{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:52:30Z","timestamp":1788310350748,"version":"build-2803163510"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T00:00:00Z","timestamp":1388448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1007\/s13277-013-1554-9","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T13:18:06Z","timestamp":1388409486000},"page":"4233-4245","source":"Crossref","is-referenced-by-count":7,"title":["MTHFR genetic polymorphisms may contribute to the risk of chronic myelogenous leukemia in adults: a meta-analysis of 12 genetic association studies"],"prefix":"10.1007","volume":"35","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juping","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shudan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,31]]},"reference":[{"key":"1554_CR1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/caac.20073","volume":"60","author":"A Jemal","year":"2010","unstructured":"Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277\u2013300.","journal-title":"CA Cancer J Clin"},{"key":"1554_CR2","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature05690","volume":"446","author":"CG Mullighan","year":"2007","unstructured":"Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature. 2007;446:758\u201364.","journal-title":"Nature"},{"key":"1554_CR3","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1200\/JCO.2009.27.1460","volume":"28","author":"B Gyurkocza","year":"2010","unstructured":"Gyurkocza B, Storb R, Storer BE, Chauncey TR, Lange T, et al. Nonmyeloablative allogeneic hematopoietic cell transplantation in patients with acute myeloid leukemia. J Clin Oncol. 2010;28:2859\u201367.","journal-title":"J Clin Oncol"},{"key":"1554_CR4","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1182\/blood-2002-04-1199","volume":"100","author":"JW Vardiman","year":"2002","unstructured":"Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002;100:2292\u2013302.","journal-title":"Blood"},{"key":"1554_CR5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrc1592","volume":"5","author":"BJ Huntly","year":"2005","unstructured":"Huntly BJ, Gilliland DG. Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer. 2005;5:311\u201321.","journal-title":"Nat Rev Cancer"},{"key":"1554_CR6","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood.V96.10.3343","volume":"96","author":"MW Deininger","year":"2000","unstructured":"Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood. 2000;96:3343\u201356.","journal-title":"Blood"},{"key":"1554_CR7","doi-asserted-by":"crossref","first-page":"973","DOI":"10.4065\/81.7.973","volume":"81","author":"A Quintas-Cardama","year":"2006","unstructured":"Quintas-Cardama A, Cortes JE. Chronic myeloid leukemia: diagnosis and treatment. Mayo Clin Proc. 2006;81:973\u201388.","journal-title":"Mayo Clin Proc"},{"key":"1554_CR8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","volume":"27","author":"SY Lunt","year":"2011","unstructured":"Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27:441\u201364.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1554_CR9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mgme.2000.3027","volume":"71","author":"M Lucock","year":"2000","unstructured":"Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab. 2000;71:121\u201338.","journal-title":"Mol Genet Metab"},{"key":"1554_CR10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1207\/S15327914NC372_18","volume":"37","author":"SJ Duthie","year":"2000","unstructured":"Duthie SJ, Narayanan S, Blum S, Pirie L, Brand GM. Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer. 2000;37:245\u201351.","journal-title":"Nutr Cancer"},{"key":"1554_CR11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/jn\/129.4.779","volume":"129","author":"LB Bailey","year":"1999","unstructured":"Bailey LB, Gregory 3rd JF. Folate metabolism and requirements. J Nutr. 1999;129:779\u201382.","journal-title":"J Nutr"},{"key":"1554_CR12","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1073\/pnas.061408298","volume":"98","author":"JL Wiemels","year":"2001","unstructured":"Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, et al. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci U S A. 2001;98:4004\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1554_CR13","first-page":"20","volume":"13","author":"M Fodinger","year":"2000","unstructured":"Fodinger M, Horl WH, Sunder-Plassmann G. Molecular biology of 5,10-methylenetetrahydrofolate reductase. J Nephrol. 2000;13:20\u201333.","journal-title":"J Nephrol"},{"key":"1554_CR14","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1258\/0007142991902646","volume":"55","author":"SJ Duthie","year":"1999","unstructured":"Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull. 1999;55:578\u201392.","journal-title":"Br Med Bull"},{"key":"1554_CR15","doi-asserted-by":"crossref","first-page":"2444S","DOI":"10.1093\/jn\/132.8.2444S","volume":"132","author":"SJ Duthie","year":"2002","unstructured":"Duthie SJ, Narayanan S, Brand GM, Pirie L, Grant G. Impact of folate deficiency on DNA stability. J Nutr. 2002;132:2444S\u20139S.","journal-title":"J Nutr"},{"key":"1554_CR16","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1182\/blood-2003-06-1794","volume":"103","author":"M Krajinovic","year":"2004","unstructured":"Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Theoret Y, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood. 2004;103:252\u20137.","journal-title":"Blood"},{"key":"1554_CR17","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/clinchem\/47.4.661","volume":"47","author":"NQ Hanson","year":"2001","unstructured":"Hanson NQ, Aras O, Yang F, Tsai MY. C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease. Clin Chem. 2001;47:661\u20136.","journal-title":"Clin Chem"},{"key":"1554_CR18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/mgme.1998.2714","volume":"64","author":"I Weisberg","year":"1998","unstructured":"Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 1998;64:169\u201372.","journal-title":"Mol Genet Metab"},{"key":"1554_CR19","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","volume":"339","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.","journal-title":"BMJ"},{"key":"1554_CR20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00439-008-0592-7","volume":"125","author":"J Little","year":"2009","unstructured":"Little J, Higgins JP, Ioannidis JP, Moher D, Gagnon F, et al. Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. Hum Genet. 2009;125:131\u201351.","journal-title":"Hum Genet"},{"key":"1554_CR21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","volume":"25","author":"A Stang","year":"2010","unstructured":"Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25:603\u20135.","journal-title":"Eur J Epidemiol"},{"key":"1554_CR22","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1002\/sim.5453","volume":"31","author":"D Jackson","year":"2012","unstructured":"Jackson D, White IR, Riley RD. Quantifying the impact of between-study heterogeneity in multivariate meta-analyses. Stat Med. 2012;31:3805\u201320.","journal-title":"Stat Med"},{"key":"1554_CR23","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JP Higgins","year":"2002","unstructured":"Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539\u201358.","journal-title":"Stat Med"},{"key":"1554_CR24","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/sim.1040","volume":"21","author":"HC Houwelingen van","year":"2002","unstructured":"van Houwelingen HC, Arends LR, Stijnen T. Advanced methods in meta-analysis: multivariate approach and meta-regression. Stat Med. 2002;21:589\u2013624.","journal-title":"Stat Med"},{"key":"1554_CR25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJM198702193160806","volume":"316","author":"HS Sacks","year":"1987","unstructured":"Sacks HS, Berrier J, Reitman D, Ancona-Berk VA, Chalmers TC. Meta-analyses of randomized controlled trials. N Engl J Med. 1987;316:450\u20135.","journal-title":"N Engl J Med"},{"key":"1554_CR26","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1001\/jama.295.6.676","volume":"295","author":"JL Peters","year":"2006","unstructured":"Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L. Comparison of two methods to detect publication bias in meta-analysis. JAMA. 2006;295:676\u201380.","journal-title":"JAMA"},{"key":"1554_CR27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629\u201334.","journal-title":"BMJ"},{"key":"1554_CR28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S1415-47572008000100005","volume":"31","author":"CG Barbosa","year":"2008","unstructured":"Barbosa CG, Souza CL, de Moura Neto JP, Arruda M, Barreto JH, et al. Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genet Mol Biol. 2008;31:29\u201332.","journal-title":"Genet Mol Biol"},{"key":"1554_CR29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF03260036","volume":"7","author":"U Deligezer","year":"2003","unstructured":"Deligezer U, Akisik E, Dalay N. Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis. Mol Diagn. 2003;7:181\u20135.","journal-title":"Mol Diagn"},{"key":"1554_CR30","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2257.2006.00769.x","volume":"28","author":"M Hur","year":"2006","unstructured":"Hur M, Park JY, Cho HC, Lee KM, Shin HY, et al. Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphoblastic leukaemia and chronic myelogenous leukaemia in the Korean population. Clin Lab Haematol. 2006;28:154\u20139.","journal-title":"Clin Lab Haematol"},{"key":"1554_CR31","doi-asserted-by":"crossref","first-page":"e227","DOI":"10.1016\/j.canep.2012.02.008","volume":"36","author":"SR Hussain","year":"2012","unstructured":"Hussain SR, Naqvi H, Raza ST, Ahmed F, Babu SG, et al. Methylenetetrahydrofolate reductase C677T genetic polymorphisms and risk of leukaemia among the North Indian population. Cancer Epidemiol. 2012;36:e227\u201331.","journal-title":"Cancer Epidemiol"},{"key":"1554_CR32","first-page":"8","volume":"43","author":"SI Ismail","year":"2009","unstructured":"Ismail SI, Ababneh NA, Awidi A. Methylenetetrahydrofolate reductase (MTHFR) genotype association with the risk of chronic myelogenous leukemia. Jordan Med J. 2009;43:8\u201314.","journal-title":"Jordan Med J"},{"key":"1554_CR33","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3109\/10428194.2011.645210","volume":"53","author":"K Jakovljevic","year":"2012","unstructured":"Jakovljevic K, Malisic E, Cavic M, Radulovic S, Jankovic R. Association between methylenetetrahydrofolate reductase polymorphism C677T and risk of chronic myeloid leukemia in Serbian population. Leuk Lymphoma. 2012;53:1327\u201330.","journal-title":"Leuk Lymphoma"},{"key":"1554_CR34","doi-asserted-by":"crossref","unstructured":"Jankovic RN, Jakovljevic K, Cavic M, Malisic E. Relation of methylenetetrahydrofolate reductase C677T polymorphism to chronic myeloid leukemia in Serbia. J Clin Oncol. 2011;29.","DOI":"10.1200\/jco.2011.29.15_suppl.6581"},{"key":"1554_CR35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.leukres.2008.07.026","volume":"33","author":"HN Kim","year":"2009","unstructured":"Kim HN, Kim YK, Lee IK, Yang DH, Lee JJ, et al. Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies. Leuk Res. 2009;33:82\u20137.","journal-title":"Leuk Res"},{"key":"1554_CR36","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4238\/2012.April.19.6","volume":"11","author":"GS Lordelo","year":"2012","unstructured":"Lordelo GS, Miranda-Vilela AL, Akimoto AK, Alves PC, Hiragi CO, et al. Association between methylene tetrahydrofolate reductase and glutathione s-transferase M1 gene polymorphisms and chronic myeloid leukemia in a Brazilian population. Genet Mol Res. 2012;11:1013\u201326.","journal-title":"Genet Mol Res"},{"key":"1554_CR37","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.leukres.2006.10.016","volume":"31","author":"HW Moon","year":"2007","unstructured":"Moon HW, Kim TY, Oh BR, Min HC, Cho HI, et al. MTHFR 677CC\/1298CC genotypes are highly associated with chronic myelogenous leukemia: a case-control study in Korea. Leuk Res. 2007;31:1213\u20137.","journal-title":"Leuk Res"},{"key":"1554_CR38","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1309\/LMA6H9RW9CKNLNDV","volume":"41","author":"P Vahid","year":"2010","unstructured":"Vahid P, Farnaz R, Zaker F, Farzaneh A, Parisa R. Methylenetetrahydrofolate reductase gene polymorphisms and risk of myeloid leukemia. Lab Med. 2010;41:490\u20134.","journal-title":"Lab Med"},{"key":"1554_CR39","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1200\/JCO.2004.07.151","volume":"22","author":"PM Das","year":"2004","unstructured":"Das PM, Singal R. DNA methylation and cancer. J Clin Oncol. 2004;22:4632\u201342.","journal-title":"J Clin Oncol"},{"key":"1554_CR40","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1158\/1055-9965.511.13.4","volume":"13","author":"YI Kim","year":"2004","unstructured":"Kim YI. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev. 2004;13:511\u20139.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"1554_CR41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.tig.2004.06.014","volume":"20","author":"MR Munafo","year":"2004","unstructured":"Munafo MR, Flint J. Meta-analysis of genetic association studies. Trends Genet. 2004;20:439\u201344.","journal-title":"Trends Genet"},{"key":"1554_CR42","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.ejca.2009.01.020","volume":"45","author":"JL Bai","year":"2009","unstructured":"Bai JL, Zheng MH, Xia X, Ter-Minassian M, Chen YP, et al. MTHFR C677T polymorphism contributes to prostate cancer risk among Caucasians: a meta-analysis of 3511 cases and 2762 controls. Eur J Cancer. 2009;45:1443\u20139.","journal-title":"Eur J Cancer"},{"key":"1554_CR43","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1158\/1055-9965.EPI-09-0223","volume":"18","author":"SM Collin","year":"2009","unstructured":"Collin SM, Metcalfe C, Zuccolo L, Lewis SJ, Chen L, et al. Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2009;18:2528\u201339.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"1554_CR44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.canlet.2008.07.026","volume":"273","author":"S Boccia","year":"2009","unstructured":"Boccia S, Boffetta P, Brennan P, Ricciardi G, Gianfagna F, et al. Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer. Cancer Lett. 2009;273:55\u201361.","journal-title":"Cancer Lett"},{"key":"1554_CR45","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/aje\/kwm344","volume":"167","author":"S Boccia","year":"2008","unstructured":"Boccia S, Hung R, Ricciardi G, Gianfagna F, Ebert MP, et al. Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. Am J Epidemiol. 2008;167:505\u201316.","journal-title":"Am J Epidemiol"},{"key":"1554_CR46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.arcmed.2010.01.001","volume":"41","author":"X Dong","year":"2010","unstructured":"Dong X, Wu J, Liang P, Li J, Yuan L, et al. Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analysis. Arch Med Res. 2010;41:125\u201333.","journal-title":"Arch Med Res"},{"key":"1554_CR47","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10549-010-0938-4","volume":"122","author":"A Eroglu","year":"2010","unstructured":"Eroglu A, Akar N. Methylenetetrahydrofolate reductase C677T polymorphism in breast cancer risk. Breast Cancer Res Treat. 2010;122:897\u20138.","journal-title":"Breast Cancer Res Treat"},{"key":"1554_CR48","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.7314\/APJCP.2012.13.8.3937","volume":"13","author":"XP Ding","year":"2012","unstructured":"Ding XP, Feng L, Ma L. MTHFR C677T polymorphism and ovarian cancer risk: a meta-analysis. Asian Pac J Cancer Prev. 2012;13:3937\u201342.","journal-title":"Asian Pac J Cancer Prev"},{"key":"1554_CR49","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.mehy.2013.01.025","volume":"80","author":"H Chen","year":"2013","unstructured":"Chen H, Zhu J. C677T polymorphism of methylenetetrahydrofolate reductase may contribute to cervical cancer risk in complete over-dominant model. Med Hypotheses. 2013;80:679\u201383.","journal-title":"Med Hypotheses"},{"key":"1554_CR50","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.7314\/APJCP.2012.13.5.2193","volume":"13","author":"LN Guo","year":"2012","unstructured":"Guo LN. Methylenetetrahydrofolate reductase C677T polymorphism and cervical cancer risk: a meta-analysis. Asian Pac J Cancer Prev. 2012;13:2193\u20137.","journal-title":"Asian Pac J Cancer Prev"},{"key":"1554_CR51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3748\/wjg.v11.i3.331","volume":"11","author":"K Chen","year":"2005","unstructured":"Chen K, Jiang QT, He HQ. Relationship between metabolic enzyme polymorphism and colorectal cancer. World J Gastroenterol. 2005;11:331\u20135.","journal-title":"World J Gastroenterol"},{"key":"1554_CR52","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/aje\/kwg024","volume":"157","author":"K Robien","year":"2003","unstructured":"Robien K, Ulrich CM. 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a huGE minireview. Am J Epidemiol. 2003;157:571\u201382.","journal-title":"Am J Epidemiol"},{"key":"1554_CR53","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1158\/1055-9965.EPI-06-0334","volume":"15","author":"TV Pereira","year":"2006","unstructured":"Pereira TV, Rudnicki M, Pereira AC, Pombo-de-Oliveira MS, Franco RF. 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006;15:1956\u201363.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"1554_CR54","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.leukres.2010.03.034","volume":"34","author":"J Wang","year":"2010","unstructured":"Wang J, Zhan P, Chen B, Zhou R, Yang Y, et al. MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis. Leuk Res. 2010;34:1596\u2013600.","journal-title":"Leuk Res"},{"key":"1554_CR55","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/pbc.23137","volume":"58","author":"J Yan","year":"2012","unstructured":"Yan J, Yin M, Dreyer ZE, Scheurer ME, Kamdar K, et al. A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children. Pediatr Blood Cancer. 2012;58:513\u20138.","journal-title":"Pediatr Blood Cancer"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-013-1554-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-013-1554-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-013-1554-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T11:08:07Z","timestamp":1688900887000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-013-1554-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,31]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["1554"],"URL":"https:\/\/doi.org\/10.1007\/s13277-013-1554-9","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,31]]}}}