{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:44:31Z","timestamp":1791575071695,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T00:00:00Z","timestamp":1433548800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1007\/s13277-015-3594-9","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T18:41:58Z","timestamp":1433443318000},"page":"8685-8695","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer"],"prefix":"10.1007","volume":"36","author":[{"given":"Yoon Yang","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja Seung","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,6]]},"reference":[{"issue":"1","key":"3594_CR1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semcdb.2009.10.010","volume":"21","author":"OE Franco","year":"2010","unstructured":"Franco OE, Shaw AK, Strand DW, Hayward SW. Cancer associated fibroblasts in cancer pathogenesis. Semin Cell Dev Biol. 2010;21(1):33\u20139.","journal-title":"Semin Cell Dev Biol"},{"key":"3594_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2014.02.004","volume":"25","author":"A Ostman","year":"2014","unstructured":"Ostman A. Cancer-associated fibroblasts: recent developments and emerging challenges. Semin Cancer Biol. 2014;25:1\u20132.","journal-title":"Semin Cancer Biol"},{"issue":"5","key":"3594_CR3","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.2353\/ajpath.2007.060661","volume":"171","author":"L Mueller","year":"2007","unstructured":"Mueller L, Goumas FA, Affeldt M, Sandtner S, Gehling UM, Brilloff S, et al. Stromal fibroblasts in colorectal liver metastases originate from resident fibroblasts and generate an inflammatory microenvironment. Am J Pathol. 2007;171(5):1608\u201318.","journal-title":"Am J Pathol"},{"issue":"6","key":"3594_CR4","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/stem.63","volume":"27","author":"DL Worthley","year":"2009","unstructured":"Worthley DL, Ruszkiewicz A, Davies R, Moore S, Nivison-Smith I, Bik To L, et al. Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation. Stem Cells. 2009;27(6):1463\u20138.","journal-title":"Stem Cells"},{"issue":"6","key":"3594_CR5","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1158\/1541-7786.MCR-09-0460","volume":"8","author":"SR Mink","year":"2010","unstructured":"Mink SR, Vashistha S, Zhang W, Hodge A, Agus DB, Jain A. Cancer-associated fibroblasts derived from EGFR-TKI-resistant tumors reverse EGFR pathway inhibition by EGFR-TKIs. Mol Cancer Res. 2010;8(6):809\u201320.","journal-title":"Mol Cancer Res"},{"issue":"21","key":"3594_CR6","doi-asserted-by":"crossref","first-page":"10123","DOI":"10.1158\/0008-5472.CAN-07-3127","volume":"67","author":"EM Zeisberg","year":"2007","unstructured":"Zeisberg EM, Potenta S, Xie L, Zeisberg M, Kalluri R. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 2007;67(21):10123\u20138.","journal-title":"Cancer Res"},{"issue":"18","key":"3594_CR7","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1158\/0008-5472.CAN-13-0530","volume":"73","author":"L Bochet","year":"2013","unstructured":"Bochet L, Lehuede C, Dauvillier S, Wang YY, Dirat B, Laurent V, et al. Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer. Cancer Res. 2013;73(18):5657\u201368.","journal-title":"Cancer Res"},{"issue":"5\u20136","key":"3594_CR8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1387\/ijdb.041802ad","volume":"48","author":"A Desmouliere","year":"2004","unstructured":"Desmouliere A, Guyot C, Gabbiani G. The stroma reaction myofibroblast: a key player in the control of tumor cell behavior. Int J Dev Biol. 2004;48(5\u20136):509\u201317.","journal-title":"Int J Dev Biol"},{"issue":"9","key":"3594_CR9","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1096\/fj.03-1110fje","volume":"18","author":"O Wever De","year":"2004","unstructured":"De Wever O, Nguyen QD, Van Hoorde L, Bracke M, Bruyneel E, Gespach C, et al. Tenascin-C and SF\/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J. 2004;18(9):1016\u20138.","journal-title":"FASEB J"},{"issue":"12","key":"3594_CR10","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.4161\/cbt.5.12.3354","volume":"5","author":"H Sugimoto","year":"2006","unstructured":"Sugimoto H, Mundel TM, Kieran MW, Kalluri R. Identification of fibroblast heterogeneity in the tumor microenvironment. Cancer Biol Ther. 2006;5(12):1640\u20136.","journal-title":"Cancer Biol Ther"},{"issue":"5","key":"3594_CR11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1535-6108(03)00089-8","volume":"3","author":"K Pietras","year":"2003","unstructured":"Pietras K, Sjoblom T, Rubin K, Heldin CH, Ostman A. PDGF receptors as cancer drug targets. Cancer Cell. 2003;3(5):439\u201343.","journal-title":"Cancer Cell"},{"issue":"6005","key":"3594_CR12","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1195300","volume":"330","author":"M Kraman","year":"2010","unstructured":"Kraman M, Bambrough PJ, Arnold JN, Roberts EW, Magiera L, Jones JO, et al. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science. 2010;330(6005):827\u201330.","journal-title":"Science"},{"issue":"5","key":"3594_CR13","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/ijc.23611","volume":"123","author":"A Kawase","year":"2008","unstructured":"Kawase A, Ishii G, Nagai K, Ito T, Nagano T, Murata Y, et al. Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. Int J Cancer. 2008;123(5):1053\u20139.","journal-title":"Int J Cancer"},{"issue":"15","key":"3594_CR14","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1074\/jbc.M112.442939","volume":"288","author":"DM Gilkes","year":"2013","unstructured":"Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. J Biol Chem. 2013;288(15):10819\u201329.","journal-title":"J Biol Chem"},{"key":"3594_CR15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcancer.2013.12.010","volume":"25","author":"E Cortez","year":"2014","unstructured":"Cortez E, Roswall P, Pietras K. Functional subsets of mesenchymal cell types in the tumor microenvironment. Semin Cancer Biol. 2014;25:3\u20139.","journal-title":"Semin Cancer Biol"},{"issue":"5","key":"3594_CR16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2559.1991.tb00229.x","volume":"19","author":"CW Elston","year":"1991","unstructured":"Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991;19(5):403\u201310.","journal-title":"Histopathology"},{"issue":"16","key":"3594_CR17","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1200\/JCO.2009.25.6529","volume":"28","author":"ME Hammond","year":"2010","unstructured":"Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, et al. American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Clin Oncol. 2010;28(16):2784\u201395.","journal-title":"J Clin Oncol"},{"issue":"31","key":"3594_CR18","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1200\/JCO.2013.50.9984","volume":"31","author":"AC Wolff","year":"2013","unstructured":"Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, Allison KH, et al. Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists clinical practice guideline update. J Clin Oncol Off J Am Soc Clin Oncol. 2013;31(31):3997\u20134013.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"6","key":"3594_CR19","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1158\/1078-0432.CCR-06-1746","volume":"13","author":"LR Henry","year":"2007","unstructured":"Henry LR, Lee HO, Lee JS, Klein-Szanto A, Watts P, Ross EA, et al. Clinical implications of fibroblast activation protein in patients with colon cancer. Clin Cancer Res. 2007;13(6):1736\u201341.","journal-title":"Clin Cancer Res"},{"issue":"8","key":"3594_CR20","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1093\/annonc\/mdr304","volume":"22","author":"A Goldhirsch","year":"2011","unstructured":"Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ. Strategies for subtypes\u2014dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011;22(8):1736\u201347.","journal-title":"Ann Oncol"},{"issue":"3","key":"3594_CR21","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s004280100530","volume":"440","author":"PJ Barth","year":"2002","unstructured":"Barth PJ, Ebrahimsade S, Ramaswamy A, Moll R. CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions. Virchows Arch. 2002;440(3):298\u2013303.","journal-title":"Virchows Arch"},{"issue":"1","key":"3594_CR22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13402-011-0012-1","volume":"34","author":"C Jotzu","year":"2011","unstructured":"Jotzu C, Alt E, Welte G, Li J, Hennessy BT, Devarajan E, et al. Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor-derived factors. Cell Oncol (Dordr). 2011;34(1):55\u201367.","journal-title":"Cell Oncol (Dordr)"},{"issue":"12","key":"3594_CR23","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1073\/pnas.91.12.5657","volume":"91","author":"MJ Scanlan","year":"1994","unstructured":"Scanlan MJ, Raj BK, Calvo B, Garin-Chesa P, Sanz-Moncasi MP, Healey JH, et al. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc Natl Acad Sci U S A. 1994;91(12):5657\u201361.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3594_CR24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/1471-2407-11-245","volume":"11","author":"HO Lee","year":"2011","unstructured":"Lee HO, Mullins SR, Franco-Barraza J, Valianou M, Cukierman E, Cheng JD. FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. BMC Cancer. 2011;11:245.","journal-title":"BMC Cancer"},{"issue":"7","key":"3594_CR25","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1158\/0008-5472.CAN-12-1646","volume":"73","author":"M Ehnman","year":"2013","unstructured":"Ehnman M, Missiaglia E, Folestad E, Selfe J, Strell C, Thway K, et al. Distinct effects of ligand-induced PDGFRalpha and PDGFRbeta signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments. Cancer Res. 2013;73(7):2139\u201349.","journal-title":"Cancer Res"},{"issue":"7","key":"3594_CR26","first-page":"2929","volume":"61","author":"K Pietras","year":"2001","unstructured":"Pietras K, Ostman A, Sjoquist M, Buchdunger E, Reed RK, Heldin CH, et al. Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res. 2001;61(7):2929\u201334.","journal-title":"Cancer Res"},{"issue":"38","key":"3594_CR27","doi-asserted-by":"crossref","first-page":"16002","DOI":"10.1073\/pnas.1109493108","volume":"108","author":"JT O\u2019Connell","year":"2011","unstructured":"O\u2019Connell JT, Sugimoto H, Cooke VG, MacDonald BA, Mehta AI, LeBleu VS, et al. VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci U S A. 2011;108(38):16002\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3594_CR28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ajpath.2010.11.017","volume":"178","author":"J Zhang","year":"2011","unstructured":"Zhang J, Chen L, Xiao M, Wang C, Qin Z. FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. Am J Pathol. 2011;178(1):382\u201390.","journal-title":"Am J Pathol"},{"issue":"9","key":"3594_CR29","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1158\/0008-5472.CAN-12-3022","volume":"73","author":"J Zhang","year":"2013","unstructured":"Zhang J, Chen L, Liu X, Kammertoens T, Blankenstein T, Qin Z. Fibroblast-specific protein 1\/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens. Cancer Res. 2013;73(9):2770\u201381.","journal-title":"Cancer Res"},{"issue":"4","key":"3594_CR30","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/path.1398","volume":"200","author":"O Wever De","year":"2003","unstructured":"De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol. 2003;200(4):429\u201347.","journal-title":"J Pathol"},{"key":"3594_CR31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1755-8794-5-39","volume":"5","author":"J Tchou","year":"2012","unstructured":"Tchou J, Kossenkov AV, Chang L, Satija C, Herlyn M, Showe LC, et al. Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles. BMC Med Genomics. 2012;5:39.","journal-title":"BMC Med Genomics"},{"issue":"1","key":"3594_CR32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000330170","volume":"79","author":"C Kamphues","year":"2012","unstructured":"Kamphues C, Wittschieber D, Klauschen F, Kasajima A, Dietel M, Schmidt SC, et al. Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer. Pathobiology. 2012;79(1):11\u20137.","journal-title":"Pathobiology"},{"issue":"3","key":"3594_CR33","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00432-014-1593-7","volume":"140","author":"T Tanaka","year":"2014","unstructured":"Tanaka T, Torigoe T, Hirohashi Y, Sato E, Honma I, Kitamura H, et al. Hypoxia-inducible factor (HIF)-independent expression mechanism and novel function of HIF prolyl hydroxylase-3 in renal cell carcinoma. J Cancer Res Clin Oncol. 2014;140(3):503\u201313.","journal-title":"J Cancer Res Clin Oncol"},{"key":"3594_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-14-1","volume":"14","author":"G Xiong","year":"2014","unstructured":"Xiong G, Deng L, Zhu J, Rychahou PG, Xu R. Prolyl-4-hydroxylase alpha subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014;14:1.","journal-title":"BMC Cancer"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3594-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-015-3594-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-3594-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T01:15:26Z","timestamp":1566782126000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-015-3594-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,6]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["3594"],"URL":"https:\/\/doi.org\/10.1007\/s13277-015-3594-9","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,6]]}}}