{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:09:46Z","timestamp":1769594986324,"version":"3.49.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T00:00:00Z","timestamp":1453420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai (CN)","doi-asserted-by":"publisher","award":["12ZR1424300"],"award-info":[{"award-number":["12ZR1424300"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["30600674"],"award-info":[{"award-number":["30600674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Tumor Biol."],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s13277-016-4848-x","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T21:45:03Z","timestamp":1453499103000},"page":"9671-9680","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["NANOG regulates epithelial-mesenchymal transition and chemoresistance through activation of the STAT3 pathway in epithelial ovarian cancer"],"prefix":"10.1007","volume":"37","author":[{"given":"Suqing","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youji","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,22]]},"reference":[{"key":"4848_CR1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3322\/caac.21208","volume":"64","author":"R Siegel","year":"2014","unstructured":"Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9\u201329.","journal-title":"CA Cancer J Clin"},{"issue":"Suppl 1","key":"4848_CR2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1525-1438.2005.15351.x","volume":"15","author":"RF Ozols","year":"2005","unstructured":"Ozols RF. Treatment goals in ovarian cancer. Int J Gynecol Cancer. 2005;15 Suppl 1:3\u201311.","journal-title":"Int J Gynecol Cancer"},{"key":"4848_CR3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nature05284","volume":"444","author":"J Wang","year":"2006","unstructured":"Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, et al. A protein interaction network for pluripotency of embryonic stem cells. Nature. 2006;444:364\u20138.","journal-title":"Nature"},{"key":"4848_CR4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0092-8674(03)00392-1","volume":"113","author":"I Chambers","year":"2003","unstructured":"Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 2003;113:643\u201355.","journal-title":"Cell"},{"key":"4848_CR5","doi-asserted-by":"crossref","first-page":"e160","DOI":"10.1111\/j.1365-2605.2011.01148.x","volume":"34","author":"AJ Gillis","year":"2011","unstructured":"Gillis AJ, Stoop H, Biermann K, van Gurp RJ, Swartzman E, Cribbes S, et al. Expression and interdependencies of pluripotency factors LIN28, OCT3\/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis. Int J Androl. 2011;34:e160\u201374.","journal-title":"Int J Androl"},{"key":"4848_CR6","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/hep.25745","volume":"56","author":"J Shan","year":"2012","unstructured":"Shan J, Shen J, Liu L, Xia F, Xu C, Duan G, et al. Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma. Hepatology. 2012;56:1004\u201314.","journal-title":"Hepatology"},{"key":"4848_CR7","doi-asserted-by":"crossref","first-page":"10433","DOI":"10.1158\/0008-5472.CAN-10-2638","volume":"70","author":"SH Chiou","year":"2010","unstructured":"Chiou SH, Wang ML, Chou YT, Chen CJ, Hong CF, Hsieh WJ, et al. Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. Cancer Res. 2010;70:10433\u201344.","journal-title":"Cancer Res"},{"key":"4848_CR8","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1038\/onc.2011.114","volume":"30","author":"CR Jeter","year":"2011","unstructured":"Jeter CR, Liu B, Liu X, Chen X, Liu C, Calhoun-Davis T, et al. NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene. 2011;30:3833\u201345.","journal-title":"Oncogene"},{"key":"4848_CR9","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1002\/cncr.21432","volume":"104","author":"UI Ezeh","year":"2005","unstructured":"Ezeh UI, Turek PJ, Reijo RA, Clark AT. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer. 2005;104:2255\u201365.","journal-title":"Cancer"},{"key":"4848_CR10","doi-asserted-by":"crossref","first-page":"10803","DOI":"10.18632\/oncotarget.2506","volume":"5","author":"D Wang","year":"2014","unstructured":"Wang D, Lu P, Zhang H, Luo M, Zhang X, Wei X, et al. Oct-4 and Nanog promote the epithelial-mesenchymal transition of breast cancer stem cells and are associated with poor prognosis in breast cancer patients. Oncotarget. 2014;5:10803\u201315.","journal-title":"Oncotarget"},{"key":"4848_CR11","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.18632\/oncotarget.2298","volume":"5","author":"Y Ding","year":"2014","unstructured":"Ding Y, Yu AQ, Li CL, Fang J, Zeng Y, Li DS. TALEN-mediated Nanog disruption results in less invasiveness, more chemosensitivity and reversal of EMT in Hela cells. Oncotarget. 2014;5:8393\u2013401.","journal-title":"Oncotarget"},{"key":"4848_CR12","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ajpath.2012.04.008","volume":"181","author":"TT Gu","year":"2012","unstructured":"Gu TT, Liu SY, Zheng PS. Cytoplasmic NANOG-positive stromal cells promote human cervical cancer progression. Am J Pathol. 2012;181:652\u201361.","journal-title":"Am J Pathol"},{"key":"4848_CR13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s13402-013-0142-8","volume":"36","author":"J Di","year":"2013","unstructured":"Di J, Duiveman-de Boer T, Zusterzeel PL, Figdor CG, Massuger LF, Torensma R. The stem cell markers Oct4A, Nanog and c-Myc are expressed in ascites cells and tumor tissue of ovarian cancer patients. Cell Oncol. 2013;36:363\u201374.","journal-title":"Cell Oncol"},{"key":"4848_CR14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000320866","volume":"77","author":"Y Pan","year":"2010","unstructured":"Pan Y, Jiao J, Zhou C, Cheng Q, Hu Y, Chen H. Nanog is highly expressed in ovarian serous cystadenocarcinoma and correlated with clinical stage and pathological grade. Pathobiology. 2010;77:283\u20138.","journal-title":"Pathobiology"},{"key":"4848_CR15","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1097\/IGJ.0b013e3182738307","volume":"22","author":"M Lee","year":"2012","unstructured":"Lee M, Nam EJ, Kim SW, Kim S, Kim JH, Kim YT. Prognostic impact of the cancer stem cell-related marker NANOG in ovarian serous carcinoma. Int J Gynecol Cancer. 2012;22:1489\u201396.","journal-title":"Int J Gynecol Cancer"},{"key":"4848_CR16","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1158\/1541-7786.MCR-11-0271","volume":"9","author":"A Yadav","year":"2011","unstructured":"Yadav A, Kumar B, Datta J, Teknos TN, Kumar P. IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway. Mol Cancer Res. 2011;9:1658\u201367.","journal-title":"Mol Cancer Res"},{"key":"4848_CR17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13045-015-0119-3","volume":"8","author":"X Yin","year":"2015","unstructured":"Yin X, Zhang BH, Zheng SS, Gao DM, Qiu SJ, Wu WZ, et al. Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3\/Snail signaling. J Hematol Oncol. 2015;8:23.","journal-title":"J Hematol Oncol"},{"key":"4848_CR18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/onc.2011.222","volume":"31","author":"LY Bourguignon","year":"2012","unstructured":"Bourguignon LY, Earle C, Wong G, Spevak CC, Krueger K. Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan\/CD44-activated head and neck squamous cell carcinoma cells. Oncogene. 2012;31:149\u201360.","journal-title":"Oncogene"},{"key":"4848_CR19","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.18632\/oncotarget.2957","volume":"6","author":"WT Chiu","year":"2015","unstructured":"Chiu WT, Huang YF, Tsai HY, Chen CC, Chang CH, Huang SC, et al. FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells. Oncotarget. 2015;6:2349\u201365.","journal-title":"Oncotarget"},{"key":"4848_CR20","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.biocel.2013.02.017","volume":"45","author":"C Sun","year":"2013","unstructured":"Sun C, Sun L, Jiang K, Gao DM, Kang XN, Wang C, et al. NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL\/SMAD3 signaling pathway. Int J Biochem Cell Biol. 2013;45:1099\u2013108.","journal-title":"Int J Biochem Cell Biol"},{"key":"4848_CR21","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.18632\/oncotarget.2006","volume":"5","author":"CW Liu","year":"2014","unstructured":"Liu CW, Li CH, Peng YJ, Cheng YW, Chen HW, Liao PL, et al. Snail regulates Nanog status during the epithelial-mesenchymal transition via the Smad1\/Akt\/GSK3beta signaling pathway in non-small-cell lung cancer. Oncotarget. 2014;5:3880\u201394.","journal-title":"Oncotarget"},{"key":"4848_CR22","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/1471-2407-11-396","volume":"11","author":"H Dang","year":"2011","unstructured":"Dang H, Ding W, Emerson D, Rountree CB. Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics. BMC Cancer. 2011;11:396.","journal-title":"BMC Cancer"},{"key":"4848_CR23","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3892\/ijo.2013.2054","volume":"43","author":"Z Zhang","year":"2013","unstructured":"Zhang Z, Zhu Y, Lai Y, Wu X, Feng Z, Yu Y, et al. Follicle-stimulating hormone inhibits apoptosis in ovarian cancer cells by regulating the OCT4 stem cell signaling pathway. Int J Oncol. 2013;43:1194\u2013204.","journal-title":"Int J Oncol"},{"key":"4848_CR24","first-page":"504","volume":"27","author":"Y Wei","year":"2012","unstructured":"Wei Y, Zhang Z, Liao H, Wu L, Wu X, Zhou D, et al. Nuclear estrogen receptor-mediated Notch signaling and GPR30-mediated PI3K\/AKT signaling in the regulation of endometrial cancer cell proliferation. Oncol Rep. 2012;27:504\u201310.","journal-title":"Oncol Rep"},{"key":"4848_CR25","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1158\/1078-0432.CCR-07-4404","volume":"14","author":"SH Chiou","year":"2008","unstructured":"Chiou SH, Yu CC, Huang CY, Lin SC, Liu CJ, Tsai TH, et al. Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin Cancer Res. 2008;14:4085\u201395.","journal-title":"Clin Cancer Res"},{"key":"4848_CR26","doi-asserted-by":"crossref","first-page":"e87207","DOI":"10.1371\/journal.pone.0087207","volume":"9","author":"LL Tsai","year":"2014","unstructured":"Tsai LL, Hu FW, Lee SS, Yu CH, Yu CC, Chang YC. Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition. PLoS One. 2014;9:e87207.","journal-title":"PLoS One"},{"key":"4848_CR27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrc2620","volume":"9","author":"K Polyak","year":"2009","unstructured":"Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009;9:265\u201373.","journal-title":"Nat Rev Cancer"},{"key":"4848_CR28","doi-asserted-by":"crossref","first-page":"8477","DOI":"10.1038\/srep08477","volume":"5","author":"W Cao","year":"2015","unstructured":"Cao W, Liu Y, Zhang R, Zhang B, Wang T, Zhu X, et al. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6\/JAK1\/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Sci Rep. 2015;5:8477.","journal-title":"Sci Rep"},{"key":"4848_CR29","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1089\/adt.2015.663","volume":"13","author":"PA Johnston","year":"2015","unstructured":"Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, et al. HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines. Assay Drug Dev Technol. 2015;13:356\u201376.","journal-title":"Assay Drug Dev Technol"},{"key":"4848_CR30","doi-asserted-by":"publisher","unstructured":"Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, Zhong Z, Taniguchi K, Levitzki A, Karin M. Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. Oncogene. 2015. doi: 10.1038\/onc.2015.326 .","DOI":"10.1038\/onc.2015.326"},{"key":"4848_CR31","doi-asserted-by":"crossref","first-page":"31927","DOI":"10.18632\/oncotarget.5578","volume":"6","author":"H Zhao","year":"2015","unstructured":"Zhao H, Guo Y, Li S, Han R, Ying J, Zhu H, et al. A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6\/Jak2\/Stat3 pathway. Oncotarget. 2015;6:31927\u201343.","journal-title":"Oncotarget"},{"key":"4848_CR32","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJMra061808","volume":"355","author":"CT Jordan","year":"2006","unstructured":"Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med. 2006;355:1253\u201361.","journal-title":"N Engl J Med"},{"key":"4848_CR33","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","volume":"133","author":"SA Mani","year":"2008","unstructured":"Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704\u201315.","journal-title":"Cell"},{"key":"4848_CR34","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.semcancer.2012.04.001","volume":"22","author":"C Scheel","year":"2012","unstructured":"Scheel C, Weinberg RA. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol. 2012;22:396\u2013403.","journal-title":"Semin Cancer Biol"},{"key":"4848_CR35","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1038\/onc.2010.215","volume":"29","author":"A Singh","year":"2010","unstructured":"Singh A, Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene. 2010;29:4741\u201351.","journal-title":"Oncogene"},{"key":"4848_CR36","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/sj.bjc.6605626","volume":"102","author":"L Hu","year":"2010","unstructured":"Hu L, McArthur C, Jaffe RB. Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant. Br J Cancer. 2010;102:1276\u201383.","journal-title":"Br J Cancer"},{"key":"4848_CR37","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1089\/scd.2009.0113","volume":"18","author":"V Kashyap","year":"2009","unstructured":"Kashyap V, Rezende NC, Scotland KB, Shaffer SM, Persson JL, Gudas LJ, et al. Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev. 2009;18:1093\u2013108.","journal-title":"Stem Cells Dev"},{"key":"4848_CR38","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1038\/onc.2012.363","volume":"32","author":"MK Siu","year":"2013","unstructured":"Siu MK, Wong ES, Kong DS, Chan HY, Jiang L, Wong OG, et al. Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers. Oncogene. 2013;32:3500\u20139.","journal-title":"Oncogene"},{"key":"4848_CR39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/156800909788166493","volume":"9","author":"K Goda","year":"2009","unstructured":"Goda K, Bacso Z, Szabo G. Multidrug resistance through the spectacle of P-glycoprotein. Curr Cancer Drug Targets. 2009;9:281\u201397.","journal-title":"Curr Cancer Drug Targets"},{"key":"4848_CR40","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2174\/138945006777709566","volume":"7","author":"H Lage","year":"2006","unstructured":"Lage H. MDR1\/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance. Curr Drug Targets. 2006;7:813\u201321.","journal-title":"Curr Drug Targets"},{"key":"4848_CR41","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.2174\/092986706777585077","volume":"13","author":"R Perez-Tomas","year":"2006","unstructured":"Perez-Tomas R. Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Curr Med Chem. 2006;13:1859\u201376.","journal-title":"Curr Med Chem"},{"key":"4848_CR42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1756-9966-30-104","volume":"30","author":"Y He","year":"2011","unstructured":"He Y, Bi Y, Hua Y, Liu D, Wen S, Wang Q, et al. Ultrasound microbubble-mediated delivery of the siRNAs targeting MDR1 reduces drug resistance of yolk sac carcinoma L2 cells. J Exp Clin Cancer Res. 2011;30:104.","journal-title":"J Exp Clin Cancer Res"},{"key":"4848_CR43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/09674845.2011.11730326","volume":"68","author":"D Lu","year":"2011","unstructured":"Lu D, Shi HC, Wang ZX, Gu XW, Zeng YJ. Multidrug resistance-associated biomarkers PGP, GST-pi, Topo-II and LRP as prognostic factors in primary ovarian carcinoma. Br J Biomed Sci. 2011;68:69\u201374.","journal-title":"Br J Biomed Sci"},{"key":"4848_CR44","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1002\/jcb.23199","volume":"112","author":"A Latifi","year":"2011","unstructured":"Latifi A, Abubaker K, Castrechini N, Ward AC, Liongue C, Dobill F, et al. Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile. J Cell Biochem. 2011;112:2850\u201364.","journal-title":"J Cell Biochem"},{"key":"4848_CR45","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1158\/1078-0432.CCR-06-2313","volume":"13","author":"S Huang","year":"2007","unstructured":"Huang S. Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin Cancer Res. 2007;13:1362\u20136.","journal-title":"Clin Cancer Res"},{"key":"4848_CR46","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1158\/0008-5472.CAN-03-3959","volume":"64","author":"DL Silver","year":"2004","unstructured":"Silver DL, Naora H, Liu J, Cheng W, Montell DJ. Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. Cancer Res. 2004;64:3550\u20138.","journal-title":"Cancer Res"},{"key":"4848_CR47","doi-asserted-by":"crossref","first-page":"17635","DOI":"10.1074\/jbc.M800109200","volume":"283","author":"LY Bourguignon","year":"2008","unstructured":"Bourguignon LY, Peyrollier K, Xia W, Gilad E. Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J Biol Chem. 2008;283:17635\u201351.","journal-title":"J Biol Chem"},{"key":"4848_CR48","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(95)90311-9","volume":"82","author":"Z Wen","year":"1995","unstructured":"Wen Z, Zhong Z, Darnell Jr JE. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 1995;82:241\u201350.","journal-title":"Cell"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-016-4848-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13277-016-4848-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13277-016-4848-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T08:38:29Z","timestamp":1600072709000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13277-016-4848-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,22]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["4848"],"URL":"https:\/\/doi.org\/10.1007\/s13277-016-4848-x","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,22]]}}}