{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T10:14:51Z","timestamp":1778062491928,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The high-level talents scientific research start-up funds of the Affliated Hospital of Guangdong Medical University","award":["GCC2022029"],"award-info":[{"award-number":["GCC2022029"]}]},{"name":"Zhanjiang unfunded Science and Technology Research Plan project","award":["2024B01292"],"award-info":[{"award-number":["2024B01292"]}]},{"name":"Youth Research Foundation of Guangdong Medical University","award":["GDMUQ2021035"],"award-info":[{"award-number":["GDMUQ2021035"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genes Genom"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s13258-026-01740-4","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:47:44Z","timestamp":1771926464000},"page":"659-671","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histone lactatation-related genes GPR19 and SLC22A16 are important diagnostic markers and drug treatment targets for prostate cancer"],"prefix":"10.1007","volume":"48","author":[{"given":"Yunkun","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mushi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianchang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"issue":"2","key":"1740_CR16","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"J Bowden","year":"2015","unstructured":"Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect Estimation and bias detection through Egger regression. Int J Epidemiol 44(2):512\u2013525","journal-title":"Int J Epidemiol"},{"issue":"4","key":"1740_CR17","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"J Bowden","year":"2016","unstructured":"Bowden J, Davey Smith G, Haycock PC, Burgess S (2016) Consistent Estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40(4):304\u2013314","journal-title":"Genet Epidemiol"},{"issue":"3","key":"1740_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229\u2013263","journal-title":"CA Cancer J Clin"},{"key":"1740_CR6","doi-asserted-by":"publisher","first-page":"101454","DOI":"10.1016\/j.redox.2020.101454","volume":"35","author":"GA Brooks","year":"2020","unstructured":"Brooks GA (2020) Lactate as a fulcrum of metabolism. Redox Biol 35:101454","journal-title":"Redox Biol"},{"issue":"7","key":"1740_CR18","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","volume":"30","author":"S Burgess","year":"2015","unstructured":"Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG (2015) Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30(7):543\u2013552","journal-title":"Eur J Epidemiol"},{"issue":"12","key":"1740_CR22","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/nrurol.2013.195","volume":"10","author":"DT Chang","year":"2013","unstructured":"Chang DT, Challacombe B, Lawrentschuk N (2013) Transperineal biopsy of the prostate\u2013is this the future. Nat Rev Urol 10(12):690\u2013702","journal-title":"Nat Rev Urol"},{"issue":"1","key":"1740_CR3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.eururo.2019.08.005","volume":"77","author":"MB Culp","year":"2020","unstructured":"Culp MB, Soerjomataram I, Efstathiou JA, Bray F, Jemal A (2020) Recent global patterns in prostate cancer incidence and mortality rates. Eur Urol 77(1):38\u201352","journal-title":"Eur Urol"},{"issue":"1","key":"1740_CR28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s43046-021-00082-4","volume":"33","author":"GA Dos Santos","year":"2021","unstructured":"Dos Santos GA, Viana NI, Pimenta R et al (2021) Prognostic value of TERF1 expression in prostate cancer. J Egypt Natl Canc Inst 33(1):24","journal-title":"J Egypt Natl Canc Inst"},{"key":"1740_CR21","doi-asserted-by":"publisher","first-page":"695865","DOI":"10.3389\/fimmu.2021.695865","volume":"12","author":"D Fu","year":"2021","unstructured":"Fu D, Zhang B, Wu S et al (2021) Prognosis and characterization of immune microenvironment in acute myeloid leukemia through identification of an Autophagy-Related signature. Front Immunol 12:695865","journal-title":"Front Immunol"},{"issue":"5","key":"1740_CR27","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.prp.2018.03.002","volume":"214","author":"L Gao","year":"2018","unstructured":"Gao L, Zhang LJ, Li SH et al (2018) Role of miR-452-5p in the tumorigenesis of prostate cancer: A study based on the cancer genome Atl(TCGA), gene expression omnibus (GEO), and bioinformatics analysis. Pathol Res Pract 214(5):732\u2013749","journal-title":"Pathol Res Pract"},{"issue":"1","key":"1740_CR23","doi-asserted-by":"publisher","first-page":"18993","DOI":"10.1038\/s41598-023-46395-3","volume":"13","author":"L Gerlach","year":"2023","unstructured":"Gerlach L, Beyer AL, Kaemmerer D et al (2023) Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues. Sci Rep 13(1):18993","journal-title":"Sci Rep"},{"key":"1740_CR20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann S, Castelo R, Guinney J (2013) GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14:7","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"1740_CR19","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1093\/ije\/dyx102","volume":"46","author":"FP Hartwig","year":"2017","unstructured":"Hartwig FP, Davey Smith G, Bowden J (2017) Robust inference in summary data Mendelian randomization via the zero modal Pleiotropy assumption. Int J Epidemiol 46(6):1985\u20131998","journal-title":"Int J Epidemiol"},{"key":"1740_CR15","doi-asserted-by":"publisher","first-page":"e34408","DOI":"10.7554\/eLife.34408","volume":"7","author":"G Hemani","year":"2018","unstructured":"Hemani G, Zheng J, Elsworth B et al (2018) The MR-Base platform supports systematic causal inference across the human phenome. Elife 7:e34408","journal-title":"Elife"},{"issue":"3","key":"1740_CR5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.tibs.2019.12.004","volume":"45","author":"MV Liberti","year":"2020","unstructured":"Liberti MV, Locasale JW (2020) Histone lactylation: A new role for glucose metabolism. Trends Biochem Sci 45(3):179\u2013182","journal-title":"Trends Biochem Sci"},{"issue":"12","key":"1740_CR13","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated Estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15(12):550","journal-title":"Genome Biol"},{"issue":"7043","key":"1740_CR26","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nature03702","volume":"435","author":"J Lu","year":"2005","unstructured":"Lu J, Getz G, Miska EA et al (2005) MicroRNA expression profiles classify human cancers. Nature 435(7043):834\u2013838","journal-title":"Nature"},{"key":"1740_CR8","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1017\/erm.2022.42","volume":"25","author":"X Lv","year":"2023","unstructured":"Lv X, Lv Y, Dai X (2023) Lactate, histone lactylation and cancer hallmarks. Expert Rev Mol Med 25:e7","journal-title":"Expert Rev Mol Med"},{"issue":"3","key":"1740_CR10","doi-asserted-by":"publisher","first-page":"eabi6696","DOI":"10.1126\/sciadv.abi6696","volume":"8","author":"C Moreno-Yruela","year":"2022","unstructured":"Moreno-Yruela C, Zhang D, Wei W et al (2022) Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Sci Adv 8(3):eabi6696","journal-title":"Sci Adv"},{"issue":"12","key":"1740_CR2","doi-asserted-by":"publisher","first-page":"a030361","DOI":"10.1101\/cshperspect.a030361","volume":"8","author":"CH Pernar","year":"2018","unstructured":"Pernar CH, Ebot EM, Wilson KM, Mucci LA (2018) The epidemiology of prostate cancer. Cold Spring Harb Perspect Med 8(12):a030361","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1740_CR9","doi-asserted-by":"publisher","first-page":"1284344","DOI":"10.3389\/fimmu.2023.1284344","volume":"14","author":"J Qu","year":"2023","unstructured":"Qu J, Li P, Sun Z (2023) Histone lactylation regulates cancer progression by reshaping the tumor microenvironment. Front Immunol 14:1284344","journal-title":"Front Immunol"},{"issue":"7","key":"1740_CR24","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.bbamcr.2017.05.001","volume":"1864","author":"A Rao","year":"2017","unstructured":"Rao A, Herr DR (2017) G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells. Biochim Biophys Acta Mol Cell Res 1864(7):1318\u20131327","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"4","key":"1740_CR29","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1039\/C7BM01201B","volume":"6","author":"G Wang","year":"2018","unstructured":"Wang G, Zhang D, Yang S, Wang Y, Tang Z, Fu X (2018) Co-administration of genistein with doxorubicin-loaded polypeptide nanoparticles weakens the metastasis of malignant prostate cancer by amplifying oxidative damage. Biomater Sci 6(4):827\u2013835","journal-title":"Biomater Sci"},{"issue":"11","key":"1740_CR11","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1161\/CIRCRESAHA.122.320488","volume":"131","author":"N Wang","year":"2022","unstructured":"Wang N, Wang W, Wang X et al (2022) Histone lactylation boosts reparative gene activation Post-Myocardial infarction. Circ Res 131(11):893\u2013908","journal-title":"Circ Res"},{"issue":"2","key":"1740_CR4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1037\/a0037357","volume":"70","author":"J Wardle","year":"2015","unstructured":"Wardle J, Robb K, Vernon S, Waller J (2015) Screening for prevention and early diagnosis of cancer. Am Psychol 70(2):119\u2013133","journal-title":"Am Psychol"},{"issue":"8","key":"1740_CR25","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1007\/s10495-015-1137-x","volume":"20","author":"Y Wu","year":"2015","unstructured":"Wu Y, Hurren R, MacLean N et al (2015) Carnitine transporter CT2 (SLC22A16) is over-expressed in acute myeloid leukemia (AML) and target knockdown reduces growth and viability of AML cells. Apoptosis 20(8):1099\u20131108","journal-title":"Apoptosis"},{"issue":"3","key":"1740_CR14","first-page":"100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu T, Hu E, Xu S et al (2021) ClusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innov (Camb) 2(3):100141","journal-title":"Innov (Camb)"},{"issue":"1","key":"1740_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13059-021-02308-z","volume":"22","author":"J Yu","year":"2021","unstructured":"Yu J, Chai P, Xie M et al (2021) Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma. Genome Biol 22(1):85","journal-title":"Genome Biol"},{"issue":"7779","key":"1740_CR7","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","volume":"574","author":"D Zhang","year":"2019","unstructured":"Zhang D, Tang Z, Huang H et al (2019) Metabolic regulation of gene expression by histone lactylation. Nature 574(7779):575\u2013580","journal-title":"Nature"}],"container-title":["Genes & Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-026-01740-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13258-026-01740-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13258-026-01740-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:36:59Z","timestamp":1778060219000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13258-026-01740-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["1740"],"URL":"https:\/\/doi.org\/10.1007\/s13258-026-01740-4","relation":{},"ISSN":["1976-9571","2092-9293"],"issn-type":[{"value":"1976-9571","type":"print"},{"value":"2092-9293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"11 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors approved this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}]}}