{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:18:48Z","timestamp":1789186728142,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T00:00:00Z","timestamp":1452124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s13277-015-4737-8","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T03:16:44Z","timestamp":1452136604000},"page":"8721-8729","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Neferine induces autophagy of human ovarian cancer cells via p38 MAPK\/ JNK activation"],"prefix":"10.1007","volume":"37","author":[{"given":"Limei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-jun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changshun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,7]]},"reference":[{"key":"4737_CR1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrc3144","volume":"11","author":"S Vaughan","year":"2011","unstructured":"Vaughan S, Coward JI, Bast Jr RC, Berchuck A, Berek JS, Brenton JD, et al. Rethinking ovarian cancer: recommendations for improving outcomes. Nat Rev Cancer. 2011;11:719\u201325.","journal-title":"Nat Rev Cancer"},{"key":"4737_CR2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1757-2215-7-45","volume":"7","author":"CD Gamarra-Luques","year":"2014","unstructured":"Gamarra-Luques CD, Hapon MB, Goyeneche AA, Telleria CM. Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity. J Ovarian Res. 2014;7:45.","journal-title":"J Ovarian Res"},{"key":"4737_CR3","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.foodchem.2012.07.112","volume":"136","author":"P Poornima","year":"2013","unstructured":"Poornima P, Quency RS, Padma VV. Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in hepg2 cells. Food Chem. 2013;136:659\u201367.","journal-title":"Food Chem"},{"key":"4737_CR4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/biof.1115","volume":"40","author":"P Poornima","year":"2014","unstructured":"Poornima P, Weng CF, Padma VV. Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by mapk activation and cell cycle arrest. Biofactors. 2014;40:121\u201331.","journal-title":"Biofactors"},{"key":"4737_CR5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejphar.2011.12.035","volume":"677","author":"X Zhang","year":"2012","unstructured":"Zhang X, Liu Z, Xu B, Sun Z, Gong Y, Shao C. Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 mapk-mediated p21 stabilization. Eur J Pharmacol. 2012;677:47\u201354.","journal-title":"Eur J Pharmacol"},{"key":"4737_CR6","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.4161\/auto.24632","volume":"9","author":"T Li","year":"2013","unstructured":"Li T, Su L, Zhong N, Hao X, Zhong D, Singhal S, et al. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy. 2013;9:1057\u201368.","journal-title":"Autophagy"},{"key":"4737_CR7","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc1692","volume":"5","author":"Y Kondo","year":"2005","unstructured":"Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer. 2005;5:726\u201334.","journal-title":"Nat Rev Cancer"},{"key":"4737_CR8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4161\/auto.2.2.2463","volume":"2","author":"Y Kondo","year":"2006","unstructured":"Kondo Y, Kondo S. Autophagy and cancer therapy. Autophagy. 2006;2:85\u201390.","journal-title":"Autophagy"},{"key":"4737_CR9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.drup.2007.05.001","volume":"10","author":"L Moretti","year":"2007","unstructured":"Moretti L, Yang ES, Kim KW, Lu B. Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy. Drug Resist Updat. 2007;10:135\u201343.","journal-title":"Drug Resist Updat"},{"key":"4737_CR10","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/cdd.2009.33","volume":"16","author":"A Eisenberg-Lerner","year":"2009","unstructured":"Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A. Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 2009;16:966\u201375.","journal-title":"Cell Death Differ"},{"key":"4737_CR11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bcp.2011.09.017","volume":"83","author":"G Viola","year":"2012","unstructured":"Viola G, Bortolozzi R, Hamel E, Moro S, Brun P, Castagliuolo I, et al. Mg-2477, a new tubulin inhibitor, induces autophagy through inhibition of the akt\/mtor pathway and delayed apoptosis in a549 cells. Biochem Pharmacol. 2012;83:16\u201326.","journal-title":"Biochem Pharmacol"},{"key":"4737_CR12","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.4161\/cc.20544","volume":"11","author":"W Shan","year":"2012","unstructured":"Shan W, Mercado-Uribe I, Zhang J, Rosen D, Zhang S, Wei J, et al. Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications. Cell Cycle. 2012;11:2107\u201313.","journal-title":"Cell Cycle"},{"key":"4737_CR13","doi-asserted-by":"crossref","first-page":"12579","DOI":"10.1038\/srep12579","volume":"5","author":"X Zhang","year":"2015","unstructured":"Zhang X, Wang X, Wu T, Li B, Liu T, Wang R, et al. Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ros generation and p38 mapk\/jnk activation. Sci Rep. 2015;5:12579.","journal-title":"Sci Rep"},{"key":"4737_CR14","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2337\/db12-1474","volume":"62","author":"E Bachar-Wikstrom","year":"2013","unstructured":"Bachar-Wikstrom E, Wikstrom JD, Ariav Y, Tirosh B, Kaiser N, Cerasi E, et al. Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes. Diabetes. 2013;62:1227\u201337.","journal-title":"Diabetes"},{"key":"4737_CR15","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.cellsig.2014.08.019","volume":"26","author":"D Heras-Sandoval","year":"2014","unstructured":"Heras-Sandoval D, Perez-Rojas JM, Hernandez-Damian J, Pedraza-Chaverri J. The role of pi3k\/akt\/mtor pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell Signal. 2014;26:2694\u2013701.","journal-title":"Cell Signal"},{"key":"4737_CR16","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/1471-2164-9-348","volume":"9","author":"H Heinonen","year":"2008","unstructured":"Heinonen H, Nieminen A, Saarela M, Kallioniemi A, Klefstrom J, Hautaniemi S, et al. Deciphering downstream gene targets of pi3k\/mtor\/p70s6k pathway in breast cancer. BMC Genomics. 2008;9:348.","journal-title":"BMC Genomics"},{"key":"4737_CR17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ncb0310-207","volume":"12","author":"TE Rusten","year":"2010","unstructured":"Rusten TE, Stenmark H. P62, an autophagy hero or culprit? Nat Cell Biol. 2010;12:207\u20139.","journal-title":"Nat Cell Biol"},{"key":"4737_CR18","doi-asserted-by":"crossref","first-page":"832704","DOI":"10.1155\/2014\/832704","volume":"2014","author":"M Lippai","year":"2014","unstructured":"Lippai M, Low P. The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy. BioMed Res Int. 2014;2014:832704.","journal-title":"BioMed Res Int"},{"key":"4737_CR19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4161\/auto.27344","volume":"10","author":"MH Sahani","year":"2014","unstructured":"Sahani MH, Itakura E, Mizushima N. Expression of the autophagy substrate sqstm1\/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids. Autophagy. 2014;10:431\u201341.","journal-title":"Autophagy"},{"key":"4737_CR20","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1016\/j.foodchem.2013.05.138","volume":"141","author":"P Poornima","year":"2013","unstructured":"Poornima P, Weng CF, Padma VV. Neferine from nelumbo nucifera induces autophagy through the inhibition of pi3k\/akt\/mtor pathway and ros hyper generation in a549 cells. Food Chem. 2013;141:3598\u2013605.","journal-title":"Food Chem"},{"key":"4737_CR21","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.3390\/molecules20033496","volume":"20","author":"VK Wong","year":"2015","unstructured":"Wong VK, Wu AG, Wang JR, Liu L, Law BY. Neferine attenuates the protein level and toxicity of mutant huntingtin in pc-12 cells via induction of autophagy. Molecules. 2015;20:3496\u2013514.","journal-title":"Molecules"},{"key":"4737_CR22","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1158\/1940-6207.CAPR-11-0551","volume":"5","author":"W Chen","year":"2012","unstructured":"Chen W, Liu L, Luo Y, Odaka Y, Awate S, Zhou H, et al. Cryptotanshinone activates p38\/jnk and inhibits erk1\/2 leading to caspase-independent cell death in tumor cells. Cancer Prev Res (Phila). 2012;5:778\u201387.","journal-title":"Cancer Prev Res (Phila)"},{"key":"4737_CR23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/jcp.21470","volume":"217","author":"YH Kang","year":"2008","unstructured":"Kang YH, Lee SJ. The role of p38 mapk and jnk in arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells. J Cell Physiol. 2008;217:23\u201333.","journal-title":"J Cell Physiol"},{"key":"4737_CR24","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s10495-014-0979-y","volume":"19","author":"K Zikaki","year":"2014","unstructured":"Zikaki K, Aggeli IK, Gaitanaki C, Beis I. Curcumin induces the apoptotic intrinsic pathway via upregulation of reactive oxygen species and jnks in h9c2 cardiac myoblasts. Apoptosis. 2014;19:958\u201374.","journal-title":"Apoptosis"},{"key":"4737_CR25","doi-asserted-by":"crossref","first-page":"e87050","DOI":"10.1371\/journal.pone.0087050","volume":"9","author":"DR Avisetti","year":"2014","unstructured":"Avisetti DR, Babu KS, Kalivendi SV. Activation of p38\/jnk pathway is responsible for embelin induced apoptosis in lung cancer cells: transitional role of reactive oxygen species. PLoS One. 2014;9:e87050.","journal-title":"PLoS One"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-4737-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-015-4737-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-015-4737-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T15:43:55Z","timestamp":1559490235000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-015-4737-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["4737"],"URL":"https:\/\/doi.org\/10.1007\/s13277-015-4737-8","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,7]]}}}