{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:07:15Z","timestamp":1787677635417,"version":"build-2784847793"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2022R1A6A3A01087141"],"award-info":[{"award-number":["2022R1A6A3A01087141"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience and Biotechnology","doi-asserted-by":"publisher","award":["KGM5192531"],"award-info":[{"award-number":["KGM5192531"]}],"id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience and Biotechnology","doi-asserted-by":"publisher","award":["KGM5192531"],"award-info":[{"award-number":["KGM5192531"]}],"id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s13258-025-01677-0","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T11:12:13Z","timestamp":1756984333000},"page":"1267-1276","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deep learning-driven whole-slide image analysis predicts chemo-resistance and motility subtypes in muscle-invasive bladder cancer"],"prefix":"10.1007","volume":"47","author":[{"given":"Il-San","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee-Woo","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4664-4162","authenticated-orcid":false,"given":"Seung-Woo","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"1677_CR1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","volume":"18","author":"D Aran","year":"2017","unstructured":"Aran D, Hu Z, Butte AJ (2017) Xcell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol 18:220","journal-title":"Genome Biol"},{"key":"1677_CR2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.eururo.2021.08.010","volume":"81","author":"M Babjuk","year":"2022","unstructured":"Babjuk M, Burger M, Capoun O, Cohen D, Comperat EM, Dominguez Escrig JL, Gontero P, Liedberg F, Masson-Lecomte A, Mostafid AH et al (2022) European Association of Urology guidelines on non-muscle-invasive bladder cancer (Ta, T1, and carcinoma in situ). Eur Urol 81:75\u201394","journal-title":"Eur Urol"},{"key":"1677_CR3","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229\u2013263","journal-title":"CA Cancer J Clin"},{"key":"1677_CR4","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41596-024-01047-2","volume":"20","author":"OSM El Nahhas","year":"2025","unstructured":"El Nahhas OSM, van Treeck M, Wolflein G, Unger M, Ligero M, Lenz T, Wagner SJ, Hewitt KJ, Khader F, Foersch S et al (2025) From whole-slide image to biomarker prediction: end-to-end weakly supervised deep learning in computational pathology. Nat Protoc 20:293\u2013316","journal-title":"Nat Protoc"},{"key":"1677_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2019.101563","volume":"58","author":"S Graham","year":"2019","unstructured":"Graham S, Vu QD, Raza SEA, Azam A, Tsang YW, Kwak JT, Rajpoot N (2019) Hover-net: simultaneous segmentation and classification of nuclei in multi-tissue histology images. Med Image Anal 58:101563","journal-title":"Med Image Anal"},{"key":"1677_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217339","volume":"610","author":"MS Jeong","year":"2025","unstructured":"Jeong MS, Baek SW, Yang GE, Mun JY, Kim JA, Kim TN, Nam JK, Choi YH, Lee JS, Chu IS et al (2025) Chemoresistance-motility signature of molecular evolution to chemotherapy in non-muscle-invasive bladder cancer and its clinical implications. Cancer Lett 610:217339","journal-title":"Cancer Lett"},{"key":"1677_CR7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.eururo.2019.09.006","volume":"77","author":"A Kamoun","year":"2020","unstructured":"Kamoun A, de Reynies A, Allory Y, Sjodahl G, Robertson AG, Seiler R, Hoadley KA, Groeneveld CS, Al-Ahmadie H, Choi W et al (2020) A consensus molecular classification of muscle-invasive bladder cancer. Eur Urol 77:420\u2013433","journal-title":"Eur Urol"},{"key":"1677_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002730","volume":"16","author":"JN Kather","year":"2019","unstructured":"Kather JN, Krisam J, Charoentong P, Luedde T, Herpel E, Weis CA, Gaiser T, Marx A, Valous NA, Ferber D et al (2019) Predicting survival from colorectal cancer histology slides using deep learning: a retrospective multicenter study. PLoS Med 16:e1002730","journal-title":"PLoS Med"},{"key":"1677_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-022-00186-5","volume":"2","author":"J Pocock","year":"2022","unstructured":"Pocock J, Graham S, Vu QD, Jahanifar M, Deshpande S, Hadjigeorghiou G, Shephard A, Bashir RMS, Bilal M, Lu W et al (2022) Tiatoolbox as an end-to-end library for advanced tissue image analytics. Commun Med 2:120","journal-title":"Commun Med"},{"key":"1677_CR10","first-page":"10","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A (2025) Cancer statistics, 2025. CA Cancer J Clin 75:10\u201345","journal-title":"CA Cancer J Clin"},{"key":"1677_CR11","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1136\/gutjnl-2019-319866","volume":"70","author":"K Sirinukunwattana","year":"2021","unstructured":"Sirinukunwattana K, Domingo E, Richman SD, Redmond KL, Blake A, Verrill C, Leedham SJ, Chatzipli A, Hardy C, Whalley CM et al (2021) Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning. Gut 70:544\u2013554","journal-title":"Gut"},{"key":"1677_CR12","doi-asserted-by":"publisher","first-page":"4052","DOI":"10.1038\/s41467-024-48179-3","volume":"15","author":"Y Song","year":"2024","unstructured":"Song Y, Na H, Lee SE, Kim YM, Moon J, Nam TW, Ji Y, Jin Y, Park JH, Cho SC et al (2024) Dysfunctional adipocytes promote tumor progression through YAP\/TAZ-dependent cancer-associated adipocyte transformation. Nat Commun 15:4052","journal-title":"Nat Commun"},{"key":"1677_CR13","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41568-020-00313-1","volume":"21","author":"L Tran","year":"2021","unstructured":"Tran L, Xiao JF, Agarwal N, Duex JE, Theodorescu D (2021) Advances in bladder cancer biology and therapy. Nat Rev Cancer 21:104\u2013121","journal-title":"Nat Rev Cancer"},{"key":"1677_CR14","unstructured":"van der Heijden AG BH, Carrion A et al (2025) EAU guidelines on muscle-invasive and metastatic bladder cancer. Edn. presented at the EAU Annual Congress Madrid 2025 edn., Arnhem"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01677-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-025-01677-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01677-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T11:49:30Z","timestamp":1765194570000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-025-01677-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1677"],"URL":"https:\/\/doi.org\/10.1007\/s13258-025-01677-0","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]},"assertion":[{"value":"9 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original was revised due to an error in affiliation.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was not required for this study in accordance with guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}