{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:05:28Z","timestamp":1791309928896,"version":"4.3.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,2,17]],"date-time":"2013-02-17T00:00:00Z","timestamp":1361059200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s13277-013-0688-0","type":"journal-article","created":{"date-parts":[[2013,2,16]],"date-time":"2013-02-16T06:46:52Z","timestamp":1360997212000},"page":"1579-1588","source":"Crossref","is-referenced-by-count":57,"title":["Overexpression of microRNA-21 regulating PDCD4 during tumorigenesis of liver fluke-associated cholangiocarcinoma contributes to tumor growth and metastasis"],"prefix":"10.1007","volume":"34","author":[{"given":"P.","family":"Chusorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Namwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Loilome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Techasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pairojkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Khuntikeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dechakhamphu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Talabnin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Chan-On","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. T.","family":"Teh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Yongvanit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,17]]},"reference":[{"issue":"9493","key":"688_CR1","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0140-6736(05)67530-7","volume":"366","author":"SA Khan","year":"2005","unstructured":"Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD. Cholangiocarcinoma. Lancet. 2005;366(9493):1303\u201314.","journal-title":"Lancet"},{"issue":"2","key":"688_CR2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-2004-828889","volume":"24","author":"Y Shaib","year":"2004","unstructured":"Shaib Y, El-Serag HB. The epidemiology of cholangiocarcinoma. Semin Liver Dis. 2004;24(2):115\u201325.","journal-title":"Semin Liver Dis"},{"issue":"1","key":"688_CR3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/ncpgasthep0389","volume":"3","author":"T Patel","year":"2006","unstructured":"Patel T. Cholangiocarcinoma. Nat Clin Pract Gastroenterol Hepatol. 2006;3(1):33\u201342.","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"issue":"7","key":"688_CR4","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1371\/journal.pmed.0040201","volume":"4","author":"B Sripa","year":"2007","unstructured":"Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, et al. Liver fluke induces cholangiocarcinoma. PLoS Med. 2007;4(7):e201.","journal-title":"PLoS Med"},{"issue":"1","key":"688_CR5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4239\/wjd.v1.i1.12","volume":"1","author":"G Fava","year":"2010","unstructured":"Fava G. Molecular mechanisms of cholangiocarcinoma. World J Gastrointest Pathophysiol. 2010;1(1):12\u201322.","journal-title":"World J Gastrointest Pathophysiol"},{"issue":"1","key":"688_CR6","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1053\/gast.2001.20875","volume":"120","author":"M Jaiswal","year":"2001","unstructured":"Jaiswal M, LaRusso NF, Shapiro RA, Billiar TR, Gores GJ. Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. Gastroenterology. 2001;120(1):190\u20139.","journal-title":"Gastroenterology"},{"issue":"3","key":"688_CR7","doi-asserted-by":"crossref","first-page":"G626","DOI":"10.1152\/ajpgi.2001.281.3.G626","volume":"281","author":"M Jaiswal","year":"2001","unstructured":"Jaiswal M, LaRusso NF, Gores GJ. Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis. Am J Physiol Gastrointest Liver Physiol. 2001;281(3):G626\u201334.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"Suppl 1","key":"688_CR8","doi-asserted-by":"crossref","first-page":"S158","DOI":"10.1016\/j.actatropica.2010.07.006","volume":"120","author":"B Sripa","year":"2011","unstructured":"Sripa B, Bethony JM, Sithithaworn P, Kaewkes S, Mairiang E, Loukas A, et al. Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos. Acta Trop. 2011;120 Suppl 1:S158\u201368.","journal-title":"Acta Trop"},{"issue":"2","key":"688_CR9","first-page":"299","volume":"10","author":"N Songserm","year":"2009","unstructured":"Songserm N, Prasongwattana J, Sithithaworn P, Sripa B, Pipitkool V. Cholangiocarcinoma in experimental hamsters with long-standing Opisthorchis viverrini infection. Asian Pac J Cancer Prev. 2009;10(2):299\u2013302.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"3","key":"688_CR10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/MOG.0b013e3282fbf9b3","volume":"24","author":"B Sripa","year":"2008","unstructured":"Sripa B, Pairojkul C. Cholangiocarcinoma: lessons from Thailand. Curr Opin Gastroenterol. 2008;24(3):349\u201356.","journal-title":"Curr Opin Gastroenterol"},{"issue":"1","key":"688_CR11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cld.2007.11.003","volume":"12","author":"BR Blechacz","year":"2008","unstructured":"Blechacz BR, Gores GJ. Cholangiocarcinoma. Clin Liver Dis. 2008;12(1):131\u201350.","journal-title":"Clin Liver Dis"},{"issue":"3","key":"688_CR12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1383-5769(00)00052-0","volume":"49","author":"S Tesana","year":"2000","unstructured":"Tesana S, Takahashi Y, Sithithaworn P, Ando K, Sakakura T, Yutanawiboonchai W, et al. Ultrastructural and immunohistochemical analysis of cholangiocarcinoma in immunized Syrian golden hamsters infected with Opisthorchis viverrini and administered with dimethylnitrosamine. Parasitol Int. 2000;49(3):239\u201351.","journal-title":"Parasitol Int"},{"issue":"6","key":"688_CR13","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0020-7519(94)90009-4","volume":"24","author":"P Sithithaworn","year":"1994","unstructured":"Sithithaworn P, Haswell-Elkins MR, Mairiang P, Satarug S, Mairiang E, Vatanasapt V, et al. Parasite-associated morbidity: liver fluke infection and bile duct cancer in northeast Thailand. Int J Parasitol. 1994;24(6):833\u201343.","journal-title":"Int J Parasitol"},{"issue":"5","key":"688_CR14","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nrm1644","volume":"6","author":"VN Kim","year":"2005","unstructured":"Kim VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol. 2005;6(5):376\u201385.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"688_CR15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.gde.2005.01.002","volume":"15","author":"AE Pasquinelli","year":"2005","unstructured":"Pasquinelli AE, Hunter S, Bracht J. MicroRNAs: a developing story. Curr Opin Genet Dev. 2005;15(2):200\u20135.","journal-title":"Curr Opin Genet Dev"},{"issue":"4","key":"688_CR16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","volume":"6","author":"A Esquela-Kerscher","year":"2006","unstructured":"Esquela-Kerscher A, Slack FJ. Oncomirs\u2014microRNAs with a role in cancer. Nat Rev Cancer. 2006;6(4):259\u201369.","journal-title":"Nat Rev Cancer"},{"key":"688_CR17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.med.59.053006.104707","volume":"60","author":"R Garzon","year":"2009","unstructured":"Garzon R, Calin GA, Croce CM. MicroRNAs in cancer. Annu Rev Med. 2009;60:167\u201379.","journal-title":"Annu Rev Med"},{"issue":"3","key":"688_CR18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bbrc.2009.08.044","volume":"388","author":"Q Yao","year":"2009","unstructured":"Yao Q, Xu H, Zhang QQ, Zhou H, Qu LH. MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells. Biochem Biophys Res Commun. 2009;388(3):539\u201342.","journal-title":"Biochem Biophys Res Commun"},{"issue":"11\u201312","key":"688_CR19","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.cca.2010.02.074","volume":"411","author":"JG Zhang","year":"2010","unstructured":"Zhang JG, Wang JJ, Zhao F, Liu Q, Jiang K, Yang GH. MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Clin Chim Acta. 2010;411(11\u201312):846\u201352.","journal-title":"Clin Chim Acta"},{"issue":"5","key":"688_CR20","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/hep.22838","volume":"49","author":"FM Selaru","year":"2009","unstructured":"Selaru FM, Olaru AV, Kan T, David S, Cheng Y, Mori Y, et al. MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. Hepatology. 2009;49(5):1595\u2013601.","journal-title":"Hepatology"},{"key":"688_CR21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1471-2407-9-163","volume":"9","author":"L Qi","year":"2009","unstructured":"Qi L, Bart J, Tan LP, Platteel I, Sluis T, Huitema S, et al. Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma. BMC Cancer. 2009;9:163.","journal-title":"BMC Cancer"},{"issue":"Pt 4","key":"688_CR22","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1042\/BST0370918","volume":"37","author":"SD Selcuklu","year":"2009","unstructured":"Selcuklu SD, Donoghue MT, Spillane C. miR-21 as a key regulator of oncogenic processes. Biochem Soc Trans. 2009;37(Pt 4):918\u201325.","journal-title":"Biochem Soc Trans"},{"issue":"18","key":"688_CR23","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1158\/1078-0432.CCR-09-0627","volume":"15","author":"AJ Schetter","year":"2009","unstructured":"Schetter AJ, Nguyen GH, Bowman ED, Mathe EA, Yuen ST, Hawkes JE, et al. Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma. Clin Cancer Res. 2009;15(18):5878\u201387.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"688_CR24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/carcin\/bgp272","volume":"31","author":"AJ Schetter","year":"2010","unstructured":"Schetter AJ, Heegaard NH, Harris CC. Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis. 2010;31(1):37\u201349.","journal-title":"Carcinogenesis"},{"issue":"4","key":"688_CR25","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1182\/blood-2007-03-081133","volume":"110","author":"D Loffler","year":"2007","unstructured":"Loffler D, Brocke-Heidrich K, Pfeifer G, Stocsits C, Hackermuller J, Kretzschmar AK, et al. Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. Blood. 2007;110(4):1330\u20133.","journal-title":"Blood"},{"issue":"7200","key":"688_CR26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature07086","volume":"454","author":"BN Davis","year":"2008","unstructured":"Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008;454(7200):56\u201361.","journal-title":"Nature"},{"issue":"5\u20136","key":"688_CR27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cytogfr.2009.10.004","volume":"20","author":"A Hata","year":"2009","unstructured":"Hata A, Davis BN. Control of microRNA biogenesis by TGFbeta signaling pathway\u2014a novel role of Smads in the nucleus. Cytokine Growth Factor Rev. 2009;20(5\u20136):517\u201321.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"19","key":"688_CR28","doi-asserted-by":"crossref","first-page":"14328","DOI":"10.1074\/jbc.M611393200","volume":"282","author":"S Zhu","year":"2007","unstructured":"Zhu S, Si ML, Wu H, Mo YY. MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem. 2007;282(19):14328\u201336.","journal-title":"J Biol Chem"},{"issue":"15","key":"688_CR29","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/sj.onc.1210856","volume":"27","author":"IA Asangani","year":"2008","unstructured":"Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene. 2008;27(15):2128\u201336.","journal-title":"Oncogene"},{"key":"688_CR30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1756-9966-29-29","volume":"29","author":"B Song","year":"2010","unstructured":"Song B, Wang C, Liu J, Wang X, Lv L, Wei L, et al. MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression. J Exp Clin Cancer Res. 2010;29:29.","journal-title":"J Exp Clin Cancer Res"},{"issue":"17","key":"688_CR31","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1128\/MCB.00479-08","volume":"28","author":"G Gabriely","year":"2008","unstructured":"Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008;28(17):5369\u201380.","journal-title":"Mol Cell Biol"},{"issue":"6","key":"688_CR32","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.onc.1204137","volume":"20","author":"HS Yang","year":"2001","unstructured":"Yang HS, Jansen AP, Nair R, Shibahara K, Verma AK, Cmarik JL, et al. A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation. Oncogene. 2001;20(6):669\u201376.","journal-title":"Oncogene"},{"issue":"2","key":"688_CR33","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.canlet.2008.06.034","volume":"272","author":"Y Chen","year":"2008","unstructured":"Chen Y, Liu W, Chao T, Zhang Y, Yan X, Gong Y, et al. MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G. Cancer Lett. 2008;272(2):197\u2013205.","journal-title":"Cancer Lett"},{"issue":"2","key":"688_CR34","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1074\/jbc.M707224200","volume":"283","author":"LB Frankel","year":"2008","unstructured":"Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem. 2008;283(2):1026\u201333.","journal-title":"J Biol Chem"},{"issue":"1","key":"688_CR35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhep.2010.02.021","volume":"53","author":"C Liu","year":"2010","unstructured":"Liu C, Yu J, Yu S, Lavker RM, Cai L, Liu W, et al. MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. J Hepatol. 2010;53(1):98\u2013107.","journal-title":"J Hepatol"},{"issue":"3","key":"688_CR36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.critrevonc.2009.09.001","volume":"73","author":"H Allgayer","year":"2010","unstructured":"Allgayer H. Pdcd4, a colon cancer prognostic that is regulated by a microRNA. Crit Rev Oncol Hematol. 2010;73(3):185\u201391.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"9","key":"688_CR37","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1128\/MCB.24.9.3894-3906.2004","volume":"24","author":"HS Yang","year":"2004","unstructured":"Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH. A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol. 2004;24(9):3894\u2013906.","journal-title":"Mol Cell Biol"},{"issue":"45","key":"688_CR38","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1038\/sj.onc.1209634","volume":"25","author":"H Zhang","year":"2006","unstructured":"Zhang H, Ozaki I, Mizuta T, Hamajima H, Yasutake T, Eguchi Y, et al. Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma. Oncogene. 2006;25(45):6101\u201312.","journal-title":"Oncogene"},{"issue":"4","key":"688_CR39","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1128\/MCB.26.4.1297-1306.2006","volume":"26","author":"HS Yang","year":"2006","unstructured":"Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, et al. Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. Mol Cell Biol. 2006;26(4):1297\u2013306.","journal-title":"Mol Cell Biol"},{"issue":"11","key":"688_CR40","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/sj.onc.1210793","volume":"27","author":"Q Wang","year":"2008","unstructured":"Wang Q, Sun Z, Yang HS. Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin\/Tcf and AP-1-dependent transcription in colon carcinoma cells. Oncogene. 2008;27(11):1527\u201335.","journal-title":"Oncogene"},{"issue":"1","key":"688_CR41","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/onc.2009.302","volume":"29","author":"Q Wang","year":"2010","unstructured":"Wang Q, Sun ZX, Allgayer H, Yang HS. Downregulation of E-cadherin is an essential event in activating beta-catenin\/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells. Oncogene. 2010;29(1):128\u201338.","journal-title":"Oncogene"},{"issue":"7","key":"688_CR42","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1053\/j.gastro.2006.02.057","volume":"130","author":"F Meng","year":"2006","unstructured":"Meng F, Henson R, Lang M, Wehbe H, Maheshwari S, Mendell JT, et al. Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology. 2006;130(7):2113\u201329.","journal-title":"Gastroenterology"},{"issue":"2","key":"688_CR43","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jhep.2008.09.015","volume":"50","author":"L Chen","year":"2009","unstructured":"Chen L, Yan HX, Yang W, Hu L, Yu LX, Liu Q, et al. The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma. J Hepatol. 2009;50(2):358\u201369.","journal-title":"J Hepatol"},{"issue":"1\u20132","key":"688_CR44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mrfmmm.2010.06.003","volume":"691","author":"S Dechakhamphu","year":"2010","unstructured":"Dechakhamphu S, Pinlaor S, Sitthithaworn P, Bartsch H, Yongvanit P. Accumulation of miscoding etheno-DNA adducts and highly expressed DNA repair during liver fluke-induced cholangiocarcinogenesis in hamsters. Mutat Res. 2010;691(1\u20132):9\u201316.","journal-title":"Mutat Res"},{"issue":"3","key":"688_CR45","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/01.TP.0000110292.73873.25","volume":"77","author":"M Maruyama","year":"2004","unstructured":"Maruyama M, Kobayashi N, Westerman KA, Sakaguchi M, Allain JE, Totsugawa T, et al. Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT. Transplantation. 2004;77(3):446\u201351.","journal-title":"Transplantation"},{"issue":"2","key":"688_CR46","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.niox.2004.08.004","volume":"11","author":"S Pinlaor","year":"2004","unstructured":"Pinlaor S, Hiraku Y, Ma N, Yongvanit P, Semba R, Oikawa S, et al. Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis. Nitric Oxide. 2004;11(2):175\u201383.","journal-title":"Nitric Oxide"},{"issue":"4","key":"688_CR47","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4269\/ajtmh.1978.27.787","volume":"27","author":"N Bhamarapravati","year":"1978","unstructured":"Bhamarapravati N, Thammavit W, Vajrasthira S. Liver changes in hamsters infected with a liver fluke of man, Opisthorchis viverrini. AmJTrop Med Hyg. 1978;27(4):787\u201394.","journal-title":"AmJTrop Med Hyg"},{"issue":"3","key":"688_CR48","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1365-3024.2006.00929.x","volume":"29","author":"J Jittimanee","year":"2007","unstructured":"Jittimanee J, Sermswan RW, Puapairoj A, Maleewong W, Wongratanacheewin S. Cytokine expression in hamsters experimentally infected with Opisthorchis viverrini. Parasite Immunol. 2007;29(3):159\u201367.","journal-title":"Parasite Immunol"},{"issue":"7","key":"688_CR49","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ijpara.2008.12.002","volume":"39","author":"S Prakobwong","year":"2009","unstructured":"Prakobwong S, Pinlaor S, Yongvanit P, Sithithaworn P, Pairojkul C, Hiraku Y. Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury. Int J Parasitol. 2009;39(7):825\u201335.","journal-title":"Int J Parasitol"},{"issue":"5","key":"688_CR50","doi-asserted-by":"crossref","first-page":"e1654","DOI":"10.1371\/journal.pntd.0001654","volume":"6","author":"B Sripa","year":"2012","unstructured":"Sripa B, Thinkhamrop B, Mairiang E, Laha T, Kaewkes S, Sithithaworn P, et al. Elevated plasma IL-6 associates with increased risk of advanced fibrosis and cholangiocarcinoma in individuals infected by Opisthorchis viverrini. PLoS Negl Trop Dis. 2012;6(5):e1654.","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"688_CR51","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/hep.23134","volume":"50","author":"B Sripa","year":"2009","unstructured":"Sripa B, Mairiang E, Thinkhamrop B, Laha T, Kaewkes S, Sithithaworn P, et al. Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6. Hepatology. 2009;50(4):1273\u201381.","journal-title":"Hepatology"},{"issue":"11","key":"688_CR52","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1002\/ijc.25266","volume":"127","author":"S Prakobwong","year":"2010","unstructured":"Prakobwong S, Yongvanit P, Hiraku Y, Pairojkul C, Sithithaworn P, Pinlaor P, et al. Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model. Int J Cancer. 2010;127(11):2576\u201387.","journal-title":"Int J Cancer"},{"issue":"11","key":"688_CR53","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1261\/rna.1034808","volume":"14","author":"LX Yan","year":"2008","unstructured":"Yan LX, Huang XF, Shao Q, Huang MY, Deng L, Wu QL, et al. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA. 2008;14(11):2348\u201360.","journal-title":"RNA"},{"issue":"2","key":"688_CR54","doi-asserted-by":"crossref","first-page":"e31060","DOI":"10.1371\/journal.pone.0031060","volume":"7","author":"MS Zaman","year":"2012","unstructured":"Zaman MS, Shahryari V, Deng G, Thamminana S, Saini S, Majid S, et al. Up-regulation of microRNA-21 correlates with lower kidney cancer survival. PLoS One. 2012;7(2):e31060.","journal-title":"PLoS One"},{"issue":"6","key":"688_CR55","doi-asserted-by":"crossref","first-page":"371","DOI":"10.5732\/cjc.011.10132","volume":"30","author":"LE Buscaglia","year":"2011","unstructured":"Buscaglia LE, Li Y. Apoptosis and the target genes of microRNA-21. Chin J Cancer. 2011;30(6):371\u201380.","journal-title":"Chin J Cancer"},{"issue":"12","key":"688_CR56","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1158\/1078-0432.CCR-08-3257","volume":"15","author":"N Yamamichi","year":"2009","unstructured":"Yamamichi N, Shimomura R, Inada K, Sakurai K, Haraguchi T, Ozaki Y, et al. Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development. Clin Cancer Res. 2009;15(12):4009\u201316.","journal-title":"Clin Cancer Res"},{"issue":"3","key":"688_CR57","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/cr.2008.24","volume":"18","author":"S Zhu","year":"2008","unstructured":"Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res. 2008;18(3):350\u20139.","journal-title":"Cell Res"},{"issue":"12","key":"688_CR58","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/labinvest.2008.94","volume":"88","author":"Z Zhang","year":"2008","unstructured":"Zhang Z, Li Z, Gao C, Chen P, Chen J, Liu W, et al. miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest. 2008;88(12):1358\u201366.","journal-title":"Lab Invest"},{"issue":"5","key":"688_CR59","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s00535-010-0345-y","volume":"46","author":"N Namwat","year":"2011","unstructured":"Namwat N, Puetkasichonpasutha J, Loilome W, Yongvanit P, Techasen A, Puapairoj A, et al. Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases. J Gastroenterol. 2011;46(5):664\u201375.","journal-title":"J Gastroenterol"},{"issue":"2","key":"688_CR60","first-page":"65","volume":"27","author":"CZ Liu","year":"2012","unstructured":"Liu CZ, Liu W, Zheng Y, Su JM, Li JJ, Yu L, et al. PTEN and PDCD4 are bona fide targets of microRNA-21 in human cholangiocarcinoma. Chin Med Sci J. 2012;27(2):65\u201372.","journal-title":"Chin Med Sci J"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-013-0688-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-013-0688-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-013-0688-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T20:35:00Z","timestamp":1562704500000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-013-0688-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,17]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["688"],"URL":"https:\/\/doi.org\/10.1007\/s13277-013-0688-0","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,17]]}}}