{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:09:37Z","timestamp":1789945777860,"version":"4.0.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s13277-015-4067-x","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T19:14:25Z","timestamp":1443554065000},"page":"3033-3041","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Analgesic-antitumor peptide inhibits the migration and invasion of HepG2 cells by an upregulated VGSC \u03b21 subunit"],"prefix":"10.1007","volume":"37","author":[{"given":"Guili","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,29]]},"reference":[{"key":"4067_CR1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/bj2570509","volume":"257","author":"XH Zhou","year":"1989","unstructured":"Zhou XH, Yang D, Zhang JH, Liu CM, Lei KJ. Purification and N-terminal partial sequence of anti-epilepsy peptide from venom of the scorpion Buthus martensii Karsch. Biochem J. 1989;257:509\u201317.","journal-title":"Biochem J"},{"key":"4067_CR2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1081\/PB-120015456","volume":"32","author":"YF Liu","year":"2002","unstructured":"Liu YF, Hu J, Zhang JH, Wang SL, Wu CF. Isolation, purification, and N-terminal partial sequence of an antitumoral peptide from the venom of the Chinese scorpion Buthus martensii Karsch. Prep Biochem Biotechnol. 2002;32:317\u201327.","journal-title":"Prep Biochem Biotechnol"},{"key":"4067_CR3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbrc.2010.02.179","volume":"394","author":"R Ma","year":"2010","unstructured":"Ma R, Cui Y, Zhou Y, Bao YM, Yang WY, Liu YF, et al. Location of the analgesic domain in scorpion toxin BmK AGAP by mutagenesis of disulfide bridges. Biochem Biophys Res Commun. 2010;394:330\u20134.","journal-title":"Biochem Biophys Res Commun"},{"key":"4067_CR4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1046-5928(02)00609-5","volume":"27","author":"YF Liu","year":"2003","unstructured":"Liu YF, Ma RL, Wang SL, Duan ZY, Zhang JH, Wu LJ, et al. Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii Karsch in Escherichia coli. Protein Expr Purif. 2003;27:253\u20138.","journal-title":"Protein Expr Purif"},{"key":"4067_CR5","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/btpr.433","volume":"26","author":"P Cao","year":"2010","unstructured":"Cao P, Yu JM, Lu WG, Cai XT, Wang ZG, Gu ZH, et al. Expression and purification of an antitumor-analgesic peptide from the venom of Mesobuthus martensii Karsch by small ubiquitin-related modifier fusion in Escherichia coli. Biotechnol Prog. 2010;26:1240\u20134.","journal-title":"Biotechnol Prog"},{"key":"4067_CR6","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1002\/jcb.23166","volume":"112","author":"YL Zhao","year":"2011","unstructured":"Zhao YL, Cai XT, Ye TM, Huo JG, Liu C, Zhang SQ, et al. Analgesic-antitumor peptide inhibits proliferation and migration of SHG-44 human malignant glioma cells. J Cell Biochem. 2011;112:2424\u201334.","journal-title":"J Cell Biochem"},{"key":"4067_CR7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/gb-2003-4-3-207","volume":"4","author":"FH Yu","year":"2003","unstructured":"Yu FH, Catteral WA. Overview of the voltage-gated sodium channel family. Genome Biol. 2003;4:207.","journal-title":"Genome Biol"},{"key":"4067_CR8","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1073\/pnas.030362197","volume":"97","author":"K Morgan","year":"2000","unstructured":"Morgan K, Stevens EB, Shah B, Cox PJ, Dixon AK, Lee K, et al. Beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proc Natl Acad Sci U S A. 2000;97:2308\u201313.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4067_CR9","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neulet.2009.07.020","volume":"462","author":"DP McEwen","year":"2009","unstructured":"McEwen DP, Chen C, Meadows LS, Lopez-Santiaqo L, Isom LL. The voltage-gated Na+ channel beta 3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin. Neurosci Lett. 2009;462:272\u20135.","journal-title":"Neurosci Lett"},{"key":"4067_CR10","doi-asserted-by":"crossref","first-page":"7577","DOI":"10.1523\/JNEUROSCI.23-20-07577.2003","volume":"23","author":"FH Yu","year":"2003","unstructured":"Yu FH, Westenbroek RE, Silos-Santiagol I, McCormick KA, Lawson D, Ge P, et al. Sodium channel beta 4, a new disulfide-linked auxiliary subunit with similarity to beta 2. J Neurosci. 2003;23:7577\u201385.","journal-title":"J Neurosci"},{"key":"4067_CR11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/sj.pcan.4501012","volume":"11","author":"JK Diss","year":"2008","unstructured":"Diss JK, Fraser SP, Walker MM, Patel A, Latchman DS, Djamgoz MB. Beta-subunits of voltage-gated sodium channels in human prostate cancer: quantitative in vitro and in vivo analyses of mRNA expression. Prostate Cancer Prostatic Dis. 2008;11:325\u201333.","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"4067_CR12","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.biocel.2008.11.001","volume":"41","author":"AM Chioni","year":"2009","unstructured":"Chioni AM, Brackenbury WJ, Calhoun JD, Isom LL, Djamgoz MB. A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ \u03b21 subunit. Int J Biochem Cell Biol. 2009;41:1216\u201327.","journal-title":"Int J Biochem Cell Biol"},{"key":"4067_CR13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69\u201390.","journal-title":"CA Cancer J Clin"},{"key":"4067_CR14","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1159\/000357302","volume":"7","author":"A Igawa","year":"2013","unstructured":"Igawa A, Oka S, Tanaka S, Nakano M, Aoyama T, Watari I, et al. Small bowel metastasis of hepatocellular carcinoma detected by capsule endoscopy. Case Rep Gastroenterol. 2013;7:492\u20137.","journal-title":"Case Rep Gastroenterol"},{"key":"4067_CR15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.peptides.2010.03.017","volume":"31","author":"Y Cui","year":"2010","unstructured":"Cui Y, Guo GL, Ma L, Hu N, Song YB, Liu YF, et al. Structure and function relationship of toxin from Chinese scorpion Buthus martensii Karsch (BmKAGAP): gaining insight into related sites of analgesic activity. Peptides. 2010;31:995\u20131000.","journal-title":"Peptides"},{"key":"4067_CR16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2006.04.025","volume":"542","author":"L Candenas","year":"2006","unstructured":"Candenas L, Seda M, Noheda P, Buschmann H, Cintado CG, Martin JD, et al. Molecular diversity of voltage-gated sodium channels alpha and beta subunit mRNAs in human tissues. Eur J Pharmacol. 2006;542:9\u201316.","journal-title":"Eur J Pharmacol"},{"key":"4067_CR17","first-page":"1213","volume":"150","author":"ME Laniado","year":"1997","unstructured":"Laniado ME, Lalani EN, Fraser SP, Grimes HA, Bhangal G, Djamgoz MB, et al. Expression and functional analysis of voltage activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro. Am J Pathol. 1997;150:1213\u201321.","journal-title":"Am J Pathol"},{"key":"4067_CR18","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1460-9568.2005.04280.x","volume":"22","author":"SW Ou","year":"2005","unstructured":"Ou SW, Kameyama A, Hao LY, Horiuchi M, Minobe E, Wang WY, et al. Tetrodotoxin-resistant Na+ channels in human neuroblastoma cells are encoded by new variants of Nav1.5\/SCN5A. Eur J Neurosci. 2005;22:793\u2013801.","journal-title":"Eur J Neurosci"},{"key":"4067_CR19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0092-8674(02)00655-4","volume":"108","author":"G Orphanides","year":"2002","unstructured":"Orphanides G, Reinberg D. A unified theory of gene expression. Cell. 2002;108:439\u201351.","journal-title":"Cell"},{"key":"4067_CR20","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/jcp.20846","volume":"210","author":"WJ Brackenbury","year":"2007","unstructured":"Brackenbury WJ, Djamgoz MB. Nerve growth factor enhances voltage-gated Na+ channel activity and transwell migration in Mat-LyLu rat prostate cancer cell line. J Cell Physiol. 2007;210:602\u20138.","journal-title":"J Cell Physiol"},{"key":"4067_CR21","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1523\/JNEUROSCI.2211-06.2006","volume":"26","author":"LF Lopez-Santiago","year":"2006","unstructured":"Lopez-Santiago LF, Pertin M, Morsod X, Chen C, Hong S, Wiley J, et al. Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. J Neurosci. 2006;26:7984\u201394.","journal-title":"J Neurosci"},{"key":"4067_CR22","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1523\/JNEUROSCI.5446-07.2008","volume":"28","author":"WJ Brackenbury","year":"2008","unstructured":"Brackenbury WJ, Davis TH, Chen C, Slat EA, Detrow MJ, Dickendesher TL, et al. Voltage-gated Na+ channel beta subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. J Neurosci. 2008;28:3246\u201356.","journal-title":"J Neurosci"},{"key":"4067_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/S13277-014-2239-8","author":"QF Jing","year":"2014","unstructured":"Jing QF, Tian YW, Shen Q, Xue HZ, Li K. SENP2 regulated the stability of \u03b2-catenin through WWOX in hepatocellular carcinoma cell. Tumor Biol. 2014. doi: 10.1007\/S13277-014-2239-8 .","journal-title":"Tumor Biol"},{"key":"4067_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2267-4","author":"Q Lin","year":"2014","unstructured":"Lin Q, Wei Y, Zhong YS, Zhu DX, Ren L, Xu PP, et al. Aberrant expression of sphingosin-1-phosphate receptor 1 correlates with metachronous liver metastasis and poor prognosis in colorectal cancer. Tumor Biol. 2014. doi: 10.1007\/s13277-014-2267-4 .","journal-title":"Tumor Biol"},{"key":"4067_CR25","doi-asserted-by":"crossref","first-page":"11383","DOI":"10.1074\/jbc.275.15.11383","volume":"275","author":"JD Malhotra","year":"2000","unstructured":"Malhotra JD, Kazen-Gillespie K, Hortsch M, Isom LL. Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. J Biol Chem. 2000;275:11383\u20138.","journal-title":"J Biol Chem"},{"key":"4067_CR26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/107385840100700108","volume":"7","author":"LL Isom","year":"2001","unstructured":"Isom LL. Sodium channel beta subunits: anything but auxiliary. Neuroscientist. 2001;7:42\u201354.","journal-title":"Neuroscientist"},{"key":"4067_CR27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1432-1327.1999.00625.x","volume":"264","author":"LD Possani","year":"1999","unstructured":"Possani LD, Becerril B, Delepierre M, Tytgat J. Scorpion toxins specific for Na+-channels. Eur J Biochem. 1999;264:287\u2013300.","journal-title":"Eur J Biochem"},{"key":"4067_CR28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1113\/jphysiol.2006.106906","volume":"573","author":"WJ Brackenbury","year":"2006","unstructured":"Brackenbury WJ, Djamgoz MB. Activity-dependent regulation of voltage-gated Na+ channel expression in Mat-LyLu rat prostate cancer cell line. J Physiol. 2006;573:343\u201356.","journal-title":"J Physiol"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-4067-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-015-4067-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-4067-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-4067-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T03:03:49Z","timestamp":1567220629000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-015-4067-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,29]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["4067"],"URL":"https:\/\/doi.org\/10.1007\/s13277-015-4067-x","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,29]]}}}