{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:56:24Z","timestamp":1770911784655,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s13277-015-3423-1","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T01:10:16Z","timestamp":1428887416000},"page":"7061-7067","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The high expression of TC1 (C8orf4) was correlated with the expression of \u03b2-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue"],"prefix":"10.1007","volume":"36","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Lin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song-Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian-He","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"En-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,14]]},"reference":[{"issue":"2","key":"3423_CR1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69\u201390.","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"3423_CR2","first-page":"3255","volume":"7","author":"MV Souza de","year":"2014","unstructured":"de Souza MV, Servato JP, Loyola AM, Cardoso SV, Chammas R, Liu FT, et al. Expression of APC protein during tongue malignant transformation in galectin-3-deficient mice challenged by the carcinogen 4-nitroquniline-n-oxide. Int J Clin Exp Pathol. 2014;7(6):3255\u201363.","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"3423_CR3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2334\/josnusd.54.105","volume":"54","author":"AC Henriques","year":"2012","unstructured":"Henriques AC, de Matos FR, Galvao HC, Freitas RA. Immunohistochemical expression of MMP-9 and VEGF in squamous cell carcinoma of the tongue. J Oral Sci. 2012;54(1):105\u201311.","journal-title":"J Oral Sci"},{"issue":"7","key":"3423_CR4","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/CAD.0b013e32834249ba","volume":"22","author":"N Sahu","year":"2011","unstructured":"Sahu N, Grandis JR. New advances in molecular approaches to head and neck squamous cell carcinoma. Anticancer Drugs. 2011;22(7):656\u201364.","journal-title":"Anticancer Drugs"},{"issue":"3-4","key":"3423_CR5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10555-007-9082-y","volume":"26","author":"D Sano","year":"2007","unstructured":"Sano D, Myers JN. Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metastasis Rev. 2007;26(3-4):645\u201362.","journal-title":"Cancer Metastasis Rev"},{"issue":"8","key":"3423_CR6","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1158\/0008-5472.CAN-03-2093","volume":"64","author":"M Sunde","year":"2004","unstructured":"Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP, et al. TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer. Cancer Res. 2004;64(8):2766\u201373.","journal-title":"Cancer Res"},{"issue":"3","key":"3423_CR7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/geno.2000.6348","volume":"69","author":"EL Chua","year":"2000","unstructured":"Chua EL, Young L, Wu WM, Turtle JR, Dong Q. Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer. Genomics. 2000;69(3):342\u20137.","journal-title":"Genomics"},{"issue":"10","key":"3423_CR8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.5483\/BMBRep.2008.41.10.733","volume":"41","author":"YD Wang","year":"2008","unstructured":"Wang YD, Bian GH, Lv XY, Zheng R, Sun H, Zhang Z, et al. TC1 (C8orf4) is involved in ERK1\/2 pathway-regulated G(1)- to S-phase transition. BMB Rep. 2008;41(10):733\u20138.","journal-title":"BMB Rep"},{"issue":"1","key":"3423_CR9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ijc.20235","volume":"111","author":"JB Friedman","year":"2004","unstructured":"Friedman JB, Brunschwig EB, Platzer P, Wilson K, Markowitz SD. C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer. Int J Cancer. 2004;111(1):72\u20135.","journal-title":"Int J Cancer"},{"issue":"2","key":"3423_CR10","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1158\/0008-5472.CAN-05-3124","volume":"66","author":"Y Jung","year":"2006","unstructured":"Jung Y, Bang S, Choi K, Kim E, Kim Y, Kim J, et al. TC1 (C8orf4) enhances the Wnt\/beta-catenin pathway by relieving antagonistic activity of Chibby. Cancer Res. 2006;66(2):723\u20138.","journal-title":"Cancer Res"},{"issue":"11 Pt 1","key":"3423_CR11","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1158\/1078-0432.CCR-05-2440","volume":"12","author":"B Kim","year":"2006","unstructured":"Kim B, Koo H, Yang S, Bang S, Jung Y, Kim Y, et al. TC1(C8orf4) correlates with Wnt\/beta-catenin target genes and aggressive biological behavior in gastric cancer. Clin Cancer Res. 2006;12(11 Pt 1):3541\u20138.","journal-title":"Clin Cancer Res"},{"issue":"6","key":"3423_CR12","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.4049\/jimmunol.0900956","volume":"183","author":"J Kim","year":"2009","unstructured":"Kim J, Kim Y, Kim HT, Kim DW, Ha Y, Kim CH, et al. TC1(C8orf4) is a novel endothelial inflammatory regulator enhancing NF-kappaB activity. J Immunol. 2009;183(6):3996\u20134002.","journal-title":"J Immunol"},{"issue":"14","key":"3423_CR13","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1016\/j.febslet.2006.05.036","volume":"580","author":"Y Kim","year":"2006","unstructured":"Kim Y, Kim J, Park J, Bang S, Jung Y, Choe J, et al. TC1(C8orf4) is upregulated by IL-1beta\/TNF-alpha and enhances proliferation of human follicular dendritic cells. FEBS Lett. 2006;580(14):3519\u201324.","journal-title":"FEBS Lett"},{"issue":"6","key":"3423_CR14","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/ijc.22831","volume":"121","author":"ZQ Yang","year":"2007","unstructured":"Yang ZQ, Moffa AB, Haddad R, Streicher KL, Ethier SP. Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways. Int J Cancer. 2007;121(6):1265\u201373.","journal-title":"Int J Cancer"},{"issue":"1","key":"3423_CR15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jss.2013.05.075","volume":"185","author":"K Su","year":"2014","unstructured":"Su K, Huang L, Li W, Yan X, Li X, Zhang Z, et al. TC-1 (c8orf4) enhances aggressive biologic behavior in lung cancer through the Wnt\/beta-catenin pathway. J Surg Res. 2014;185(1):255\u201363.","journal-title":"J Surg Res"},{"issue":"3","key":"3423_CR16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00428-013-1375-7","volume":"462","author":"HT Xu","year":"2013","unstructured":"Xu HT, Liu Y, Liu SL, Miao Y, Li QC, Wang EH. TC-1 (C8orf4) expression is correlated with differentiation in ovarian carcinomas and might distinguish metastatic ovarian from metastatic colorectal carcinomas. Virchows Arch. 2013;462(3):281\u20137.","journal-title":"Virchows Arch"},{"issue":"6","key":"3423_CR17","volume":"9","author":"Y Jung","year":"2014","unstructured":"Jung Y, Kim M, Soh H, Lee S, Kim J, Park S, et al. TC1(C8orf4) regulates hematopoietic stem\/progenitor cells and hematopoiesis. PLoS One. 2014;9(6), e100311.","journal-title":"PLoS One"},{"issue":"4","key":"3423_CR18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/0022034510363373","volume":"89","author":"F Liu","year":"2010","unstructured":"Liu F, Millar SE. Wnt\/beta-catenin signaling in oral tissue development and disease. J Dent Res. 2010;89(4):318\u201330.","journal-title":"J Dent Res"},{"issue":"5","key":"3423_CR19","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jhep.2013.07.001","volume":"59","author":"F Pez","year":"2013","unstructured":"Pez F, Lopez A, Kim M, Wands JR, Caron de Fromentel C, Merle P. Wnt signaling and hepatocarcinogenesis: molecular targets for the development of innovative anticancer drugs. J Hepatol. 2013;59(5):1107\u201317.","journal-title":"J Hepatol"},{"issue":"3","key":"3423_CR20","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cellsig.2013.11.032","volume":"26","author":"M Krausova","year":"2014","unstructured":"Krausova M, Korinek V. Wnt signaling in adult intestinal stem cells and cancer. Cell Signal. 2014;26(3):570\u20139.","journal-title":"Cell Signal"},{"issue":"1","key":"3423_CR21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2014.07.010","volume":"353","author":"Y Xi","year":"2014","unstructured":"Xi Y, Chen Y. Wnt signaling pathway: Implications for therapy in lung cancer and bone metastasis. Cancer Lett. 2014;353(1):8\u201316.","journal-title":"Cancer Lett"},{"issue":"5","key":"3423_CR22","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.3892\/ijo.2013.2084","volume":"43","author":"XM Xie","year":"2013","unstructured":"Xie XM, Zhang ZY, Yang LH, Yang DL, Tang N, Zhao HY, et al. Aberrant hypermethylation and reduced expression of disabled-2 promote the development of lung cancers. Int J Oncol. 2013;43(5):1636\u201342.","journal-title":"Int J Oncol"},{"issue":"2","key":"3423_CR23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1600-0463.2012.02946.x","volume":"121","author":"HT Xu","year":"2013","unstructured":"Xu HT, Xie XM, Li QC, Liu SL, Dai SD, Liu Y, et al. Atonal homolog 1 expression in lung cancer correlates with inhibitors of the Wnt pathway as well as the differentiation and primary tumor stage. APMIS. 2013;121(2):111\u20139.","journal-title":"APMIS"},{"issue":"3","key":"3423_CR24","first-page":"873","volume":"32","author":"J Noguti","year":"2012","unstructured":"Noguti J, DEM CF, Hossaka TA, Franco M, Oshima CT, Dedivitis RA, et al. The role of canonical WNT signaling pathway in oral carcinogenesis: a comprehensive review. Anticancer Res. 2012;32(3):873\u20138.","journal-title":"Anticancer Res"},{"issue":"9","key":"3423_CR25","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.oraloncology.2014.06.005","volume":"50","author":"MA Gonzalez-Moles","year":"2014","unstructured":"Gonzalez-Moles MA, Ruiz-Avila I, Gil-Montoya JA, Plaza-Campillo J, Scully C. Beta-catenin in oral cancer: an update on current knowledge. Oral Oncol. 2014;50(9):818\u201324.","journal-title":"Oral Oncol"},{"issue":"3","key":"3423_CR26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.humpath.2004.12.009","volume":"36","author":"T Odajima","year":"2005","unstructured":"Odajima T, Sasaki Y, Tanaka N, Kato-Mori Y, Asanuma H, Ikeda T, et al. Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. Hum Pathol. 2005;36(3):234\u201341.","journal-title":"Hum Pathol"},{"issue":"12","key":"3423_CR27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00432-005-0027-y","volume":"131","author":"S Iwai","year":"2005","unstructured":"Iwai S, Katagiri W, Kong C, Amekawa S, Nakazawa M, Yura Y. Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2005;131(12):773\u201382.","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"3423_CR28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1750-2187-7-6","volume":"7","author":"V Fischer","year":"2012","unstructured":"Fischer V, Brown-Grant DA, Li FQ. Chibby suppresses growth of human SW480 colon adenocarcinoma cells through inhibition of \u03b2-catenin signaling. J Mol Signal. 2012;7(1):6.","journal-title":"J Mol Signal"},{"issue":"11","key":"3423_CR29","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1600-0463.2011.02799.x","volume":"119","author":"HT Xu","year":"2011","unstructured":"Xu HT, Li QC, Dai SD, Xie XM, Liu DI, Wang EH. The expression patterns and correlations of chibby, beta-catenin, and DNA methyltransferase-1 and their clinicopathological significance in lung cancers. APMIS. 2011;119(11):750\u20138.","journal-title":"APMIS"},{"issue":"7","key":"3423_CR30","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.yexcr.2010.01.019","volume":"316","author":"K Vandepoele","year":"2010","unstructured":"Vandepoele K, Staes K, Andries V, van Roy F. Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma. Exp Cell Res. 2010;316(7):1225\u201333.","journal-title":"Exp Cell Res"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3423-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-015-3423-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3423-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T06:00:31Z","timestamp":1566540031000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-015-3423-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,14]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["3423"],"URL":"https:\/\/doi.org\/10.1007\/s13277-015-3423-1","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,14]]}}}