{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:37:39Z","timestamp":1779914259430,"version":"3.53.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T00:00:00Z","timestamp":1402012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s13277-014-2129-0","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T21:56:43Z","timestamp":1402005403000},"page":"8991-8998","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["In vitro antileukaemic activity of extracts from Daphne gnidium leaves against sensitive and multidrug resistant K562\/R7 cells"],"prefix":"10.1007","volume":"35","author":[{"given":"Fadwa","family":"Chaabane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounira","family":"Krifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Matera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Loussaeif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Genevi\u00e8ve","family":"Dijoux-Franca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Ghedira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Dumontet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Chekir-Ghedira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"2129_CR1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0308-8146(96)00065-9","volume":"57","author":"PCH Hollman","year":"1996","unstructured":"Hollman PCH, Hertog MGL, Katan MB. Analysis and health effects of flavonoids. Food Chem. 1996;57:43\u20136.","journal-title":"Food Chem"},{"key":"2129_CR2","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1021\/jf9801973","volume":"46","author":"YS Velioglu","year":"1998","unstructured":"Velioglu YS, Mazza G, Gao L, Oomah BD. Antioxidant activity and total phenolics content in selected fruits, vegetables, and grain products. J Agric Food Chem. 1998;46:4113\u20137.","journal-title":"J Agric Food Chem"},{"key":"2129_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408690490263756","volume":"44","author":"SM Hannum","year":"2004","unstructured":"Hannum SM. Potential impact of strawberries on human health a review of the science. Crit Rev Sci Nutr. 2004;44:1\u201317.","journal-title":"Crit Rev Sci Nutr"},{"key":"2129_CR4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.21273\/HORTSCI.26.1.10","volume":"26","author":"JL Maas","year":"1991","unstructured":"Maas JL, Galletta GJ. Ellagic acid, an anticarcinogen in fruits, especially in strawberries: a review. Hort Sci. 1991;26:10\u20134.","journal-title":"Hort Sci"},{"key":"2129_CR5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.bi.62.070193.002125","volume":"62","author":"MM Gottesman","year":"1993","unstructured":"Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem. 1993;62:385\u2013427.","journal-title":"Annu Rev Biochem"},{"key":"2129_CR6","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/jnci\/92.16.1295","volume":"92","author":"P Borst","year":"2000","unstructured":"Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst. 2000;92:1295\u2013302.","journal-title":"J Natl Cancer Inst"},{"key":"2129_CR7","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/bjc.1993.458","volume":"68","author":"CH Versantvoort","year":"1993","unstructured":"Versantvoort CH, Schuurhuis GJ, Pinedo HM, Eekman CA, Kuiper CM, Lankelma J, et al. Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells. Br J Cancer. 1993;68:939\u201346.","journal-title":"Br J Cancer"},{"key":"2129_CR8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00280-004-0848-4","volume":"54","author":"P Limtrakul","year":"2004","unstructured":"Limtrakul P, Khantamat O, Pintha K. Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract. Cancer Chemother Pharmacol. 2004;54:525\u201330.","journal-title":"Cancer Chemother Pharmacol"},{"key":"2129_CR9","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1126\/science.1114315","volume":"187","author":"SM Kupchan","year":"1975","unstructured":"Kupchan SM, Baxter R. Mezerein: Antileukemic principle isolated from Daphne mezereum L. Science. 1975;187:652\u20133.","journal-title":"Science"},{"key":"2129_CR10","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1021\/jo00886a016","volume":"41","author":"SM Kupchan","year":"1976","unstructured":"Kupchan SM, Shizuri Y, Sumner WC, Haynes HR, Leighton AP, Sickles BR. Isolation and structural elucidation of new potent antileukemic diterpenoid esters from Gnidia species. J Org Chem. 1976;41:3850\u20133.","journal-title":"J Org Chem"},{"key":"2129_CR11","first-page":"542","volume":"64","author":"W Chaouki","year":"2009","unstructured":"Chaouki W, Leger DD, Liagre B, Cherrah Y, Beneytout JL, Hmamouchi M. Roots of Daphne gnidium L. inhibit cell proliferation and induce apoptosis in the human breast cancer cell line MCF-7. Pharmazie. 2009;64:542\u20136.","journal-title":"Pharmazie"},{"key":"2129_CR12","unstructured":"Jouglard J. Intoxications d'origine v\u00e9g\u00e9tale Encycl Med- Chir, Paris, Intoxications, 2-16065 A-10 et A-20 1977."},{"key":"2129_CR13","volume-title":"La pharmacop\u00e9e marocaine traditionnelle: m\u00e9decine arabe ancienne et savoirs populaires","author":"J Bellakhdar","year":"1997","unstructured":"Bellakhdar J. La pharmacop\u00e9e marocaine traditionnelle: m\u00e9decine arabe ancienne et savoirs populaires. France: Ibis Press; 1997."},{"key":"2129_CR14","unstructured":"Pottier-Alapetite G. Flore de la Tunisia: Angiospermes, Dicotyledones, Apetales, Dialypetales. Tunisia: Minist\u00e8re de L\u2019Enseignement Sup\u00e9rieur et de la Recherche Scientifique et Minist\u00e8re de l\u2019Agriculture 1979."},{"key":"2129_CR15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.foodchem.2004.04.039","volume":"91","author":"VY Yuan","year":"2005","unstructured":"Yuan VY, Bone DE, Carrington F. Antioxidant activity of dulse (Palmaria palmata) extract evaluated in vitro. Food Chem. 2005;91:485\u201394.","journal-title":"Food Chem"},{"key":"2129_CR16","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.foodchem.2005.12.015","volume":"100","author":"A Kumar","year":"2006","unstructured":"Kumar A, Chattopadhyay S. DNA damage protecting activity and antioxidant potential of pudina extract. Food Chem. 2006;100:1377\u201384.","journal-title":"Food Chem"},{"key":"2129_CR17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.canlet.2007.04.011","volume":"255","author":"J Raju","year":"2007","unstructured":"Raju J, Bird RP. Diosgenin, a naturally occurring steroid saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. Cancer Lett. 2007;255:194\u2013204.","journal-title":"Cancer Lett"},{"key":"2129_CR18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0308-8146(98)00102-2","volume":"64","author":"J Zhishen","year":"1999","unstructured":"Zhishen J, Mengcheng T, Jianming W. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 1999;64:555\u20139.","journal-title":"Food Chem"},{"key":"2129_CR19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2141.1989.tb06268.x","volume":"71","author":"PR Twentyman","year":"1989","unstructured":"Twentyman PR, Fox NE, Rees JK. Chemosensitivity testing of fresh leukaemic cells using the MTT colourimetric assay. Br J Haematol. 1989;71:19\u201324.","journal-title":"Br J Haematol"},{"key":"2129_CR20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1021\/jm991128y","volume":"44","author":"G Comte","year":"2001","unstructured":"Comte G, Daskiewicz JB, Bayet C, Conseil G, Viornery-Vanier A, Dumontet C, et al. C-isoprenylation of flavonoids enhances binding affinity towards P-glycoprotein and modulation of cancer cell chemoresistance. Med Chem. 2001;44:763\u20138.","journal-title":"Med Chem"},{"key":"2129_CR21","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1124\/mol.58.6.1287","volume":"58","author":"X Li","year":"2000","unstructured":"Li X, Tong W, Bornmann W, Schwartz GK. Huanglian Chinese herbal extract, inhibits cell growth by suppressing the expression of cyclin B1 inhibiting CDC2 kinase activity in human cancer cells. Mol Pharmacol. 2000;58:1287\u201393.","journal-title":"Mol Pharmacol"},{"key":"2129_CR22","first-page":"448","volume":"54","author":"H Yano","year":"1994","unstructured":"Yano H, Mizoguchi A, Fukuda K, Haramaki M, Ogasawara S, Momosaki S, et al. The herbal medicine Sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0\/G1 phase. Cancer Res. 1994;54:448\u201354.","journal-title":"Cancer Res"},{"key":"2129_CR23","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1081\/CNV-120005926","volume":"20","author":"A Vickers","year":"2002","unstructured":"Vickers A. Botanical medicines for the treatment of cancer: rationale, overview of current data, and methodological considerations for Phase I and II trials. Cancer Invest. 2002;20:1069\u201379.","journal-title":"Cancer Invest"},{"key":"2129_CR24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jnutbio.2007.11.003","volume":"19","author":"CM Kaefer","year":"2008","unstructured":"Kaefer CM, Milner JA. The role of herbs and spices in cancer prevention. J Nutr Biochem. 2008;19:347\u201361.","journal-title":"J Nutr Biochem"},{"key":"2129_CR25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.nu.16.070196.000341","volume":"16","author":"B Halliwell","year":"1996","unstructured":"Halliwell B. Antioxidants in human health and disease. Annu Rev Nutr. 1996;16:33\u201350.","journal-title":"Annu Rev Nutr"},{"key":"2129_CR26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2407-7-80","volume":"7","author":"JA Menendez","year":"2007","unstructured":"Menendez JA, Vazquez-Martin A, Colomer R, Brunet J, Carrasco-Pancorbo A, Garcia-Villalba R, et al. Olive oil\u2019s bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer. 2007;7:80.","journal-title":"BMC Cancer"},{"key":"2129_CR27","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/j.fct.2007.03.012","volume":"45","author":"YK Rao","year":"2007","unstructured":"Rao YK, Madamanchi G, Shih-Hua F. Yew-Min Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: a comparative study. Food Chem Toxicol. 2007;45:1770\u20136.","journal-title":"Food Chem Toxicol"},{"key":"2129_CR28","first-page":"1365","volume":"10","author":"J Boubaker","year":"2011","unstructured":"Boubaker J, Bhouri W, Ben Sghaier M, Ghedira K, Dijoux Franca MG, Chekir-Ghedira L. Ethyl acetate extract and its major constituent, isorhamnetin 3-O-rutinoside, from Nitraria retusa leaves, promote apoptosis of human myelogenous erythroleukaemia cells. Cell Prolif. 2011;10:1365\u20132184.","journal-title":"Cell Prolif"},{"key":"2129_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2006.10.003","volume":"165","author":"A Abdelwahed","year":"2007","unstructured":"Abdelwahed A, Bouhlel I, Skandrani I, Valenti K, Kadri M, Guiraud P, et al. Study of antimutagenic and antioxidant activities of gallic acid and 1,2,3,4,6-pentagalloylglucose from Pistacia lentiscus. Confirmation by microarray expression profiling. Chem Biol Interact. 2007;165:1\u201313.","journal-title":"Chem Biol Interact"},{"key":"2129_CR30","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0024-3205(94)00641-5","volume":"55","author":"T Hirano","year":"1994","unstructured":"Hirano T, Gotoh M, Oka K. Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Life Sci. 1994;55:1061\u20139.","journal-title":"Life Sci"},{"key":"2129_CR31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s003940050054","volume":"38","author":"S Kuntz","year":"1999","unstructured":"Kuntz S, Wenzel U, Daniel H. Comparative analysis of effects of flavonoids on proliferation, antiproliferativity and apoptosis in human colon cancer cell lines. Eur J Nutr. 1999;38:133\u201342.","journal-title":"Eur J Nutr"},{"key":"2129_CR32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0304-3835(98)00323-1","volume":"136","author":"AA Narayanann","year":"1999","unstructured":"Narayanann AA, Geoffroy O, Willingham MC, Re GG, Nixon DW. p35\/p21 (WAF1\/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett. 1999;136:215\u201321.","journal-title":"Cancer Lett"},{"key":"2129_CR33","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0006-2952(97)00260-8","volume":"54","author":"TB Kang","year":"1997","unstructured":"Kang TB, Liang NC. Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. Biochem Pharmacol. 1997;54:1013\u20138.","journal-title":"Biochem Pharmacol"},{"key":"2129_CR34","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1093\/carcin\/17.11.2367","volume":"17","author":"DM Lepley","year":"1996","unstructured":"Lepley DM, Li B, Birt DF, Pelling JC. The chemopreventive flavonoid apigenin induces G2-M arrest in keratinocytes. Carcinogenesis. 1996;17:2367\u201375.","journal-title":"Carcinogenesis"},{"key":"2129_CR35","first-page":"309","volume":"44","author":"JA Hadfield","year":"2003","unstructured":"Hadfield JA, Ducki S, Hirst N, McGown AT. Tubulin and microtubules as targets for anticancer drugs. Progress Cell Cycle Res. 2003;44:309\u201325.","journal-title":"Progress Cell Cycle Res"},{"key":"2129_CR36","doi-asserted-by":"crossref","first-page":"380923","DOI":"10.1155\/2011\/380923","volume":"2011","author":"SY Yuan","year":"2011","unstructured":"Yuan SY, Lin CC, Hsu SL, Cheng YW, Wu JH, Cheng CL, et al. Leaf Extracts of Calocedrus formosana (Florin) Induce G2\/M cell cycle arrest and apoptosis in human bladder cancer cells. Evid Based Complement Alternat Med. 2011;2011:380923.","journal-title":"Evid Based Complement Alternat Med"},{"key":"2129_CR37","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0165-6147(03)00161-5","volume":"24","author":"PM Checchi","year":"2003","unstructured":"Checchi PM, Nettles JH, Zhou J, Snyder JP, Joshi HC. Microtubule-interacting drugs for cancer treatment. Trends Pharmacol Sci. 2003;24:361\u20135.","journal-title":"Trends Pharmacol Sci"},{"key":"2129_CR38","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.vascn.2006.02.014","volume":"54","author":"W Li","year":"2006","unstructured":"Li W, Lam MS, Birkeland A, Riffel A, Montana L, Sullivan ME. Post JM.) Cell-based assays for profiling activity and safety properties of cancer drugs. J Pharmacol Toxicol Methods. 2006;54:313\u20139.","journal-title":"J Pharmacol Toxicol Methods"},{"key":"2129_CR39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/ptr.2020","volume":"21","author":"SJ Bae","year":"2007","unstructured":"Bae SJ, Choi YH. Methanol Extract of the seaweed Gloiopeltis furcata induces G2\/M arrest and inhibits cyclooxygenase-2 activity in human hepatocarcinoma HepG2 cells. Phytother Res. 2007;21:52\u20137.","journal-title":"Phytother Res"},{"key":"2129_CR40","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.taap.2004.10.012","volume":"204","author":"EM Leslie","year":"2005","unstructured":"Leslie EM, Deeley RG, Cole SPC. Multidrug resistance proteins in toxicology: role of P-glycoprotein, MRP1, MRP2 and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol. 2005;204:216\u201337.","journal-title":"Toxicol Appl Pharmacol"},{"key":"2129_CR41","first-page":"2225","volume":"18","author":"M Lehnert","year":"1998","unstructured":"Lehnert M. Chemotherapy resistance in breast cancer. Anticancer Res. 1998;18:2225\u20136.","journal-title":"Anticancer Res"},{"key":"2129_CR42","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1042\/bj3170515","volume":"317","author":"S Orlowski","year":"1996","unstructured":"Orlowski S, Mir LM, Belehradek Jr J, Garrigos M. Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators. Biochem J. 1996;317:515\u201322.","journal-title":"Biochem J"},{"key":"2129_CR43","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1248\/bpb.28.2274","volume":"28","author":"S Kitagawa","year":"2005","unstructured":"Kitagawa S, Nabekura T, Takahashi T, Nakamura Y, Sakamoto H, Tano H, et al. Structure\u2013activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells. Biol Pharm Bull. 2005;28:2274\u20138.","journal-title":"Biol Pharm Bull"},{"key":"2129_CR44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/sj.bjp.0702807","volume":"128","author":"C Martin","year":"1999","unstructured":"Martin C, Berridge G, Mistry P, Higgins C, Charlton P, Callaghan R. The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein. Br J Pharmacol. 1999;128:403\u201311.","journal-title":"Br J Pharmacol"},{"key":"2129_CR45","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0304-3835(02)00593-1","volume":"20","author":"J Fernandes","year":"2003","unstructured":"Fernandes J, Castilho RO, da Costa MR, Wagner-Souza K, Coelho Kaplan MA, Gattass CR. Pentacyclic triterpenes from Chrysobalanaceae species: cytotoxicity on multidrug resistant and sensitive leukemia cell lines. Cancer Lett. 2003;20:165\u20139.","journal-title":"Cancer Lett"},{"key":"2129_CR46","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.bcp.2006.06.036","volume":"72","author":"W Chi-Keung","year":"2006","unstructured":"Chi-Keung W, Guo-Yuan Z, Xiao-Ling S, Apurba C, Saibal D, Wang-Fun F. Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells. Biochem Pharmacol. 2006;72:824\u201337.","journal-title":"Biochem Pharmacol"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-014-2129-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-014-2129-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-014-2129-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T07:21:22Z","timestamp":1746256882000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-014-2129-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,6]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["2129"],"URL":"https:\/\/doi.org\/10.1007\/s13277-014-2129-0","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,6]]}}}