{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:37:58Z","timestamp":1790735878248,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s13277-014-2864-2","type":"journal-article","created":{"date-parts":[[2015,1,4]],"date-time":"2015-01-04T05:15:32Z","timestamp":1420348532000},"page":"2509-2516","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Pathologic and imunohistochemical characterization of tumoral inflammatory cell infiltrate in invasive penile squamous cell carcinomas: Fox-P3 expression is an independent predictor of recurrence"],"prefix":"10.1007","volume":"36","author":[{"given":"Jos\u00e9","family":"Vassallo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Fellipe Freitas","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Hugo J. F. M.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Malagoli","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Werneck","family":"da Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00eanio C\u00e1ssio","family":"Zequi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Cardoso","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Paulo","family":"da Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademar","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cubilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Augusto","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,5]]},"reference":[{"key":"2864_CR1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.eururo.2010.01.039","volume":"57","author":"G Pizzocaro","year":"2010","unstructured":"Pizzocaro G, Algaba F, Horenblas S, Solsona E, Tana S, et al. EAU penile cancer guidelines 2009. Eur Urol. 2010;57:1002\u201312.","journal-title":"Eur Urol"},{"key":"2864_CR2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.urolonc.2007.03.025","volume":"26","author":"JS Barnholtz-Sloan","year":"2008","unstructured":"Barnholtz-Sloan JS, Maldonado JL, Pow-sang J, Guiliano AR. Incidence trends in primary malignant penile cancer. Urol Oncol Semin Orig Investig. 2008;26:361\u20137.","journal-title":"Urol Oncol Semin Orig Investig"},{"key":"2864_CR3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11912-011-0163-2","volume":"13","author":"GC Guimar\u00e3es","year":"2011","unstructured":"Guimar\u00e3es GC, Rocha RM, Zequi SC, Cunha IW, Soares FA. Penile cancer: epidemiology and treatment. Curr Oncol Rep. 2011;13:231\u20139.","journal-title":"Curr Oncol Rep"},{"issue":"suppl 2A","key":"2864_CR4","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.urology.2010.04.008","volume":"76","author":"V Ficarra","year":"2010","unstructured":"Ficarra V, Akduman B, Bouchot O, Palou J, Tobias-Machado M. Prognostic factors in penile cancer. Urology. 2010;76(suppl 2A):S66\u201373.","journal-title":"Urology"},{"key":"2864_CR5","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.juro.2009.04.028","volume":"182","author":"GC Guimar\u00e3es","year":"2009","unstructured":"Guimar\u00e3es GC, Cunha IW, Soares FA, Lopes A, Torres J, et al. Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. J Urol. 2009;182:528\u201334.","journal-title":"J Urol"},{"issue":"2 Suppl.","key":"2864_CR6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S1569-9056(10)60542-8","volume":"9","author":"P Kirrander","year":"2010","unstructured":"Kirrander P, Kolaric A, Helenius G, Windahl T, Andr\u00e9n O, et al. Human papillomavirus prevalence and correlation to histopathological status in penile carcinoma. Eur Urol. 2010;9(2 Suppl):188.","journal-title":"Eur Urol"},{"key":"2864_CR7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nri1936","volume":"6","author":"L Zitvogel","year":"2006","unstructured":"Zitvogel L, Antoine Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol. 2006;6:715\u201327.","journal-title":"Nat Rev Immunol"},{"key":"2864_CR8","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1200\/JCO.2009.27.2146","volume":"28","author":"ML Disis","year":"2010","unstructured":"Disis ML. Immune regulation of cancer. J Clin Oncol. 2010;28:4531\u20138.","journal-title":"J Clin Oncol"},{"key":"2864_CR9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1447-0756.2007.00492.x","volume":"33","author":"BC Sheu","year":"2007","unstructured":"Sheu BC, Chang WC, Lin HH, Chow SN, Huang SC. Immune concept of human papillomaviruses and related antigens in local cancer milieu of human cervical neoplasia. J Obstet Gynecol Res. 2007;33:103\u201313.","journal-title":"J Obstet Gynecol Res"},{"key":"2864_CR10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/CJI.0b013e31803240fa","volume":"30","author":"I Zehbe","year":"2007","unstructured":"Zehbe I, Kaufmam AM, Schmidt M, Hohn H, Maeurer M. Human papillomavirus 16 E6-specific CD45RA+ CCR7+ high avidity CD8+ T cells fail to control tumor growth despite interferon-gamma production in patients with cervical cancer. J Immunother. 2007;30:523\u201332.","journal-title":"J Immunother"},{"key":"2864_CR11","doi-asserted-by":"crossref","first-page":"7681","DOI":"10.4049\/jimmunol.180.11.7681","volume":"180","author":"Y Cao","year":"2008","unstructured":"Cao Y, Zhao J, Lei Z, Shen S, Liu C, et al. Local accumulation of Fox-P3 regulatory T cells: evidence for an immune evasion mechanism in patients with large condylomata acuminata. J Immunol. 2008;180:7681\u20136.","journal-title":"J Immunol"},{"key":"2864_CR12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0897.2008.00590.x","volume":"60","author":"S Adurthi","year":"2008","unstructured":"Adurthi S, Krishna S, Mukherjee G, Bafna UD, Devi U, Jayshree RS. Regulatory T cells in a spectrum of HPV-induced cervical lesions: cervicitis, cervical intraepithelial neoplasia and squamous cell carcinoma. Am J Reprod Immunol. 2008;60:55\u201365.","journal-title":"Am J Reprod Immunol"},{"key":"2864_CR13","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.2353\/ajpath.2009.090295","volume":"175","author":"F Jaafar","year":"2009","unstructured":"Jaafar F, Righi E, Lindstrom V, Linton C, Nohadani M, et al. Correlation of CXCL12 expression and Fox-P3 cell infiltrating with human papillomavirus infection and clinicopathological progression of cervical cancer. Am J Pathol. 2009;175:1525\u201335.","journal-title":"Am J Pathol"},{"key":"2864_CR14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/GCO.0b013e32831a9890","volume":"21","author":"S Patel","year":"2009","unstructured":"Patel S, Chiplunkar S. Host immune responses to cervical cancer. Curr Op Obstetr Gynecol. 2009;21:54\u20139.","journal-title":"Curr Op Obstetr Gynecol"},{"key":"2864_CR15","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1463-1318.2010.02283.x","volume":"13","author":"M Yaghoobi","year":"2011","unstructured":"Yaghoobi M, Le Gouvello S, Aloulou N, Duprez-Dutreuil C, Walker F, Sobhani I. Fox-P3 overexpression and CD1a\u2009+\u2009and CD3+ depletion in anal tissue as possible mechanisms for increased risk of human papillomavirus-related anal carcinoma in HIV infection. Colorectal Dis. 2011;13:768\u201373.","journal-title":"Colorectal Dis"},{"key":"2864_CR16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/cmi.2010.56","volume":"8","author":"W Shah","year":"2011","unstructured":"Shah W, Yan X, Jing L, Zhou Y, Chen H, Wang Y. A reversed CD4\/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4\u2009+\u2009Fox-P3+ regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix. Cell Mol Immunol. 2011;8:59\u201366.","journal-title":"Cell Mol Immunol"},{"key":"2864_CR17","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/j.1349-7006.2009.01153.x","volume":"100","author":"C Loddenkemper","year":"2009","unstructured":"Loddenkemper C, Hoffmann C, Stanke J, Nagorsen D, Baron U, et al. Regulatory (Fox-P3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer. Cancer Sci. 2009;100:1112\u20137.","journal-title":"Cancer Sci"},{"key":"2864_CR18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/PAS.0b013e318203cdba","volume":"35","author":"AL Cubilla","year":"2011","unstructured":"Cubilla AL, Lloveras B, Alejo M, Clavero O, Chaux A, et al. Value of p16INK4a in the pathology of invasive penile squamous cell carcinomas: a report of 202 cases. Am J Surg Pathol. 2011;35:253\u201361.","journal-title":"Am J Surg Pathol"},{"key":"2864_CR19","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/ijc.25464","volume":"127","author":"CM Wilke","year":"2010","unstructured":"Wilke CM, Wu K, Zhao E, Wang G, Zou W. Prognostic significance of regulatory T cells in tumor. Int J Cancer. 2010;127:748\u201358.","journal-title":"Int J Cancer"},{"key":"2864_CR20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.coi.2010.12.011","volume":"23","author":"WH Fridman","year":"2011","unstructured":"Fridman WH, Mlecnik B, Bindea G, Pag\u00e8s F, Galon J. Immunosurveillance in human non-viral cancers. Curr Op Immunol. 2011;23:272\u20138.","journal-title":"Curr Op Immunol"},{"key":"2864_CR21","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1200\/JCO.2008.17.9036","volume":"27","author":"A Merlo","year":"2009","unstructured":"Merlo A, Casalini P, Carcangiu ML, Malventano C, Triulzi T, et al. Fox-P3 expression and overall survival in breast cancer. J Clin Oncol. 2009;27:1746\u201352.","journal-title":"J Clin Oncol"},{"key":"2864_CR22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s12032-011-9903-2","volume":"29","author":"DS Sun","year":"2012","unstructured":"Sun DS, Zhao MQ, Xia M, Li L, Jiang YH. The correlation between tumor infiltrating Fox-P3+ regulatory T cells and cyclooxygenase-2 expression and their association with recurrence in resected head and neck cancers. Med Oncol. 2012;29:707\u201313.","journal-title":"Med Oncol"},{"issue":"7","key":"2864_CR23","doi-asserted-by":"crossref","first-page":"e22047","DOI":"10.1371\/journal.pone.0022047","volume":"6","author":"A Chew","year":"2011","unstructured":"Chew A, Salama P, Robbshaw A. SPARC, FOXP3, CD8 and CD45 correlation with disease recurrence and long-term disease-free survival in colorectal cancer. PLoS ONE. 2011;6(7):e22047.","journal-title":"PLoS ONE"},{"key":"2864_CR24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/lary.22133","volume":"122","author":"D Wansom","year":"2012","unstructured":"Wansom D, Light E, Thomas D, Worden F, Prince M, et al. Infiltrating lymphocytes and human papillomavirus-16 associated oropharynx cancer. Laryngostope. 2012;122:121\u20137.","journal-title":"Laryngostope"},{"key":"2864_CR25","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ijc.25429","volume":"127","author":"H Nishikawa","year":"2010","unstructured":"Nishikawa H, Sakaguchi S. Regulatory T cells in tumor immunity. Int J Cancer. 2010;127:759\u201367.","journal-title":"Int J Cancer"},{"key":"2864_CR26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/eji.200636929","volume":"37","author":"SF Ziegler","year":"2007","unstructured":"Ziegler SF. FOXP3: not just for regulatory T cells anymore. Eur J Immunol. 2007;37:21\u20133.","journal-title":"Eur J Immunol"},{"key":"2864_CR27","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1038\/onc.2010.174","volume":"29","author":"F Martin","year":"2010","unstructured":"Martin F, Ladoire S, Mignot G, Apetoh L, Ghiringhelli F. Human FOXP3 and cancer. Oncogene. 2010;29:4121\u20139.","journal-title":"Oncogene"},{"key":"2864_CR28","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00262-011-1046-y","volume":"60","author":"S Ladoire","year":"2011","unstructured":"Ladoire S, Martin F, Ghiringhelli F. Prognostic role of Fox-P3 regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer. Cancer Immunol Immunother. 2011;60:909\u201318.","journal-title":"Cancer Immunol Immunother"},{"key":"2864_CR29","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1136\/jcp.2008.056200","volume":"61","author":"YL Woo","year":"2008","unstructured":"Woo YL, Sterling J, Crawford R, van der Burg SH, Coleman N, Stanley M. Fox-P3 immunohistochemistry on formalin-fixed paraffin-embedded tissue: poor correlation between different antibodies. J Clin Pathol. 2008;61:969\u201371.","journal-title":"J Clin Pathol"},{"key":"2864_CR30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00281-011-0264-x","volume":"33","author":"G Bindea","year":"2011","unstructured":"Bindea G, Mleenik B, Fridman WH, Galon J. The prognostic impact of anti-cancer immune response: a novel classification of cancer patients. Semin Immunopathol. 2011;33:335\u201340.","journal-title":"Semin Immunopathol"},{"key":"2864_CR31","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/modpathol.2010.69","volume":"23","author":"A Chaux","year":"2010","unstructured":"Chaux A, Tamboli P, Ayala A, Soares F, Rodr\u00edguez I, et al. Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases. Mod Pathol. 2010;23:896\u2013904.","journal-title":"Mod Pathol"},{"issue":"7","key":"2864_CR32","doi-asserted-by":"crossref","first-page":"vii243","DOI":"10.1093\/annonc\/mdq454","volume":"21","author":"S Syrj\u00e4nen","year":"2010","unstructured":"Syrj\u00e4nen S. The role of human papillomavirus infection in head and neck cancers. Ann Oncol. 2010;21(7):vii243\u20135.","journal-title":"Ann Oncol"},{"key":"2864_CR33","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/CAD.0b013e328344ec44","volume":"22","author":"A Psyrri","year":"2011","unstructured":"Psyrri A, Boutati E, Karageorgopoulou S. Human papillomavirus in head and neck cancers: biology, prognosis, hope of treatment, and vaccines. Anti-Cancer Drugs. 2011;22:586\u201390.","journal-title":"Anti-Cancer Drugs"},{"key":"2864_CR34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/PAS.0b013e3181cdad23","volume":"34","author":"A Chaux","year":"2010","unstructured":"Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Distinctive Association of p16INK4a, et al. Overexpression with penile intraepithelial neoplasia depicting warty and\/or basaloid features: a study of 141 cases evaluating a new nomenclature. Am J Surg Pathol. 2010;34:385\u201392.","journal-title":"Am J Surg Pathol"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-014-2864-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-014-2864-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-014-2864-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-014-2864-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T07:46:02Z","timestamp":1717659962000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-014-2864-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,5]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["2864"],"URL":"https:\/\/doi.org\/10.1007\/s13277-014-2864-2","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,5]]}}}