{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:59:53Z","timestamp":1771981193603,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s13258-025-01695-y","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:58:13Z","timestamp":1761040693000},"page":"349-368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-target mechanisms of Creatine in Parkinson's disease: an in-silico and in-vivo investigation"],"prefix":"10.1007","volume":"48","author":[{"given":"Sneha","family":"Kispotta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratap Kumar","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utkalika","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monalisa","family":"Rout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran Anjum","family":"Jew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alok","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-6126","authenticated-orcid":false,"given":"Shakti Ketan","family":"Prusty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debajyoti","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"issue":"W1","key":"1695_CR1","doi-asserted-by":"publisher","first-page":"W537","DOI":"10.1093\/nar\/gky379","volume":"46","author":"E Afgan","year":"2018","unstructured":"Afgan E, Baker D, Batut B, Van Den Beek M, Bouvier D, \u010cech M, Chilton J, Clements D, Coraor N, Gr\u00fcning BA, Guerler A (2018) The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update. Nucleic Acids Res 46(W1):W537\u2013W544. https:\/\/doi.org\/10.1093\/nar\/gky379","journal-title":"Nucleic Acids Res"},{"key":"1695_CR2","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.neuroscience.2005.03.004","volume":"133","author":"RH Andres","year":"2005","unstructured":"Andres RH, Huber AW, Schlattner U, P\u00e9rez-Bouza A, Krebs SH, Seiler RW, Wallimann T, Widmer HR (2005) Effects of creatine treatment on the survival of dopaminergic neurons in cultured fetal ventral mesencephalic tissue. Neuroscience 133:701\u2013713. https:\/\/doi.org\/10.1016\/j.neuroscience.2005.03.004","journal-title":"Neuroscience"},{"key":"1695_CR3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.5958\/0974-360X.2018.00038.0","volume":"11","author":"HS Baul","year":"2018","unstructured":"Baul HS, Rajiniraja R (2018) Favorable binding of quercetin to \u03b1-synuclein as potential target in Parkinson disease: an in silico approach. Res J Pharm Technol 11:203\u2013206. https:\/\/doi.org\/10.5958\/0974-360X.2018.00038.0","journal-title":"Res J Pharm Technol"},{"key":"1695_CR4","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41582-021-00486-9","volume":"17","author":"D Berg","year":"2021","unstructured":"Berg D, Borghammer P, Fereshtehnejad SM, Heinzel S, Horsager J, Schaeffer E, Postuma RB (2021) Prodromal Parkinson disease subtypes\u2014key to understanding heterogeneity. Nat Rev Neurol 17:349\u2013361. https:\/\/doi.org\/10.1038\/s41582-021-00486-9","journal-title":"Nat Rev Neurol"},{"key":"1695_CR5","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuint.2016.10.001","volume":"101","author":"N Bhattacharjee","year":"2016","unstructured":"Bhattacharjee N, Borah A (2016) Oxidative stress and mitochondrial dysfunction are the underlying events of dopaminergic neurodegeneration in homocysteine rat model of Parkinson\u2019s disease. Neurochem Int 101:48\u201355. https:\/\/doi.org\/10.1016\/j.neuint.2016.10.001","journal-title":"Neurochem Int"},{"key":"1695_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-020-00524-9","author":"P Biradar","year":"2020","unstructured":"Biradar P, Patil V, Joshi H, Khanal P, Mallapur S (2020) Experimental validation and network pharmacology evaluation to decipher the mechanism of action of Erythrina variegata L. bark against scopolamine-induced memory impairment in rats. Adv Tradit Med. https:\/\/doi.org\/10.1007\/s13596-020-00524-9","journal-title":"Adv Tradit Med"},{"key":"1695_CR7","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.addr.2008.06.002","volume":"60","author":"M Bortolato","year":"2008","unstructured":"Bortolato M, Chen K, Shih JC (2008) Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliv Rev 60:1527\u20131533. https:\/\/doi.org\/10.1016\/j.addr.2008.06.002","journal-title":"Adv Drug Deliv Rev"},{"key":"1695_CR9","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/S1474-4422(10)70218-0","volume":"9","author":"P Calabresi","year":"2010","unstructured":"Calabresi P, Di Filippo M, Ghiglieri V, Tambasco N, Picconi B (2010) Levodopa-induced dyskinesias in patients with Parkinson\u2019s disease: filling the bench-to-bedside gap. Lancet Neurol 9:1106\u20131117. https:\/\/doi.org\/10.1016\/S1474-4422(10)70218-0","journal-title":"Lancet Neurol"},{"key":"1695_CR10","doi-asserted-by":"publisher","first-page":"105587","DOI":"10.1016\/j.clineuro.2019.105587","volume":"188","author":"B Dong","year":"2020","unstructured":"Dong B, Wu R (2020) Plasma homocysteine, folate and vitamin B12 levels in Parkinson\u2019s disease in China: a meta-analysis. Clin Neurol Neurosurg 188:105587. https:\/\/doi.org\/10.1016\/j.clineuro.2019.105587","journal-title":"Clin Neurol Neurosurg"},{"key":"1695_CR04","doi-asserted-by":"publisher","unstructured":"Essmann U, Perera L, Berkowitz ML, Darden T, Lee H, Pedersen LG (1995) A smooth particle mesh Ewald method. J Chem Phys 103(19):8577\u20138593. https:\/\/doi.org\/10.1063\/1.470117","DOI":"10.1063\/1.470117"},{"key":"1695_CR11","doi-asserted-by":"publisher","first-page":"8043","DOI":"10.3390\/ijms21218043","volume":"21","author":"P Gracia","year":"2020","unstructured":"Gracia P, Camino JD, Volpicelli-Daley L, Cremades N (2020) Multiplicity of \u03b1-synuclein aggregated species and their possible roles in disease. Int J Mol Sci 21:8043. https:\/\/doi.org\/10.3390\/ijms21218043","journal-title":"Int J Mol Sci"},{"key":"1695_CR02","doi-asserted-by":"publisher","unstructured":"Holian BL, Evans DJ (1985) Classical response theory in the Heisenberg picture. J Chem Phys 87(7):5143\u20135150. https:\/\/doi.org\/10.1063\/1.4531213","DOI":"10.1063\/1.4531213"},{"issue":"6","key":"1695_CR12","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1107\/S2059798322002741","volume":"78","author":"G Jones","year":"2022","unstructured":"Jones G, Jindal A, Ghani U, Kotelnikov S, Egbert M, Hashemi N, Vajda S, Padhorny D, Kozakov D (2022) Elucidation of protein function using computational docking and hotspot analysis by ClusPro and FTMap. Biol Crystallogr 78(6):690\u2013697. https:\/\/doi.org\/10.1107\/S2059798322002741","journal-title":"Biol Crystallogr"},{"key":"1695_CR13","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1016\/j.apsb.2020.04.009","volume":"10","author":"S Kang","year":"2020","unstructured":"Kang S, Yang M, Hong Z, Zhang L, Huang Z, Chen X, He S, Zhou Z, Zhou Z, Chen Q, Yan Y (2020) Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. Acta Pharm Sin B 10:1228\u20131238. https:\/\/doi.org\/10.1016\/j.apsb.2020.04.009","journal-title":"Acta Pharm Sin B"},{"key":"1695_CR14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11030-012-9420-z","volume":"17","author":"P Kare","year":"2013","unstructured":"Kare P, Bhat J, Sobhia ME (2013) Structure-based design and analysis of MAO-B inhibitors for Parkinson\u2019s disease: Using in silico approaches. Mol Divers 17:111\u2013122. https:\/\/doi.org\/10.1007\/s11030-012-9420-z","journal-title":"Mol Divers"},{"issue":"5","key":"1695_CR15","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nprot.2015.043","volume":"10","author":"D Kozakov","year":"2015","unstructured":"Kozakov D, Grove LE, Hall DR, Bohnuud T, Mottarella SE, Luo L, Xia B, Beglov D, Vajda S (2015) The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins. Nat Protoc 10(5):733\u2013755. https:\/\/doi.org\/10.1038\/nprot.2015.043","journal-title":"Nat Protoc"},{"key":"1695_CR16","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s00213-008-1300-y","volume":"201","author":"SK Kulkarni","year":"2008","unstructured":"Kulkarni SK, Bhutani MK, Bishnoi M (2008) Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology 201:435\u2013442. https:\/\/doi.org\/10.1007\/s00213-008-1300-y","journal-title":"Psychopharmacology"},{"key":"1695_CR17","doi-asserted-by":"publisher","first-page":"10478","DOI":"10.3390\/ijms130810478","volume":"13","author":"H Kumar","year":"2012","unstructured":"Kumar H, Lim HW, More SV, Kim BW, Koppula S, Kim IS, Choi DK (2012) The role of free radicals in the aging brain and Parkinson\u2019s disease: convergence and parallelism. Int J Mol Sci 13:10478\u201310504. https:\/\/doi.org\/10.3390\/ijms130810478","journal-title":"Int J Mol Sci"},{"issue":"12","key":"1695_CR18","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1002\/prot.24422","volume":"81","author":"A Lavi","year":"2013","unstructured":"Lavi A, Ngan CH, Movshovitz-Attias D, Bohnuud T, Yueh C, Beglov D et al (2013) Detection of peptide-binding sites on protein surfaces: the first step toward the modeling and targeting of peptide-mediated interactions. Proteins Struct Funct Bioinform 81(12):2096\u20132105","journal-title":"Proteins Struct Funct Bioinform"},{"key":"1695_CR19","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","volume":"15","author":"CW Law","year":"2014","unstructured":"Law CW, Chen Y, Shi W, Smyth GK (2014) voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol 15:R29. https:\/\/doi.org\/10.1186\/gb-2014-15-2-r29","journal-title":"Genome Biol"},{"key":"1695_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s12539-020-00359-7","volume":"12","author":"L Li","year":"2020","unstructured":"Li L, Qiu H, Liu M, Cai Y (2020) A network pharmacology-based study of the molecular mechanisms of Shaoyao-Gancao decoction in treating Parkinson\u2019s disease. Interdiscip Sci Comput Life Sci 12:131\u2013144. https:\/\/doi.org\/10.1007\/s12539-020-00359-7","journal-title":"Interdiscip Sci Comput Life Sci"},{"key":"1695_CR21","doi-asserted-by":"publisher","first-page":"e97","DOI":"10.1093\/nar\/gkv412","volume":"43","author":"R Liu","year":"2015","unstructured":"Liu R, Holik AZ, Su S, Jansz N, Chen K, Leong HS, Blewitt ME, Asselin-Labat ML, Smyth GK, Ritchie ME (2015) Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses. Nucleic Acids Res 43:e97. https:\/\/doi.org\/10.1093\/nar\/gkv412","journal-title":"Nucleic Acids Res"},{"key":"1695_CR22","doi-asserted-by":"publisher","unstructured":"Lopina OD (2017) Enzyme inhibitors and activators. In: Enzyme inhibitors and activators. IntechOpen. https:\/\/doi.org\/10.5772\/67248","DOI":"10.5772\/67248"},{"key":"1695_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-019-0329-1","volume":"14","author":"RM Meade","year":"2019","unstructured":"Meade RM, Fairlie DP, Mason JM (2019) Alpha-synuclein structure and Parkinson\u2019s disease: lessons and emerging principles. Mol Neurodegener 14:1\u20134. https:\/\/doi.org\/10.1186\/s13024-019-0329-1","journal-title":"Mol Neurodegener"},{"key":"1695_CR24","doi-asserted-by":"publisher","first-page":"e08935","DOI":"10.1016\/j.heliyon.2022.e08935","volume":"8","author":"D Mohapatra","year":"2022","unstructured":"Mohapatra D, Kanungo S, Pradhan SP, Jena S, Prusty SK, Sahu PK (2022) Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD-like pathology. Heliyon 8:e08935. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e08935","journal-title":"Heliyon"},{"key":"1695_CR25","doi-asserted-by":"publisher","first-page":"203","DOI":"10.5958\/0974-360X.2018.00038.0","volume":"11","author":"R Muniyan","year":"2018","unstructured":"Muniyan R (2018) Favorable binding of Quercetin to \u03b1-Synuclein as potential target in Parkinson disease: an in silico approach. Res J Pharm Technol 11:203\u2013206. https:\/\/doi.org\/10.5958\/0974-360X.2018.00038.0","journal-title":"Res J Pharm Technol"},{"issue":"Suppl 1","key":"1695_CR26","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/s1471-1931(00)00031-8","volume":"23","author":"JA Obeso","year":"2000","unstructured":"Obeso JA, Olanow CW, Nutt JG (2000) Levodopa motor complications in Parkinson\u2019s disease. Trends Neurosci 23(Suppl 1):S2\u2013S7. https:\/\/doi.org\/10.1016\/s1471-1931(00)00031-8","journal-title":"Trends Neurosci"},{"key":"1695_CR03","doi-asserted-by":"publisher","unstructured":"Parrinello M, Rahman A (1981) Polymorphic transitions in single crystals: a new molecular dynamics method. J Appl Phys 52(12):7182\u20137190. https:\/\/doi.org\/10.1063\/1.3286934","DOI":"10.1063\/1.3286934"},{"key":"1695_CR27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.4103\/0253-7613.32526","volume":"39","author":"S Pemminati","year":"2007","unstructured":"Pemminati S, Nair V, Dorababu P, Gopalakrishna HN, Pai MR (2007) Effect of ethanolic leaf extract of Ocimum sanctum on -induced catalepsy in albino mice. Indian J Pharmacol 39:87\u201389. https:\/\/doi.org\/10.4103\/0253-7613.32526","journal-title":"Indian J Pharmacol"},{"key":"1695_CR28","doi-asserted-by":"publisher","first-page":"839","DOI":"10.3390\/pharmaceutics15030839","volume":"15","author":"S Pe\u00f1a-D\u00edaz","year":"2023","unstructured":"Pe\u00f1a-D\u00edaz S, Garc\u00eda-Pardo J, Ventura S (2023) Development of small molecules targeting \u03b1-synuclein aggregation: a promising strategy to treat Parkinson\u2019s disease. Pharmaceutics 15:839. https:\/\/doi.org\/10.3390\/pharmaceutics15030839","journal-title":"Pharmaceutics"},{"key":"1695_CR29","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0031-6997(24)01490-X","volume":"53","author":"AM Persky","year":"2001","unstructured":"Persky AM, Brazeau GA (2001) Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol Rev 53:161\u2013176. https:\/\/doi.org\/10.1016\/S0031-6997(24)01490-X","journal-title":"Pharmacol Rev"},{"issue":"6","key":"1695_CR30","doi-asserted-by":"publisher","first-page":"10837","DOI":"10.53879\/id.54.06.10837","volume":"54","author":"SK Prusty","year":"2017","unstructured":"Prusty SK, Pati AK, Subudhi BB, Sahu PK (2017) Chronic forced swimming induced stress alters behavioural, histological and anti-oxidant status. Indian Drugs 54(6):10837. https:\/\/doi.org\/10.53879\/id.54.06.10837","journal-title":"Indian Drugs"},{"key":"1695_CR32","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s13530-020-00056-4","volume":"12","author":"K-T Rim","year":"2020","unstructured":"Rim K-T (2020) In silico prediction of toxicity and its applications for chemicals at work. Toxicol Environ Health Sci 12:191\u2013202. https:\/\/doi.org\/10.1007\/s13530-020-00056-4","journal-title":"Toxicol Environ Health Sci"},{"key":"1695_CR33","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.2174\/1389201024666221121160822","volume":"24","author":"Z Roy","year":"2023","unstructured":"Roy Z, Bansal R, Siddiqui L, Chaudhary N (2023) Understanding the role of free radicals and antioxidant enzymes in human diseases. Curr Pharm Biotechnol 24:1265\u20131276. https:\/\/doi.org\/10.2174\/1389201024666221121160822","journal-title":"Curr Pharm Biotechnol"},{"issue":"10 Suppl 4","key":"1695_CR34","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1212\/wnl.66.10_suppl_4.s10","volume":"66","author":"AH Schapira","year":"2006","unstructured":"Schapira AH (2006) Etiology of Parkinson\u2019s disease. Neurology 66(10 Suppl 4):S10\u2013S23. https:\/\/doi.org\/10.1212\/wnl.66.10_suppl_4.s10","journal-title":"Neurology"},{"issue":"6","key":"1695_CR35","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1261\/rna.053959.115","volume":"22","author":"NJ Schurch","year":"2016","unstructured":"Schurch NJ, Schofield P, Gierli\u0144ski M, Cole C, Sherstnev A, Singh V et al (2016) How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use? RNA 22(6):839\u2013851","journal-title":"RNA"},{"key":"1695_CR36","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.1097\/JS9.0000000000001279","volume":"110","author":"N Shaheen","year":"2024","unstructured":"Shaheen N, Flouty O (2024) Unlocking the future of deep brain stimulation: innovations, challenges, and promising horizons. Int J Surg 110:3146\u20133148. https:\/\/doi.org\/10.1097\/JS9.0000000000001279","journal-title":"Int J Surg"},{"issue":"3","key":"1695_CR37","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s11011-019-00526-w","volume":"35","author":"B Singh","year":"2020","unstructured":"Singh B, Pandey S, Rumman M, Mahdi AA (2020) Neuroprotective effects of Bacopa monnieri in Parkinson\u2019s disease model. Metab Brain Dis 35(3):517\u2013525","journal-title":"Metab Brain Dis"},{"key":"1695_CR38","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1208\/s12248-018-0270-1","volume":"20","author":"BB Subudhi","year":"2018","unstructured":"Subudhi BB, Sahu PK, Singh VK, Prusty S (2018) Conjugation to ascorbic acid enhances brain availability of losartan carboxylic acid and protects against parkinsonism in rats. AAPS J 20:110. https:\/\/doi.org\/10.1208\/s12248-018-0270-1","journal-title":"AAPS J"},{"key":"1695_CR39","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1212\/WNL.0b013e3181fd613b","volume":"75","author":"T Tokuda","year":"2010","unstructured":"Tokuda T, Qureshi MM, Ardah MT, Varghese S, Shehab SA, Kasai T, Ishigami N, Tamaoka A, Nakagawa M, El-Agnaf OM (2010) Detection of elevated levels of \u03b1-synuclein oligomers in CSF from patients with Parkinson disease. Neurology 75:1766\u20131770. https:\/\/doi.org\/10.1212\/WNL.0b013e3181fd613b","journal-title":"Neurology"},{"key":"1695_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11011-021-00878-2","volume":"37","author":"A Vannur","year":"2022","unstructured":"Vannur A, Biradar PR, Patil V (2022) Experimental validation of Vitex negundo leaves hydroalcoholic extract for neuroprotection in haloperidol-induced Parkinson\u2019s disease in rat. Metab Brain Dis 37:1\u20136. https:\/\/doi.org\/10.1007\/s11011-021-00878-2","journal-title":"Metab Brain Dis"},{"key":"1695_CR01","doi-asserted-by":"publisher","unstructured":"Vanommeslaeghe K, Hatcher E, Acharya C, Kundu S, Zhong S, Shim J, Darian E, Guvench O, Lopes P, Vorobyov I, Mackerell AD Jr (2010) CHARMM general force field: a force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields. J Comput Chem 31(4):671\u2013690. https:\/\/doi.org\/10.1002\/jcc.213672","DOI":"10.1002\/jcc.213672"},{"key":"1695_CR41","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1159\/000517750","volume":"55","author":"F Vial","year":"2021","unstructured":"Vial F, Delgado I, Idiaquez JF, Canals F, Chana-Cuevas P (2021) Epidemiology of Parkinson\u2019s disease in Chile. Neuroepidemiology 55:393\u2013397. https:\/\/doi.org\/10.1159\/000517750","journal-title":"Neuroepidemiology"},{"key":"1695_CR42","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1177\/0300985815623997","volume":"53","author":"SA Youssef","year":"2016","unstructured":"Youssef SA, Capucchio MT, Rofina JE, Chambers JK, Uchida K, Nakayama H, Head E (2016) Pathology of the aging brain in domestic and laboratory animals, and animal models of human neurodegenerative diseases. Vet Pathol 53:327\u2013348. https:\/\/doi.org\/10.1177\/0300985815623997","journal-title":"Vet Pathol"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01695-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-025-01695-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-025-01695-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:08:43Z","timestamp":1771978123000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-025-01695-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["1695"],"URL":"https:\/\/doi.org\/10.1007\/s13258-025-01695-y","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"28 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There is no conflict of interest to proclaim\n                      .","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Animal Ethics Committee, which authorized the experimental protocols (IAEC\/SPS\/SOA\/115\/2023) and conducted them\u00a0in compliance with the CPCSEA norms.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The informed consent was acquired from all participants in this study but is not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}