (2022) Identification and validation of autophagy-related gene expression for predicting prognosis in patients with idiopathic pulmonary fibrosis. Front Immunol 13:997138","journal-title":"Front Immunol"},{"issue":"4","key":"1628_CR9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3390\/cancers10040127","volume":"10","author":"R Kozaki","year":"2018","unstructured":"Kozaki R, Vogler M, Walter HS, Jayne S, Dinsdale D, Siebert R, Dyer MJS, Yoshizawa T (2018) Responses to the selective Bruton\u2019s Tyrosine Kinase (BTK) inhibitor tirabrutinib (ONO\/GS-4059) in diffuse large B-cell lymphoma cell lines. Cancers (Basel) 10(4):127","journal-title":"Cancers (Basel)"},{"key":"1628_CR10","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.cell.2006.09.019","volume":"127","author":"A Mantovani","year":"2006","unstructured":"Mantovani A, Balkwill F (2006) RalB signaling: a bridge between inflammation and cancer. Cell 127:42\u201344","journal-title":"Cell"},{"key":"1628_CR11","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.molcel.2013.12.004","volume":"53","author":"TD Martin","year":"2014","unstructured":"Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ (2014) Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell 53:209\u2013220","journal-title":"Mol Cell"},{"key":"1628_CR12","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s12105-021-01402-9","volume":"16","author":"S Muller","year":"2022","unstructured":"Muller S, Tilakaratne WM (2022) Update from the 5th edition of the World Health Organization classification of head and neck tumors Tumours of the oral cavity and mobile tongue. Head Neck Pathol 16:54\u201362","journal-title":"Head Neck Pathol"},{"key":"1628_CR13","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1358\/dot.2021.57.4.3264113","volume":"57","author":"W Munakata","year":"2021","unstructured":"Munakata W, Tobinai K (2021) Tirabrutinib hydrochloride for B-cell lymphomas. Drugs Today (Barc) 57:277\u2013289","journal-title":"Drugs Today (Barc)"},{"issue":"10","key":"1628_CR14","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.3390\/cells11101645","volume":"11","author":"DS Richardson","year":"2022","unstructured":"Richardson DS, Spehar JM, Han DT, Chakravarthy PA, Sizemore ST (2022) The RAL enigma: distinct roles of RALA and RALB in cancer. Cells 11(10):1645","journal-title":"Cells"},{"key":"1628_CR15","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1475-2867-11-22","volume":"11","author":"VA Rybko","year":"2011","unstructured":"Rybko VA, Knizhnik AV, Komelkov AV, Aushev VN, Trukhanova LS, Tchevkina EM (2011) Different metastasis promotive potency of small G-proteins RalA and RalB in in vivo hamster tumor model. Cancer Cell Int 11:22","journal-title":"Cancer Cell Int"},{"key":"1628_CR16","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/bjd.19880","volume":"185","author":"R Schneider","year":"2021","unstructured":"Schneider R, Reinau D, Stoffel S, Jick SS, Meier CR, Spoendlin J (2021) Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group. Br J Dermatol 185:343\u2013352","journal-title":"Br J Dermatol"},{"key":"1628_CR17","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1158\/2159-8290.CD-15-0235","volume":"5","author":"B Seashore-Ludlow","year":"2015","unstructured":"Seashore-Ludlow B, Rees MG, Cheah JH, Cokol M, Price EV, Coletti ME, Jones V, Bodycombe NE, Soule CK, Gould J et al (2015) Harnessing connectivity in a large-scale small-molecule sensitivity dataset. Cancer Discov 5:1210\u20131223","journal-title":"Cancer Discov"},{"key":"1628_CR18","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13020-020-00340-y","volume":"15","author":"X Shi","year":"2020","unstructured":"Shi X, Li S, Wang L, Li H, Li Z, Wang W, Bai J, Sun Y, Li J, Li X (2020) RalB degradation by dihydroartemisinin induces autophagy and IFI16\/caspase-1 inflammasome depression in the human laryngeal squamous cell carcinoma. Chin Med 15:64","journal-title":"Chin Med"},{"key":"1628_CR19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin 72:7\u201333","journal-title":"CA Cancer J Clin"},{"key":"1628_CR20","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s12094-014-1263-x","volume":"17","author":"X Song","year":"2015","unstructured":"Song X, Hua L, Xu Y, Fang Z, Wang Y, Gao J, Shi Q, Zhou X, Yu R (2015) Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion. Clin Transl Oncol 17:477\u2013485","journal-title":"Clin Transl Oncol"},{"key":"1628_CR21","doi-asserted-by":"publisher","first-page":"W556","DOI":"10.1093\/nar\/gkz430","volume":"47","author":"Z Tang","year":"2019","unstructured":"Tang Z, Kang B, Li C, Chen T, Zhang Z (2019) GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res 47:W556-w560","journal-title":"Nucleic Acids Res"},{"key":"1628_CR22","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13058-021-01438-3","volume":"23","author":"KA Thies","year":"2021","unstructured":"Thies KA, Cole MW, Schafer RE, Spehar JM, Richardson DS, Steck SA, Das M, Lian AW, Ray A, Shakya R et al (2021) The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer. Breast Cancer Res 23:65","journal-title":"Breast Cancer Res"},{"key":"1628_CR23","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/hep.32236","volume":"76","author":"L Tian","year":"2022","unstructured":"Tian L, Zhao L, Sze KM, Kam CS, Ming VS, Wang X, Zhang VX, Ho DW, Cheung TT, Chan LK et al (2022) Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma. Hepatology 76:48\u201365","journal-title":"Hepatology"},{"key":"1628_CR24","doi-asserted-by":"publisher","first-page":"8760","DOI":"10.1158\/0008-5472.CAN-10-0952","volume":"70","author":"H Wang","year":"2010","unstructured":"Wang H, Owens C, Chandra N, Conaway MR, Brautigan DL, Theodorescu D (2010) Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer Res 70:8760\u20138769","journal-title":"Cancer Res"},{"key":"1628_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108719","volume":"704","author":"Y Wang","year":"2021","unstructured":"Wang Y, Zheng Y, Chen Q, Dai Y, Li T (2021) MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by suppressing RalB via the Ral\/RAC\/PI3K pathway. Arch Biochem Biophys 704:108719","journal-title":"Arch Biochem Biophys"},{"key":"1628_CR26","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1080\/21541248.2017.1310649","volume":"10","author":"G Zago","year":"2019","unstructured":"Zago G, Biondini M, Camonis J, Parrini MC (2019) A family affair: a Ral-exocyst-centered network links Ras, Rac, Rho signaling to control cell migration. Small GTPases 10:323\u2013330","journal-title":"Small GTPases"},{"key":"1628_CR27","doi-asserted-by":"crossref","unstructured":"Zago G, Veith I, Singh MK, Fuhrmann L, De Beco S, Remorino A, Takaoka S, Palmeri M, Berger F, Brandon N, et al. (2018) RalB directly triggers invasion downstream Ras by mobilizing the Wave complex. Elife 7","DOI":"10.7554\/eLife.40474"},{"key":"1628_CR28","doi-asserted-by":"publisher","first-page":"153303382097130","DOI":"10.1177\/1533033820971306","volume":"19","author":"Q Zhang","year":"2020","unstructured":"Zhang Q, Li L, Lai Y, Zhao T (2020) Silencing of SPP1 suppresses progression of tongue cancer by mediating the PI3K\/Akt signaling pathway. Technol Cancer Res Treat 19:1533033820971306","journal-title":"Technol Cancer Res Treat"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01628-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-025-01628-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01628-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T17:07:41Z","timestamp":1749575261000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-025-01628-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,10]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1628"],"URL":"https:\/\/doi.org\/10.1007\/s13258-025-01628-9","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,10]]},"assertion":[{"value":"5 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"This study was reviewed and approved by the Animal Experiment Ethics Committee of Hebei University of Chinese Medicine with the approval number: No. DWLL2019039.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}]}}