{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:30:51Z","timestamp":1773693051430,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T00:00:00Z","timestamp":1579305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T00:00:00Z","timestamp":1579305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901106"],"award-info":[{"award-number":["81901106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jinan clinical medical science and technology innovation plan","award":["201907002"],"award-info":[{"award-number":["201907002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diabetes Ther"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s13300-020-00761-w","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T18:02:10Z","timestamp":1579370530000},"page":"633-642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Metformin Delays the Development of Atherosclerosis in Type 1 Diabetes Mellitus via the Methylglyoxal Pathway"],"prefix":"10.1007","volume":"11","author":[{"given":"Aihong","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxin","family":"Teng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guimei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-1097","authenticated-orcid":false,"given":"Wei","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,18]]},"reference":[{"key":"761_CR1","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMoa1610187","volume":"373","author":"EJ Mayer-Davis","year":"2017","unstructured":"Mayer-Davis EJ, Lawrence JM, Dabelea D, et al. Incidence trends of type 1 and type 2 diabetes among youths, 2002\u20132012. New Eng J Med. 2017;373:1419\u201329.","journal-title":"New Eng J Med"},{"key":"761_CR2","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1056\/NEJMoa1608664","volume":"376","author":"A Rawshani","year":"2017","unstructured":"Rawshani A, Rawshani A, Franz\u00e9n S, et al. Mortality and cardiovascular disease in type 1 and type 2 diabetes. N Engl J Med. 2017;376:1407\u201318.","journal-title":"N Engl J Med"},{"key":"761_CR3","doi-asserted-by":"publisher","first-page":"805","DOI":"10.2337\/dc13-1634","volume":"37","author":"ML Marcovecchio","year":"2014","unstructured":"Marcovecchio ML, Woodside J, Jones T, et al. Adolescent type 1 diabetes cardio-renal intervention trial (AdDIT): urinary screening and baseline biochemical and cardiovascular assessments. Diabetes Care. 2014;37:805\u201313.","journal-title":"Diabetes Care"},{"key":"761_CR4","doi-asserted-by":"publisher","first-page":"4448","DOI":"10.1210\/jc.2017-00781","volume":"102","author":"JJA Anderson","year":"2017","unstructured":"Anderson JJA, Couper JJ, Giles LC, et al. Effect of metformin on vascular function in children with type 1 diabetes: a 12-month randomized controlled trial. J Clin Endocrinol Metab. 2017;102:4448\u201356.","journal-title":"J Clin Endocrinol Metab"},{"key":"761_CR5","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S2213-8587(17)30194-8","volume":"5","author":"JR Petrie","year":"2017","unstructured":"Petrie JR, Chaturvedi N, Ford I, et al. Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol. 2017;5:597\u2013609.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"761_CR6","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1007\/s00125-011-2241-2","volume":"54","author":"M Nagashima","year":"2011","unstructured":"Nagashima M, Watanabe T, Terasaki M, et al. Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice. Diabetologia. 2011;54:2649\u201359.","journal-title":"Diabetologia"},{"key":"761_CR7","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1161\/CIRCULATIONAHA.107.712539","volume":"117","author":"T Watanabe","year":"2008","unstructured":"Watanabe T, Nishio K, Kanome T, et al. Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis. Circulation. 2008;117:638\u201348.","journal-title":"Circulation"},{"key":"761_CR8","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1161\/CIRCRESAHA.109.193870","volume":"105","author":"G Xu","year":"2009","unstructured":"Xu G, Watanabe T, Iso Y, et al. Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. Circ Res. 2009;105:500\u201310.","journal-title":"Circ Res"},{"key":"761_CR9","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.joca.2012.02.010","volume":"20","author":"C Kilkenny","year":"2012","unstructured":"Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. Osteoarthr Cartil. 2012;20:256\u201360.","journal-title":"Osteoarthr Cartil"},{"key":"761_CR10","doi-asserted-by":"publisher","first-page":"e70933","DOI":"10.1371\/journal.pone.0070933","volume":"8","author":"M Terasaki","year":"2013","unstructured":"Terasaki M, Nagashima M, Nohtomi K, et al. Preventive effect of dipeptidyl peptidase-4 inhibitor on atherosclerosis is mainly attributable to incretin's actions in nondiabetic and diabetic apolipoprotein E-null mice. PLoS One. 2013;8:e70933.","journal-title":"PLoS One"},{"key":"761_CR11","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s00125-011-2365-4","volume":"55","author":"Y Takeda","year":"2012","unstructured":"Takeda Y, Fujita Y, Honjo J, et al. Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice. Diabetologia. 2012;55:404\u201312.","journal-title":"Diabetologia"},{"key":"761_CR12","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/1476-511X-11-166","volume":"11","author":"H Sang","year":"2012","unstructured":"Sang H, Yuan N, Yao S, et al. Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in ApoE-deficient mice. Lipids Health Dis. 2012;11:166.","journal-title":"Lipids Health Dis"},{"key":"761_CR13","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0021-9150(00)00685-7","volume":"157","author":"P Keren","year":"2001","unstructured":"Keren P, George J, Keren G, Harats D. Non-obese diabetic (NOD) mice exhibit an increased cellular immune response to glycated-LDL but are resistant to high fat diet induced atherosclerosis. Atherosclerosis. 2001;157:285\u201392.","journal-title":"Atherosclerosis"},{"key":"761_CR14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/0092-8674(92)90362-G","volume":"71","author":"AS Plump","year":"1992","unstructured":"Plump AS, Smith JD, Hayek T, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343\u201353.","journal-title":"Cell"},{"key":"761_CR15","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.2337\/db14-1225","volume":"64","author":"SB Vasamsetti","year":"2015","unstructured":"Vasamsetti SB, Karnewar S, Kanugula AK, Thatipalli AR, Kumar JM, Kotamraju S. Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis. Diabetes. 2015;64:2028\u201341.","journal-title":"Diabetes"},{"key":"761_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/joim.12128","volume":"275","author":"J de Jager","year":"2014","unstructured":"de Jager J, Kooy A, Schalkwijk C, et al. Long-term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial. J Intern Med. 2014;275:59\u201370.","journal-title":"J Intern Med"},{"key":"761_CR17","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1089\/ars.2013.5537","volume":"20","author":"N Hermida","year":"2014","unstructured":"Hermida N, Balligand JL. Low-density lipoprotein\u2013cholesterol-induced endothelial dysfunction and oxidative stress: the role of statins. Antioxid Redox Signal. 2014;20:1216\u201337.","journal-title":"Antioxid Redox Signal"},{"key":"761_CR18","doi-asserted-by":"publisher","first-page":"198","DOI":"10.2337\/diabetes.48.1.198","volume":"48","author":"PJ Beisswenger","year":"1999","unstructured":"Beisswenger PJ, Howell SK, Touchette AD, Lal S, Szwergold BS. Metformin reduces systemic methylglyoxal levels in type 2 diabetes. Diabetes. 1999;48:198\u2013202.","journal-title":"Diabetes"},{"issue":"829\u2013837","key":"761_CR19","first-page":"837a","volume":"33","author":"U Forstermann","year":"2012","unstructured":"Forstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J. 2012;33(829\u2013837):837a\u2013837d.","journal-title":"Eur Heart J"},{"key":"761_CR20","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1042\/BST20130275","volume":"42","author":"PJ Beisswenger","year":"2014","unstructured":"Beisswenger PJ. Methylglyoxal in diabetes: link to treatment, glycaemic control and biomarkers of complications. Biochem Soc Trans. 2014;42:450\u20136.","journal-title":"Biochem Soc Trans"},{"key":"761_CR21","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1471-2431-9-79","volume":"9","author":"Adolescent type 1 Diabetes cardio-renal Intervention Trial Research Group","year":"2009","unstructured":"Adolescent type 1 Diabetes cardio-renal Intervention Trial Research Group. Adolescent type 1 diabetes cardio-renal intervention trial (AdDIT). BMC Pediatr. 2009;9:79. https:\/\/doi.org\/10.1186\/1471-2431-9-79.","journal-title":"BMC Pediatr"},{"key":"761_CR22","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1042\/bj20030763","volume":"375","author":"PJ Thornalley","year":"2003","unstructured":"Thornalley PJ, Battah S, Ahmed N, et al. Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry. Biochem J. 2003;375:581\u201392.","journal-title":"Biochem J"},{"issue":"2","key":"761_CR23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1177\/1479164114560910","volume":"12","author":"M Heier","year":"2015","unstructured":"Heier M, Margeirsdottir HD, Torjesen PA, et al. The advanced glycation end product methylglyoxal-derived hydroimidazolone-1 and early signs of atherosclerosis in childhood diabetes. Diabetes Vasc Dis Res. 2015;12(2):139\u201345.","journal-title":"Diabetes Vasc Dis Res"},{"key":"761_CR24","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1016\/S0006-2952(99)00263-4","volume":"58","author":"D Ruggiero-Lopez","year":"1999","unstructured":"Ruggiero-Lopez D, Lecomte M, Moinet G, Patereau G, Lagarde M, Wiernsperger N. Reaction of metformin with dicarbonyl compounds. Possible implication in the inhibition of advanced glycation end product formation. Biochem Pharmacol. 1999;58:1765\u201373.","journal-title":"Biochem Pharmacol"},{"key":"761_CR25","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.2337\/db09-1455","volume":"59","author":"N Rabbani","year":"2010","unstructured":"Rabbani N, Chittari BCW, Zehnder D, Ceriello A, Thornalley PJ. Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin. Diabetes. 2010;59:1038\u201345.","journal-title":"Diabetes"}],"container-title":["Diabetes Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13300-020-00761-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13300-020-00761-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13300-020-00761-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:14:26Z","timestamp":1724411666000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13300-020-00761-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,18]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["761"],"URL":"https:\/\/doi.org\/10.1007\/s13300-020-00761-w","relation":{},"ISSN":["1869-6953","1869-6961"],"issn-type":[{"value":"1869-6953","type":"print"},{"value":"1869-6961","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,18]]},"assertion":[{"value":"20 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}