{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:33:32Z","timestamp":1787585612148,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s13277-015-3063-5","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T01:20:49Z","timestamp":1421284849000},"page":"4261-4269","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition"],"prefix":"10.1007","volume":"36","author":[{"given":"Xiaolin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengzi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beihua","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"3063_CR1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3322\/caac.20113","volume":"61","author":"D Jelovac","year":"2011","unstructured":"Jelovac D, Armstrong DK. Recent progress in the diagnosis and treatment of ovarian cancer. CA Cancer J Clin. 2011;61:183\u2013203.","journal-title":"CA Cancer J Clin"},{"key":"3063_CR2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","volume":"474","author":"Cancer Genome Atlas Research N","year":"2011","unstructured":"Cancer Genome Atlas Research N. Integrated genomic analyses of ovarian carcinoma. Nature. 2011;474:609\u201315.","journal-title":"Nature"},{"key":"3063_CR3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrc3447","volume":"13","author":"B Craene De","year":"2013","unstructured":"De Craene B, Berx G. Regulatory networks defining emt during cancer initiation and progression. Nat Rev Cancer. 2013;13:97\u2013110.","journal-title":"Nat Rev Cancer"},{"key":"3063_CR4","first-page":"495754","volume":"2014","author":"MK Kim","year":"2014","unstructured":"Kim MK, Kim MA, Kim H, Kim YB, Song YS. Expression profiles of epithelial-mesenchymal transition-associated proteins in epithelial ovarian carcinoma. BioMed Res Int. 2014;2014:495754.","journal-title":"BioMed Res Int"},{"key":"3063_CR5","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.2174\/138945012803530044","volume":"13","author":"RY Huang","year":"2012","unstructured":"Huang RY, Chung VY, Thiery JP. Targeting pathways contributing to epithelial-mesenchymal transition (emt) in epithelial ovarian cancer. Curr Drug Targets. 2012;13:1649\u201353.","journal-title":"Curr Drug Targets"},{"key":"3063_CR6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.canlet.2009.09.017","volume":"291","author":"D Vergara","year":"2010","unstructured":"Vergara D, Merlot B, Lucot JP, Collinet P, Vinatier D, Fournier I, et al. Epithelial-mesenchymal transition in ovarian cancer. Cancer Lett. 2010;291:59\u201366.","journal-title":"Cancer Lett"},{"key":"3063_CR7","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.dnarep.2004.03.007","volume":"3","author":"M Stucki","year":"2004","unstructured":"Stucki M, Jackson SP. Mdc1\/nfbd1: A key regulator of the DNA damage response in higher eukaryotes. DNA Repair. 2004;3:953\u20137.","journal-title":"DNA Repair"},{"key":"3063_CR8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4161\/nucl.1.2.11176","volume":"1","author":"G Coster","year":"2010","unstructured":"Coster G, Goldberg M. The cellular response to DNA damage: A focus on mdc1 and its interacting proteins. Nucleus. 2010;1:166\u201378.","journal-title":"Nucleus"},{"key":"3063_CR9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00412-010-0266-9","volume":"119","author":"S Jungmichel","year":"2010","unstructured":"Jungmichel S, Stucki M. Mdc1: The art of keeping things in focus. Chromosoma. 2010;119:337\u201349.","journal-title":"Chromosoma"},{"key":"3063_CR10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molcel.2005.11.025","volume":"21","author":"Z Lou","year":"2006","unstructured":"Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, et al. Mdc1 maintains genomic stability by participating in the amplification of atm-dependent DNA damage signals. Mol Cell. 2006;21:187\u2013200.","journal-title":"Mol Cell"},{"key":"3063_CR11","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nature01446","volume":"421","author":"GS Stewart","year":"2003","unstructured":"Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ. Mdc1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003;421:961\u20136.","journal-title":"Nature"},{"key":"3063_CR12","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cell.2005.09.038","volume":"123","author":"M Stucki","year":"2005","unstructured":"Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. Mdc1 directly binds phosphorylated histone h2ax to regulate cellular responses to DNA double-strand breaks. Cell. 2005;123:1213\u201326.","journal-title":"Cell"},{"key":"3063_CR13","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature02118","volume":"426","author":"F d\u2019Adda di Fagagna","year":"2003","unstructured":"d\u2019Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature. 2003;426:194\u20138.","journal-title":"Nature"},{"key":"3063_CR14","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nature01445","volume":"421","author":"M Goldberg","year":"2003","unstructured":"Goldberg M, Stucki M, Falck J, D\u2019Amours D, Rahman D, Pappin D, et al. Mdc1 is required for the intra-s-phase DNA damage checkpoint. Nature. 2003;421:952\u20136.","journal-title":"Nature"},{"key":"3063_CR15","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nature01447","volume":"421","author":"Z Lou","year":"2003","unstructured":"Lou Z, Minter-Dykhouse K, Wu X, Chen J. Mdc1 is coupled to activated chk2 in mammalian DNA damage response pathways. Nature. 2003;421:957\u201361.","journal-title":"Nature"},{"key":"3063_CR16","doi-asserted-by":"crossref","first-page":"22993","DOI":"10.1074\/jbc.M611412200","volume":"282","author":"M Nakanishi","year":"2007","unstructured":"Nakanishi M, Ozaki T, Yamamoto H, Hanamoto T, Kikuchi H, Furuya K, et al. Nfbd1\/mdc1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damage. J Biol Chem. 2007;282:22993\u20133004.","journal-title":"J Biol Chem"},{"key":"3063_CR17","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrc3342","volume":"12","author":"P Bouwman","year":"2012","unstructured":"Bouwman P, Jonkers J. The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer. 2012;12:587\u201398.","journal-title":"Nat Rev Cancer"},{"key":"3063_CR18","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/nsmb.2702","volume":"20","author":"S Watanabe","year":"2013","unstructured":"Watanabe S, Watanabe K, Akimov V, Bartkova J, Blagoev B, Lukas J, et al. Jmjd1c demethylates mdc1 to regulate the rnf8 and brca1-mediated chromatin response to DNA breaks. Nat Struct Mol Biol. 2013;20:1425\u201333.","journal-title":"Nat Struct Mol Biol"},{"key":"3063_CR19","doi-asserted-by":"crossref","first-page":"20543","DOI":"10.1074\/jbc.M114.549220","volume":"289","author":"XW Meng","year":"2014","unstructured":"Meng XW, Koh BD, Zhang JS, Flatten KS, Schneider PA, Billadeau DD, et al. Poly (adp-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression. J Biol Chem. 2014;289:20543\u201358.","journal-title":"J Biol Chem"},{"key":"3063_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-010-0460-3","volume":"342","author":"Z Yang","year":"2010","unstructured":"Yang Z, Bu Y, Wang C, Liu G, Song F. Growth inhibition, morphology change, and cell cycle alterations in nfbd1-depleted human esophageal cancer cells. Mol Cell Biochem. 2010;342:1\u20136.","journal-title":"Mol Cell Biochem"},{"key":"3063_CR21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11010-011-1027-7","volume":"359","author":"C Yuan","year":"2012","unstructured":"Yuan C, Bu Y, Wang C, Yi F, Yang Z, Huang X, et al. Nfbd1\/mdc1 is a protein of oncogenic potential in human cervical cancer. Mol Cell Biochem. 2012;359:333\u201346.","journal-title":"Mol Cell Biochem"},{"key":"3063_CR22","doi-asserted-by":"crossref","unstructured":"Ye Q, Chen L, Yin X, Liu YJ, Ji Q, Zhao E: Development of serous ovarian cancer is associated with the expression of homologous recombination pathway proteins. Pathology oncology research. POR. 2014.","DOI":"10.1007\/s12253-014-9776-8"},{"key":"3063_CR23","doi-asserted-by":"crossref","first-page":"e6529","DOI":"10.1371\/journal.pone.0006529","volume":"4","author":"E Campeau","year":"2009","unstructured":"Campeau E, Ruhl VE, Rodier F, Smith CL, Rahmberg BL, Fuss JO, et al. A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One. 2009;4:e6529.","journal-title":"PLoS One"},{"key":"3063_CR24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/hmg\/10.7.705","volume":"10","author":"PL Welcsh","year":"2001","unstructured":"Welcsh PL, King MC. Brca1 and brca2 and the genetics of breast and ovarian cancer. Hum Mol Genet. 2001;10:705\u201313.","journal-title":"Hum Mol Genet"},{"key":"3063_CR25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/path.4205","volume":"230","author":"WD Foulkes","year":"2013","unstructured":"Foulkes WD, Shuen AY. In brief: Brca1 and brca2. J Pathol. 2013;230:347\u20139.","journal-title":"J Pathol"},{"key":"3063_CR26","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrc3399","volume":"12","author":"NJ Curtin","year":"2012","unstructured":"Curtin NJ. DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer. 2012;12:801\u201317.","journal-title":"Nat Rev Cancer"},{"key":"3063_CR27","doi-asserted-by":"crossref","unstructured":"Goodwin JF, Knudsen KE: Beyond DNA repair: DNA-pk function in cancer. Cancer discovery. 2014.","DOI":"10.1158\/2159-8290.CD-14-0358"},{"key":"3063_CR28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1158\/2159-8290.CD-13-0136","volume":"4","author":"E Powell","year":"2014","unstructured":"Powell E, Piwnica-Worms D, Piwnica-Worms H. Contribution of p53 to metastasis. Cancer Discov. 2014;4:405\u201314.","journal-title":"Cancer Discov"},{"key":"3063_CR29","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.mam.2013.05.003","volume":"34","author":"M Masutani","year":"2013","unstructured":"Masutani M, Fujimori H. Poly (adp-ribosyl) ation in carcinogenesis. Mol Aspects Med. 2013;34:1202\u201316.","journal-title":"Mol Aspects Med"},{"key":"3063_CR30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1667\/RR13515.1","volume":"181","author":"CG Broustas","year":"2014","unstructured":"Broustas CG, Lieberman HB. DNA damage response genes and the development of cancer metastasis. Radiat Res. 2014;181:111\u201330.","journal-title":"Radiat Res"},{"key":"3063_CR31","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1038\/sj.onc.1210553","volume":"26","author":"J Bartkova","year":"2007","unstructured":"Bartkova J, Horejsi Z, Sehested M, Nesland JM, Rajpert-De Meyts E, Skakkebaek NE, et al. DNA damage response mediators mdc1 and 53\u00a0bp1: Constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene. 2007;26:7414\u201322.","journal-title":"Oncogene"},{"key":"3063_CR32","doi-asserted-by":"crossref","first-page":"e106794","DOI":"10.1371\/journal.pone.0106794","volume":"9","author":"B Wang","year":"2014","unstructured":"Wang B, Zhang L, Qiu F, Fang W, Deng J, Zhou Y, et al. A newfound association between mdc1 functional polymorphism and lung cancer risk in chinese. PLoS One. 2014;9:e106794.","journal-title":"PLoS One"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3063-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-015-3063-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3063-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3063-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T14:59:39Z","timestamp":1566226779000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-015-3063-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,16]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["3063"],"URL":"https:\/\/doi.org\/10.1007\/s13277-015-3063-5","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,16]]}}}