{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:18:54Z","timestamp":1774264734285,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T00:00:00Z","timestamp":1428019200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s13277-015-3387-1","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T15:24:21Z","timestamp":1428074661000},"page":"6789-6795","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Ginsenoside Rh2 inhibits metastasis of glioblastoma multiforme through Akt-regulated MMP13"],"prefix":"10.1007","volume":"36","author":[{"given":"Ning","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochuan","family":"Huo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoudan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junsheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenshi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,3]]},"reference":[{"key":"3387_CR1","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1007\/s13277-014-1913-1","volume":"35","author":"J Chen","year":"2014","unstructured":"Chen J, Huang Q, Wang F. Inhibition of foxo1 nuclear exclusion prevents metastasis of glioblastoma. Tumour Biol. 2014;35:7195\u2013200.","journal-title":"Tumour Biol"},{"key":"3387_CR2","doi-asserted-by":"crossref","first-page":"11879","DOI":"10.1007\/s13277-014-2438-3","volume":"35","author":"J Gong","year":"2014","unstructured":"Gong J, Zhu S, Zhang Y, Wang J. Interplay of VEGFA and MMP2 regulates invasion of glioblastoma. Tumour Biol. 2014;35:11879\u201385.","journal-title":"Tumour Biol"},{"key":"3387_CR3","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1007\/s13277-014-1739-x","volume":"35","author":"S Li","year":"2014","unstructured":"Li S, Gao Y, Ma W, Guo W, Zhou G, Cheng T, et al. EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside rh2. Tumour Biol. 2014;35:5593\u20138.","journal-title":"Tumour Biol"},{"key":"3387_CR4","doi-asserted-by":"crossref","first-page":"8653","DOI":"10.1007\/s13277-014-2131-6","volume":"35","author":"F Wang","year":"2014","unstructured":"Wang F, Xiao W, Sun J, Han D, Zhu Y. Mirna-181c inhibits EGFR-signaling-dependent mmp9 activation via suppressing AKT phosphorylation in glioblastoma. Tumour Biol. 2014;35:8653\u20138.","journal-title":"Tumour Biol"},{"key":"3387_CR5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11060-004-2751-6","volume":"70","author":"T Demuth","year":"2004","unstructured":"Demuth T, Berens ME. Molecular mechanisms of glioma cell migration and invasion. J Neurooncol. 2004;70:217\u201328.","journal-title":"J Neurooncol"},{"key":"3387_CR6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10072-013-1604-5","volume":"35","author":"P Ramaswamy","year":"2014","unstructured":"Ramaswamy P, Aditi Devi N, Hurmath Fathima K, Dalavaikodihalli Nanjaiah N. Activation of nmda receptor of glutamate influences MMP-2 activity and proliferation of glioma cells. Neurol Sci. 2014;35:823\u20139.","journal-title":"Neurol Sci"},{"key":"3387_CR7","first-page":"851","volume":"35","author":"CS Gondi","year":"2009","unstructured":"Gondi CS, Talluri L, Dinh DH, Gujrati M, Rao JS. RNAi-mediated downregulation of MMP-2 activates the extrinsic apoptotic pathway in human glioma xenograft cells. Int J Oncol. 2009;35:851\u20139.","journal-title":"Int J Oncol"},{"key":"3387_CR8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0167-4889(98)00020-2","volume":"1403","author":"PO Esteve","year":"1998","unstructured":"Esteve PO, Tremblay P, Houde M, St-Pierre Y, Mandeville R. In vitro expression of MMP-2 and MMP-9 in glioma cells following exposure to inflammatory mediators. Biochim Biophys Acta. 1998;1403:85\u201396.","journal-title":"Biochim Biophys Acta"},{"key":"3387_CR9","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/glia.20773","volume":"57","author":"WL Yeh","year":"2009","unstructured":"Yeh WL, Lu DY, Lee MJ, Fu WM. Leptin induces migration and invasion of glioma cells through MMP-13 production. Glia. 2009;57:454\u201364.","journal-title":"Glia"},{"key":"3387_CR10","first-page":"1121","volume":"37","author":"A Inoue","year":"2010","unstructured":"Inoue A, Takahashi H, Harada H, Kohno S, Ohue S, Kobayashi K, et al. Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity. Int J Oncol. 2010;37:1121\u201331.","journal-title":"Int J Oncol"},{"key":"3387_CR11","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1007\/s11033-014-3422-0","volume":"41","author":"H Ye","year":"2014","unstructured":"Ye H, Wu Q, Zhu Y, Guo C, Zheng X. Ginsenoside rh2 alleviates dextran sulfate sodium-induced colitis via augmenting TGFbeta signaling. Mol Biol Rep. 2014;41:5485\u201390.","journal-title":"Mol Biol Rep"},{"key":"3387_CR12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00001813-199102000-00009","volume":"2","author":"Y Kikuchi","year":"1991","unstructured":"Kikuchi Y, Sasa H, Kita T, Hirata J, Tode T, Nagata I. Inhibition of human ovarian cancer cell proliferation in vitro by ginsenoside rh2 and adjuvant effects to cisplatin in vivo. Anticancer Drugs. 1991;2:63\u20137.","journal-title":"Anticancer Drugs"},{"key":"3387_CR13","first-page":"1275","volume":"45","author":"T Tode","year":"1993","unstructured":"Tode T, Kikuchi Y, Hirata J, Kita T, Imaizumi E. Nagata I: [Inhibitory effects of oral administration of ginsenoside rh2 on tumor growth in nude mice bearing serous cyst adenocarcinoma of the human ovary]. Nihon Sanka Fujinka Gakkai zasshi. 1993;45:1275\u201382.","journal-title":"Nihon Sanka Fujinka Gakkai zasshi"},{"key":"3387_CR14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF01200720","volume":"120","author":"T Tode","year":"1993","unstructured":"Tode T, Kikuchi Y, Kita T, Hirata J, Imaizumi E, Nagata I. Inhibitory effects by oral administration of ginsenoside rh2 on the growth of human ovarian cancer cells in nude mice. J Cancer Res Clin Oncol. 1993;120:24\u20136.","journal-title":"J Cancer Res Clin Oncol"},{"key":"3387_CR15","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1349-7006.1998.tb03278.x","volume":"89","author":"H Nakata","year":"1998","unstructured":"Nakata H, Kikuchi Y, Tode T, Hirata J, Kita T, Ishii K, et al. Inhibitory effects of ginsenoside rh2 on tumor growth in nude mice bearing human ovarian cancer cells. Jpn J Cancer Res. 1998;89:733\u201340.","journal-title":"Jpn J Cancer Res"},{"key":"3387_CR16","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3748\/wjg.v19.i10.1582","volume":"19","author":"XP Tang","year":"2013","unstructured":"Tang XP, Tang GD, Fang CY, Liang ZH, Zhang LY. Effects of ginsenoside rh2 on growth and migration of pancreatic cancer cells. World J Gastroenterol. 2013;19:1582\u201392.","journal-title":"World J Gastroenterol"},{"key":"3387_CR17","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.fitote.2010.05.020","volume":"81","author":"J Liu","year":"2010","unstructured":"Liu J, Shimizu K, Yu H, Zhang C, Jin F, Kondo R. Stereospecificity of hydroxyl group at c-20 in antiproliferative action of ginsenoside rh2 on prostate cancer cells. Fitoterapia. 2010;81:902\u20135.","journal-title":"Fitoterapia"},{"key":"3387_CR18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.canlet.2010.11.015","volume":"301","author":"B Li","year":"2011","unstructured":"Li B, Zhao J, Wang CZ, Searle J, He TC, Yuan CS, et al. Ginsenoside rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett. 2011;301:185\u201392.","journal-title":"Cancer Lett"},{"key":"3387_CR19","first-page":"869","volume":"14","author":"M Oh","year":"1999","unstructured":"Oh M, Choi YH, Choi S, Chung H, Kim K, Kim SI, et al. Anti-proliferating effects of ginsenoside rh2 on mcf-7 human breast cancer cells. Int J Oncol. 1999;14:869\u201375.","journal-title":"Int J Oncol"},{"key":"3387_CR20","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1007\/s11095-009-9944-9","volume":"26","author":"S Choi","year":"2009","unstructured":"Choi S, Kim TW, Singh SV. Ginsenoside rh2-mediated g1 phase cell cycle arrest in human breast cancer cells is caused by p15 ink4b and p27 kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009;26:2280\u20138.","journal-title":"Pharm Res"},{"key":"3387_CR21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","volume":"2","author":"CC Liang","year":"2007","unstructured":"Liang CC, Park AY, Guan JL. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2007;2:329\u201333.","journal-title":"Nat Protoc"},{"key":"3387_CR22","doi-asserted-by":"crossref","first-page":"E1211","DOI":"10.1073\/pnas.1321347111","volume":"111","author":"X Xiao","year":"2014","unstructured":"Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, et al. M2 macrophages promote beta-cell proliferation by up-regulation of smad7. Proc Natl Acad Sci U S A. 2014;111:E1211\u201320.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3387_CR23","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/neup.12129","volume":"34","author":"Q Xie","year":"2014","unstructured":"Xie Q, Yan Y, Huang Z, Zhong X, Huang L. MicroRNA-221 targeting pi3-k\/Akt signaling axis induces cell proliferation and bcnu resistance in human glioblastoma. Neuropathology. 2014;34:455\u201364.","journal-title":"Neuropathology"},{"key":"3387_CR24","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3892\/or_00000726","volume":"23","author":"N Zhao","year":"2010","unstructured":"Zhao N, Guo Y, Zhang M, Lin L, Zheng Z. Akt-mtor signaling is involved in notch-1-mediated glioma cell survival and proliferation. Oncol Rep. 2010;23:1443\u20137.","journal-title":"Oncol Rep"},{"key":"3387_CR25","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1074\/jbc.M601698200","volume":"282","author":"J Radeff-Huang","year":"2007","unstructured":"Radeff-Huang J, Seasholtz TM, Chang JW, Smith JM, Walsh CT, Brown JH. Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent akt activation and cyclin d expression. J Biol Chem. 2007;282:863\u201370.","journal-title":"J Biol Chem"},{"key":"3387_CR26","doi-asserted-by":"crossref","first-page":"9062","DOI":"10.1038\/sj.onc.1208093","volume":"23","author":"SE Aeder","year":"2004","unstructured":"Aeder SE, Martin PM, Soh JW, Hussaini IM. Pkc-eta mediates glioblastoma cell proliferation through the akt and mtor signaling pathways. Oncogene. 2004;23:9062\u20139.","journal-title":"Oncogene"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3387-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-015-3387-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3387-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T15:29:18Z","timestamp":1559489358000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-015-3387-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,3]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["3387"],"URL":"https:\/\/doi.org\/10.1007\/s13277-015-3387-1","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,3]]}}}