{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T23:24:23Z","timestamp":1769901863991,"version":"3.49.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2020-NR052182"],"award-info":[{"award-number":["RS-2020-NR052182"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s13258-025-01692-1","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:59:17Z","timestamp":1761040757000},"page":"15-25","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Induction of TRIM22 during Clonorchis sinensis infection triggers intracellular ROS accumulation by suppressing the mTOR-mediated Nrf2 signaling pathway"],"prefix":"10.1007","volume":"48","author":[{"given":"Ji Hoon","family":"Jeong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyeong","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-5995","authenticated-orcid":false,"given":"Jhang Ho","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"1692_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.5009\/gnl15568","volume":"11","author":"B Blechacz","year":"2017","unstructured":"Blechacz B (2017) Cholangiocarcinoma: current knowledge and new developments. Gut Liver 11:13\u201326","journal-title":"Gut Liver"},{"key":"1692_CR2","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s12253-010-9300-8","volume":"17","author":"T Boonmars","year":"2011","unstructured":"Boonmars T, Wu Z, Boonjaruspinyo S, Puapairoj A, Kaewsamut B, Nagano I, Pinlaor S, Yongvanit P, Wonkchalee O, Juasook A et al (2011) Involvement of c-Ski oncoprotein in carcinogenesis of cholangiocacinoma induced by Opisthorchis viverrini and N-nitrosodimethylamine. Pathol Oncol Res 17:219\u2013227","journal-title":"Pathol Oncol Res"},{"key":"1692_CR3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S1470-2045(09)70096-8","volume":"10","author":"V Bouvard","year":"2009","unstructured":"Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L et al (2009) A review of human carcinogens\u2013Part B: biological agents. Lancet Oncol 10:321\u2013322","journal-title":"Lancet Oncol"},{"key":"1692_CR4","doi-asserted-by":"publisher","first-page":"787","DOI":"10.4149\/neo_2017_518","volume":"64","author":"Y Chen","year":"2017","unstructured":"Chen Y, Wang J, Fan H, Xie J, Xu L, Zhou B (2017) Phosphorylated 4E-BP1 is associated with tumor progression and adverse prognosis in colorectal cancer. Neoplasma 64:787\u2013794","journal-title":"Neoplasma"},{"key":"1692_CR5","doi-asserted-by":"publisher","first-page":"1381467","DOI":"10.3389\/fonc.2024.1381467","volume":"14","author":"F Chen","year":"2024","unstructured":"Chen F, Xiao M, Hu S, Wang M (2024) Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer. Front Oncol 14:1381467","journal-title":"Front Oncol"},{"key":"1692_CR6","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1158\/1078-0432.CCR-08-1084","volume":"15","author":"JY Chung","year":"2009","unstructured":"Chung JY, Hong SM, Choi BY, Cho H, Yu E, Hewitt SM (2009) The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma. Clin Cancer Res 15:660\u2013667","journal-title":"Clin Cancer Res"},{"key":"1692_CR7","doi-asserted-by":"publisher","first-page":"4523","DOI":"10.1128\/JVI.02548-12","volume":"87","author":"A Di Pietro","year":"2013","unstructured":"Di Pietro A, Kajaste-Rudnitski A, Oteiza A, Nicora L, Towers GJ, Mechti N, Vicenzi E (2013) TRIM22 inhibits influenza A virus infection by targeting the viral nucleoprotein for degradation. J Virol 87:4523\u20134533","journal-title":"J Virol"},{"key":"1692_CR8","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/630543","volume":"2012","author":"G Fava","year":"2012","unstructured":"Fava G, Lorenzini I (2012) Molecular pathogenesis of cholangiocarcinoma. Int J Hepatol 2012:630543","journal-title":"Int J Hepatol"},{"key":"1692_CR9","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1038\/s12276-023-01007-y","volume":"55","author":"X Fei","year":"2023","unstructured":"Fei X, Dou YN, Sun K, Wei J, Guo Q, Wang L, Wu X, Lv W, Jiang X, Fei Z (2023) TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1. Exp Mol Med 55:1203\u20131217","journal-title":"Exp Mol Med"},{"key":"1692_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014697","volume":"6","author":"ME Folkers","year":"2011","unstructured":"Folkers ME, Delker DA, Maxwell CI, Nelson CA, Schwartz JJ, Nix DA, Hagedorn CH (2011) Encode tiling array analysis identifies differentially expressed annotated and novel 5\u2019 capped RNAs in hepatitis C infected liver. PLoS ONE 6:e14697","journal-title":"PLoS ONE"},{"key":"1692_CR11","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","volume":"22","author":"A Glaviano","year":"2023","unstructured":"Glaviano A, Foo ASC, Lam HY, Yap KCH, Jacot W, Jones RH, Eng H, Nair MG, Makvandi P, Geoerger B et al (2023) PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer. Mol Cancer 22:138","journal-title":"Mol Cancer"},{"key":"1692_CR12","doi-asserted-by":"publisher","first-page":"114473","DOI":"10.1016\/j.yexcr.2025.114473","volume":"446","author":"H Hu","year":"2025","unstructured":"Hu H, Li W, Ma P, Song J, Zhang X, Ruan L, Zhang J, Zheng Y (2025) Trim22 inhibits the metastasis of colorectal cancer through facilitating beta-catenin degradation. Exp Cell Res 446:114473","journal-title":"Exp Cell Res"},{"key":"1692_CR13","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.molcel.2013.08.003","volume":"51","author":"Y Ichimura","year":"2013","unstructured":"Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T et al (2013) Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 51:618\u2013631","journal-title":"Mol Cell"},{"key":"1692_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060869","author":"JH Jeong","year":"2021","unstructured":"Jeong JH, Yi J, Hwang MK, Hong SJ, Sohn WM, Kim TS, Pak JH (2021) The overactivation of NADPH oxidase during Clonorchis sinensis infection and the exposure to N-nitroso compounds promote periductal fibrosis. Antioxidants. https:\/\/doi.org\/10.3390\/antiox10060869","journal-title":"Antioxidants"},{"issue":"2","key":"1692_CR15","doi-asserted-by":"publisher","first-page":"02071","DOI":"10.1128\/jvi.02071-24","volume":"99","author":"A Kajaste-Rudnitski","year":"2025","unstructured":"Kajaste-Rudnitski A, Marelli SS, Pultrone C, Pertel T, Uchil PD, Mechti N, Mothes W, Poli G, Luban J, Vicenzi E (2025) Correction for Kajaste-Rudnitski et al.,\"TRIM22 Inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, tat, and NF-kappaB-responsive long terminal repeat elements\". J Virol 99(2):02071\u201302124","journal-title":"J Virol"},{"key":"1692_CR16","doi-asserted-by":"publisher","first-page":"R96","DOI":"10.1186\/bcr3557","volume":"15","author":"E Karlsson","year":"2013","unstructured":"Karlsson E, Perez-Tenorio G, Amin R, Bostner J, Skoog L, Fornander T, Sgroi DC, Nordenskjold B, Hallbeck AL, Stal O (2013) The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials. Breast Cancer Res 15:R96","journal-title":"Breast Cancer Res"},{"key":"1692_CR17","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00436-009-1662-z","volume":"106","author":"DM Kim","year":"2009","unstructured":"Kim DM, Ko BS, Ju JW, Cho SH, Yang SJ, Yeom YI, Kim TS, Won Y, Kim IC (2009) Gene expression profiling in mouse liver infected with Clonorchis sinensis metacercariae. Parasitol Res 106:269\u2013278","journal-title":"Parasitol Res"},{"key":"1692_CR18","doi-asserted-by":"publisher","first-page":"590","DOI":"10.5483\/BMBRep.2016.49.11.109","volume":"49","author":"TS Kim","year":"2016","unstructured":"Kim TS, Pak JH, Kim JB, Bahk YY (2016) Clonorchis sinensis, an oriental liver fluke, as a human biological agent of cholangiocarcinoma: a brief review. BMB Rep 49:590\u2013597","journal-title":"BMB Rep"},{"key":"1692_CR19","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s13071-021-04717-2","volume":"14","author":"JW Kim","year":"2021","unstructured":"Kim JW, Yi J, Park J, Jeong JH, Kim J, Won J, Chung S, Kim TS, Pak JH (2021) Transcriptomic profiling of three-dimensional cholangiocyte spheroids long term exposed to repetitive Clonorchis sinensis excretory-secretory products. Parasit Vectors 14:213","journal-title":"Parasit Vectors"},{"key":"1692_CR20","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1159\/000453013","volume":"32","author":"MM Kirstein","year":"2016","unstructured":"Kirstein MM, Vogel A (2016) Epidemiology and risk factors of cholangiocarcinoma. Visc Med 32:395\u2013400","journal-title":"Visc Med"},{"key":"1692_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.freeradbiomed.2020.03.023","volume":"157","author":"A Kopacz","year":"2020","unstructured":"Kopacz A, Kloska D, Forman HJ, Jozkowicz A, Grochot-Przeczek A (2020) Beyond repression of Nrf2: an update on Keap1. Free Radic Biol Med 157:63\u201374","journal-title":"Free Radic Biol Med"},{"key":"1692_CR22","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1002\/cbin.10989","volume":"42","author":"L Li","year":"2018","unstructured":"Li L, Qi Y, Ma X, Xiong G, Wang L, Bao C (2018) TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K\/Akt\/mTOR signaling pathway. Cell Biol Int 42:1192\u20131199","journal-title":"Cell Biol Int"},{"key":"1692_CR23","doi-asserted-by":"publisher","first-page":"62069","DOI":"10.18632\/oncotarget.18911","volume":"8","author":"L Liu","year":"2017","unstructured":"Liu L, Zhou XM, Yang FF, Miao Y, Yin Y, Hu XJ, Hou G, Wang QY, Kang J (2017) TRIM22 confers poor prognosis and promotes epithelial-mesenchymal transition through regulation of AKT\/GSK3beta\/beta-catenin signaling in non-small cell lung cancer. Oncotarget 8:62069\u201362080","journal-title":"Oncotarget"},{"key":"1692_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102344","volume":"53","author":"W Liu","year":"2022","unstructured":"Liu W, Zhao Y, Wang G, Feng S, Ge X, Ye W, Wang Z, Zhu Y, Cai W, Bai J et al (2022) TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS\/AMPK\/mTOR\/autophagy signaling. Redox Biol 53:102344","journal-title":"Redox Biol"},{"key":"1692_CR25","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ijpara.2015.11.003","volume":"46","author":"S Maeng","year":"2016","unstructured":"Maeng S, Lee HW, Bashir Q, Kim TI, Hong SJ, Lee TJ, Sohn WM, Na BK, Kim TS, Pak JH (2016) Oxidative stress-mediated mouse liver lesions caused by Clonorchis sinensis infection. Int J Parasitol 46:195\u2013204","journal-title":"Int J Parasitol"},{"key":"1692_CR26","doi-asserted-by":"publisher","first-page":"854","DOI":"10.3892\/ol.2014.1799","volume":"7","author":"P Moolthiya","year":"2014","unstructured":"Moolthiya P, Tohtong R, Keeratichamroen S, Leelawat K (2014) Role of mTOR inhibitor in cholangiocarcinoma cell progression. Oncol Lett 7:854\u2013860","journal-title":"Oncol Lett"},{"key":"1692_CR27","doi-asserted-by":"publisher","first-page":"105309","DOI":"10.1016\/j.actatropica.2019.105309","volume":"203","author":"BK Na","year":"2020","unstructured":"Na BK, Pak JH, Hong SJ (2020) Clonorchis sinensis and clonorchiasis. Acta Trop 203:105309","journal-title":"Acta Trop"},{"key":"1692_CR28","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ijpara.2011.11.001","volume":"42","author":"JH Nam","year":"2012","unstructured":"Nam JH, Moon JH, Kim IK, Lee MR, Hong SJ, Ahn JH, Chung JW, Pak JH (2012) Free radicals enzymatically triggered by Clonorchis sinensis excretory-secretory products cause NF-kappaB-mediated inflammation in human cholangiocarcinoma cells. Int J Parasitol 42:103\u2013113","journal-title":"Int J Parasitol"},{"key":"1692_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122345","author":"V Ngo","year":"2022","unstructured":"Ngo V, Duennwald ML (2022) Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease. Antioxidants. https:\/\/doi.org\/10.3390\/antiox11122345","journal-title":"Antioxidants"},{"key":"1692_CR30","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.parint.2010.09.008","volume":"59","author":"K Ninlawan","year":"2010","unstructured":"Ninlawan K, O\u2019Hara SP, Splinter PL, Yongvanit P, Kaewkes S, Surapaitoon A, LaRusso NF, Sripa B (2010) Opisthorchis viverrini excretory\/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte. Parasitol Int 59:616\u2013621","journal-title":"Parasitol Int"},{"key":"1692_CR31","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.1038\/sj.onc.1207524","volume":"23","author":"S Obad","year":"2004","unstructured":"Obad S, Brunnstrom H, Vallon-Christersson J, Borg A, Drott K, Gullberg U (2004) Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells. Oncogene 23:4050\u20134059","journal-title":"Oncogene"},{"issue":"8","key":"1692_CR32","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.3390\/cells10081864","volume":"10","author":"I Pagani","year":"2021","unstructured":"Pagani I, Poli G, Vicenzi E (2021) TRIM22 A multitasking antiviral factor. Cells 10(8):1864","journal-title":"Cells"},{"key":"1692_CR33","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.freeradbiomed.2016.08.016","volume":"99","author":"JH Pak","year":"2016","unstructured":"Pak JH, Son WC, Seo SB, Hong SJ, Sohn WM, Na BK, Kim TS (2016) Peroxiredoxin 6 expression is inversely correlated with nuclear factor-kappaB activation during Clonorchis sinensis infestation. Free Radic Biol Med 99:273\u2013285","journal-title":"Free Radic Biol Med"},{"key":"1692_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molbiopara.2017.03.002","volume":"214","author":"JH Pak","year":"2017","unstructured":"Pak JH, Bashir Q, Kim IK, Hong SJ, Maeng S, Bahk YY, Kim TS (2017a) Clonorchis sinensis excretory-secretory products promote the migration and invasion of cholangiocarcinoma cells by activating the integrin beta4-FAK\/Src signaling pathway. Mol Biochem Parasitol 214:1\u20139","journal-title":"Mol Biochem Parasitol"},{"key":"1692_CR35","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ijpara.2016.10.004","volume":"47","author":"JH Pak","year":"2017","unstructured":"Pak JH, Shin J, Song IS, Shim S, Jang SW (2017b) Clonorchis sinensis excretory-secretory products regulate migration and invasion in cholangiocarcinoma cells via extracellular signal-regulated kinase 1\/2\/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression. Int J Parasitol 47:51\u201359","journal-title":"Int J Parasitol"},{"key":"1692_CR36","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.2217\/pgs.15.122","volume":"16","author":"C Perez-Ramirez","year":"2015","unstructured":"Perez-Ramirez C, Canadas-Garre M, Molina MA, Faus-Dader MJ, Calleja-Hernandez MA (2015) PTEN and PI3K\/AKT in non-small-cell lung cancer. Pharmacogenomics 16:1843\u20131862","journal-title":"Pharmacogenomics"},{"key":"1692_CR37","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1002\/ijc.21893","volume":"119","author":"S Pinlaor","year":"2006","unstructured":"Pinlaor S, Hiraku Y, Yongvanit P, Tada-Oikawa S, Ma N, Pinlaor P, Sithithaworn P, Sripa B, Murata M, Oikawa S et al (2006) iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel. Int J Cancer 119:1067\u20131072","journal-title":"Int J Cancer"},{"key":"1692_CR38","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1080\/15569527.2022.2127750","volume":"41","author":"Y Ren","year":"2022","unstructured":"Ren Y, Dong H, Jin R, Jiang J, Zhang X (2022) TRIM22 actives PI3K\/Akt\/mTOR pathway to promote psoriasis through enhancing cell proliferation and inflammation and inhibiting autophagy. Cutan Ocul Toxicol 41:304\u2013309","journal-title":"Cutan Ocul Toxicol"},{"key":"1692_CR39","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1158\/1541-7786.MCR-23-0962","volume":"22","author":"T Tao","year":"2024","unstructured":"Tao T, Zhang Y, Guan C, Wang S, Liu X, Wang M (2024) Ubiquitin ligase TRIM22 inhibits ovarian cancer malignancy via TCF4 degradation. Mol Cancer Res 22:943\u2013956","journal-title":"Mol Cancer Res"},{"key":"1692_CR40","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/hep.24351","volume":"54","author":"GL Tyson","year":"2011","unstructured":"Tyson GL, El-Serag HB (2011) Risk factors for cholangiocarcinoma. Hepatology 54:173\u2013184","journal-title":"Hepatology"},{"key":"1692_CR41","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.cytogfr.2018.02.001","volume":"40","author":"E Vicenzi","year":"2018","unstructured":"Vicenzi E, Poli G (2018) The interferon-stimulated gene TRIM22: a double-edged sword in HIV-1 infection. Cytokine Growth Factor Rev 40:40\u201347","journal-title":"Cytokine Growth Factor Rev"},{"key":"1692_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.734750","volume":"11","author":"C Wang","year":"2021","unstructured":"Wang C, He Q, Yin Y, Wu Y, Li X (2021) Clonorchis sinensis granulin promotes malignant transformation of hepatocyte through EGFR-mediated RAS\/MAPK\/ERK and PI3K\/Akt signaling pathways. Front Cell Infect Microbiol 11:734750","journal-title":"Front Cell Infect Microbiol"},{"key":"1692_CR43","doi-asserted-by":"publisher","first-page":"6669","DOI":"10.1073\/pnas.0401771101","volume":"101","author":"S Wieland","year":"2004","unstructured":"Wieland S, Thimme R, Purcell RH, Chisari FV (2004) Genomic analysis of the host response to hepatitis B virus infection. Proc Natl Acad Sci U S A 101:6669\u20136674","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1692_CR44","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s13071-023-05891-1","volume":"16","author":"Y Wu","year":"2023","unstructured":"Wu Y, Deng X, Wu Z, Liu D, Fu X, Tang L, He S, Lv J, Wang J, Li Q et al (2023) Multilayer omics reveals the molecular mechanism of early infection of Clonorchis sinensis juvenile. Parasit Vectors 16:285","journal-title":"Parasit Vectors"},{"key":"1692_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217157","volume":"600","author":"Y Yang","year":"2024","unstructured":"Yang Y, Hao X, Zhang J, Gao T, Huo M, Liu W, Hu T, Ma T, Yuan B, Zhang M et al (2024) The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling. Cancer Lett 600:217157","journal-title":"Cancer Lett"},{"key":"1692_CR46","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.parint.2011.06.011","volume":"61","author":"P Yongvanit","year":"2012","unstructured":"Yongvanit P, Pinlaor S, Bartsch H (2012) Oxidative and nitrative DNA damage: key events in opisthorchiasis-induced carcinogenesis. Parasitol Int 61:130\u2013135","journal-title":"Parasitol Int"},{"key":"1692_CR47","doi-asserted-by":"publisher","first-page":"10463","DOI":"10.7314\/APJCP.2014.15.23.10463","volume":"15","author":"S Yothaisong","year":"2014","unstructured":"Yothaisong S, Thanee M, Namwat N, Yongvanit P, Boonmars T, Puapairoj A, Loilome W (2014) Opisthorchis viverrini infection activates the PI3K\/ AKT\/PTEN and Wnt\/beta-catenin signaling pathways in a Cholangiocarcinogenesis model. Asian Pac J Cancer Prev 15:10463\u201310468","journal-title":"Asian Pac J Cancer Prev"},{"key":"1692_CR48","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1084\/jem.20190251","volume":"216","author":"M Zarei","year":"2019","unstructured":"Zarei M, Du H, Nassar AH, Yan RE, Giannikou K, Johnson SH, Lam HC, Henske EP, Wang Y, Zhang T et al (2019) Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion. J Exp Med 216:2635\u20132652","journal-title":"J Exp Med"},{"key":"1692_CR49","first-page":"1225","volume":"56","author":"L Zhang","year":"2020","unstructured":"Zhang L, Zhang B, Wei M, Xu Z, Kong W, Deng K, Xu X, Zhang L, Zetahao X, Yan L (2020) TRIM22 inhibits endometrial cancer progression through the NOD2\/NF-kappaB signaling pathway and confers a favorable prognosis. Int J Oncol 56:1225\u20131239","journal-title":"Int J Oncol"},{"key":"1692_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.999380","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Zhang W, Zheng L, Guo Q (2022) The roles and targeting options of TRIM family proteins in tumor. Front Pharmacol 13:999380","journal-title":"Front Pharmacol"},{"key":"1692_CR51","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/s41420-021-00627-5","volume":"7","author":"Z Zhou","year":"2021","unstructured":"Zhou Z, Gao W, Yuan B, Zhang S, Wang K, Du T (2021) TRIM22 inhibits the proliferation of gastric cancer cells through the Smad2 protein. Cell Death Discov 7:234","journal-title":"Cell Death Discov"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01692-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-025-01692-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01692-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:02:44Z","timestamp":1769853764000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-025-01692-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["1692"],"URL":"https:\/\/doi.org\/10.1007\/s13258-025-01692-1","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"17 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest concerning this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The overall procedure and details of the animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of Inha University (approval no. INHA161208-460). 5\u20136-week-old male FVB\/NJ mice were purchased from Central Lab Animal Inc. (Seoul, Korea). The mice were housed and cared for according to the National Animal Care policies (Accredited Unit, Korea FDA; unit number 36) in the Animal Facility of Inha University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}