{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:45:27Z","timestamp":1759178727315,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetes Ther"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s13300-018-0498-x","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T14:02:28Z","timestamp":1536588148000},"page":"2043-2053","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Patient Profile with Glycemic Control and Hypoglycemia with Insulin Glargine 300 U\/mL in Type 2 Diabetes: A Post Hoc Patient-Level Meta-Analysis"],"prefix":"10.1007","volume":"9","author":[{"given":"Stephen M.","family":"Twigg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Escalada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Stella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Merino-Trigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando J.","family":"Lavalle-Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Cariou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi F.","family":"Meneghini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"498_CR1","first-page":"206","volume":"31","author":"J Karalliedde","year":"2016","unstructured":"Karalliedde J, Gnudi L. Diabetes mellitus, a complex and heterogeneous disease, and the role of insulin resistance as a determinant of diabetic kidney disease. Nephrol Dial Transplant. 2016;31:206\u201313.","journal-title":"Nephrol Dial Transplant"},{"issue":"Suppl 1","key":"498_CR2","first-page":"S81","volume":"37","author":"Diagnosis and classification of diabetes mellitus","year":"2014","unstructured":"Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37[Suppl 1]:S81\u201390.","journal-title":"Diabetes Care"},{"key":"498_CR3","doi-asserted-by":"publisher","first-page":"140","DOI":"10.2337\/dc14-2441","volume":"38","author":"SE Inzucchi","year":"2015","unstructured":"Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38:140\u20139.","journal-title":"Diabetes Care"},{"key":"498_CR4","doi-asserted-by":"publisher","first-page":"S55","DOI":"10.2337\/dc18-S006","volume":"41","author":"Diabetes A American","year":"2018","unstructured":"American Diabetes Association. 6. Glycemic targets: standards of medical care in diabetes\u20142018. Diabetes Care. 2018;41[Suppl 1]:S55\u201364.","journal-title":"Diabetes Care"},{"key":"498_CR5","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.2337\/dc13-2413","volume":"37","author":"PD Home","year":"2014","unstructured":"Home PD, Shen C, Hasan MI, Latif ZA, Chen JW, Gonzalez Galvez G. Predictive and explanatory factors of change in HbA1c in a 24-week observational study of 66,726 people with type 2 diabetes starting insulin analogs. Diabetes Care. 2014;37:1237\u201345.","journal-title":"Diabetes Care"},{"key":"498_CR6","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1089\/dia.2013.0246","volume":"16","author":"M Hanefeld","year":"2014","unstructured":"Hanefeld M, Fleischmann H, Schiffhorst G, Bramlage P. Predictors of response to early basal insulin treatment in patients with type 2 diabetes\u2014the EARLY experience. Diabetes Technol Ther. 2014;16:241\u20136.","journal-title":"Diabetes Technol Ther"},{"key":"498_CR7","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s40618-014-0069-6","volume":"37","author":"E Mannucci","year":"2014","unstructured":"Mannucci E, Monami M, Dicembrini I, Piselli A, Porta M. Achieving HbA1c targets in clinical trials and in the real world: a systematic review and meta-analysis. J Endocrinol Invest. 2014;37:477\u201395.","journal-title":"J Endocrinol Invest"},{"key":"498_CR8","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.diabres.2014.02.004","volume":"104","author":"A Hsieh","year":"2014","unstructured":"Hsieh A, Ong PX, Molyneaux L, et al. Age of diabetes diagnosis and diabetes duration associate with glycated haemoglobin. Diabetes Res Clin Pract. 2014;104:e1\u20134.","journal-title":"Diabetes Res Clin Pract"},{"key":"498_CR9","doi-asserted-by":"crossref","unstructured":"Becker RH, Dahmen R, Bergmann K, Lehmann A, Jax T, Heise T. New insulin glargine 300 units\u00a0mL\u22121 provides a more even activity profile and prolonged glycemic control at steady state compared with insulin glargine 100 units\u00a0mL\u22121. Diabetes Care. 2015;38(4):637\u201343.","DOI":"10.2337\/dc14-0006"},{"key":"498_CR10","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.2337\/dc14-0991","volume":"37","author":"MC Riddle","year":"2014","unstructured":"Riddle MC, Bolli GB, Ziemen M, Muehlen-Bartmer I, Bizet F, Home PD. New insulin glargine 300 units\/mL versus glargine 100 units\/mL in people with type 2 diabetes using basal and mealtime insulin: glucose control and hypoglycemia in a 6-month randomized controlled trial (EDITION 1). Diabetes Care. 2014;37:2755\u201362.","journal-title":"Diabetes Care"},{"key":"498_CR11","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.2337\/dc14-0990","volume":"37","author":"H Yki-Jarvinen","year":"2014","unstructured":"Yki-Jarvinen H, Bergenstal R, Ziemen M, et al. New insulin glargine 300 units\/mL versus glargine 100 units\/mL in people with type 2 diabetes using oral agents and basal insulin: glucose control and hypoglycemia in a 6-month randomized controlled trial (EDITION 2). Diabetes Care. 2014;37:3235\u201343.","journal-title":"Diabetes Care"},{"key":"498_CR12","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/dom.12438","volume":"17","author":"GB Bolli","year":"2015","unstructured":"Bolli GB, Riddle MC, Bergenstal RM, et al. New insulin glargine 300 U\/ml compared with glargine 100 U\/ml in insulin-naive people with type 2 diabetes on oral glucose-lowering drugs: a randomized controlled trial (EDITION 3). Diabetes Obes Metab. 2015;17:386\u201394.","journal-title":"Diabetes Obes Metab"},{"issue":"9","key":"498_CR13","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1111\/dom.12485","volume":"17","author":"R. Ritzel","year":"2015","unstructured":"Ritzel R, Roussel R, Bolli GB et al. Patient-level meta-analysis of the EDITION 1, 2 and 3 studies: glycaemic control and hypoglycaemia with new insulin glargine 300 U\/ml versus glargine 100 U\/ml in people with type 2 diabetes. Diabetes Obes Metab 2015;17:859\u201367.","journal-title":"Diabetes, Obesity and Metabolism"},{"key":"498_CR14","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. 11. Older adults: standards of medical care in diabetes\u20142018. Diabetes Care. 2018;41[Suppl 1]:S119\u201325.","DOI":"10.2337\/dc18-S011"},{"key":"498_CR15","unstructured":"World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1: diagnosis and classification of diabetes mellitus. Geneva: World Health Organization. 1999."},{"key":"498_CR16","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.2337\/diacare.28.5.1245","volume":"28","author":"ADA Workgroup on Hypoglycemia","year":"2005","unstructured":"ADA Workgroup on Hypoglycemia. Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia. Diabetes Care. 2005;28:1245\u20139.","journal-title":"Diabetes Care"},{"key":"498_CR17","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.diabres.2015.02.034","volume":"108","author":"B Balkau","year":"2015","unstructured":"Balkau B, Calvi-Gries F, Freemantle N, Vincent M, Pilorget V, Home PD. Predictors of HbA1c over 4\u00a0years in people with type 2 diabetes starting insulin therapies: the CREDIT study. Diabetes Res Clin Pract. 2015;108:432\u201340.","journal-title":"Diabetes Res Clin Pract"},{"key":"498_CR18","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.2337\/dc08-0580","volume":"31","author":"J Wong","year":"2008","unstructured":"Wong J, Molyneaux L, Constantino M, Twigg SM, Yue DK. Timing is everything: age of onset influences long-term retinopathy risk in type 2 diabetes, independent of traditional risk factors. Diabetes Care. 2008;31:1985\u201390.","journal-title":"Diabetes Care"},{"key":"498_CR19","doi-asserted-by":"publisher","first-page":"823","DOI":"10.2337\/dc15-0991","volume":"39","author":"AH Al-Saeed","year":"2016","unstructured":"Al-Saeed AH, Constantino MI, Molyneaux L, et al. An inverse relationship between age of type 2 diabetes onset and complication risk and mortality: the impact of youth-onset type 2 diabetes. Diabetes Care. 2016;39:823\u20139.","journal-title":"Diabetes Care"},{"key":"498_CR20","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.2337\/dc14-0990","volume":"37","author":"H Yki-Jarvinen","year":"2014","unstructured":"Yki-Jarvinen H, Bergenstal R, Ziemen M, et al. New insulin glargine 300 units\/mL versus glargine 100 units\/mL in people with type 2 diabetes using oral agents and basal insulin: glucose control and hypoglycemia in a 6-month randomized controlled trial (EDITION 2). Diabetes Care. 2014;37:3235\u201343.","journal-title":"Diabetes Care"},{"key":"498_CR21","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.2337\/dc17-S014","volume":"40","author":"American Diabetes Association","year":"2017","unstructured":"American Diabetes Association. Standards of medical care in diabetes\u2014older adults. Diabetes Care. 2017;40:S99\u2013104.","journal-title":"Diabetes Care"},{"key":"498_CR22","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1093\/gerona\/61.10.1075","volume":"61","author":"J Crandall","year":"2006","unstructured":"Crandall J, Schade D, Ma Y, et al. The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes. J Gerontol A Biol Sci Med Sci. 2006;61:1075\u201381.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"498_CR23","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1056\/NEJMoa012512","volume":"346","author":"WC Knowler","year":"2002","unstructured":"Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393\u2013403.","journal-title":"N Engl J Med"}],"container-title":["Diabetes Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13300-018-0498-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13300-018-0498-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13300-018-0498-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:21:26Z","timestamp":1724412086000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13300-018-0498-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,10]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["498"],"URL":"https:\/\/doi.org\/10.1007\/s13300-018-0498-x","relation":{},"ISSN":["1869-6953","1869-6961"],"issn-type":[{"type":"print","value":"1869-6953"},{"type":"electronic","value":"1869-6961"}],"subject":[],"published":{"date-parts":[[2018,9,10]]},"assertion":[{"value":"10 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2018","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}