{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:31:43Z","timestamp":1791199903091,"version":"4.2.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,10,20]],"date-time":"2012-10-20T00:00:00Z","timestamp":1350691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1007\/s13277-012-0554-5","type":"journal-article","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T03:42:19Z","timestamp":1350618139000},"page":"329-336","source":"Crossref","is-referenced-by-count":61,"title":["Characterization of H3K9me3- and H4K20me3-associated circulating nucleosomal DNA by high-throughput sequencing in colorectal cancer"],"prefix":"10.1007","volume":"34","author":[{"given":"Ugur","family":"Gezer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duran","family":"\u00dcstek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru E.","family":"Y\u00f6r\u00fcker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Cakiris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan","family":"Abaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Leszinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nejat","family":"Dalay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Holdenrieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,10,20]]},"reference":[{"key":"554_CR1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2174\/156652410790963295","volume":"10","author":"VV Vlassov","year":"2010","unstructured":"Vlassov VV, Laktionov PP, Rykova EY. Circulating nucleic acids as a potential source for cancer biomarkers. Curr Mol Med. 2010;10:142\u201365.","journal-title":"Curr Mol Med."},{"key":"554_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408360802485875","volume":"46","author":"S Holdenrieder","year":"2009","unstructured":"Holdenrieder S, Stieber P. Clinical use of circulating nucleosomes. Crit Rev Clin Lab Sci. 2009;46:1\u201324.","journal-title":"Crit Rev Clin Lab Sci."},{"key":"554_CR3","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1093\/clinchem\/48.8.1212","volume":"48","author":"EK Ng","year":"2002","unstructured":"Ng EK, Tsui NB, Lam NY, Chiu RW, Yu SC, Wong SC, et al. Presence of filterable and nonfilterable mRNA in the plasma of cancer patients and healthy individuals. Clin Chem. 2002;48:1212\u20137.","journal-title":"Clin Chem."},{"key":"554_CR4","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1373\/clinchem.2007.101766","volume":"54","author":"U Deligezer","year":"2008","unstructured":"Deligezer U, Akisik EE, Erten N, Dalay N. Sequence-specific histone methylation is detectable on circulating nucleosomes in plasma. Clin Chem. 2008;54:1125\u201331.","journal-title":"Clin Chem."},{"key":"554_CR5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng1531","volume":"37","author":"MF Fraga","year":"2005","unstructured":"Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet. 2005;37:391\u2013400.","journal-title":"Nat Genet."},{"key":"554_CR6","doi-asserted-by":"crossref","first-page":"7237","DOI":"10.1158\/1078-0432.CCR-08-0869","volume":"14","author":"A Broeck van den","year":"2008","unstructured":"van den Broeck A, Brambilla E, Moro-Sibilot D, Lantuejoul S, Brambilla C, Eymin B, et al. Loss of histone H4K20 trimethylation occurs in preneoplasia and influences prognosis of non-small cell lung cancer. Clin Cancer Res. 2008;14:7237\u201345.","journal-title":"Clin Cancer Res."},{"key":"554_CR7","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S1097-2765(03)00477-5","volume":"12","author":"AH Peters","year":"2003","unstructured":"Peters AH, Kubicek S, Mechtler K, O'Sullivan RJ, Derijck AA, Perez-Burgos L, et al. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell. 2003;12:1577\u201389.","journal-title":"Mol Cell."},{"key":"554_CR8","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S1097-2765(03)00479-9","volume":"12","author":"JC Rice","year":"2003","unstructured":"Rice JC, Briggs SD, Ueberheide B, Barber CM, Shabanowitz J, Hunt DF, et al. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell. 2003;12:1591\u20138.","journal-title":"Mol Cell."},{"key":"554_CR9","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","volume":"129","author":"A Barski","year":"2007","unstructured":"Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, et al. High-resolution profiling of histone methylations in the human genome. Cell. 2007;129:823\u201337.","journal-title":"Cell."},{"key":"554_CR10","first-page":"97","volume-title":"Circulating nucleic acids in plasma and serum","author":"U Deligezer","year":"2011","unstructured":"Deligezer U, Akisik EZ, Akisik EE, Kovancilar M, Bugra D, Erten N, et al. H3K9me3\/H4K20me3 ratio in circulating nucleosomes as potential biomarker for colorectal cancer. In: Gahan PB, editor. Circulating nucleic acids in plasma and serum. Heidelberg: Springer; 2011. p. 97\u2013103."},{"key":"554_CR11","first-page":"2199","volume":"32","author":"G Leszinski","year":"2012","unstructured":"Leszinski G, Gezer U, Siegele B, Stoetzer OJ, Holdenrieder S. Histone modifications H3K9me3 and H4K20me3 on circulating nucleosomes in cancer disease. Anticancer Res. 2012;32:2199\u2013206.","journal-title":"Anticancer Res."},{"key":"554_CR12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cca.2009.08.011","volume":"409","author":"M Vaart van der","year":"2009","unstructured":"van der Vaart M, Semenov DV, Kuligina EV. Characterization of circulating DNA by parallel tagged sequencing on the 454 platform. Clin Chim Acta. 2009;409:21\u20137.","journal-title":"Clin Chim Acta."},{"key":"554_CR13","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1373\/clinchem.2008.113597","volume":"55","author":"J Beck","year":"2009","unstructured":"Beck J, Urnovitz HB, Riggert J, Clerici M, Sch\u00fctz E. Profile of the circulating DNA in apparently healthy individuals. Clin Chem. 2009;55:730\u20138.","journal-title":"Clin Chem."},{"key":"554_CR14","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/sj.emboj.7600545","volume":"24","author":"JH Martens","year":"2005","unstructured":"Martens JH, O'Sullivan RJ, Braunschweig U, Opravil S, Radolf M, Steinlein P, Jenuwein T. The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J. 2005;24:800\u201312.","journal-title":"EMBO J."},{"key":"554_CR15","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature06008","volume":"448","author":"TS Mikkelsen","year":"2007","unstructured":"Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature. 2007;448:553\u201360.","journal-title":"Nature"},{"key":"554_CR16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1759-8753-1-2","volume":"1","author":"A Huda","year":"2010","unstructured":"Huda A, Mari\u00f1o-Ram\u00edrez L, Jordan IK. Epigenetic histone modifications of human transposable elements: genome defense versus exaptation. Mob DNA. 2010;1:2.","journal-title":"Mob DNA."},{"key":"554_CR17","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1128\/MCB.01684-06","volume":"27","author":"A Kim","year":"2007","unstructured":"Kim A, Kiefer CM, Dean A. Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences. Mol Cell Biol. 2007;27:1271\u20139.","journal-title":"Mol Cell Biol."},{"key":"554_CR18","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.1128\/MCB.01529-06","volume":"26","author":"CR Vakoc","year":"2006","unstructured":"Vakoc CR, Sachdeva MM, Wang H, Blobel GA. Profile of histone lysine methylation across transcribed mammalian chromatin. Mol Cell Biol. 2006;26:9185\u201395.","journal-title":"Mol Cell Biol."},{"key":"554_CR19","unstructured":"Scherer S. A short guide to the human genome. Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press; 2008."},{"key":"554_CR20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.tig.2004.08.008","volume":"20","author":"MK Rudd","year":"2004","unstructured":"Rudd MK, Willard HF. Analysis of the centromeric regions of the human genome assembly. Trends Genet. 2004;20:529\u201333.","journal-title":"Trends Genet."},{"key":"554_CR21","doi-asserted-by":"crossref","first-page":"e6659","DOI":"10.1371\/journal.pone.0006659","volume":"4","author":"SI Nikolaev","year":"2009","unstructured":"Nikolaev SI, Iseli C, Sharp AJ, Robyr D, Rougemont J, Gehrig C, et al. Detection of genomic variation by selection of a 9 mb DNA region and high throughput sequencing. PLoS One. 2009;4:e6659.","journal-title":"PLoS One."}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-012-0554-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-012-0554-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-012-0554-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T23:29:42Z","timestamp":1594769382000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-012-0554-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,20]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["554"],"URL":"https:\/\/doi.org\/10.1007\/s13277-012-0554-5","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,20]]}}}