{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:20:31Z","timestamp":1792981231501,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T00:00:00Z","timestamp":1431043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s13277-015-3522-z","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T15:41:09Z","timestamp":1431013269000},"page":"7897-7906","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Preoperative serum markers for individual patient prognosis in stage I\u2013III colon cancer"],"prefix":"10.1007","volume":"36","author":[{"given":"Clemens","family":"Giessen-Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Glas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Spelsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Lau-Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik Paul","family":"Modest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Heinemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorit","family":"Di Gioia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Stieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,8]]},"reference":[{"issue":"6","key":"3522_CR1","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","volume":"49","author":"J Ferlay","year":"2013","unstructured":"Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374\u2013403.","journal-title":"Eur J Cancer"},{"issue":"9","key":"3522_CR2","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.ejca.2007.03.021","volume":"43","author":"MJ Duffy","year":"2007","unstructured":"Duffy MJ, van Dalen A, Haglund C, Hansson L, Holinski-Feder E, Klapdor R, et al. Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use. Eur J Cancer. 2007;43(9):1348\u201360.","journal-title":"Eur J Cancer"},{"issue":"2","key":"3522_CR3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1349-7006.2008.01022.x","volume":"100","author":"K Yamashita","year":"2009","unstructured":"Yamashita K, Watanabe M. Clinical significance of tumor markers and an emerging perspective on colorectal cancer. Cancer Sci. 2009;100(2):195\u20139.","journal-title":"Cancer Sci"},{"issue":"suppl 5","key":"3522_CR4","doi-asserted-by":"crossref","first-page":"v93","DOI":"10.1093\/annonc\/mdq222","volume":"21","author":"E Cutsem Van","year":"2010","unstructured":"Van Cutsem E, Nordlinger B, Cervantes A, Group ObotEGW. Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment. Annals of Oncology. 2010;21 suppl 5:v93\u20137.","journal-title":"Annals of Oncology"},{"issue":"11","key":"3522_CR5","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1038\/bjc.2013.649","volume":"109","author":"SK Spencer","year":"2013","unstructured":"Spencer SK, Pommier AJ, Morgan SR, Barry ST, Robertson JD, Hoff PM, et al. Prognostic\/predictive value of 207 serum factors in colorectal cancer treated with cediranib and\/or chemotherapy. Br J Cancer. 2013;109(11):2765\u201373.","journal-title":"Br J Cancer"},{"issue":"33","key":"3522_CR6","doi-asserted-by":"crossref","first-page":"5313","DOI":"10.1200\/JCO.2006.08.2644","volume":"24","author":"GY Locker","year":"2006","unstructured":"Locker GY, Hamilton S, Harris J, Jessup JM, Kemeny N, Macdonald JS, et al. ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol. 2006;24(33):5313\u201327.","journal-title":"J Clin Oncol"},{"issue":"1","key":"3522_CR7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/172460080001500109","volume":"15","author":"AI Behbehani","year":"2000","unstructured":"Behbehani AI, Al-Sayer H, Farghaly M, Kanawati N, Mathew A, al-Bader A, et al. Prognostic significance of CEA and CA 19-9 in colorectal cancer in Kuwait. Int J Biol Markers. 2000;15(1):51\u20135.","journal-title":"Int J Biol Markers"},{"issue":"6D","key":"3522_CR8","first-page":"5195","volume":"20","author":"W Reiter","year":"2000","unstructured":"Reiter W, Stieber P, Reuter C, Nagel D, Lau-Werner U, Lamerz R. Multivariate analysis of the prognostic value of CEA and CA 19-9 serum levels in colorectal cancer. Anticancer Res. 2000;20(6D):5195\u20138.","journal-title":"Anticancer Res"},{"key":"3522_CR9","doi-asserted-by":"crossref","unstructured":"Hofmann D, Nagel D, Lau-Werner U, Wichmann Matthias W, Hornung H-M, Stenman Ulf H, et al. Prognosis in non-metastatic colorectal cancer: multivariate evaluation of preoperative levels of six tumor markers in addition to clinical parameters. Lab Med. 2007. p. 76.","DOI":"10.1515\/JLM.2007.012"},{"issue":"6","key":"3522_CR10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/ijc.90009","volume":"101","author":"J Louhimo","year":"2002","unstructured":"Louhimo J, Carpelan-Holmstrom M, Alfthan H, Stenman UH, Jarvinen HJ, Haglund C. Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer. Int J Cancer. 2002;101(6):545\u20138.","journal-title":"Int J Cancer"},{"issue":"106","key":"3522_CR11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0016-5085(11)61544-8","volume":"58","author":"XQ Yang","year":"2011","unstructured":"Yang XQ, Chen C, Hou JX, Peng CW, Huang CQ, Li Y. Preoperative serum carbohydrate antigen 242 is a useful predictive and prognostic marker in colorectal cancer. Hepatogastroenterology. 2011;58(106):377\u201382.","journal-title":"Hepatogastroenterology"},{"issue":"6","key":"3522_CR12","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/oxfordjournals.annonc.a059248","volume":"6","author":"A Webb","year":"1995","unstructured":"Webb A, Scott-Mackie P, Cunningham D, Norman A, Andreyev J, O'Brien M, et al. The prognostic value of CEA, beta HCG, AFP, CA125, CA19-9 and C-erb B-2, beta HCG immunohistochemistry in advanced colorectal cancer. Ann Oncol. 1995;6(6):581\u20137.","journal-title":"Ann Oncol"},{"issue":"5","key":"3522_CR13","first-page":"1971","volume":"32","author":"S Holdenrieder","year":"2012","unstructured":"Holdenrieder S, Stieber P, Liska V, Treska V, Topolcan O, Dreslerova J, et al. Cytokeratin serum biomarkers in patients with colorectal cancer. Anticancer Res. 2012;32(5):1971\u20136.","journal-title":"Anticancer Res"},{"issue":"6","key":"3522_CR14","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/sj.bjc.6605855","volume":"103","author":"MJ Proctor","year":"2010","unstructured":"Proctor MJ, Talwar D, Balmar SM, O'Reilly DS, Foulis AK, Horgan PG, et al. The relationship between the presence and site of cancer, an inflammation-based prognostic score and biochemical parameters. Initial results of the Glasgow Inflammation Outcome Study. Br J Cancer. 2010;103(6):870\u20136.","journal-title":"Br J Cancer"},{"issue":"2","key":"3522_CR15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2188\/jea.JE20110071","volume":"22","author":"T Tsuboya","year":"2012","unstructured":"Tsuboya T, Kuriyama S, Nagai M, Hozawa A, Sugawara Y, Tomata Y, et al. Gamma-glutamyltransferase and cancer incidence: the Ohsaki cohort study. J Epidemiol. 2012;22(2):144\u201350.","journal-title":"J Epidemiol"},{"issue":"12","key":"3522_CR16","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.ejca.2005.03.032","volume":"41","author":"LM McShane","year":"2005","unstructured":"McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM. REporting recommendations for tumour MARKer prognostic studies (REMARK). Eur J Cancer. 2005;41(12):1690\u20136.","journal-title":"Eur J Cancer"},{"issue":"10","key":"3522_CR17","doi-asserted-by":"crossref","first-page":"10237","DOI":"10.1007\/s13277-014-2338-6","volume":"35","author":"C Giessen","year":"2014","unstructured":"Giessen C, Nagel D, Glas M, Spelsberg F, Lau-Werner U, Modest DP, et al. Evaluation of preoperative serum markers for individual patient prognosis in stage I\u2013III rectal cancer. Tumour Biol. 2014;35(10):10237\u201348.","journal-title":"Tumour Biol"},{"issue":"10","key":"3522_CR18","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/annonc\/mds236","volume":"23","author":"HJ Schmoll","year":"2012","unstructured":"Schmoll HJ, Van Cutsem E, Stein A, Valentini V, Glimelius B, Haustermans K, et al. ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making. Ann Oncol. 2012;23(10):2479\u2013516.","journal-title":"Ann Oncol"},{"issue":"7","key":"3522_CR19","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/PL00012376","volume":"23","author":"YJ Park","year":"1999","unstructured":"Park YJ, Park KJ, Park JG, Lee KU, Choe KJ, Kim JP. Prognostic factors in 2230 Korean colorectal cancer patients: analysis of consecutively operated cases. World J Surg. 1999;23(7):721\u20136.","journal-title":"World J Surg"},{"issue":"2","key":"3522_CR20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s003840050193","volume":"14","author":"YJ Park","year":"1999","unstructured":"Park YJ, Youk EG, Choi HS, Han SU, Park KJ, Lee KU, et al. Experience of 1446 rectal cancer patients in Korea and analysis of prognostic factors. Int J Color Dis. 1999;14(2):101\u20136.","journal-title":"Int J Color Dis"},{"issue":"2","key":"3522_CR21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1463-1318.2008.01556.x","volume":"11","author":"F Mehrkhani","year":"2009","unstructured":"Mehrkhani F, Nasiri S, Donboli K, Meysamie A, Hedayat A. Prognostic factors in survival of colorectal cancer patients after surgery. Color Dis. 2009;11(2):157\u201361.","journal-title":"Color Dis"},{"issue":"8","key":"3522_CR22","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1200\/JCO.2004.05.041","volume":"22","author":"I Chau","year":"2004","unstructured":"Chau I, Allen MJ, Cunningham D, Norman AR, Brown G, Ford HE, et al. The value of routine serum carcino-embryonic antigen measurement and computed tomography in the surveillance of patients after adjuvant chemotherapy for colorectal cancer. J Clin Oncol. 2004;22(8):1420\u20139.","journal-title":"J Clin Oncol"},{"issue":"9","key":"3522_CR23","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/BF02239434","volume":"41","author":"N Pietra","year":"1998","unstructured":"Pietra N, Sarli L, Costi R, Ouchemi C, Grattarola M, Peracchia A. Role of follow-up in management of local recurrences of colorectal cancer: a prospective, randomized study. Dis Colon Rectum. 1998;41(9):1127\u201333.","journal-title":"Dis Colon Rectum"},{"issue":"18","key":"3522_CR24","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1200\/JCO.2001.19.18.3895","volume":"19","author":"L Stocchi","year":"2001","unstructured":"Stocchi L, Nelson H, Sargent DJ, O'Connell MJ, Tepper JE, Krook JE, et al. Impact of surgical and pathologic variables in rectal cancer: a United States community and cooperative group report. J Clin Oncol Off J Am Soc Clin Oncol. 2001;19(18):3895\u2013902.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"3-4","key":"3522_CR25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/jnci\/88.3-4.193","volume":"88","author":"SN Hochwald","year":"1996","unstructured":"Hochwald SN, Harrison LE, Rose DM, Anderson M, Burt ME. gamma-Glutamyl transpeptidase mediation of tumor glutathione utilization in vivo. J Natl Cancer Inst. 1996;88(3-4):193\u20137.","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"3522_CR26","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/bjc.2014.6","volume":"110","author":"Y Zhu","year":"2014","unstructured":"Zhu Y, Yang SR, Wang PP, Savas S, Wish T, Zhao J, et al. Influence of pre-diagnostic cigarette smoking on colorectal cancer survival: overall and by tumour molecular phenotype. Br J Cancer. 2014;110(5):1359\u201366.","journal-title":"Br J Cancer"},{"issue":"3","key":"3522_CR27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/DCR.0b013e3182a586e7","volume":"57","author":"SR Steele","year":"2014","unstructured":"Steele SR, Park GE, Johnson EK, Martin MJ, Stojadinovic A, Maykel JA, et al. The impact of age on colorectal cancer incidence, treatment, and outcomes in an equal-access health care system. Dis Colon Rectum. 2014;57(3):303\u201310.","journal-title":"Dis Colon Rectum"},{"issue":"2","key":"3522_CR28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2217\/fon.12.184","volume":"9","author":"SH Jafri","year":"2013","unstructured":"Jafri SH, Mills G. Lifestyle modification in colorectal cancer patients: an integrative oncology approach. Future Oncol. 2013;9(2):207\u201318.","journal-title":"Future Oncol"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3522-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-015-3522-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3522-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T18:31:51Z","timestamp":1566671511000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-015-3522-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,8]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["3522"],"URL":"https:\/\/doi.org\/10.1007\/s13277-015-3522-z","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,8]]}}}