{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:44:17Z","timestamp":1778525057637,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002536","name":"Mokpo National University","doi-asserted-by":"publisher","award":["2019"],"award-info":[{"award-number":["2019"]}],"id":[{"id":"10.13039\/501100002536","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s13258-025-01645-8","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T07:38:21Z","timestamp":1745825901000},"page":"761-776","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Iris bungei Maxim. extract promotes brown adipocyte differentiation"],"prefix":"10.1007","volume":"47","author":[{"given":"Jaegoo","family":"Yeon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Suk","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ui-Joung","family":"Youn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badamtsetseg","family":"Bazarragchaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganbold","family":"Enebish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-5156","authenticated-orcid":false,"given":"Jong Bae","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"1645_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ejcb.2013.06.001","volume":"92","author":"AT Ali","year":"2013","unstructured":"Ali AT, Hochfeld WE, Myburgh R, Pepper MS (2013) Adipocyte and adipogenesis. Eur J Cell Biol 92:229\u2013236","journal-title":"Eur J Cell Biol"},{"key":"1645_CR2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1080\/21623945.2020.1870060","volume":"10","author":"L Cheng","year":"2021","unstructured":"Cheng L, Wang J, Dai H, Duan Y, An Y, Shi L, Lv Y, Li H, Wang C, Ma Q et al (2021) Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus. Adipocyte 10:48\u201365","journal-title":"Adipocyte"},{"key":"1645_CR3","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3390\/ph18020150","volume":"18","author":"J Choi","year":"2025","unstructured":"Choi J, Le DD, Roh N, Lee J, Shrestha D, Dinh T, Truong V, Bazarragchaa B, Kim S-Y, Suh S-S et al (2025) Chemical composition and biological activities of Lagopsis Supina extract: antioxidant, adipogenic, and ani-Inflammatory effects. Pharmaceuticals 18:150","journal-title":"Pharmaceuticals"},{"key":"1645_CR4","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1021\/np000560b","volume":"64","author":"MI Choudhary","year":"2001","unstructured":"Choudhary MI, Nur-e-Alam M, Baig I, Akhtar F, Khan AM, Nd\u00f6gnii PO, Badarchiin T, Purevsuren G, Nahar N, Atta ur R (2001a) Four new flavones and a new isoflavone from Iris Bungei. J Nat Prod 64:857\u2013860","journal-title":"J Nat Prod"},{"key":"1645_CR5","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1248\/cpb.49.1295","volume":"49","author":"MI Choudhary","year":"2001","unstructured":"Choudhary MI, Nur EAM, Akhtar F, Ahmad S, Baig I, Ond\u00f6gnii P, Gombosurengyin P, Atta ur R (2001b) Five new peltogynoids from underground parts of Iris Bungei: a Mongolian medicinal plant. Chem Pharm Bull (Tokyo) 49:1295\u20131298","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"1645_CR6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1039\/C9FO02285F","volume":"11","author":"TY Forbes-Hern\u00e1ndez","year":"2020","unstructured":"Forbes-Hern\u00e1ndez TY, Cianciosi D, Ansary J, Mezzetti B, Bompadre S, Quiles JL, Giampieri F, Battino M (2020) Strawberry (Fragaria \u00d7 Ananassa Cv. Romina) methanolic extract promotes Browning in 3T3-L1 cells. Food Funct 11:297\u2013304","journal-title":"Food Funct"},{"key":"1645_CR7","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s11154-023-09850-0","volume":"25","author":"Z Ghesmati","year":"2024","unstructured":"Ghesmati Z, Rashid M, Fayezi S, Gieseler F, Alizadeh E, Darabi M (2024) An update on the secretory functions of brown, white, and beige adipose tissue: towards therapeutic applications. Rev Endocr Metab Disord 25:279\u2013308","journal-title":"Rev Endocr Metab Disord"},{"key":"1645_CR8","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1210\/en.2013-1403","volume":"154","author":"M Giralt","year":"2013","unstructured":"Giralt M, Villarroya F (2013) White, brown, Beige\/brite: different adipose cells for different functions? Endocrinology 154:2992\u20133000","journal-title":"Endocrinology"},{"key":"1645_CR9","doi-asserted-by":"publisher","first-page":"5246","DOI":"10.3390\/molecules29225246","volume":"29","author":"C Jiang","year":"2024","unstructured":"Jiang C, Gates PJ (2024) Systematic characterisation of the fragmentation of flavonoids using high-resolution accurate mass electrospray tandem mass spectrometry. Molecules 29:5246","journal-title":"Molecules"},{"key":"1645_CR10","doi-asserted-by":"publisher","first-page":"569","DOI":"10.3390\/ijms17040569","volume":"17","author":"M Kawser Hossain","year":"2016","unstructured":"Kawser Hossain M, Abdal Dayem A, Han J, Yin Y, Kim K, Kumar Saha S, Yang GM, Choi HY, Cho SG (2016) Molecular mechanisms of the Anti-Obesity and Anti-Diabetic properties of flavonoids. Int J Mol Sci 17:569","journal-title":"Int J Mol Sci"},{"key":"1645_CR11","first-page":"10","volume-title":"Natural Extracts That Stimulate Adipocyte Browning and Their Underlying Mechanisms","author":"MK Lee","year":"2021","unstructured":"Lee MK, Lee B, Kim CY (2021) Natural extracts that stimulate adipocyte Browning and their underlying mechanisms. Antioxidants (Basel, p 10"},{"key":"1645_CR12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.tem.2008.11.005","volume":"20","author":"MI Lefterova","year":"2009","unstructured":"Lefterova MI, Lazar MA (2009) New developments in adipogenesis. Trends Endocrinol Metab 20:107\u2013114","journal-title":"Trends Endocrinol Metab"},{"key":"1645_CR13","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.fitote.2011.07.016","volume":"82","author":"B Lin","year":"2011","unstructured":"Lin B, Wang G, Wang Q, Ge C, Qin M (2011) A new Belamcandaquinone from the seeds of Iris Bungei Maxim. Fitoterapia 82:1137\u20131139","journal-title":"Fitoterapia"},{"key":"1645_CR14","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.bbrc.2005.05.002","volume":"332","author":"H Maeda","year":"2005","unstructured":"Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K (2005) Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun 332:392\u2013397","journal-title":"Biochem Biophys Res Commun"},{"key":"1645_CR15","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.1111\/febs.15470","volume":"288","author":"S Maurer","year":"2021","unstructured":"Maurer S, Harms M, Boucher J (2021) The colorful versatility of adipocytes: white-to-brown transdifferentiation and its therapeutic potential in humans. Febs J 288:3628\u20133646","journal-title":"Febs J"},{"key":"1645_CR16","doi-asserted-by":"publisher","first-page":"7827","DOI":"10.1080\/10408398.2021.1919051","volume":"62","author":"AKS Oliveira","year":"2022","unstructured":"Oliveira AKS, de Oliveira ESAM, Pereira RO, Santos AS, Barbosa Junior EV, Bezerra MT, Barreto RSS, Quintans-Junior LJ, Quintans JSS (2022) Anti-obesity properties and mechanism of action of flavonoids: A review. Crit Rev Food Sci Nutr 62:7827\u20137848","journal-title":"Crit Rev Food Sci Nutr"},{"key":"1645_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.tips.2016.10.011","volume":"38","author":"RA Quinn","year":"2017","unstructured":"Quinn RA, Nothias L-F, Vining O, Meehan M, Esquenazi E, Dorrestein PC (2017) Molecular networking as a drug discovery, drug metabolism, and precision medicine strategy. Trends Pharmacol Sci 38:143\u2013154","journal-title":"Trends Pharmacol Sci"},{"key":"1645_CR18","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1248\/cpb.48.738","volume":"48","author":"AU Rahman","year":"2000","unstructured":"Rahman AU, Choudhary MI, Alam MN, Ndognii PO, Badarchiin T, Purevsuren G (2000) Two new Quinones from Iris Bungei. Chem Pharm Bull (Tokyo) 48:738\u2013739","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"1645_CR19","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/med.21740","volume":"41","author":"AT Rufino","year":"2021","unstructured":"Rufino AT, Costa VM, Carvalho F, Fernandes E (2021) Flavonoids as antiobesity agents: A review. Med Res Rev 41:556\u2013585","journal-title":"Med Res Rev"},{"key":"1645_CR20","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/0021-9673(93)83025-N","volume":"634","author":"TJ Schmidt","year":"1993","unstructured":"Schmidt TJ, Merfort I, Matthiesen U (1993) Resolution of complex mixtures of flavonoid aglycones by analysis of gas chromatographic-mass spectrometric data. J Chromatogr A 634:350\u2013355","journal-title":"J Chromatogr A"},{"key":"1645_CR21","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s42255-018-0003-x","volume":"1","author":"JB Seo","year":"2019","unstructured":"Seo JB, Riopel M, Cabrales P, Huh JY, Bandyopadhyay GK, Andreyev AY, Murphy AN, Beeman SC, Smith GI, Klein S et al (2019) Knockdown of Ant2 reduces adipocyte hypoxia and improves insulin resistance in obesity. Nat Metab 1:86\u201397","journal-title":"Nat Metab"},{"key":"1645_CR22","doi-asserted-by":"publisher","first-page":"204","DOI":"10.5187\/jast.2024.e6","volume":"66","author":"D Shrestha","year":"2024","unstructured":"Shrestha D, Kim E, Shrestha KK, Suh SS, Kim SH, Seo JB (2024) Methanol extract of Elsholtzia fruticosa promotes 3T3-L1 preadipocyte differentiation. J Anim Sci Technol 66:204\u2013218","journal-title":"J Anim Sci Technol"},{"key":"1645_CR23","doi-asserted-by":"publisher","first-page":"593058","DOI":"10.3389\/fimmu.2020.593058","volume":"11","author":"J Song","year":"2020","unstructured":"Song J, Deng T (2020) The adipocyte and adaptive immunity. Front Immunol 11:593058","journal-title":"Front Immunol"},{"key":"1645_CR24","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/S1044-0305(97)00082-2","volume":"8","author":"T Yalcin","year":"1997","unstructured":"Yalcin T, Wang J, Wen D, Harrisoncor AG (1997) C-C and C-H bond activation in the fragmentation of the [M\u2009+\u2009Ni]\u2009+\u2009adducts of aliphatic amino acids. J Am Soc Mass Spectrom 8:749\u2013755","journal-title":"J Am Soc Mass Spectrom"},{"key":"1645_CR25","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1166\/jnn.2021.19160","volume":"21","author":"J Yeon","year":"2021","unstructured":"Yeon J, Suh SS, Youn UJ, Bazarragchaa B, Enebish G, Seo JB (2021) Methanol extract of Mongolian Iris Bungei Maxim. Stimulates 3T3-L1 adipocyte differentiation. J Nanosci Nanotechnol 21:3943\u20133949","journal-title":"J Nanosci Nanotechnol"},{"key":"1645_CR26","doi-asserted-by":"publisher","first-page":"e0300520","DOI":"10.1371\/journal.pone.0300520","volume":"19","author":"J Yeon","year":"2024","unstructured":"Yeon J, Kim E, Bazarragchaa B, Kim SY, Huh JY, Park H, Suh SS, Seo JB (2024) Stellera Chamaejasme L. extract inhibits adipocyte differentiation through activation of the extracellular signal-regulated kinase pathway. PLoS ONE 19:e0300520","journal-title":"PLoS ONE"},{"key":"1645_CR27","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s12161-016-0669-1","volume":"10","author":"H Yuan","year":"2017","unstructured":"Yuan H, Sun L, Chen M, Wang J (2017) The simultaneous analysis of Amadori and Heyns compounds in dried fruits by high performance liquid chromatography tandem mass spectrometry. Food Anal Methods 10:1097\u20131105","journal-title":"Food Anal Methods"},{"key":"1645_CR28","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.cmet.2017.12.002","volume":"27","author":"RK Zwick","year":"2018","unstructured":"Zwick RK, Guerrero-Juarez CF, Horsley V, Plikus MV (2018) Anatomical, physiological, and functional diversity of adipose tissue. Cell Metab 27:68\u201383","journal-title":"Cell Metab"},{"key":"1645_CR29","doi-asserted-by":"crossref","unstructured":"Park WY, Choe SK, Park J, Um JY (2019) Black raspberry (Rubus Coreanus Miquel) promotes Browning of preadipocytes and inguinal white adipose tissue in Cold-Induced mice. Nutrients 11","DOI":"10.3390\/nu11092164"},{"key":"1645_CR30","doi-asserted-by":"crossref","unstructured":"Seo YJ, Kim KJ, Choi J, Koh EJ, Lee BY (2018) Spirulina maxima extract reduces obesity through suppression of adipogenesis and activation of Browning in 3T3-L1 cells and High-Fat Diet-Induced obese mice. Nutrients 10","DOI":"10.3390\/nu10060712"},{"key":"1645_CR31","doi-asserted-by":"crossref","unstructured":"Sung YY, Son E, Im G, Kim DS (2020) Herbal Combination of Phyllostachys pubescens and Scutellaria baicalensis Inhibits Adipogenesis and Promotes Browning via AMPK Activation in 3T3-L1 Adipocytes. (Plants (Basel) 9)","DOI":"10.3390\/plants9111422"}],"container-title":["Genes &amp; Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01645-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-025-01645-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01645-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T17:07:41Z","timestamp":1749575261000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-025-01645-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1645"],"URL":"https:\/\/doi.org\/10.1007\/s13258-025-01645-8","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]},"assertion":[{"value":"8 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study does not involve any research on human or animal subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}