{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:40:31Z","timestamp":1780461631918,"version":"3.54.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2022YFS0633"],"award-info":[{"award-number":["2022YFS0633"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Medical Science and Technology Innovation Research Association","award":["YCH-KY-YCZD2024-298"],"award-info":[{"award-number":["YCH-KY-YCZD2024-298"]}]},{"name":"Beijing Huaxia Cancer Prevention and Treatment Research Institute","award":["202401"],"award-info":[{"award-number":["202401"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100632"],"award-info":[{"award-number":["82100632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s13258-025-01675-2","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:55:15Z","timestamp":1757584515000},"page":"1079-1097","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The PAR-score based on PANoptosis genes predicts the progression of ulcerative colitis and the response to anti-TNF-\u03b1 treatment"],"prefix":"10.1007","volume":"47","author":[{"given":"Yantong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xisheng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5831-2491","authenticated-orcid":false,"given":"Xiaolin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"issue":"10","key":"1675_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105351","volume":"23","author":"M Afonso","year":"2022","unstructured":"Afonso M, Brito MA (2022) Therapeutic options in neuro-oncology. Int J Mol Sci 23(10):5351. https:\/\/doi.org\/10.3390\/ijms23105351","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1675_CR2","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12876-023-02720-8","volume":"23","author":"B Albayrak","year":"2023","unstructured":"Albayrak B, Sebin E (2023) A novel inflammatory marker for extensive ulcerative colitis; endocan. BMC Gastroenterol 23(1):118. https:\/\/doi.org\/10.1186\/s12876-023-02720-8","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"1675_CR3","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1093\/ibd\/izab031","volume":"28","author":"A Anderson","year":"2022","unstructured":"Anderson A, Cherfane C, Click B et al (2022) Monocytosis is a biomarker of severity in inflammatory bowel disease: analysis of a 6-year prospective natural history registry. Inflamm Bowel Dis 28(1):70\u201378. https:\/\/doi.org\/10.1093\/ibd\/izab031","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"1675_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","volume":"20","author":"D Aran","year":"2019","unstructured":"Aran D, Looney AP, Liu L et al (2019) Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol 20(2):163\u2013172. https:\/\/doi.org\/10.1038\/s41590-018-0276-y","journal-title":"Nat Immunol"},{"issue":"Database","key":"1675_CR5","doi-asserted-by":"publisher","first-page":"D885","DOI":"10.1093\/nar\/gkn764","volume":"37","author":"T Barrett","year":"2009","unstructured":"Barrett T, Troup DB, Wilhite SE et al (2009) Ncbi geo: archive for high-throughput functional genomic data. Nucleic Acids Res 37(Database):D885\u2013D890. https:\/\/doi.org\/10.1093\/nar\/gkn764","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"1675_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810968","volume":"23","author":"D Bencze","year":"2022","unstructured":"Bencze D, Fekete T, P\u00e1zm\u00e1ndi K (2022) Correlation between type I interferon associated factors and COVID-19 severity. Int J Mol Sci 23(18):10968. https:\/\/doi.org\/10.3390\/ijms231810968","journal-title":"Int J Mol Sci"},{"key":"1675_CR7","doi-asserted-by":"publisher","DOI":"10.1111\/sji.13412","author":"R Chandwaskar","year":"2024","unstructured":"Chandwaskar R, Dalal R, Gupta S et al (2024) Dysregulation of T cell response in the pathogenesis of inflammatory bowel disease. Scand J Immunol. https:\/\/doi.org\/10.1111\/sji.13412","journal-title":"Scand J Immunol"},{"issue":"1","key":"1675_CR8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12935-024-03232-5","volume":"24","author":"R Chang","year":"2024","unstructured":"Chang R, Tsui KH, Pan LF, Li CJ (2024) Spatial and single-cell analyses uncover links between ALKBH1 and tumor-associated macrophages in gastric cancer. Cancer Cell Int 24(1):57. https:\/\/doi.org\/10.1186\/s12935-024-03232-5","journal-title":"Cancer Cell Int"},{"key":"1675_CR9","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10018","author":"S Chen","year":"2019","unstructured":"Chen S, Li X, Wang Y et al (2019) Ginsenoside Rb1 attenuates intestinal ischemia\/reperfusion-induced inflammation and oxidative stress via activation of the PI3K\/Akt\/Nrf2 signaling pathway. Mol Med Rep. https:\/\/doi.org\/10.3892\/mmr.2019.10018","journal-title":"Mol Med Rep"},{"issue":"1","key":"1675_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28010052","volume":"28","author":"X Chen","year":"2022","unstructured":"Chen X, Dai Y, Wan X et al (2022) ZBP1-mediated necroptosis: mechanisms and therapeutic implications. Molecules 28(1):52. https:\/\/doi.org\/10.3390\/molecules28010052","journal-title":"Molecules"},{"key":"1675_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2024.07.008","volume":"79","author":"Z Chen","year":"2024","unstructured":"Chen Z, Jiang P, Su D, Zhao Y, Zhang M (2024) Therapeutic inhibition of the JAK-STAT pathway in the treatment of inflammatory bowel disease. Cytokine Growth Factor Rev 79:1\u201315. https:\/\/doi.org\/10.1016\/j.cytogfr.2024.07.008","journal-title":"Cytokine Growth Factor Rev"},{"key":"1675_CR12","doi-asserted-by":"publisher","first-page":"175628482110364","DOI":"10.1177\/17562848211036456","volume":"14","author":"H Cicho\u017c-Lach","year":"2021","unstructured":"Cicho\u017c-Lach H, Michalak A, Kopertowska-Majchrzak M et al (2021) Characteristics of patients with moderate-to-severe ulcerative colitis treated with vedolizumab: results from a Polish multicenter, prospective, observational real-life study (the POLONEZ study). Ther Adv Gastroenterol 14:17562848211036456. https:\/\/doi.org\/10.1177\/17562848211036456","journal-title":"Ther Adv Gastroenterol"},{"issue":"28","key":"1675_CR13","doi-asserted-by":"publisher","first-page":"4055","DOI":"10.3748\/wjg.v26.i28.4055","volume":"26","author":"F Cordes","year":"2020","unstructured":"Cordes F, Foell D, Ding JN, Varga G, Bettenworth D (2020) Differential regulation of JAK\/STAT-signaling in patients with ulcerative colitis and Crohn\u2019s disease. World J Gastroenterol 26(28):4055\u20134075. https:\/\/doi.org\/10.3748\/wjg.v26.i28.4055","journal-title":"World J Gastroenterol"},{"key":"1675_CR14","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i9.918","author":"ZW Dong","year":"2022","unstructured":"Dong ZW, Liu H, Su FF, Fan XZ, Zhang Y, Liu P (2022) Cystic fibrosis transmembrane conductance regulator prevents ischemia\/reperfusion induced intestinal apoptosis via inhibiting PI3K\/AKT\/NF-\u03baB pathway. World J Gastroenterol. https:\/\/doi.org\/10.3748\/wjg.v28.i9.918","journal-title":"World J Gastroenterol"},{"issue":"11","key":"1675_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187737","volume":"12","author":"T Fukuda","year":"2017","unstructured":"Fukuda T, Naganuma M, Sugimoto S et al (2017) The risk factor of clinical relapse in ulcerative colitis patients with low dose 5-aminosalicylic acid as maintenance therapy: a report from the IBD registry. PLoS ONE 12(11):e0187737. https:\/\/doi.org\/10.1371\/journal.pone.0187737","journal-title":"PLoS ONE"},{"issue":"1","key":"1675_CR16","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/1471-2105-11-367","volume":"11","author":"R Gaujoux","year":"2010","unstructured":"Gaujoux R, Seoighe C (2010) A flexible R package for nonnegative matrix factorization. BMC Bioinf 11(1):367. https:\/\/doi.org\/10.1186\/1471-2105-11-367","journal-title":"BMC Bioinf"},{"issue":"37","key":"1675_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035020","volume":"102","author":"M Guo","year":"2023","unstructured":"Guo M, Wang X (2023) Pathological mechanism and targeted drugs of ulcerative colitis: a review. Medicine (Baltimore) 102(37):e35020. https:\/\/doi.org\/10.1097\/MD.0000000000035020","journal-title":"Medicine (Baltimore)"},{"key":"1675_CR18","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.7051","author":"P Guo","year":"2017","unstructured":"Guo P, Pu T, Chen S et al (2017) Breast cancers with EGFR and HER2 co-amplification favor distant metastasis and poor clinical outcome. Oncol Lett. https:\/\/doi.org\/10.3892\/ol.2017.7051","journal-title":"Oncol Lett"},{"issue":"10","key":"1675_CR19","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1111\/j.1582-4934.2009.00959.x","volume":"14","author":"G Hundorfean","year":"2010","unstructured":"Hundorfean G, Neurath MF, Sitaru C (2010) Autoimmunity against type VII collagen in inflammatory bowel disease. J Cell Mol Med 14(10):2393\u20132403. https:\/\/doi.org\/10.1111\/j.1582-4934.2009.00959.x","journal-title":"J Cell Mol Med"},{"issue":"1","key":"1675_CR20","doi-asserted-by":"publisher","first-page":"G7","DOI":"10.1152\/ajpgi.00079.2004","volume":"287","author":"SH Itzkowitz","year":"2004","unstructured":"Itzkowitz SH, Yio X (2004) Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol-Gastrointest Liver Physiol 287(1):G7\u2013G17. https:\/\/doi.org\/10.1152\/ajpgi.00079.2004","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"key":"1675_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00237","author":"TD Kanneganti","year":"2020","unstructured":"Kanneganti TD (2020) Identification of the PANoptosome: a molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis). Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2020.00237","journal-title":"Front Cell Infect Microbiol"},{"key":"1675_CR22","unstructured":"Karki R, Man SM, Kanneganti TD. Inflammasomes and Cancer. Published online 2018."},{"key":"1675_CR23","doi-asserted-by":"crossref","unstructured":"Karki R, Sundaram B, Sharma BR, et al. ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis. Published online 2022.","DOI":"10.1016\/j.celrep.2021.109858"},{"issue":"1","key":"1675_CR24","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/metabo14010002","volume":"14","author":"SY Kim","year":"2023","unstructured":"Kim SY, Shin SY, Saeed M et al (2023) Prediction of clinical remission with Adalimumab therapy in patients with ulcerative colitis by Fourier transform-infrared spectroscopy coupled with machine learning algorithms. Metabolites 14(1):2. https:\/\/doi.org\/10.3390\/metabo14010002","journal-title":"Metabolites"},{"issue":"1","key":"1675_CR25","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinf 9(1):559. https:\/\/doi.org\/10.1186\/1471-2105-9-559","journal-title":"BMC Bioinf"},{"issue":"10401","key":"1675_CR26","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","volume":"402","author":"C Le Berre","year":"2023","unstructured":"Le Berre C, Honap S, Peyrin-Biroulet L (2023) Ulcerative colitis. Lancet 402(10401):571\u2013584. https:\/\/doi.org\/10.1016\/S0140-6736(23)00966-2","journal-title":"Lancet"},{"issue":"1","key":"1675_CR27","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1146\/annurev.immunol.16.1.293","volume":"16","author":"WJ Leonard","year":"1998","unstructured":"Leonard WJ, O\u2019Shea JJ (1998) JAKS and STATS: biological implications. Annu Rev Immunol 16(1):293\u2013322. https:\/\/doi.org\/10.1146\/annurev.immunol.16.1.293","journal-title":"Annu Rev Immunol"},{"issue":"2","key":"1675_CR28","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.cyto.2011.07.021","volume":"56","author":"C Li","year":"2011","unstructured":"Li C, Chan YR (2011) Lipocalin 2 regulation and its complex role in inflammation and cancer. Cytokine 56(2):435\u2013441. https:\/\/doi.org\/10.1016\/j.cyto.2011.07.021","journal-title":"Cytokine"},{"key":"1675_CR29","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3389\/fcimb.2019.00406","volume":"9","author":"RKS Malireddi","year":"2019","unstructured":"Malireddi RKS, Kesavardhana S, Kanneganti TD (2019) ZBP1 and TAK1: master regulators of NLRP3 inflammasome\/pyroptosis, apoptosis, and necroptosis (PAN-optosis). Front Cell Infect Microbiol 9:406. https:\/\/doi.org\/10.3389\/fcimb.2019.00406","journal-title":"Front Cell Infect Microbiol"},{"issue":"7203","key":"1675_CR30","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454(7203):436\u2013444","journal-title":"Nature"},{"issue":"9","key":"1675_CR31","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.4049\/jimmunol.2200508","volume":"209","author":"N Pandian","year":"2022","unstructured":"Pandian N, Kanneganti TD (2022) PANoptosis: a unique innate immune inflammatory cell death modality. J Immunol 209(9):1625\u20131633. https:\/\/doi.org\/10.4049\/jimmunol.2200508","journal-title":"J Immunol"},{"key":"1675_CR32","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S353380","author":"L Peng","year":"2022","unstructured":"Peng L, Zhu N, Wang D, Zhou Y, Liu Y (2022) Comprehensive analysis of prognostic value and immune infiltration of NLRC4 and CASP1 in colorectal cancer. Int J Gen Med. https:\/\/doi.org\/10.2147\/IJGM.S353380","journal-title":"Int J Gen Med"},{"issue":"4","key":"1675_CR33","doi-asserted-by":"publisher","first-page":"177","DOI":"10.21037\/atm-23-276","volume":"11","author":"R Qian","year":"2023","unstructured":"Qian R, Tang M, Ouyang Z, Cheng H, Xing S (2023) Identification of ferroptosis-related genes in ulcerative colitis: a diagnostic model with machine learning. Ann Transl Med 11(4):177\u2013177. https:\/\/doi.org\/10.21037\/atm-23-276","journal-title":"Ann Transl Med"},{"issue":"8","key":"1675_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e10314","volume":"8","author":"W Qin","year":"2022","unstructured":"Qin W, Luo H, Yang L et al (2022) Rubia cordifolia L. ameliorates DSS-induced ulcerative colitis in mice through dual inhibition of NLRP3 inflammasome and IL-6\/JAK2\/STAT3 pathways. Heliyon 8(8):e10314. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e10314","journal-title":"Heliyon"},{"issue":"9","key":"1675_CR35","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.3390\/biom11091286","volume":"11","author":"X Qiu","year":"2021","unstructured":"Qiu X, Chen C, Chen X (2021) Lipocalin 2 deficiency restrains aging-related reshaping of gut microbiota structure and metabolism. Biomolecules 11(9):1286. https:\/\/doi.org\/10.3390\/biom11091286","journal-title":"Biomolecules"},{"issue":"3","key":"1675_CR36","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/bjs.6874","volume":"97","author":"J Randall","year":"2010","unstructured":"Randall J, Singh B, Warren BF, Travis SPL, Mortensen NJ, George BD (2010) Delayed surgery for acute severe colitis is associated with increased risk of postoperative complications. Br J Surg 97(3):404\u2013409. https:\/\/doi.org\/10.1002\/bjs.6874","journal-title":"Br J Surg"},{"issue":"9","key":"1675_CR37","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.3390\/cancers11091280","volume":"11","author":"C R\u00e9b\u00e9","year":"2019","unstructured":"R\u00e9b\u00e9 C, Ghiringhelli F (2019) STAT3, a master regulator of anti-tumor immune response. Cancers 11(9):1280. https:\/\/doi.org\/10.3390\/cancers11091280","journal-title":"Cancers"},{"key":"1675_CR38","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000152","author":"DT Rubin","year":"2019","unstructured":"Rubin DT, Ananthakrishnan AN, Siegel CA, Sauer BG (2019) ACG clinical guideline: ulcerative colitis in adults. Am J Gastroenterol. https:\/\/doi.org\/10.14309\/ajg.0000000000000152","journal-title":"Am J Gastroenterol"},{"key":"1675_CR39","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baq020","author":"M Safran","year":"2010","unstructured":"Safran M, Dalah I, Alexander J et al (2010) GeneCards Version 3: the human gene integrator. Database. https:\/\/doi.org\/10.1093\/database\/baq020","journal-title":"Database"},{"key":"1675_CR40","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042718-041717","author":"S Sakaguchi","year":"2020","unstructured":"Sakaguchi S, Mikami N, Wing JB, Tanaka A, Ichiyama K, Ohkura N (2020) Regulatory t cells and human disease. Annu Rev Immunol. https:\/\/doi.org\/10.1146\/annurev-immunol-042718-041717","journal-title":"Annu Rev Immunol"},{"key":"1675_CR41","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44055","author":"Y Santos","year":"2023","unstructured":"Santos Y, Jaramillo AP (2023) Effectiveness of mesalamine in patients with ulcerative colitis: a systematic review. Cureus. https:\/\/doi.org\/10.7759\/cureus.44055","journal-title":"Cureus."},{"issue":"11","key":"1675_CR42","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303","journal-title":"Genome Res"},{"key":"1675_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12040800","author":"J Shin","year":"2024","unstructured":"Shin J, Baek GH, Cha B et al (2024) Complementary therapeutic effect of fecal microbiota transplantation in ulcerative colitis after the response to anti-tumor necrosis factor alpha agent was lost: a case report. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines12040800","journal-title":"Biomedicines"},{"key":"1675_CR44","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000515","author":"J Stallhofer","year":"2015","unstructured":"Stallhofer J, Friedrich M, Konrad-Zerna A et al (2015) Lipocalin-2 Is a disease activity marker in inflammatory bowel disease regulated by IL-17A, IL-22, and TNF-\u03b1 and modulated by IL23R genotype status. Inflamm Bowel Dis. https:\/\/doi.org\/10.1097\/MIB.0000000000000515","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"1675_CR45","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/imr.13279","volume":"321","author":"X Sun","year":"2024","unstructured":"Sun X, Yang Y, Meng X, Li J, Liu X, Liu H (2024) PANoptosis\u202f: Mechanisms, biology, and role in disease. Immunol Rev 321(1):246\u2013262. https:\/\/doi.org\/10.1111\/imr.13279","journal-title":"Immunol Rev"},{"issue":"1","key":"1675_CR46","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12935-025-03728-8","volume":"25","author":"M Sun","year":"2025","unstructured":"Sun M, Zhang Z, Chen C et al (2025) Exploring the potential mechanisms of sorafenib resistance in hepatocellular carcinoma cell lines based on RNA sequencing. Cancer Cell Int 25(1):91. https:\/\/doi.org\/10.1186\/s12935-025-03728-8","journal-title":"Cancer Cell Int"},{"key":"1675_CR47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1003","author":"D Szklarczyk","year":"2015","unstructured":"Szklarczyk D, Franceschini A, Wyder S et al (2015) String v10: protein\u2013protein interaction networks, integrated over the tree of life. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gku1003","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"1675_CR48","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41576-019-0127-1","volume":"20","author":"V Tam","year":"2019","unstructured":"Tam V, Patel N, Turcotte M, Boss\u00e9 Y, Par\u00e9 G, Meyre D (2019) Benefits and limitations of genome-wide association studies. Nat Rev Genet 20(8):467\u2013484. https:\/\/doi.org\/10.1038\/s41576-019-0127-1","journal-title":"Nat Rev Genet"},{"issue":"4","key":"1675_CR49","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.3892\/ijo.2014.2259","volume":"44","author":"SW Wang","year":"2014","unstructured":"Wang SW, Sun YM (2014) The IL-6\/JAK\/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer. Int J Oncol 44(4):1032\u20131040. https:\/\/doi.org\/10.3892\/ijo.2014.2259","journal-title":"Int J Oncol"},{"issue":"2","key":"1675_CR50","doi-asserted-by":"publisher","first-page":"12722","DOI":"10.1080\/21655979.2021.2010368","volume":"12","author":"YX Wang","year":"2021","unstructured":"Wang YX, Lin C, Cui LJ et al (2021) Mechanism of M2 macrophage-derived extracellular vesicles carrying lncRNA MEG3 in inflammatory responses in ulcerative colitis. Bioengineered 12(2):12722\u201312739. https:\/\/doi.org\/10.1080\/21655979.2021.2010368","journal-title":"Bioengineered"},{"issue":"1","key":"1675_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010348","volume":"25","author":"JM Wang","year":"2023","unstructured":"Wang JM, Yang J, Xia WY et al (2023a) Comprehensive analysis of PANoptosis-related gene signature of ulcerative colitis. Int J Mol Sci 25(1):348. https:\/\/doi.org\/10.3390\/ijms25010348","journal-title":"Int J Mol Sci"},{"key":"1675_CR52","doi-asserted-by":"publisher","first-page":"1129649","DOI":"10.3389\/fonc.2023.1129649","volume":"13","author":"L Wang","year":"2023","unstructured":"Wang L, Zhuang H, Xu X, Zhou J, Jiao Y (2023b) Efficacy and survival analysis of nimotuzumab combined with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma. Front Oncol 13:1129649. https:\/\/doi.org\/10.3389\/fonc.2023.1129649","journal-title":"Front Oncol"},{"key":"1675_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115696","volume":"168","author":"Y Xiong","year":"2023","unstructured":"Xiong Y (2023) The emerging role of PANoptosis in cancer treatment. Biomed Pharmacother 168:115696. https:\/\/doi.org\/10.1016\/j.biopha.2023.115696","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"1675_CR54","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i4.520","volume":"12","author":"T Yamamoto","year":"2006","unstructured":"Yamamoto T (2006) Safety and clinical efficacy of granulocyte and monocyte adsorptive apheresis therapy for ulcerative colitis. World J Gastroenterol 12(4):520. https:\/\/doi.org\/10.3748\/wjg.v12.i4.520","journal-title":"World J Gastroenterol"},{"issue":"44","key":"1675_CR55","doi-asserted-by":"publisher","first-page":"16389","DOI":"10.3748\/wjg.v20.i44.16389","volume":"20","author":"M Yashiro","year":"2014","unstructured":"Yashiro M (2014) Ulcerative colitis-associated colorectal cancer. World J Gastroenterol 20(44):16389. https:\/\/doi.org\/10.3748\/wjg.v20.i44.16389","journal-title":"World J Gastroenterol"},{"issue":"15","key":"1675_CR56","doi-asserted-by":"publisher","first-page":"8520","DOI":"10.1093\/nar\/gkab638","volume":"49","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Liu T, Hu X et al (2021) Cell call: integrating paired ligand\u2013receptor and transcription factor activities for cell\u2013cell communication. Nucleic Acids Res 49(15):8520\u20138534. https:\/\/doi.org\/10.1093\/nar\/gkab638","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1675_CR57","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/imr.12909","volume":"297","author":"M Zheng","year":"2020","unstructured":"Zheng M, Kanneganti T (2020) The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis). Immunol Rev 297(1):26\u201338. https:\/\/doi.org\/10.1111\/imr.12909","journal-title":"Immunol Rev"}],"container-title":["Genes &amp; Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01675-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-025-01675-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01675-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:03:35Z","timestamp":1760209415000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-025-01675-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,11]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["1675"],"URL":"https:\/\/doi.org\/10.1007\/s13258-025-01675-2","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,11]]},"assertion":[{"value":"23 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No potential conflicts of interest were disclosed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the animal ethics committee of Southwest Medical University (Ethical approval number: 20250307\u2013027).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}