{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:01:16Z","timestamp":1781643676836,"version":"3.54.5"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH382"],"award-info":[{"award-number":["ZR2023QH382"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s13258-025-01632-z","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T20:47:04Z","timestamp":1742503624000},"page":"599-613","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Whole transcriptome profiling of cardiac injury: insights from a neonatal mouse sepsis model"],"prefix":"10.1007","volume":"47","author":[{"given":"Wenjin","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanqi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"issue":"24","key":"1632_CR1","doi-asserted-by":"publisher","first-page":"9590","DOI":"10.3390\/ijms21249590","volume":"21","author":"Y Abe","year":"2020","unstructured":"Abe Y, Ochiai D, Sato Y, Kanzaki S, Ikenoue S, Kasuga Y, Tanaka M (2020) Prophylactic therapy with human amniotic fluid stem cells improves long-term cognitive impairment in rat neonatal sepsis survivors. Int J Mol Sci 21(24):9590","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1632_CR2","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.jcrc.2014.03.028","volume":"29","author":"E Antonucci","year":"2014","unstructured":"Antonucci E, Fiaccadori E, Donadello K, Taccone FS, Franchi F, Scolletta S (2014) Myocardial depression in sepsis: from pathogenesis to clinical manifestations and treatment. J Crit Care 29(4):500\u2013511","journal-title":"J Crit Care"},{"key":"1632_CR3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00383-023-05596-7","volume":"40","author":"F Balsamo","year":"2023","unstructured":"Balsamo F, Li B, Chusilp S, Lee D, Biouss G, Lee C, Maynes JT, Pierro A (2023) Argon inhalation attenuates systemic inflammation and rescues lung architecture during experimental neonatal sepsis. Pediatr Surg Int 40:21","journal-title":"Pediatr Surg Int"},{"key":"1632_CR4","first-page":"e59167","volume":"143","author":"B Brook","year":"2019","unstructured":"Brook B, Amenyogbe N, Ben-Othman R, Cai B, Harbeson D, Francis F, Liu AC, Varankovich N, Wynn J, Kollmann TR (2019) A controlled mouse model for neonatal polymicrobial sepsis. J vis Exp 143:e59167","journal-title":"J vis Exp"},{"key":"1632_CR5","doi-asserted-by":"publisher","first-page":"5928","DOI":"10.1007\/s12035-015-9495-5","volume":"53","author":"CM Comim","year":"2016","unstructured":"Comim CM, Bussmann RM, Sim\u00e3o SR, Ventura L, Freiberger V, Patr\u00edcio JJ, Palmas D, Mendon\u00e7a BP, Cassol OJ Jr, Quevedo J (2016) Experimental neonatal sepsis causes long-term cognitive impairment. Mol Neurobiol 53:5928\u20135934","journal-title":"Mol Neurobiol"},{"key":"1632_CR6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s40477-021-00590-y","volume":"25","author":"S Deshpande","year":"2022","unstructured":"Deshpande S, Suryawanshi P, Holkar S, Singh Y, Yengkhom R, Klimek J, Gupta S (2022) Pulmonary hypertension in late onset neonatal sepsis using functional echocardiography: a prospective study. J Ultrasound 25:233\u2013239","journal-title":"J Ultrasound"},{"key":"1632_CR7","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1038\/s41390-023-02926-2","volume":"95","author":"SM Duignan","year":"2024","unstructured":"Duignan SM, Lakshminrusimha S, Armstrong K, de Boode WP, El-Khuffash A, Franklin O, Molloy EJ (2024) Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology. Pediatr Res 95:1207\u20131216","journal-title":"Pediatr Res"},{"issue":"1","key":"1632_CR8","doi-asserted-by":"publisher","first-page":"11021","DOI":"10.1038\/s41598-019-46791-8","volume":"9","author":"C Ehlting","year":"2019","unstructured":"Ehlting C, Rex J, Albrecht U, Deenen R, Tiedje C, K\u00f6hrer K, Sawodny O, Gaestel M, H\u00e4ussinger D, Bode JG (2019) Cooperative and distinct functions of MK2 and MK3 in the regulation of the macrophage transcriptional response to lipopolysaccharide. Sci Rep 9(1):11021","journal-title":"Sci Rep"},{"key":"1632_CR9","doi-asserted-by":"publisher","first-page":"685333","DOI":"10.3389\/fmed.2021.685333","volume":"8","author":"RB Falc\u00e3o-Holanda","year":"2021","unstructured":"Falc\u00e3o-Holanda RB, Brunialti MKC, Jasiulionis MG, Salom\u00e3o R (2021) Epigenetic regulation in sepsis: role in pathophysiology and therapeutic perspective. Front Med 8:685333","journal-title":"Front Med"},{"key":"1632_CR10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","volume":"6","author":"C Fleischmann-Struzek","year":"2018","unstructured":"Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N (2018) The global burden of pediatric and neonatal sepsis: a systematic review. Lancet Respir Med 6:223\u2013230","journal-title":"Lancet Respir Med"},{"key":"1632_CR11","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/978-94-007-4572-8_13","volume":"62","author":"M Hogg","year":"2012","unstructured":"Hogg M, Johansson E (2012) DNA polymerase \u03b5. Subcell Biochem 62:237\u2013257","journal-title":"Subcell Biochem"},{"key":"1632_CR12","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41569-020-00492-2","volume":"18","author":"SM Hollenberg","year":"2021","unstructured":"Hollenberg SM, Singer M (2021) Pathophysiology of sepsis-induced cardiomyopathy. Nat Rev Cardiol 18:424\u2013434","journal-title":"Nat Rev Cardiol"},{"issue":"2","key":"1632_CR13","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41390-021-01855-2","volume":"91","author":"A Kharrat","year":"2022","unstructured":"Kharrat A, Jain A (2022) Hemodynamic dysfunction in neonatal sepsis. Pediatr Res 91(2):413\u2013424","journal-title":"Pediatr Res"},{"issue":"3","key":"1632_CR14","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1084\/jem.183.3.949","volume":"183","author":"A Kumar","year":"1996","unstructured":"Kumar A, Thota V, Dee L, Olson J, Uretz E, Parrillo JE (1996) Tumor necrosis factor alpha and interleukin 1\u03b2 are responsible for in vitro myocardial cell depression induced by human septic shock serum. J Exp Med 183(3):949\u2013958","journal-title":"J Exp Med"},{"issue":"1","key":"1632_CR15","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1080\/21655979.2021.1903207","volume":"12","author":"X Li","year":"2021","unstructured":"Li X, Liao Z, Deng Z, Chen N, Zhao L (2021) Combining bulk and single-cell RNA sequencing data to reveal gene expression pattern of chondrocytes in the osteoarthritic knee. Bioengineered 12(1):997\u20131007","journal-title":"Bioengineered"},{"issue":"6","key":"1632_CR16","doi-asserted-by":"publisher","first-page":"152072","DOI":"10.1016\/j.acthis.2023.152072","volume":"125","author":"J Mao","year":"2023","unstructured":"Mao J, Shen J, Lu X, Cai Y, Tao R, Deng Y, Zhang Y, Wu Y, Chen W (2023) MCM5 is an oncogene of colon adenocarcinoma and promotes progression through cell cycle control. Acta Histochem 125(6):152072","journal-title":"Acta Histochem"},{"key":"1632_CR17","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.yexcr.2008.11.005","volume":"315","author":"N Pregi","year":"2009","unstructured":"Pregi N, Wenker S, Vittori D, Leir\u00f3s CP, Nesse A (2009) TNF-alpha-induced apoptosis is prevented by erythropoietin treatment on SH-SY5Y cells. Exp Cell Res 315:419\u2013431","journal-title":"Exp Cell Res"},{"issue":"10104","key":"1632_CR18","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1016\/S0140-6736(17)31002-4","volume":"390","author":"AL Shane","year":"2017","unstructured":"Shane AL, S\u00e1nchez PJ, Stoll BJ (2017) Neonatal sepsis. Lancet 390(10104):1770\u20131780","journal-title":"Lancet"},{"issue":"10","key":"1632_CR19","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1007\/s12519-022-00569-7","volume":"18","author":"T Sljivancanin Jakovljevic","year":"2022","unstructured":"Sljivancanin Jakovljevic T, Martic J, Jacimovic J, Nikolic N, Milasin J, Mitrovi\u0107 TL (2022) Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis. World J Pediatr 18(10):654\u2013670","journal-title":"World J Pediatr"},{"issue":"12","key":"1632_CR20","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1177\/0885066618823151","volume":"35","author":"S Takauji","year":"2020","unstructured":"Takauji S, Hayakawa M, Fujita S (2020) A nationwide comparison between Sepsis-2 and Sepsis-3 definition in Japan. J Intensive Care Med 35(12):1389\u20131395","journal-title":"J Intensive Care Med"},{"issue":"1","key":"1632_CR21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12967-022-03249-2","volume":"20","author":"Z Tang","year":"2022","unstructured":"Tang Z, Yang Y, Chen W, Li E, Liang T (2022) Demethylation at enhancer upregulates MCM2 and NUP37 expression predicting poor survival in hepatocellular carcinoma patients. J Transl Med 20(1):49","journal-title":"J Transl Med"},{"issue":"13","key":"1632_CR22","doi-asserted-by":"publisher","first-page":"5236","DOI":"10.1523\/JNEUROSCI.19-13-05236.1999","volume":"19","author":"NJ Wagoner","year":"1999","unstructured":"Wagoner NJ, Oh JW, Repovic P, Benveniste EN (1999) Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor. J Neurosci 19(13):5236\u20135244","journal-title":"J Neurosci"},{"key":"1632_CR23","doi-asserted-by":"publisher","first-page":"131365","DOI":"10.1016\/j.ijcard.2023.131365","volume":"393","author":"Q Wang","year":"2023","unstructured":"Wang Q, Fu B, Hu P, Liao X, Guo W, Yu D, Wang Z, Wei X (2023) Clinical evaluation of Sepsis-1 and Sepsis-3 in infective endocarditis. Int J Cardiol 393:131365","journal-title":"Int J Cardiol"},{"issue":"6","key":"1632_CR24","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1097\/shk.0b013e3180556d09","volume":"28","author":"JL Wynn","year":"2007","unstructured":"Wynn JL, Scumpia PO, Delano MJ, O\u2019Malley KA, Ungaro R, Abouhamze A, Moldawer LL (2007) Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock 28(6):675\u2013683","journal-title":"Shock"},{"issue":"1","key":"1632_CR25","doi-asserted-by":"publisher","first-page":"152132","DOI":"10.1016\/j.acthis.2023.152132","volume":"126","author":"L Xiu","year":"2024","unstructured":"Xiu L, Ma B, Ding L (2024) Antioncogenic roles of USP9Y and DDX3Y in lung cancer: USP9Y stabilizes DDX3Y by preventing its degradation through deubiquitination. Acta Histochem 126(1):152132","journal-title":"Acta Histochem"},{"key":"1632_CR26","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.cca.2020.11.002","volume":"512","author":"C Yang","year":"2021","unstructured":"Yang C, Xiao X, Huang L, Zhou F, Chen LH, Zhao YY, Qu SL, Zhang C (2021) Role of Kruppel-like factor 4 in atherosclerosis. Clin Chim Acta 512:135\u2013141","journal-title":"Clin Chim Acta"},{"key":"1632_CR27","doi-asserted-by":"publisher","first-page":"782755","DOI":"10.3389\/fonc.2021.782755","volume":"11","author":"J Zhang","year":"2021","unstructured":"Zhang J, Zhang H, Wang Y, Wang Q (2021) MCM2-7 in clear cell renal cell carcinoma: MCM7 promotes tumor cell proliferation. Front Oncol 11:782755","journal-title":"Front Oncol"},{"key":"1632_CR28","doi-asserted-by":"publisher","first-page":"8182358","DOI":"10.1155\/2020\/8182358","volume":"2020","author":"X Zheng","year":"2020","unstructured":"Zheng X, Luo Y, Li Q, Feng J, Zhao C, Lu J, Luo J, Zhang J (2020) Two gene set variation index as biomarker of bacterial and fungal sepsis. Biomed Res Int 2020:8182358","journal-title":"Biomed Res Int"}],"container-title":["Genes &amp; Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01632-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-025-01632-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01632-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T08:10:25Z","timestamp":1747296625000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-025-01632-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["1632"],"URL":"https:\/\/doi.org\/10.1007\/s13258-025-01632-z","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,20]]},"assertion":[{"value":"24 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In this study, all animal experiments were conducted in accordance with ethical guidelines and approved by the relevant Institutional Animal Care and Use Committee (IACUC). The protocols strictly adhered to ethical standards to ensure the humane treatment of animals throughout the experimental process, including appropriate measures to minimize suffering. Ethical number: 2022C242.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}