{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:52:39Z","timestamp":1790146359284,"version":"4.0.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,10,19]],"date-time":"2014-10-19T00:00:00Z","timestamp":1413676800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s13277-014-2738-7","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T07:51:35Z","timestamp":1413618695000},"page":"1045-1053","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Evaluation of human epididymis protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA) as diagnostic tools of type I and type II epithelial ovarian cancer in Japanese women"],"prefix":"10.1007","volume":"36","author":[{"given":"Hiroyuki","family":"Fujiwara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Takeshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eizo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyosuke","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokuni","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,19]]},"reference":[{"key":"2738_CR1","unstructured":"Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]: http:\/\/globocan.iarc.fr ."},{"key":"2738_CR2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bpobgyn.2003.10.002","volume":"18","author":"L Valentin","year":"2004","unstructured":"Valentin L. Use of morphology to characterize and manage common adnexal masses. Best Pract Res Clin Obstet Gynaecol. 2004;18:71\u201389.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2738_CR3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/07357909709039725","volume":"15","author":"BY Karlan","year":"1997","unstructured":"Karlan BY. The status of ultrasound and color Doppler imaging for the early detection of ovarian carcinoma. Cancer Invest. 1997;15:265\u20139.","journal-title":"Cancer Invest"},{"issue":"Suppl. 10","key":"2738_CR4","doi-asserted-by":"crossref","first-page":"x111","DOI":"10.1093\/annonc\/mds300","volume":"23","author":"J Prat","year":"2012","unstructured":"Prat J. New insights into ovarian cancer pathology. Ann Oncol. 2012;23 Suppl 10:x111\u2013117.","journal-title":"Ann Oncol"},{"key":"2738_CR5","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.humpath.2011.03.003","volume":"42","author":"RJ Kurman","year":"2011","unstructured":"Kurman RJ, Shih IM. Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer\u2014shifting the paradigm. Hum Pathol. 2011;42:918\u201331.","journal-title":"Hum Pathol"},{"key":"2738_CR6","doi-asserted-by":"crossref","unstructured":"Integrated genomic analyses of ovarian carcinoma. Nature 2011;474:609\u201315.","DOI":"10.1038\/nature10166"},{"key":"2738_CR7","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/cncr.22919","volume":"110","author":"U Guth","year":"2007","unstructured":"Guth U, Huang DJ, Bauer G, Stieger M, Wight E, Singer G. Metastatic patterns at autopsy in patients with ovarian carcinoma. Cancer. 2007;110:1272\u201380.","journal-title":"Cancer"},{"key":"2738_CR8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0090-8258(88)90039-X","volume":"30","author":"VR Zurawski Jr","year":"1988","unstructured":"Zurawski Jr VR, Knapp RC, Einhorn N, Kenemans P, Mortel R, Ohmi K, et al. An initial analysis of preoperative serum CA 125 levels in patients with early stage ovarian carcinoma. Gynecol Oncol. 1988;30:7\u201314.","journal-title":"Gynecol Oncol"},{"key":"2738_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humrep\/4.suppl_1.1","volume":"4","author":"I Jacobs","year":"1989","unstructured":"Jacobs I, Bast Jr RC. The CA 125 tumor-associated antigen: a review of the literature. Hum Reprod. 1989;4:1\u201312.","journal-title":"Hum Reprod"},{"key":"2738_CR10","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1038\/sj.onc.1205363","volume":"21","author":"L Bingle","year":"2002","unstructured":"Bingle L, Singleton V, Bingle CD. The putative ovarian tumor marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. Oncogene. 2002;21:2768\u201373.","journal-title":"Oncogene"},{"key":"2738_CR11","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/modpathol.3800612","volume":"19","author":"MT Galgano","year":"2006","unstructured":"Galgano MT, Hampton GM, Frierson Jr HF. Comprehensive analysis of HE4 expression in normal and malignant human tissues. Mod Pathol. 2006;19:847\u201353.","journal-title":"Mod Pathol"},{"key":"2738_CR12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0378-1119(99)00342-X","volume":"238","author":"M Schummer","year":"1999","unstructured":"Schummer M, Ng WV, Bumgarner RE, Nelson PS, Schummer B, Bednarski DW, et al. Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas. Gene. 1999;238:375\u20138.","journal-title":"Gene"},{"key":"2738_CR13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ygyno.2007.10.017","volume":"108","author":"RG Moore","year":"2008","unstructured":"Moore RG, Brown AK, Miller MC, Skates S, Allard WJ, Verch T, et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. Gynecol Oncol. 2008;108:402\u20138.","journal-title":"Gynecol Oncol"},{"key":"2738_CR14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ygyno.2008.08.031","volume":"112","author":"RG Moore","year":"2009","unstructured":"Moore RG, McMeekin DS, Brown AK, DiSilvestro P, Miller MC, Allard WJ, et al. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass. Gynecol Oncol. 2009;112:40\u20136.","journal-title":"Gynecol Oncol"},{"key":"2738_CR15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1515\/CCLM.2011.085","volume":"49","author":"YM Kim","year":"2011","unstructured":"Kim YM, Whang DH, Park J, Kim SH, Lee SW, Park HA, et al. Evaluation of the accuracy of serum human epididymis protein 4 in combination with CA125 for detecting ovarian cancer: a prospective case\u2013control study in a Korean population. Clin Chem LabMed. 2011;49:527\u201343.","journal-title":"Clin Chem LabMed"},{"key":"2738_CR16","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.cca.2011.04.028","volume":"412","author":"G Ruggeri","year":"2011","unstructured":"Ruggeri G, Bandiera E, Zanotti L, Belloli S, Ravaggi A, Romani C, et al. HE4 and epithelial ovarian cancer: comparison and clinical evaluation of two immunoassays and a combination algorithm. Clin Chim Acta. 2011;412:1447\u201353.","journal-title":"Clin Chim Acta"},{"key":"2738_CR17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/AOG.0b013e318224fce2","volume":"118","author":"RG Moore","year":"2011","unstructured":"Moore RG, Miller MC, Disilvestro P, Landrum LM, Gajewski W, Ball JJ, et al. Evaluation of the diagnostic accuracy of the Risk of Ovarian Malignancy Algorithm in women with a pelvic mass. Obstet Gynecol. 2011;118:280\u20138.","journal-title":"Obstet Gynecol"},{"key":"2738_CR18","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1158\/1055-9965.EPI-11-0635","volume":"20","author":"E Bandiera","year":"2011","unstructured":"Bandiera E, Romani C, Specchia C, Zanotti L, Galli C, Ruggeri G, et al. Serum human epididymis protein 4 and Risk for Ovarian Malignancy Algorithm as new diagnostic and prognostic tools for epithelial ovarian cancer management. Cancer Epidemiol Biomarkers Prev. 2011;20:2496\u2013506.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2738_CR19","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1525-1438.2007.01058.x","volume":"18","author":"AV Yemelyanova","year":"2008","unstructured":"Yemelyanova AV, Cosin JA, Bidus MA, Boice CR, Seidman JD. Pathology of stage I versus stage III ovarian carcinoma with implications for pathogenesis and screening. Int J Gynecol Cancer. 2008;18:465\u20139.","journal-title":"Int J Gynecol Cancer"},{"key":"2738_CR20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ygyno.2011.05.039","volume":"122","author":"D Lu","year":"2011","unstructured":"Lu D, Kuhn E, Bristow RE, Giuntoli II RL, Kjaer SK, Shih IM, et al. Comparison of candidate serologic markers for type I and type II ovarian cancer. Gynecol Oncol. 2011;122:560\u20136.","journal-title":"Gynecol Oncol"},{"key":"2738_CR21","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1373\/clinchem.2008.105601","volume":"54","author":"CM Sturgeon","year":"2008","unstructured":"Sturgeon CM, Duffy MJ, Stenman UH, Lilja H, Brunner N, Chan DW, et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for use of tumor markers in testicular, prostate, colorectal, breast and ovarian cancer. Clin Chem. 2008;54:e11\u201379.","journal-title":"Clin Chem"},{"key":"2738_CR22","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/clinchem\/37.8.1379","volume":"37","author":"R Molina","year":"1991","unstructured":"Molina R, Filella X, Bruix J, Mengual P, Bosch J, Calvet X, et al. Cancer antigen 125 in serum and ascitic fluid for patients with liver disease. Clin Chem. 1991;37:1379\u201383.","journal-title":"Clin Chem"},{"key":"2738_CR23","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.clinbiochem.2011.04.011","volume":"44","author":"Y Park","year":"2011","unstructured":"Park Y, Lee JH, Hong DJ, Lee EY, Kim HS. Diagnostic performances of HE4 and CA125 for the detection of ovarian cancer from patients with various gynecologic and non-gynecologic diseases. Clinical Biochem. 2011;44:884\u20138.","journal-title":"Clinical Biochem"},{"key":"2738_CR24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ygyno.2010.02.005","volume":"117","author":"B Nolen","year":"2010","unstructured":"Nolen B, Velikokhatnaya L, Marrangoni A, Geest KD, Lomakin A, Bast Jr RC, et al. Serum biomarker panels for the discrimination of benign from malignant cases in patients with an adnexal mass. Gynecol Oncol. 2010;117:440\u20135.","journal-title":"Gynecol Oncol"},{"key":"2738_CR25","doi-asserted-by":"crossref","unstructured":"Moore RG, Jabre-Raughley M, Brown AK, Robison KM, Miller C, Allard WJ, et al. Comparison of a novel multiple marker assay vs the Risk of Malignancy Index for the prediction of epithelial ovarian cancer in patients with a pelvic mass. Am J Obstet Gynecol. 2010;203:228.e1-6","DOI":"10.1016\/j.ajog.2010.03.043"},{"key":"2738_CR26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ygyno.2012.09.034","volume":"128","author":"KK Chan","year":"2013","unstructured":"Chan KK, Chen CA, Nam JH, Ochiai K, Wilailak S, Choon AT, et al. The use of HE4 in the prediction of ovarian cancer in Asian women with a pelvic mass. Gynecol Oncol. 2013;128:239\u201344.","journal-title":"Gynecol Oncol"},{"key":"2738_CR27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ygyno.2012.11.026","volume":"128","author":"MT Sandri","year":"2013","unstructured":"Sandri MT, Bottari F, Franchi D, Boveri S, Candiani M, Ronzoni S, et al. Comparison of HE4, CA125 and ROMA algorithm in women with a pelvic mass: correlation with pathological outcome. Gynecol Oncol. 2013;128:233\u20138.","journal-title":"Gynecol Oncol"},{"key":"2738_CR28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ygyno.2013.07.094","volume":"131","author":"B Kristjansdottir","year":"2013","unstructured":"Kristjansdottir B, Levan K, Partheen K, Sundfeldt K. Diagnostic performance of the biomarkers HE4 and CA125 in type I and type II epithelial ovarian cancer. Gynecol Oncol. 2013;131:52\u20138.","journal-title":"Gynecol Oncol"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-014-2738-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-014-2738-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-014-2738-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-014-2738-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T06:42:01Z","timestamp":1689576121000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-014-2738-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,19]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["2738"],"URL":"https:\/\/doi.org\/10.1007\/s13277-014-2738-7","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,19]]}}}